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Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis

  • Authors:
    • Zixuan Yang
    • Zibiao Zhong
    • Mingxia Li
    • Yan Xiong
    • Yanfeng Wang
    • Guizhu Peng
    • Qifa Ye
  • View Affiliations / Copyright

    Affiliations: Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 161-171
    |
    Published online on: May 12, 2016
       https://doi.org/10.3892/ijmm.2016.2586
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Abstract

There is an urgent need to improve the quality of donor organs obtained after cardiac death. In the present study, we examined the potential mechanisms through which A20 protects renal cells against ischemia/reperfusion injury (IRI) following either hypothermic machine perfusion (HMP) or static cold storage (CS) of the kidneys in a rabbit model. The expression of markers of apoptosis, necroptosis and inflammation in frozen kidney tissues were detected by western blot analysis, RT-qPCR and ELISA. Compared with the CS group, A20 expression was significantly higher in the tissue from the HMP group (P<0.01). By contrast, the expression of nuclear factor-κB (NF-κB) and tumor necrosis factor-α (TNF-α) was significantly lower in HMP group (P<0.01), whereas IκBα expression was significantly higher (P<0.01). The expression of apoptosis signal-regulating kinase 1 (ASK1), phosphorylated (p-)c-Jun N-terminal kinase (JNK) and activated caspase-3 in the HMP group was significantly downregulated compared with that in the CS group (all P<0.01). In addition, A20 inhibited receptor-interacting protein kinase 3 (RIPK3)‑mediated necroptosis in the kidney. RIPK3 expression in the HMP group was significantly lower than that in the CS group (P<0.01), although the levels in both groups were higher than those in the sham group (P<0.01). Based on these findings, we propose a novel mechanism underlying the anti-apoptotic effect of A20 in renal cells in which A20 binds to ASK1 and promotes the degradation of ASK1 leading to the suppression of JNK activation and eventually, to the blockade of apoptosis. Thus, HMP reduces inflammation, apoptosis and necroptosis by upregulating the expression of A20; this mechanism may be responsible for protecting the kidney against IRI.
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1 

Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, Held PJ and Port FK: Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 341:1725–1730. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Nicholson ML, Metcalfe MS, White SA, Waller JR, Doughman TM, Horsburgh T, Feehally J, Carr SJ and Veitch PS: A comparison of the results of renal transplantation from non-heart-beating, conventional cadaveric, and living donors. Kidney Int. 58:2585–2591. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Perico N, Cattaneo D, Sayegh MH and Remuzzi G: Delayed graft function in kidney transplantation. Lancet. 364:1814–1827. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Curci C, Castellano G, Stasi A, Divella C, Loverre A, Gigante M, Simone S, Cariello M, Montinaro V, Lucarelli G, et al: Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway. Nephrol Dial Transplant. 29:799–808. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Gueler F, Gwinner W, Schwarz A and Haller H: Long-term effects of acute ischemia and reperfusion injury. Kidney Int. 66:523–527. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Kosieradzki M and Rowiński W: Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention. Transplant Proc. 40:3279–3288. 2008. View Article : Google Scholar : PubMed/NCBI

7 

St Peter SD, Imber CJ and Friend PJ: Liver and kidney preservation by perfusion. Lancet. 359:604–613. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Moers C, Smits JM, Maathuis MH, Treckmann J, van Gelder F, Napieralski BP, van Kasterop-Kutz M, van der Heide JJ, Squifflet JP, van Heurn E, et al: Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med. 360:7–19. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Moers C, Pirenne J, Paul A and Ploeg RJ; Machine Preservation Trial Study Group: Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med. 366:770–771. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Y, Fu Z, Zhong Z, Wang R, Hu L, Xiong Y, Wang Y and Ye Q: Hypothermic machine perfusion decreases renal cell apoptosis during ischemia/reperfusion injury via the Ezrin/AKT pathway. Artif Organs. 40:129–135. 2016. View Article : Google Scholar

11 

Schold JD, Kaplan B, Howard RJ, Reed AI, Foley DP and Meier-Kriesche HU: Are we frozen in time? Analysis of the utilization and efficacy of pulsatile perfusion in renal transplantation. Am J Transplant. 5:1681–1688. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Eddy AA: Progression in chronic kidney disease. Adv Chronic Kidney Dis. 12:353–365. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Akcay A, Nguyen Q and Edelstein CL: Mediators of inflammation in acute kidney injury. Mediators Inflamm. 2009:1370722009. View Article : Google Scholar

14 

Kono H, Nakagawa K, Morita S, Shinoda K, Mizuno R, Kikuchi E, Miyajima A, Umezawa K and Oya M: Effect of a novel nuclear factor-κB activation inhibitor on renal ischemia-reperfusion injury. Transplantation. 96:863–870. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Latanich CA and Toledo-Pereyra LH: Searching for NF-kappaB-based treatments of ischemia reperfusion injury. J Invest Surg. 22:301–315. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Cao CC, Ding XQ, Ou ZL, Liu CF, Li P, Wang L and Zhu CF: In vivo transfection of NF-kappaB decoy oligodeoxynucleotides attenuate renal ischemia/reperfusion injury in rats. Kidney Int. 65:834–845. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Hatada EN, Krappmann D and Scheidereit C: NF-kappaB and the innate immune response. Curr Opin Immunol. 12:52–58. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Daemen MA, van't Veer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M, Vandenabeele P and Buurman WA: Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest. 104:541–549. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Linkermann A and Green DR: Necroptosis. N Engl J Med. 370:455–465. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Kaushal GP, Basnakian AG and Shah SV: Apoptotic pathways in ischemic acute renal failure. Kidney Int. 66:500–506. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Kaushal GP, Kaushal V, Hong X and Shah SV: Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells. Kidney Int. 60:1726–1736. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Lau A, Wang S, Jiang J, Haig A, Pavlosky A, Linkermann A, Zhang ZX and Jevnikar AM: RIPK3-mediated necroptosis promotes donor kidney inflammatory injury and reduces allograft survival. Am J Transplant. 13:2805–2818. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Opipari AW Jr, Boguski MS and Dixit VM: The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. 265:14705–14708. 1990.PubMed/NCBI

24 

Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP and Ma A: Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science. 289:2350–2354. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, et al: The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol. 5:1052–1060. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Catrysse L, Vereecke L, Beyaert R and van Loo G: A20 in inflammation and autoimmunity. Trends Immunol. 35:22–31. 2014. View Article : Google Scholar

27 

Ma A and Malynn BA: A20: Linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol. 12:774–785. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Daniel S, Arvelo MB, Patel VI, Longo CR, Shrikhande G, Shukri T, Mahiou J, Sun DW, Mottley C, Grey ST and Ferran C: A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood. 104:2376–2384. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Kunter U, Daniel S, Arvelo MB, Choi J, Shukri T, Patel VI, Longo CR, Scali ST, Shrikhande G, Rocha E, et al: Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. Kidney Int. 68:1520–1532. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Grey ST, Longo C, Shukri T, Patel VI, Csizmadia E, Daniel S, Arvelo MB, Tchipashvili V and Ferran C: Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. J Immunol. 170:6250–6256. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Coornaert B, Carpentier I and Beyaert R: A20: Central gatekeeper in inflammation and immunity. J Biol Chem. 284:8217–8221. 2009. View Article : Google Scholar :

32 

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, et al: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 16:618–627. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Bodonyi-Kovacs G, Strom TB and Putheti P: A20 - a biomarker of allograft outcome: a showcase in kidney transplantation. Adv Exp Med Biol. 809:103–116. 2014. View Article : Google Scholar

34 

Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, Sun L, Chen ZJ, Marynen P and Beyaert R: T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol. 9:263–271. 2008. View Article : Google Scholar : PubMed/NCBI

35 

De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, Cong R and Franzoso G: Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature. 414:308–313. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M and Lin A: Inhibition of JNK activation through NF-kappaB target genes. Nature. 414:313–317. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC and Karin M: The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 124:601–613. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Vanden Berghe T, Grootjans S, Goossens V, Dondelinger Y, Krysko DV, Takahashi N and Vandenabeele P: Determination of apoptotic and necrotic cell death in vitro and in vivo. Methods. 61:117–129. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Barba J, Zudaire JJ, Robles JE, Rosell D, Berian JM and Pascual I: Complications of kidney transplantation with grafts from expanded criteria donors. World J Urol. 31:893–900. 2013. View Article : Google Scholar

40 

McLaren AJ, Jassem W, Gray DW, Fuggle SV, Welsh KI and Morris PJ: Delayed graft function: risk factors and the relative effects of early function and acute rejection on long-term survival in cadaveric renal transplantation. Clin Transplant. 13:266–272. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Padanilam BJ: Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol. 284:F608–F627. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Bonegio R and Lieberthal W: Role of apoptosis in the pathogenesis of acute renal failure. Curr Opin Nephrol Hypertens. 11:301–308. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Bonventre JV and Zuk A: Ischemic acute renal failure: an inflammatory disease? Kidney Int. 66:480–485. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Linkermann A, Bräsen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U and Krautwald S: Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int. 81:751–761. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Toronyi E: Role of apoptosis in the kidney after reperfusion. Orv Hetil. 149:305–315. 2008.In Hungarian. View Article : Google Scholar : PubMed/NCBI

46 

da Silva CG, Maccariello ER, Wilson SW, Putheti P, Daniel S, Damrauer SM, Peterson CR, Siracuse JJ, Kaczmarek E and Ferran C: Hepatocyte growth factor preferentially activates the anti-inflammatory arm of NF-κB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation. J Cell Physiol. 227:1382–1390. 2012. View Article : Google Scholar :

47 

Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG and Karin M: NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 453:807–811. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Li C and Jackson RM: Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol. 282:C227–C241. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Grey ST, Arvelo MB, Hasenkamp W, Bach FH and Ferran C: A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets. J Exp Med. 190:1135–1146. 1999. View Article : Google Scholar : PubMed/NCBI

50 

Arvelo MB, Cooper JT, Longo C, Daniel S, Grey ST, Mahiou J, Czismadia E, Abu-Jawdeh G and Ferran C: A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. Hepatology. 35:535–543. 2002. View Article : Google Scholar : PubMed/NCBI

51 

Lutz J, Luong A, Strobl M, Deng M, Huang H, Anton M, Zakkar M, Enesa K, Chaudhury H, Haskard DO, et al: The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. J Mol Med Berl. 86:1329–1339. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Opipari AW Jr, Hu HM, Yabkowitz R and Dixit VM: The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem. 267:12424–12427. 1992.PubMed/NCBI

53 

Hess S, Gottfried E, Smola H, Grunwald U, Schuchmann M and Engelmann H: CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell line. Eur J Immunol. 28:3594–3604. 1998. View Article : Google Scholar : PubMed/NCBI

54 

Heyninck K, Denecker G, De Valck D, Fiers W and Beyaert R: Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20. Anticancer Res. 19:2863–2868. 1999.

55 

Lademann U, Kallunki T and Jäättelä M: A20 zinc finger protein inhibits TNF-induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins. Cell Death Differ. 8:265–272. 2001. View Article : Google Scholar : PubMed/NCBI

56 

Du C, Guan Q, Yin Z, Zhong R and Jevnikar AM: IL-2-mediated apoptosis of kidney tubular epithelial cells is regulated by the caspase-8 inhibitor c-FLIP. Kidney Int. 67:1397–1409. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Du C, Wang S, Diao H, Guan Q, Zhong R and Jevnikar AM: Increasing resistance of tubular epithelial cells to apoptosis by shRNA therapy ameliorates renal ischemia-reperfusion injury. Am J Transplant. 6:2256–2267. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Won M, Park KA, Byun HS, Sohn KC, Kim YR, Jeon J, Hong JH, Park J, Seok JH, Kim JM, et al: Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation. Cell Death Differ. 17:1830–1841. 2010. View Article : Google Scholar : PubMed/NCBI

59 

Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Z, Takubo K, Suda T, Oda H, et al: Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. PLoS One. 9:e874252014. View Article : Google Scholar : PubMed/NCBI

60 

Zamzami N and Kroemer G: The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol. 2:67–71. 2001. View Article : Google Scholar : PubMed/NCBI

61 

Cho BB and Toledo-Pereyra LH: Caspase-independent programmed cell death following ischemic stroke. J Invest Surg. 21:141–147. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Peltz M, He TT, Adams GA IV, Koshy S, Burgess SC, Chao RY, Meyer DM and Jessen ME: Perfusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex vivo rat heart transplantation model. Surgery. 138:795–805. 2005. View Article : Google Scholar : PubMed/NCBI

63 

Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, et al: Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 19:107–120. 2012. View Article : Google Scholar :

64 

Chan FK: Fueling the flames: mammalian programmed necrosis in inflammatory diseases. Cold Spring Harb Perspect Biol. 4:a0088052012. View Article : Google Scholar : PubMed/NCBI

65 

Kaczmarek A, Vandenabeele P and Krysko DV: Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity. 38:209–223. 2013. View Article : Google Scholar : PubMed/NCBI

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Yang Z, Zhong Z, Li M, Xiong Y, Wang Y, Peng G and Ye Q: Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis. Int J Mol Med 38: 161-171, 2016.
APA
Yang, Z., Zhong, Z., Li, M., Xiong, Y., Wang, Y., Peng, G., & Ye, Q. (2016). Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis. International Journal of Molecular Medicine, 38, 161-171. https://doi.org/10.3892/ijmm.2016.2586
MLA
Yang, Z., Zhong, Z., Li, M., Xiong, Y., Wang, Y., Peng, G., Ye, Q."Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis". International Journal of Molecular Medicine 38.1 (2016): 161-171.
Chicago
Yang, Z., Zhong, Z., Li, M., Xiong, Y., Wang, Y., Peng, G., Ye, Q."Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis". International Journal of Molecular Medicine 38, no. 1 (2016): 161-171. https://doi.org/10.3892/ijmm.2016.2586
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Z, Zhong Z, Li M, Xiong Y, Wang Y, Peng G and Ye Q: Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis. Int J Mol Med 38: 161-171, 2016.
APA
Yang, Z., Zhong, Z., Li, M., Xiong, Y., Wang, Y., Peng, G., & Ye, Q. (2016). Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis. International Journal of Molecular Medicine, 38, 161-171. https://doi.org/10.3892/ijmm.2016.2586
MLA
Yang, Z., Zhong, Z., Li, M., Xiong, Y., Wang, Y., Peng, G., Ye, Q."Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis". International Journal of Molecular Medicine 38.1 (2016): 161-171.
Chicago
Yang, Z., Zhong, Z., Li, M., Xiong, Y., Wang, Y., Peng, G., Ye, Q."Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis". International Journal of Molecular Medicine 38, no. 1 (2016): 161-171. https://doi.org/10.3892/ijmm.2016.2586
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