Biological effects of rutin on skin aging

  • Authors:
    • Seong Jin Choi
    • Sung-Nae Lee
    • Karam Kim
    • Da Hye Joo
    • Shanghun Shin
    • Jeongju Lee
    • Hyun Kyung Lee
    • Jihyun Kim
    • Seung Bin Kwon
    • Min Jung Kim
    • Kyu Joong Ahn
    • In-Sook An
    • Sungkwan An
    • Hwa Jun Cha
  • View Affiliations

  • Published online on: May 24, 2016     https://doi.org/10.3892/ijmm.2016.2604
  • Pages: 357-363
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Abstract

Rutin, a quercetin glycoside is a member of the bioflavonoid family which is known to possess antioxidant properties. In the present study, we aimed to confirm the anti‑aging effects of rutin on human dermal fibroblasts (HDFs) and human skin. We examined the effects of rutin using a cell viability assay, senescence-associated-β-galactosidase assay, reverse transcription-quantitative polymerase chain reaction, and by measuring reactive oxygen species (ROS) scavenging activity in vitro. To examine the effects of rutin in vivo, rutin‑containing cream was applied to human skin. A double-blind clinical study was conducted in 40 subjects aged between 30-50 years and divided into control and experimental groups. The test material was applied for 4 weeks. After 2 and 4 weeks, dermal density, skin elasticity, the length and area of crow's feet, and number of under-eye wrinkles following the application of either the control or the rutin-containing cream were analyzed. Rutin increased the mRNA expression of collagen, type I, alpha 1 (COL1A1) and decreased the mRNA expression of matrix metallopeptidase 1 (MMP1) in HDFs. We verified that ROS scavenging activity was stimulated by rutin in a dose‑dependent manner and we identified that rutin exerted protective effects under conditions of oxidative stress. Furthermore, rutin increased skin elasticity and decreased the length, area and number of wrinkles. The consequences of human aging are primarily visible on the skin, such as increased wrinkling, sagging and decreased elasticity. Overall, this study demonstrated the biological effects of rutin on ROS-induced skin aging.
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July-2016
Volume 38 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Choi SJ, Lee S, Kim K, Joo DH, Shin S, Lee J, Lee HK, Kim J, Kwon SB, Kim MJ, Kim MJ, et al: Biological effects of rutin on skin aging. Int J Mol Med 38: 357-363, 2016
APA
Choi, S.J., Lee, S., Kim, K., Joo, D.H., Shin, S., Lee, J. ... Cha, H.J. (2016). Biological effects of rutin on skin aging. International Journal of Molecular Medicine, 38, 357-363. https://doi.org/10.3892/ijmm.2016.2604
MLA
Choi, S. J., Lee, S., Kim, K., Joo, D. H., Shin, S., Lee, J., Lee, H. K., Kim, J., Kwon, S. B., Kim, M. J., Ahn, K. J., An, I., An, S., Cha, H. J."Biological effects of rutin on skin aging". International Journal of Molecular Medicine 38.1 (2016): 357-363.
Chicago
Choi, S. J., Lee, S., Kim, K., Joo, D. H., Shin, S., Lee, J., Lee, H. K., Kim, J., Kwon, S. B., Kim, M. J., Ahn, K. J., An, I., An, S., Cha, H. J."Biological effects of rutin on skin aging". International Journal of Molecular Medicine 38, no. 1 (2016): 357-363. https://doi.org/10.3892/ijmm.2016.2604