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Article

Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress

  • Authors:
    • Hwayoung Lee
    • Hansol Won
    • Jiyun Im
    • Young Ock Kim
    • Sanghyun Lee
    • Ik-Hyun Cho
    • Hyung-Ki Kim
    • Jun-Tack Kwon
    • Hak-Jae Kim
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea, Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Republic of Korea, Department of Integrative Plant Science, Chung-Ang University, Anseong, Republic of Korea, Department of Convergence Medical Science and Brain Korea 21 Plus Program, Institute of Korean Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
  • Pages: 251-258
    |
    Published online on: May 16, 2016
       https://doi.org/10.3892/ijmm.2016.2589
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Abstract

Exposing a pregnant female to stress is a risk factor for the development of psychiatric disorders in the offspring. In the present study, we examined the effects of an extract of Valeriana fauriei (VF) root (100 mg/kg/day, administered on postnatal days 35-56) on behavioral patterns as well as protein expression in the prefrontal cortex of the offspring of prenatally-stressed rats. Modified behavioral tests, including the forced swim test, the open field test, a social interaction test and the prepulse inhibition test were performed and many of the parameters were found to decrease in the offspring of the rats exposed to PNS compared with the offspring of the non-stressed rats. Western blot and immunohistochemical analyses of the prefrontal cortex revealed that the downregulation of several neurodevelopmental proteins in the offspring of rats dams exposed to PNS was reversed after treatment with VF extract. These findings demonstrate that the downregulation of several proteins in the prefrontal cortex of the offspring of prenatally‑stressed rats may be associated with subsequent behavioral changes, and that these phenomena recovered following VF treatment. Our results suggest that VF decreases the incidence of prenatal stress related-psychiatric disorders, such as depression and schizophrenia.
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View References

1 

Stevinson C and Ernst E: Valerian for insomnia: a systematic review of randomized clinical trials. Sleep Med. 1:91–99. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Circosta C, De Pasquale R, Samperi S, Pino A and Occhiuto F: Biological and analytical characterization of two extracts from Valeriana officinalis. J Ethnopharmacol. 112:361–367. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Kim JS, Ahn JD and Cho SI: Effects of Valerianae Radix et Rhizoma extract on psychological stress in mice. Pharmacogn Mag. 11:381–388. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Barton DL, Atherton PJ, Bauer BA, Moore DF Jr, Mattar BI, Lavasseur BI, Rowland KM Jr, Zon RT, Lelindqwister NA, Nagargoje GG, et al: The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5). J Support Oncol. 9:24–31. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Rezvani ME, Roohbakhsh A, Allahtavakoli M and Shamsizadeh A: Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. J Ethnopharmacol. 127:313–318. 2010. View Article : Google Scholar

6 

Murphy K, Kubin ZJ, Shepherd JN and Ettinger RH: Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine. 17:674–678. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Wang PC, Ran XH, Chen R, Luo HR, Liu YQ, Zhou J and Zhao YX: Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia. J Nat Prod. 73:1563–1567. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Letchamo W, Ward W, Heard B and Heard D: Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. J Agric Food Chem. 52:3915–3919. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Leuschner J, Müller J and Rudmann M: Characterisation of the central nervous depressant activity of a commercially available valerian root extract. Arzneimittelforschung. 43:638–641. 1993.PubMed/NCBI

10 

Hadley S and Petry JJ: Valerian. Am Fam Physician. 67:1755–1758. 2003.PubMed/NCBI

11 

Yuan CS, Mehendale S, Xiao Y, Aung HH, Xie JT and Ang-Lee MK: The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg. 98:353–358. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Sudati JH, Fachinetto R, Pereira RP, Boligon AA, Athayde ML, Soares FA, de Vargas Barbosa NB and Rocha JB: In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. Neurochem Res. 34:1372–1379. 2009. View Article : Google Scholar : PubMed/NCBI

13 

de Oliveria DM, Barreto G, De Andrade DVG, Saraceno E, Aon-Bertolino L, Capani F, Dos Santos El, Bachá R and Giraldez LD: Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease. Neurochem Res. 34:215–220. 2009. View Article : Google Scholar

14 

Malva JO, Santos S and Macedo T: Neuroprotective properties of Valeriana officinalis extracts. Neurotox Res. 6:131–140. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Pereira RP, Fachinetto R, de Souza Prestes A, Wagner C, Sudati JH, Boligon AA, Athayde ML, Morsch VM and Rocha JBT: Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats. J Neural Transm Vienna. 118:1547–1557. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Brown AS, van Os J, Driessens C, Hoek HW and Susser ES: Further evidence of relation between prenatal famine and major affective disorder. Am J Psychiatry. 157:190–195. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Sullivan PF: The genetics of schizophrenia. PLoS Med. 2:e2122005. View Article : Google Scholar : PubMed/NCBI

18 

Huttunen MO and Niskanen P: Prenatal loss of father and psychiatric disorders. Arch Gen Psychiatry. 35:429–431. 1978. View Article : Google Scholar : PubMed/NCBI

19 

King M, Nazroo J, Weich S, McKenzie K, Bhui K, Karlsen S, Stansfeld S, Tyrer P, Blanchard M, Lloyd K, et al: Psychotic symptoms in the general population of England - a comparison of ethnic groups (The EMPIRIC study). Soc Psychiatry Psychiatr Epidemiol. 40:375–381. 2005. View Article : Google Scholar : PubMed/NCBI

20 

King S, Laplante D and Joober R: Understanding putative risk factors for schizophrenia: retrospective and prospective studies. J Psychiatry Neurosci. 30:342–348. 2005.PubMed/NCBI

21 

Lim C, Chong SA and Keefe R: Psychosocial factors in the neurobiology of schizophrenia: a selective review. Ann Acad Med Singapore. 38:402–406. 2009.PubMed/NCBI

22 

Imamura Y, Nakane Y, Ohta Y and Kondo H: Lifetime prevalence of schizophrenia among individuals prenatally exposed to atomic bomb radiation in Nagasaki City. Acta Psychiatr Scand. 100:344–349. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Meyer U and Feldon J: Epidemiology-driven neurodevelopmental animal models of schizophrenia. Prog Neurobiol. 90:285–326. 2010. View Article : Google Scholar

24 

Weinstock M: The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev. 32:1073–1086. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Seckl JR: Prenatal glucocorticoids and long-term programming. Eur J Endocrinol. 151(Suppl 3): U49–U62. 2004. View Article : Google Scholar : PubMed/NCBI

26 

de Kloet ER, Sibug RM, Helmerhorst FM and Schmidt MV: Stress, genes and the mechanism of programming the brain for later life. Neurosci Biobehav Rev. 29:271–281. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Beydoun H and Saftlas AF: Physical and mental health outcomes of prenatal maternal stress in human and animal studies: a review of recent evidence. Paediatr Perinat Epidemiol. 22:438–466. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Lee PR, Brady DL, Shapiro RA, Dorsa DM and Koenig JI: Prenatal stress generates deficits in rat social behavior: reversal by oxytocin. Brain Res. 1156:152–167. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Kinnunen AK, Koenig JI and Bilbe G: Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole. J Neurochem. 86:736–748. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Koenig JI, Elmer GI, Shepard PD, Lee PR, Mayo C, Joy B, Hercher E and Brady DL: Stress during gestation produces alterations in adult rat behavior: relevance to schizophrenia. Soc Neurosci abs. 495:pp. 6http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Detail?AbsYear=2002&AbsID=7512.

31 

Koenig JI, Elmer GI, Shepard PD, Lee PR, Mayo C, Joy B, Hercher E and Brady DL: Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behav Brain Res. 156:251–261. 2005. View Article : Google Scholar

32 

Lemaire V, Koehl M, Le Moal M and Abrous DN: Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci USA. 97:11032–11037. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Martínez-Téllez RI, Hernández-Torres E, Gamboa C and Flores G: Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring. Synapse. 63:794–804. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Van den Hove DL, Kenis G, Brass A, Opstelten R, Rutten BP, Bruschettini M, Blanco CE, Lesch KP, Steinbusch HW and Prickaerts J: Vulnerability versus resilience to prenatal stress in male and female rats; implications from gene expression profiles in the hippocampus and frontal cortex. Eur Neuropsychopharmacol. 23:1226–1246. 2013. View Article : Google Scholar

35 

Mairesse J, Vercoutter-Edouart AS, Marrocco J, Zuena AR, Giovine A, Nicoletti F, Michalski JC, Maccari S and Morley-Fletcher S: Proteomic characterization in the hippocampus of prenatally stressed rats. J Proteomics. 75:1764–1770. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Lee H, Joo J, Nah SS, Kim JW, Kim HK, Kwon JT, Lee HY, Kim YO and Kim HJ: Changes in Dpysl2 expression are associated with prenatally stressed rat offspring and susceptibility to schizophrenia in humans. Int J Mol Med. 35:1574–1586. 2015.PubMed/NCBI

37 

Kim YO, Lee HY, Won H, Nah SS, Lee HY, Kim HK, Kwon JT and Kim HJ: Influence of Panax ginseng on the offspring of adult rats exposed to prenatal stress. Int J Mol Med. 35:103–109. 2015.

38 

Dulawa SC, Holick KA, Gundersen B and Hen R: Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology. 29:1321–1330. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Schroeder M, Sultany T and Weller A: Prenatal stress effects on emotion regulation differ by genotype and sex in prepubertal rats. Dev Psychobiol. 55:176–192. 2013. View Article : Google Scholar

40 

Becker A, Peters B, Schroeder H, Mann T, Huether G and Grecksch G: Ketamine-induced changes in rat behaviour: a possible animal model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 27:687–700. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Koenig JI, Elmer GI, Shepard PD, Lee PR, Mayo C, Joy B, Hercher E and Brady DL: Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behav Brain Res. 156:251–261. 2005. View Article : Google Scholar

42 

Chang CH, Hsiao YH, Chen YW, Yu YJ and Gean PW: Social isolation-induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice. Hippocampus. 25:474–485. 2015. View Article : Google Scholar

43 

Morley-Fletcher S, Darnaudery M, Koehl M, Casolini P, Van Reeth O and Maccari S: Prenatal stress in rats predicts immobility behavior in the forced swim test. Effects of a chronic treatment with tianeptine. Brain Res. 989:246–251. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Joo J, Lee S, Nah SS, Kim YO, Kim DS, Shim SH, Hwangbo Y, Kim HK, Kwon JT, Kim JW, et al: Lasp1 is down-regulated in NMDA receptor antagonist-treated mice and implicated in human schizophrenia susceptibility. J Psychiatr Res. 47:105–112. 2013. View Article : Google Scholar

45 

Liu XG, Gao PY, Wang GS, Song SJ, Li LZ, Li X, Yao XS and Zhang ZX: In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana fauriei Briq. Fitoterapia. 83:599–603. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Ortiz JG, Nieves-Natal J and Chavez P: Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H] GABA uptake, and hippocampal [3H]GABA release. Neurochem Res. 24:1373–1378. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Patočka and Jakl J: Biomedically relevant chemical constituents of Valeriana officinalis. J Appl Biomed. 8:11–18. 2010. View Article : Google Scholar

48 

Santos MS, Ferreira F, Cunha AP, Carvalho AP and Macedo T: An aqueous extract of valerian influences the transport of GABA in synaptosomes. Planta Med. 60:278–279. 1994. View Article : Google Scholar : PubMed/NCBI

49 

Merz K, Herold S and Lie DC: CREB in adult neurogenesis - master and partner in the development of adult-born neurons? Eur J Neurosci. 33:1078–1086. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Charil A, Laplante DP, Vaillancourt C and King S: Prenatal stress and brain development. Brain Res Brain Res Rev. 65:56–79. 2010. View Article : Google Scholar

51 

Kelley ME, Gilbertson M, Mouton A and van Kammen DP: Deterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patients. Am J Psychiatry. 149:1543–1548. 1992. View Article : Google Scholar : PubMed/NCBI

52 

Møller P and Husby R: The initial prodrome in schizophrenia: searching for naturalistic core dimensions of experience and behavior. Schizophr Bull. 26:217–232. 2000. View Article : Google Scholar

53 

Cornblatt BA: The New York high risk project to the Hillside recognition and prevention (RAP) program. Am J Med Genet. 114:956–966. 2002. View Article : Google Scholar : PubMed/NCBI

54 

Geyer MA, Krebs-Thomson K, Braff DL and Swerdlow NR: Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl). 156:117–154. 2001. View Article : Google Scholar

55 

Swerdlow NR and Geyer MA: Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull. 24:285–301. 1998. View Article : Google Scholar : PubMed/NCBI

56 

Braff DL: Information processing and attention dysfunctions in schizophrenia. Schizophr Bull. 19:233–259. 1993. View Article : Google Scholar : PubMed/NCBI

57 

de Bruin NM, van Luijtelaar EL, Cools AR and Ellenbroek BA: Auditory information processing in rat genotypes with different dopaminergic properties. Psychopharmacology (Berl). 156:352–359. 2001. View Article : Google Scholar

58 

Lipska BK and Weinberger DR: To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology. 23:223–239. 2000. View Article : Google Scholar : PubMed/NCBI

59 

Tueting P, Costa E, Dwivedi Y, Guidotti A, Impagnatiello F, Manev R and Pesold C: The phenotypic characteristics of heterozygous reeler mouse. Neuroreport. 10:1329–1334. 1999. View Article : Google Scholar : PubMed/NCBI

60 

Day-Wilson KM, Jones DN, Southam E, Cilia J and Totterdell S: Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle. Neuroscience. 141:1113–1121. 2006. View Article : Google Scholar : PubMed/NCBI

61 

Borrell J, Vela JM, Arévalo-Martin A, Molina-Holgado E and Guaza C: Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology. 26:204–215. 2002. View Article : Google Scholar : PubMed/NCBI

62 

Shi L, Fatemi SH, Sidwell RW and Patterson PH: Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci. 23:297–302. 2003.PubMed/NCBI

63 

Lehmann J, Stöhr T and Feldon J: Long-term effects of prenatal stress experiences and postnatal maternal separation on emotionality and attentional processes. Behav Brain Res. 107:133–144. 2000. View Article : Google Scholar : PubMed/NCBI

64 

Faraday MM, O'Donoghue VA and Grunberg NE: Effects of nicotine and stress on startle amplitude and sensory gating depend on rat strain and sex. Pharmacol Biochem Behav. 62:273–284. 1999. View Article : Google Scholar : PubMed/NCBI

65 

Stöhr T, Schulte Wermeling D, Szuran T, Pliska V, Domeney A, Welzl H, Weiner I and Feldon J: Differential effects of prenatal stress in two inbred strains of rats. Pharmacol Biochem Behav. 59:799–805. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee H, Won H, Im J, Kim YO, Lee S, Cho I, Kim H, Kwon J and Kim H: Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress. Int J Mol Med 38: 251-258, 2016.
APA
Lee, H., Won, H., Im, J., Kim, Y.O., Lee, S., Cho, I. ... Kim, H. (2016). Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress. International Journal of Molecular Medicine, 38, 251-258. https://doi.org/10.3892/ijmm.2016.2589
MLA
Lee, H., Won, H., Im, J., Kim, Y. O., Lee, S., Cho, I., Kim, H., Kwon, J., Kim, H."Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress". International Journal of Molecular Medicine 38.1 (2016): 251-258.
Chicago
Lee, H., Won, H., Im, J., Kim, Y. O., Lee, S., Cho, I., Kim, H., Kwon, J., Kim, H."Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress". International Journal of Molecular Medicine 38, no. 1 (2016): 251-258. https://doi.org/10.3892/ijmm.2016.2589
Copy and paste a formatted citation
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Spandidos Publications style
Lee H, Won H, Im J, Kim YO, Lee S, Cho I, Kim H, Kwon J and Kim H: Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress. Int J Mol Med 38: 251-258, 2016.
APA
Lee, H., Won, H., Im, J., Kim, Y.O., Lee, S., Cho, I. ... Kim, H. (2016). Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress. International Journal of Molecular Medicine, 38, 251-258. https://doi.org/10.3892/ijmm.2016.2589
MLA
Lee, H., Won, H., Im, J., Kim, Y. O., Lee, S., Cho, I., Kim, H., Kwon, J., Kim, H."Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress". International Journal of Molecular Medicine 38.1 (2016): 251-258.
Chicago
Lee, H., Won, H., Im, J., Kim, Y. O., Lee, S., Cho, I., Kim, H., Kwon, J., Kim, H."Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress". International Journal of Molecular Medicine 38, no. 1 (2016): 251-258. https://doi.org/10.3892/ijmm.2016.2589
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