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Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase

  • Authors:
    • Song-Tao Tang
    • Huan Su
    • Qiu Zhang
    • Hai-Qin Tang
    • Chang-Jiang Wang
    • Qing Zhou
    • Wei Wei
    • Hua-Qing Zhu
    • Yuan Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Clinical Pharmacology, Anhui Medical University, Hefei, Anhui, P.R. China, Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Hefei, Anhui, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R. China, Department of Geriatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1558-1566
    |
    Published online on: April 26, 2016
       https://doi.org/10.3892/ijmm.2016.2578
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Abstract

Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors, including sitagliptin, exert favourable effects on the vascular endothelium. DPP-4 inhibitors suppress the degradation of glucagon-like peptide-1 (GLP‑1), which has been reported to enhance nitric oxide (NO) production. However, the effects of DPP-4 inhibitors on endothelin-1 (ET-1) expression in the aorta, as well as the underlying mechanisms responsible for these effects, have yet to be investigated in animal models of diabetes mellitus (DM). In the present study, the rats were randomly divided into the following four groups: i) control; ii) DM; iii) DM + low‑dose sitagliptin (10 mg/kg); and iv) DM + high‑dose sitagliptin (30 mg/kg). Apart from the control group, all the rats received a high-fat diet for 8 weeks prior to the induction of diabetes with an intraperitoneal injection of streptozotocin. The treatments were then administered for 12 weeks. The serum levels of ET-1, NO, GLP-1 and insulin were measured as well as endothelial function. The expression of ET-1, AMP-activated protein kinase (AMPK) and nuclear factor (NF)-κB/IκBα were determined. After 12 weeks of treatment, the diabetic rats receiving sitagliptin showed significantly elevated serum levels of GLP-1 and NO, and reduced levels of ET-1. Moreover, sitagliptin significantly attenuated endothelial dysfunction as well as the remodeling of the aortic wall. Notably, sitagliptin inhibited ET-1 expression at the transcriptional and translational level in the aorta, which may have been mediated by the suppression of the NF-κB/IκBα system induced by AMPK activation. The majority of the above-mentioned effects were dose dependent. Taken together, the findings of the present study indicate that sitagliptin inhibits ET-1 expression in the aortic endothelium by suppressing the NF-κB/IκBα system through the activation of the AMPK pathway in diabetic rats. These findings further demonstrate some of the vasoprotective properties of DPP-4 inhibitors in vivo.
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1 

Wang J, Luben R, Khaw KT, Bingham S, Wareham NJ and Forouhi NG: Dietary energy density predicts the risk of clinically incident type 2 diabetes: the EPIC-Norfolk study. Diabetes Care. 31:2120–2125. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Wilmot EG, Edwardson CL, Achana FA, Davies MJ, Gorely T, Gray LJ, Khunti K, Yates T and Biddle SJ: Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis. Diabetologia. 55:2895–2905. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Li J, Dong Y, Wu T and Tong N: Differences between western and Asian type 2 diabetes patients in the incidence of vascular complications and mortality: A systematic review of randomized controlled trials on lowering blood glucose. J Diabetes. Dec 11–2015.Epub ahead of print. View Article : Google Scholar

4 

Sena CM, Pereira AM and Seiça R: Endothelial dysfunction - a major mediator of diabetic vascular disease. Biochim Biophys Acta. 1832:2216–2231. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Roberts AC and Porter KE: Cellular and molecular mechanisms of endothelial dysfunction in diabetes. Diab Vasc Dis Res. 10:472–482. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Drucker DJ: Glucagon-like peptides. Diabetes. 47:159–169. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Luft VC, Schmidt MI, Pankow JS, Hoogeveen RC, Couper D, Heiss G and Duncan BB; Atherosclerosis Risk in Communities Investigators: Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care. 33:1109–1011. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Matheeussen V1, Waumans Y, Martinet W, Van Goethem S, Van der Veken P, Scharpé S, Augustyns K, De Meyer GR and De Meester I: Dipeptidyl peptidase in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis. Basic Res Cardiol. 108(350)2013. View Article : Google Scholar

9 

Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ and Husain M: Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation. 117:2340–2350. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Nyström T1, Gutniak MK, Zhang Q, Zhang F, Holst JJ, Ahrén B and Sjöholm A: Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab. 287:E1209–E1215. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Noyan-Ashraf MH, Shikatani EA, Schuiki I, Mukovozov I, Wu J, Li RK, Volchuk A, Robinson LA, Billia F, Drucker DJ and Husain M: A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation. 127:74–85. 2013. View Article : Google Scholar

12 

Vittone F, Liberman A, Vasic D, Ostertag R, Esser M, Walcher D, Ludwig A, Marx N and Burgmaier M: Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (−/−) mice. Diabetologia. 55:2267–2275. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Shah Z1, Kampfrath T, Deiuliis JA, Zhong J, Pineda C, Ying Z, Xu X, Lu B, Moffatt-Bruce S, Durairaj R, et al: Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation. 124:2338–2349. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, et al: A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J Am Coll Cardiol. 59:265–276. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Han L, Yu Y, Sun X and Wang B: Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways. Diabetes Res Clin Pract. 97:453–460. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Chen YX, Wang XQ, Fu Y, Yao YJ, Kong MY, Nie RQ and Wang JF: Pivotal role of inflammation in vascular endothelial dysfunction of hyperlipidemic rabbit and effects by atorvastatin. Int J Cardiol. 146:140–144. 2011. View Article : Google Scholar

17 

Drolet MC, Plante E, Battistini B, Couet J and Arsenault M: Early endothelial dysfunction in cholesterol-fed rabbits: a non-invasive in vivo ultrasound study. Cardiovasc Ultrasound. 2(10)2004. View Article : Google Scholar : PubMed/NCBI

18 

Tang ST, Su H, Zhang Q, Tang HQ, Wang CJ, Zhou Q, Wei W, Zhu HQ and Wang Y: Melatonin attenuates aortic endothelial permeability and arteriosclerosis in streptozotocin-induced diabetic rats: possible role of MLCK- and MLCP-dependent MLC phosphorylation. J Cardiovasc Pharmacol Ther. 21:82–92. 2016. View Article : Google Scholar

19 

Zhou B1, Pan Y, Hu Z, Wang X, Han J, Zhou Q, Zhai Z and Wang Y: All-trans-retinoic acid ameliorated high fat diet-induced atherosclerosis in rabbits by inhibiting platelet activation and inflammation. J Biomed Biotechnol. 2012(259693)2012. View Article : Google Scholar

20 

Picatoste B1, Ramírez E, Caro-Vadillo A, Iborra C, Ares-Carrasco S, Egido J, Tuñón J and Lorenzo O: Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms. PLoS One. 8:e783302013. View Article : Google Scholar : PubMed/NCBI

21 

Zhao HJ, Xu Q, Zhang GY, Liu Y, Yu T, Li HY, Yang LN, Wang HY and Xie LB: Therapeutic effects of GLP-1 analog on rats with experimental diabetes mellitus. J Jilin University. 33:474–479. 2007.

22 

Pasterkamp G: Methods of accelerated atherosclerosis in diabetic patients. Heart. 99:743–749. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Böhm F and Pernow J: The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. Cardiovasc Res. 76:8–18. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Cicek FA, Kandilci HB and Turan B: Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta. Cardiovasc Diabetol. 12(51)2013. View Article : Google Scholar : PubMed/NCBI

25 

Piechota A and Goraca A: Influence of nuclear factor-κB inhibition on endothelin-1 induced lung edema and oxidative stress in rats. J Physiol Pharmacol. 62:183–188. 2011.PubMed/NCBI

26 

Quehenberger P, Bierhaus A, Fasching P, Muellner C, Klevesath M, Hong M, Stier G, Sattler M, Schleicher E, Speiser W and Nawroth PP: Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE- stimulated cultured endothelial cells. Diabetes. 49:1561–1570. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Ho FM, Lin WW, Chen BC, Chao CM, Yang CR, Lin LY, Lai CC, Liu SH and Liau CS: High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt eNOS pathway. Cell Signal. 18:391–399. 2006. View Article : Google Scholar

28 

Suzuki J, Ogawa M, Muto S, Itai A, Isobe M, Hirata Y and Nagai R: Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases. Expert Opin Investig Drugs. 20:395–405. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R and Watada H: Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes. 59:1030–1037. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Hattori Y, Jojima T, Tomizawa A, Satoh H, Hattori S, Kasai K and Hayashi T: A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells. Diabetologia. 53:2256–2563. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Zeng Y, Li C, Guan M, Zheng Z, Li J, Xu W, Wang L, He F and Xue Y: The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK-and MAPK-dependent mechanisms. Cardiovasc Diabetol. 13(32)2014. View Article : Google Scholar

32 

Dai Y, Mehta JL and Chen M: Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation. Cardiovasc Drugs Ther. 27:371–380. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang S, Su H, Zhang Q, Tang H, Wang C, Zhou Q, Wei W, Zhu H and Wang Y: Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase. Int J Mol Med 37: 1558-1566, 2016.
APA
Tang, S., Su, H., Zhang, Q., Tang, H., Wang, C., Zhou, Q. ... Wang, Y. (2016). Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase. International Journal of Molecular Medicine, 37, 1558-1566. https://doi.org/10.3892/ijmm.2016.2578
MLA
Tang, S., Su, H., Zhang, Q., Tang, H., Wang, C., Zhou, Q., Wei, W., Zhu, H., Wang, Y."Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase". International Journal of Molecular Medicine 37.6 (2016): 1558-1566.
Chicago
Tang, S., Su, H., Zhang, Q., Tang, H., Wang, C., Zhou, Q., Wei, W., Zhu, H., Wang, Y."Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase". International Journal of Molecular Medicine 37, no. 6 (2016): 1558-1566. https://doi.org/10.3892/ijmm.2016.2578
Copy and paste a formatted citation
x
Spandidos Publications style
Tang S, Su H, Zhang Q, Tang H, Wang C, Zhou Q, Wei W, Zhu H and Wang Y: Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase. Int J Mol Med 37: 1558-1566, 2016.
APA
Tang, S., Su, H., Zhang, Q., Tang, H., Wang, C., Zhou, Q. ... Wang, Y. (2016). Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase. International Journal of Molecular Medicine, 37, 1558-1566. https://doi.org/10.3892/ijmm.2016.2578
MLA
Tang, S., Su, H., Zhang, Q., Tang, H., Wang, C., Zhou, Q., Wei, W., Zhu, H., Wang, Y."Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase". International Journal of Molecular Medicine 37.6 (2016): 1558-1566.
Chicago
Tang, S., Su, H., Zhang, Q., Tang, H., Wang, C., Zhou, Q., Wei, W., Zhu, H., Wang, Y."Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase". International Journal of Molecular Medicine 37, no. 6 (2016): 1558-1566. https://doi.org/10.3892/ijmm.2016.2578
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