Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress

  • Authors:
    • Hwayoung Lee
    • Hansol Won
    • Jiyun Im
    • Young Ock Kim
    • Sanghyun Lee
    • Ik-Hyun Cho
    • Hyung-Ki Kim
    • Jun-Tack Kwon
    • Hak-Jae Kim
  • View Affiliations

  • Published online on: May 16, 2016     https://doi.org/10.3892/ijmm.2016.2589
  • Pages: 251-258
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Abstract

Exposing a pregnant female to stress is a risk factor for the development of psychiatric disorders in the offspring. In the present study, we examined the effects of an extract of Valeriana fauriei (VF) root (100 mg/kg/day, administered on postnatal days 35-56) on behavioral patterns as well as protein expression in the prefrontal cortex of the offspring of prenatally-stressed rats. Modified behavioral tests, including the forced swim test, the open field test, a social interaction test and the prepulse inhibition test were performed and many of the parameters were found to decrease in the offspring of the rats exposed to PNS compared with the offspring of the non-stressed rats. Western blot and immunohistochemical analyses of the prefrontal cortex revealed that the downregulation of several neurodevelopmental proteins in the offspring of rats dams exposed to PNS was reversed after treatment with VF extract. These findings demonstrate that the downregulation of several proteins in the prefrontal cortex of the offspring of prenatally‑stressed rats may be associated with subsequent behavioral changes, and that these phenomena recovered following VF treatment. Our results suggest that VF decreases the incidence of prenatal stress related-psychiatric disorders, such as depression and schizophrenia.
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July-2016
Volume 38 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lee H, Won H, Im J, Kim YO, Lee S, Cho I, Kim H, Kwon J and Kim H: Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress. Int J Mol Med 38: 251-258, 2016
APA
Lee, H., Won, H., Im, J., Kim, Y.O., Lee, S., Cho, I. ... Kim, H. (2016). Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress. International Journal of Molecular Medicine, 38, 251-258. https://doi.org/10.3892/ijmm.2016.2589
MLA
Lee, H., Won, H., Im, J., Kim, Y. O., Lee, S., Cho, I., Kim, H., Kwon, J., Kim, H."Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress". International Journal of Molecular Medicine 38.1 (2016): 251-258.
Chicago
Lee, H., Won, H., Im, J., Kim, Y. O., Lee, S., Cho, I., Kim, H., Kwon, J., Kim, H."Effect of Valeriana fauriei extract on the offspring of adult rats exposed to prenatal stress". International Journal of Molecular Medicine 38, no. 1 (2016): 251-258. https://doi.org/10.3892/ijmm.2016.2589