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Review

Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)

  • Authors:
    • Hwa Jun Cha
    • Congfen He
    • Hua Zhao
    • Yinmao Dong
    • In-Sook An
    • Sungkwan An
  • View Affiliations / Copyright

    Affiliations: Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143-701, Republic of Korea, Beijing Key Laboratory of Plant Resources Research and Development, China Cosmetic Research Center, Beijing Technology and Business University, Beijing 100048, P.R. China, GeneCellPharm Incorporated, Cheongju-si, Chungcheongbuk-do 361-951, Republic of Korea
  • Pages: 16-22
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    Published online on: May 20, 2016
       https://doi.org/10.3892/ijmm.2016.2600
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Abstract

The skin consists of the epidermis, dermis and subcutis. The epidermis is primarily comprised of keratinocytes and is separated into four layers according to the stage of differentiation of the keratinocytes. Corneocytes are terminally differentiated keratinocytes that closely interact with other corneocytes through corneodesmosomes, and synthesize lamellar bodies and the intercellular multilamellar barrier, which protects the body from the external environment. As ceramides are the principal components of lamellar bodies and the multilamellar barrier, it is important to understand the biosynthesis of ceramides and their functions in skin. Ceramides are synthesized by amide bond‑mediated interactions between sphingoid bases, long‑chain amino alcohols [long-chain base] and fatty acids through a de novo pathway, a sphingomyelin (SM) hydrolysis pathway and a catabolic pathway. The majority of ceramides produced by the de novo pathway form the epidermal barrier. Ceramides used as signaling molecules are synthesized by the SM and catabolic pathways. Synthesized ceramides are released from corneocytes and form the multilamellar barrier. Additionally, ceramides and their metabolites regulate the apoptosis, proliferation and differentiation of skin cells as well as the formation of the skin barrier. Thus, the study of ceramides and their metabolites is crucial to understanding the function and regulation of the skin barrier.
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View References

1 

Natarajan VT, Ganju P, Ramkumar A, Grover R and Gokhale RS: Multifaceted pathways protect human skin from UV radiation. Nat Chem Biol. 10:542–551. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Rawlings AV and Harding CR: Moisturization and skin barrier function. Dermatol Ther (Heidelb). 17(Suppl 1): 43–48. 2004. View Article : Google Scholar

3 

Wertz PW: Current understanding of skin biology pertinent to skin penetration: skin biochemistry. Skin Pharmacol Physiol. 26:217–226. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Del Rosso JQ and Levin J: Clinical relevance of maintaining the structural and functional integrity of the stratum corneum: why is it important to you? J Drugs Dermatol. 10(Suppl): s5–s12. 2011.PubMed/NCBI

5 

Jacobi OT: About the mechanism of moisture regulation in the horny layer of the skin. Proc Sci Sect Toilet Goods Assoc. 31:22–24. 1959.

6 

Blank IH: Factors which influence the water content of the stratum corneum. J Invest Dermatol. 18:433–440. 1952. View Article : Google Scholar : PubMed/NCBI

7 

Elias PM: Epidermal lipids, barrier function, and desquamation. J Invest Dermatol. 80(Suppl): 44s–49s. 1983. View Article : Google Scholar : PubMed/NCBI

8 

Feingold KR: Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis. J Lipid Res. 48:2531–2546. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Feingold KR and Elias PM: Role of lipids in the formation and maintenance of the cutaneous permeability barrier. Biochim Biophys Acta. 1841:280–294. 2014. View Article : Google Scholar

10 

Elias PM and Wakefield JS: Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis. J Allergy Clin Immunol. 134:781–791.e1. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Candi E, Schmidt R and Melino G: The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol. 6:328–340. 2005. View Article : Google Scholar : PubMed/NCBI

12 

van Smeden J, Janssens M, Gooris GS and Bouwstra JA: The important role of stratum corneum lipids for the cutaneous barrier function. Biochim Biophys Acta. 1841:295–313. 2014. View Article : Google Scholar

13 

Feingold KR: The regulation and role of epidermal lipid synthesis. Adv Lipid Res. 24:57–82. 1991.PubMed/NCBI

14 

Coderch L, López O, de la Maza A and Parra JL: Ceramides and skin function. Am J Clin Dermatol. 4:107–129. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Choi MJ and Maibach HI: Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 6:215–223. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Ogretmen B and Hannun YA: Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 4:604–616. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Arana L, Gangoiti P, Ouro A, Trueba M and Gómez-Muñoz A: Ceramide and ceramide 1-phosphate in health and disease. Lipids Health Dis. 9:152010. View Article : Google Scholar : PubMed/NCBI

18 

Mimeault M, Hauke R and Batra SK: Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther. 83:673–691. 2008. View Article : Google Scholar

19 

Robson KJ, Stewart ME, Michelsen S, Lazo ND and Downing DT: 6-Hydroxy-4-sphingenine in human epidermal ceramides. J Lipid Res. 35:2060–2068. 1994.PubMed/NCBI

20 

t'Kindt R, Jorge L, Dumont E, Couturon P, David F, Sandra P and Sandra K: Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry. Anal Chem. 84:403–411. 2012. View Article : Google Scholar

21 

Masukawa Y, Narita H, Shimizu E, Kondo N, Sugai Y, Oba T, Homma R, Ishikawa J, Takagi Y, Kitahara T, et al: Characterization of overall ceramide species in human stratum corneum. J Lipid Res. 49:1466–1476. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC and Merrill AH Jr: Biodiversity of sphingoid bases ('sphingosines') and related amino alcohols. J Lipid Res. 49:1621–1639. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Farwanah H, Pierstorff B, Schmelzer CE, Raith K, Neubert RH, Kolter T and Sandhoff K: Separation and mass spectrometric characterization of covalently bound skin ceramides using LC/APCI-MS and Nano-ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 852:562–570. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Stewart ME and Downing DT: Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines. J Invest Dermatol. 105:613–618. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Nugteren DH: The enzymic chain elongation of fatty acids by rat-liver microsomes. Biochim Biophys Acta. 106:280–290. 1965. View Article : Google Scholar : PubMed/NCBI

26 

Guillou H, Zadravec D, Martin PG and Jacobsson A: The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice. Prog Lipid Res. 49:186–199. 2010. View Article : Google Scholar

27 

Jakobsson A, Westerberg R and Jacobsson A: Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res. 45:237–249. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Breiden B and Sandhoff K: The role of sphingolipid metabolism in cutaneous permeability barrier formation. Biochim Biophys Acta. 1841:441–452. 2014. View Article : Google Scholar

29 

Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, et al: Loss of ceramide synthase 3 causes lethal skin barrier disruption. Hum Mol Genet. 21:586–608. 2012. View Article : Google Scholar

30 

Rabionet M, Gorgas K and Sandhoff R: Ceramide synthesis in the epidermis. Biochim Biophys Acta. 1841:422–434. 2014. View Article : Google Scholar

31 

Marekov LN and Steinert PM: Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. J Biol Chem. 273:17763–17770. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Wertz PW and Downing DT: Ceramides of pig epidermis: structure determination. J Lipid Res. 24:759–765. 1983.PubMed/NCBI

33 

Mizutani Y, Mitsutake S, Tsuji K, Kihara A and Igarashi Y: Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie. 91:784–790. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Eckl KM, Tidhar R, Thiele H, Oji V, Hausser I, Brodesser S, Preil ML, Onal-Akan A, Stock F, Müller D, et al: Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length. J Invest Dermatol. 133:2202–2211. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Holleran WM, Takagi Y and Uchida Y: Epidermal sphingolipids: metabolism, function, and roles in skin disorders. FEBS Lett. 580:5456–5466. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Ebel P, Imgrund S, Vom Dorp K, Hofmann K, Maier H, Drake H, Degen J, Dörmann P, Eckhardt M, Franz T and Willecke K: Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. Biochem J. 461:147–158. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Wertz PW: Lipids and barrier function of the skin. Acta Derm Venereol Suppl (Stockh). 208:7–11. 2000. View Article : Google Scholar

38 

Farwanah H, Raith K, Neubert RH and Wohlrab J: Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin. Arch Dermatol Res. 296:514–521. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M and Hidano A: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol. 96:523–526. 1991. View Article : Google Scholar : PubMed/NCBI

40 

Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM and Uchida Y: Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J Lipid Res. 47:1063–1070. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Bouwstra JA, Gooris GS, Dubbelaar FE, Weerheim AM, Ijzerman AP and Ponec M: Role of ceramide 1 in the molecular organization of the stratum corneum lipids. J Lipid Res. 39:186–196. 1998.PubMed/NCBI

42 

Bouwstra JA, Gooris GS, Dubbelaar FE and Ponec M: Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide 1. J Invest Dermatol. 118:606–617. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Hanada K: Intracellular trafficking of ceramide by ceramide transfer protein. Proc Jpn Acad Ser B Phys Biol Sci. 86:426–437. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A and Ogretmen B: Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol. 6:1603–1624. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Jensen JM, Förl M, Winoto-Morbach S, Seite S, Schunck M, Proksch E and Schütze S: Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging. Exp Dermatol. 14:609–618. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Jensen JM, Fölster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schütze S and Proksch E: Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J Invest Dermatol. 122:1423–1431. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Swanbeck G and Thyresson N: A study of the state of aggregation of the lipids in normal and psoriatic horny layer. Acta Derm Venereol. 42:445–447. 1962.PubMed/NCBI

48 

Swanbeck G and Thyresson N: An x-ray diffraction study of scales from different dermatoses. Acta Derm Venereol. 41:289–296. 1961.PubMed/NCBI

49 

Breathnach AS, Goodman T, Stolinski C and Gross M: Freeze-fracture replication of cells of stratum corneum of human epidermis. J Anat. 114:65–81. 1973.PubMed/NCBI

50 

Breathnach AS: Aspects of epidermal ultrastructure. J Invest Dermatol. 65:2–15. 1975. View Article : Google Scholar : PubMed/NCBI

51 

White SH, Mirejovsky D and King GI: Structure of lamellar lipid domains and corneocyte envelopes of murine stratum corneum. An X-ray diffraction study. Biochemistry. 27:3725–3732. 1988. View Article : Google Scholar : PubMed/NCBI

52 

Schreiner V, Gooris GS, Pfeiffer S, Lanzendörfer G, Wenck H, Diembeck W, Proksch E and Bouwstra J: Barrier characteristics of different human skin types investigated with X-ray diffraction, lipid analysis, and electron microscopy imaging. J Invest Dermatol. 114:654–660. 2000. View Article : Google Scholar : PubMed/NCBI

53 

Moore DJ, Rerek ME and Mendelsohn R: Lipid domains and orthorhombic phases in model stratum corneum: evidence from Fourier transform infrared spectroscopy studies. Biochem Biophys Res Commun. 231:797–801. 1997. View Article : Google Scholar : PubMed/NCBI

54 

Hannun YA: Functions of ceramide in coordinating cellular responses to stress. Science. 274:1855–1859. 1996. View Article : Google Scholar : PubMed/NCBI

55 

Ruvolo PP: Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol Res. 47:383–392. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Ballou LR, Laulederkind SJ, Rosloniec EF and Raghow R: Ceramide signalling and the immune response. Biochim Biophys Acta. 1301:273–287. 1996. View Article : Google Scholar : PubMed/NCBI

57 

Geilen CC, Wieder T and Orfanos CE: Ceramide signalling: regulatory role in cell proliferation, differentiation and apoptosis in human epidermis. Arch Dermatol Res. 289:559–566. 1997. View Article : Google Scholar : PubMed/NCBI

58 

Uchida Y: Ceramide signaling in mammalian epidermis. Biochim Biophys Acta. 1841:453–462. 2014. View Article : Google Scholar :

59 

Senkal CE, Ponnusamy S, Bielawski J, Hannun YA and Ogretmen B: Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 24:296–308. 2010. View Article : Google Scholar :

60 

Tonnetti L, Veri MC, Bonvini E and D'Adamio L: A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction. J Exp Med. 189:1581–1589. 1999. View Article : Google Scholar : PubMed/NCBI

61 

Gómez-Muñoz A: Ceramide-1-phosphate: a novel regulator of cell activation. FEBS Lett. 562:5–10. 2004. View Article : Google Scholar : PubMed/NCBI

62 

Gómez-Muñoz A, Kong JY, Salh B and Steinbrecher UP: Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res. 45:99–105. 2004. View Article : Google Scholar

63 

Gomez-Muñoz A, Martin A, O'Brien L and Brindley DN: Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J Biol Chem. 269:8937–8943. 1994.PubMed/NCBI

64 

Gómez-Muñoz A, Kong JY, Parhar K, Wang SW, Gangoiti P, González M, Eivemark S, Salh B, Duronio V and Steinbrecher UP: Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. FEBS Lett. 579:3744–3750. 2005. View Article : Google Scholar : PubMed/NCBI

65 

Bourbon NA, Sandirasegarane L and Kester M: Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. J Biol Chem. 277:3286–3292. 2002. View Article : Google Scholar

66 

Schubert KM, Scheid MP and Duronio V: Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. J Biol Chem. 275:13330–13335. 2000. View Article : Google Scholar : PubMed/NCBI

67 

Grether-Beck S, Bonizzi G, Schmitt-Brenden H, Felsner I, Timmer A, Sies H, Johnson JP, Piette J and Krutmann J: Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. EMBO J. 19:5793–5800. 2000. View Article : Google Scholar : PubMed/NCBI

68 

Wakita H, Tokura Y, Yagi H, Nishimura K, Furukawa F and Takigawa M: Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine. Arch Dermatol Res. 286:350–354. 1994. View Article : Google Scholar : PubMed/NCBI

69 

Sayama K, Hanakawa Y, Shirakata Y, Yamasaki K, Sawada Y, Sun L, Yamanishi K, Ichijo H and Hashimoto K: Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation. J Biol Chem. 276:999–1004. 2001. View Article : Google Scholar

70 

Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C and Feingold KR: Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 22:113–118. 2013. View Article : Google Scholar : PubMed/NCBI

71 

Ma nggau M, K i m DS, Ruwisch L, Vogler R, Kor ting HC, Schäfer-Kor ting M and Kleuser B: 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J Invest Dermatol. 117:1241–1249. 2001. View Article : Google Scholar

72 

Kim DS, Kim SY, Moon SJ, Chung JH, Kim KH, Cho KH and Park KC: Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. Pigment Cell Res. 14:110–115. 2001. View Article : Google Scholar : PubMed/NCBI

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Cha HJ, He C, Zhao H, Dong Y, An I and An S: Intercellular and intracellular functions of ceramides and their metabolites in skin (Review). Int J Mol Med 38: 16-22, 2016.
APA
Cha, H.J., He, C., Zhao, H., Dong, Y., An, I., & An, S. (2016). Intercellular and intracellular functions of ceramides and their metabolites in skin (Review). International Journal of Molecular Medicine, 38, 16-22. https://doi.org/10.3892/ijmm.2016.2600
MLA
Cha, H. J., He, C., Zhao, H., Dong, Y., An, I., An, S."Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)". International Journal of Molecular Medicine 38.1 (2016): 16-22.
Chicago
Cha, H. J., He, C., Zhao, H., Dong, Y., An, I., An, S."Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)". International Journal of Molecular Medicine 38, no. 1 (2016): 16-22. https://doi.org/10.3892/ijmm.2016.2600
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Spandidos Publications style
Cha HJ, He C, Zhao H, Dong Y, An I and An S: Intercellular and intracellular functions of ceramides and their metabolites in skin (Review). Int J Mol Med 38: 16-22, 2016.
APA
Cha, H.J., He, C., Zhao, H., Dong, Y., An, I., & An, S. (2016). Intercellular and intracellular functions of ceramides and their metabolites in skin (Review). International Journal of Molecular Medicine, 38, 16-22. https://doi.org/10.3892/ijmm.2016.2600
MLA
Cha, H. J., He, C., Zhao, H., Dong, Y., An, I., An, S."Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)". International Journal of Molecular Medicine 38.1 (2016): 16-22.
Chicago
Cha, H. J., He, C., Zhao, H., Dong, Y., An, I., An, S."Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)". International Journal of Molecular Medicine 38, no. 1 (2016): 16-22. https://doi.org/10.3892/ijmm.2016.2600
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