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International Journal of Molecular Medicine
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Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion

  • Authors:
    • Xiaochen Yang
    • Florian Steinberg
    • Lei Zhuang
    • Ralph Bessey
    • Beat Trueb
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Research, University of Bern, CH-3008 Bern, Switzerland
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 30-38
    |
    Published online on: May 23, 2016
       https://doi.org/10.3892/ijmm.2016.2601
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Abstract

Fibroblast growth factor receptor (FGFR)-like protein 1 (FGFRL1) is the most recently discovered member of the FGFR family. Owing to the fact that it interacts with FGF ligands, but lacks the intracellular tyrosine kinase domain, several researchers have speculated that it may function as a decoy receptor and exert a negative effect on cell proliferation. In this study, we performed overexpression experiments with TetOn‑inducible cell clones and downregulation experiments with siRNA oligonucleotides, and found that FGFRL1 had absolutely no effect on cell growth and proliferation. Likewise, we did not observe any influence of FGFRL1 on ERK1/2 activation and on the phosphorylation of 250 other signaling proteins analyzed by the Kinexus antibody microarray. On the other hand, with bacterial petri dishes, we observed a clear effect of FGFRL1 on cell adhesion during the initial hours after cell seeding. Our results suggest that FGFRL1 is a cell adhesion protein similar to the nectins rather than a signaling receptor similar to FGFR1-FGFR4.
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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Steinberg F, Zhuang L, Bessey R and Trueb B: Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion. Int J Mol Med 38: 30-38, 2016.
APA
Yang, X., Steinberg, F., Zhuang, L., Bessey, R., & Trueb, B. (2016). Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion. International Journal of Molecular Medicine, 38, 30-38. https://doi.org/10.3892/ijmm.2016.2601
MLA
Yang, X., Steinberg, F., Zhuang, L., Bessey, R., Trueb, B."Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion". International Journal of Molecular Medicine 38.1 (2016): 30-38.
Chicago
Yang, X., Steinberg, F., Zhuang, L., Bessey, R., Trueb, B."Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion". International Journal of Molecular Medicine 38, no. 1 (2016): 30-38. https://doi.org/10.3892/ijmm.2016.2601
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Steinberg F, Zhuang L, Bessey R and Trueb B: Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion. Int J Mol Med 38: 30-38, 2016.
APA
Yang, X., Steinberg, F., Zhuang, L., Bessey, R., & Trueb, B. (2016). Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion. International Journal of Molecular Medicine, 38, 30-38. https://doi.org/10.3892/ijmm.2016.2601
MLA
Yang, X., Steinberg, F., Zhuang, L., Bessey, R., Trueb, B."Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion". International Journal of Molecular Medicine 38.1 (2016): 30-38.
Chicago
Yang, X., Steinberg, F., Zhuang, L., Bessey, R., Trueb, B."Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion". International Journal of Molecular Medicine 38, no. 1 (2016): 30-38. https://doi.org/10.3892/ijmm.2016.2601
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