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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2016 Volume 38 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)

Masaru Katoh
Pages: 3-15
Published online on: 31 May 2016

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Review

Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)

Hwa Jun Cha, Congfen He, Hua Zhao, Yinmao Dong, In-Sook An, Sungkwan An
Pages: 16-22
Published online on: 20 May 2016

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Review Open Access

Advances in stem cell therapy for cardiovascular disease (Review)

Rongrong Sun, Xianchi Li, Min Liu, Yi Zeng, Shuang Chen, Peying Zhang
Pages: 23-29
Published online on: 25 May 2016

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Article Open Access

Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion

Xiaochen Yang, Florian Steinberg, Lei Zhuang, Ralph Bessey, Beat Trueb
Pages: 30-38
Published online on: 23 May 2016

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Article Open Access

Identification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screening

Nana Gao, Jixia Ren, Li Hou, Yue Zhou, Ling Xin, Jiedong Wang, Heming Yu, Yong Xie, Huiping Wang
Pages: 39-44
Published online on: 23 May 2016

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Article Open Access

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

Baoxia Dong, Ally-Khan Somani, Paul E. Love, Xuan Zheng, Xiequn Chen, Jinyi Zhang
Pages: 45-56
Published online on: 17 May 2016

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Article Open Access

Magnetically induced electrostimulation of human osteoblasts results in enhanced cell viability and osteogenic differentiation

Bettina Hiemer, Josefin Ziebart, Anika Jonitz-Heincke, Philip Christian Grunert, Yukun Su, Doris Hansmann, Rainer Bader
Pages: 57-64
Published online on: 16 May 2016

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Article Open Access

Correlation of 5-HTT, BDNF and NPSR1 gene polymorphisms with anxiety and depression in asthmatic patients

Yuan Yang, Mingzhe Zhao, Yuqun Zhang, Xinhua Shen, Yonggui Yuan
Pages: 65-74
Published online on: 09 May 2016

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Article Open Access

Involvement of NADPH oxidases in alkali burn-induced corneal injury

Xue-Jun Gu, Xian Liu, Ying-Ying Chen, Yao Zhao, Man Xu, Xiao-Jian Han, Qiu-Ping Liu, Jing-Lin Yi, Jing-Ming Li
Pages: 75-82
Published online on: 17 May 2016

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Article Open Access

Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway Corrigendum in /10.3892/ijmm.2021.5045

Tianxin Hu, Guo Wei, Miaomiao Xi, Jiajia Yan, Xiaoxiao Wu, Yanhua Wang, Yanrong Zhu, Chao Wang, Aidong Wen
Pages: 83-94
Published online on: 11 May 2016

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Article Open Access

In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse

Xiuhui Chen, Xianchao Kong, Dongzhe Liu, Peng Gao, Yanhua Zhang, Peiling Li, Meimei Liu
Pages: 95-104
Published online on: 17 May 2016

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Article Open Access

GABA A receptor π subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia

Junjie Lu, Qian Zhang, Dongmei Tan, Wenping Luo, Hai Zhao, Jing Ma, Hao Liang, Yi Tan
Pages: 105-112
Published online on: 25 May 2016

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Article Open Access

miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression

Sen Jiang, Chao Zhao, Xiaodi Yang, Xiangyang Li, Qing Pan, Haijin Huang, Xuyang Wen, Husheng Shan, Qianwen Li, Yunxiang Du, Yaping Zhao
Pages: 113-122
Published online on: 31 May 2016

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Article Open Access

Tert-butylhydroquinone attenuates the ethanol-induced apoptosis of and activates the Nrf2 antioxidant defense pathway in H9c2 cardiomyocytes

Xiaojing Shi, Yang Li, Jun Hu, Bo Yu
Pages: 123-130
Published online on: 25 May 2016

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Article Open Access

Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis Retraction in /10.3892/ijmm.2024.5476

Dong-Yu Liang, Yan-Qiang Hou, Li-Jun Luo, Li Ao
Pages: 131-138
Published online on: 26 May 2016

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Article Open Access

Zoledronic acid suppresses transforming growth factor-β-induced fibrogenesis by human gingival fibroblasts

Yuko Komatsu, Miho Ibi, Naoyuki Chosa, Seiko Kyakumoto, Masaharu Kamo, Toshiyuki Shibata, Yoshiki Sugiyama, Akira Ishisaki
Pages: 139-147
Published online on: 10 May 2016

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Article Open Access

Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function

Changli Xie, Cuiying Liu, Bitao Wu, Yan Lin, Tingting Ma, Haiyu Xiong, Qin Wang, Ziwei Li, Chenyu Ma, Zhiguang Tu
Pages: 148-160
Published online on: 10 May 2016

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Article Open Access

Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis

Zixuan Yang, Zibiao Zhong, Mingxia Li, Yan Xiong, Yanfeng Wang, Guizhu Peng, Qifa Ye
Pages: 161-171
Published online on: 12 May 2016

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Article Open Access

Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425

Liping Fang, Jiuhan Zhao, Dan Wang, Liyu Zhu, Jian Wang, Kui Jiang
Pages: 172-182
Published online on: 30 May 2016

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Article Open Access

miR-223 enhances the sensitivity of non-small cell lung cancer cells to erlotinib by targeting the insulin-like growth factor-1 receptor

Feng-Yi Zhao, Jing Han, Xie-Wan Chen, Jiang Wang, Xu-Dong Wang, Jian-Guo Sun, Zheng-Tang Chen
Pages: 183-191
Published online on: 13 May 2016

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Article Open Access

Interleukin-6 and rs1800796 locus single nucleotide polymorphisms in response to hypoxia/reoxygenation in hepatocytes

Zhaowen Wang, Shaohan Wu, Jianhua Liao, Lin Zhong, Tonghai Xing, Junwei Fan, Zhihai Peng
Pages: 192-200
Published online on: 18 May 2016

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Article Open Access

MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis

Shiju Yan, Meng Wang, Jian Zhao, Hongtao Zhang, Chengpei Zhou, Lei Jin, Yinglong Zhang, Xiuchun Qiu, Baoan Ma, Qingyu Fan
Pages: 201-209
Published online on: 31 May 2016

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Article Open Access

Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway

Yanyan Jia, Jinyi Zhao, Meiyou Liu, Bingling Li, Ying Song, Yuwen Li, Aidong Wen, Lei Shi
Pages: 210-216
Published online on: 31 May 2016

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Article

Tat-ATOX1 inhibits streptozotocin-induced cell death in pancreatic RINm5F cells and attenuates diabetes in a mouse model

Eun Hee Ahn, Dae Won Kim, Min Jea Shin, Eun Ji Ryu, Ji In Yong, Seok Young Chung, Hyun Ju Cha, Sang Jin Kim, Yeon Joo Choi, Duk-Soo Kim, Sung-Woo Cho, Keunwook Lee, Yoon Shin Cho, Hyeok Yil Kwon, Jinseu Park, Won Sik Eum, Soo Young Choi
Pages: 217-224
Published online on: 20 May 2016

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Article

Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways

Eun Jeong Sohn, Min Jea Shin, Won Sik Eum, Dae Won Kim, Ji In Yong, Eun Ji Ryu, Jung Hwan Park, Su Bin Cho, Hyun Ju Cha, Sang Jin Kim, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Seung Kwon Im, Hae Young Kweon, Duk-Soo Kim, Yeon Hee Yu, Sung-Woo Cho, Meeyoung Park, Jinseu Park, Yong-Jun Cho, Soo Young Choi
Pages: 225-235
Published online on: 19 May 2016

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Article

Network analysis of genes involved in the enhancement of hyperthermia sensitivity by the knockdown of BAG3 in human oral squamous cell carcinoma cells

Tatsuya Yunoki, Yoshiaki Tabuchi, Atsushi Hayashi, Takashi Kondo
Pages: 236-242
Published online on: 31 May 2016

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Article

Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia

Judith W.J. Bergs, Arlene L. Oei, Rosemarie ten Cate, Hans M. Rodermond, Lukas J. Stalpers, Gerrit W. Barendsen, Nicolaas A.P. Franken
Pages: 243-250
Published online on: 27 May 2016

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Article

Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress

Hwayoung Lee, Hansol Won, Jiyun Im, Young Ock Kim, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Kim
Pages: 251-258
Published online on: 16 May 2016

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Article

Roles of ZIC family genes in human gastric cancer

Gang Ma, Weijie Dai, Aiyu Sang, Xiaozhong Yang, Qianjun Li
Pages: 259-266
Published online on: 12 May 2016

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Article

RbAp48, a novel inhibitory factor that regulates the transcription of human immunodeficiency virus type 1

Juan Wang, Jin Yang, Zongxing Yang, Xiangyun Lu, Changzhong Jin, Linfang Cheng, Nanping Wu
Pages: 267-274
Published online on: 19 May 2016

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Article

Protective role of magnesium isoglycyrrhizinate in non-alcoholic fatty liver disease and the associated molecular mechanisms

Qian Xu, Ji Wang, Feifei Chen, Kaisu Lin, Mingao Zhu, Lei Chen, Xiumin Zhou, Chong Li, Hong Zhu
Pages: 275-282
Published online on: 24 May 2016

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Article

Upregulation of microRNA-450 inhibits the progression of lung cancer in vitro and in vivo by targeting interferon regulatory factor 2

Fabing Liu, Xiaobo Yu, Haihua Huang, Xi Chen, Jin Wang, Xiaomiao Zhang, Qiang Lin
Pages: 283-290
Published online on: 27 May 2016

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Article

Cedrol induces autophagy and apoptotic cell death in A549 non-small cell lung carcinoma cells through the P13K/Akt signaling pathway, the loss of mitochondrial transmembrane potential and the generation of ROS

Shi-Yi Zhang, Xue-Bo Li, Sheng-Guang Hou, Yao Sun, Yi-Ran Shi, Song-Sen Lin
Pages: 291-299
Published online on: 11 May 2016

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Article

Functional analysis of HBO1 in tumor development and inhibitor screening

Ling-Li Guo, Su-Yang Yu, Meng Li
Pages: 300-304
Published online on: 31 May 2016

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Article

Proliferative effects of gamma-amino butyric acid on oral squamous cell carcinoma cells are associated with mitogen-activated protein kinase signaling pathways

Jing Ma, Yan Zhang, Jun Wang, Tianyu Zhao, Ping Ji, Jinlin Song, Hongmei Zhang, Wenping Luo
Pages: 305-311
Published online on: 19 May 2016

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Article

MicroRNA-205‑5b inhibits HMGB1 expression in LPS-induced sepsis

Wenhai Zhou, Jing Wang, Zhifeng Li, Jianguo Li, Ming Sang
Pages: 312-318
Published online on: 27 May 2016

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Article

IL-1α induces apoptosis and inhibits the osteoblast differentiation of MC3T3-E1 cells through the JNK and p38 MAPK pathways

Chun Guo, Xu-Guang Yang, Fei Wang, Xu-Yuan Ma
Pages: 319-327
Published online on: 25 May 2016

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Article

Epigallocatechin gallate exerts protective effects against myocardial ischemia/reperfusion injury through the PI3K/Akt pathway-mediated inhibition of apoptosis and the restoration of the autophagic flux

Feifei Xuan, Jie Jian
Pages: 328-336
Published online on: 31 May 2016

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Article

Icariin alters the expression of glucocorticoid receptor, FKBP5 and SGK1 in rat brains following exposure to chronic mild stress

Kai Wei, Yizhe Xu, Zhengxiao Zhao, Xiao Wu, Yijie Du, Jing Sun, Tao Yi, Jingcheng Dong, Baojun Liu
Pages: 337-344
Published online on: 17 May 2016

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Article

Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke

Gun Ho Choi, Ki Han Ko, Jung Oh Kim, Jinkwon Kim, Seung Hun Oh, In Bo Han, Kyung Gi Cho, Ok Joon Kim, Jinkun Bae, Nam Keun Kim
Pages: 345-356
Published online on: 25 May 2016

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Article

Biological effects of rutin on skin aging

Seong Jin Choi, Sung-Nae Lee, Karam Kim, Da Hye Joo, Shanghun Shin, Jeongju Lee, Hyun Kyung Lee, Jihyun Kim, Seung Bin Kwon, Min Jung Kim, Kyu Joong Ahn, In-Sook An, Sungkwan An, Hwa Jun Cha
Pages: 357-363
Published online on: 24 May 2016

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review)

Hang Ruan, Xiao-Yan Shen, Shi-Yan Liu, Shu-Sheng Li
Article Number: 87
Published online on: 06 February 2026

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Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Article Open Access

Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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Correction Open Access

[Corrigendum] p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
Article Number: 83
Published online on: 04 February 2026

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Review Open Access

Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)

Yongchun Liang, Xinbiao Fan, Xiaofei Geng, Yunfeng Jia, Wenyu Shang, Xitong Sun, Jun Ge, Guijun Ye, Boyu Zhu, Zheng Zhang, Yuxin Kang, Xiaoyu Shan, Junping Zhang
Article Number: 82
Published online on: 03 February 2026

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IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review)

Hao Zhu, Hao Wang, Xia Li, Weisong Zhang, Yihao Wang, Qingze Tan, Dongxu Ying, Zhan Shi, Jianxiang Song
Article Number: 81
Published online on: 03 February 2026

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Article Open Access

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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Correction Open Access

[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes

Wen-Fan Gao, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
Article Number: 79
Published online on: 02 February 2026

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Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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