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Article

Biological effects of rutin on skin aging

  • Authors:
    • Seong Jin Choi
    • Sung-Nae Lee
    • Karam Kim
    • Da Hye Joo
    • Shanghun Shin
    • Jeongju Lee
    • Hyun Kyung Lee
    • Jihyun Kim
    • Seung Bin Kwon
    • Min Jung Kim
    • Kyu Joong Ahn
    • In-Sook An
    • Sungkwan An
    • Hwa Jun Cha
  • View Affiliations / Copyright

    Affiliations: Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143-701, Republic of Korea, GeneCellPharm Incorporated, Cheongju-si, Chungcheongbuk-do 361-951, Republic of Korea, Department of Dermatology, Konkuk University School of Medicine, Seoul 143-701, Republic of Korea
  • Pages: 357-363
    |
    Published online on: May 24, 2016
       https://doi.org/10.3892/ijmm.2016.2604
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Abstract

Rutin, a quercetin glycoside is a member of the bioflavonoid family which is known to possess antioxidant properties. In the present study, we aimed to confirm the anti‑aging effects of rutin on human dermal fibroblasts (HDFs) and human skin. We examined the effects of rutin using a cell viability assay, senescence-associated-β-galactosidase assay, reverse transcription-quantitative polymerase chain reaction, and by measuring reactive oxygen species (ROS) scavenging activity in vitro. To examine the effects of rutin in vivo, rutin‑containing cream was applied to human skin. A double-blind clinical study was conducted in 40 subjects aged between 30-50 years and divided into control and experimental groups. The test material was applied for 4 weeks. After 2 and 4 weeks, dermal density, skin elasticity, the length and area of crow's feet, and number of under-eye wrinkles following the application of either the control or the rutin-containing cream were analyzed. Rutin increased the mRNA expression of collagen, type I, alpha 1 (COL1A1) and decreased the mRNA expression of matrix metallopeptidase 1 (MMP1) in HDFs. We verified that ROS scavenging activity was stimulated by rutin in a dose‑dependent manner and we identified that rutin exerted protective effects under conditions of oxidative stress. Furthermore, rutin increased skin elasticity and decreased the length, area and number of wrinkles. The consequences of human aging are primarily visible on the skin, such as increased wrinkling, sagging and decreased elasticity. Overall, this study demonstrated the biological effects of rutin on ROS-induced skin aging.
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1 

Zouboulis CC and Makrantonaki E: Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol. 29:3–14. 2011. View Article : Google Scholar

2 

Beckman KB and Ames BN: The free radical theory of aging matures. Physiol Rev. 78:547–581. 1998.PubMed/NCBI

3 

Pons B, Belmont AS, Masson-Genteuil G, Chapuis V, Oddos T and Sauvaigo S: Age-associated modifications of Base Excision Repair activities in human skin fibroblast extracts. Mech Ageing Dev. 131:661–665. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Poljšak B, Dahmane RG and Godić A: Intrinsic skin aging: the role of oxidative stress. Acta Dermatovenerol Alp Pannonica Adriat. 21:33–36. 2012.

5 

Farage MA, Miller KW, Elsner P and Maibach HI: Intrinsic and extrinsic factors in skin ageing: a review. Int J Cosmet Sci. 30:87–95. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Kim KH, Lee KW, Kim DY, Park HH, Kwon IB and Lee HJ: Optimal recovery of high-purity rutin crystals from the whole plant of Fagopyrum esculentum Moench (buckwheat) by extraction, fractionation, and recrystallization. Bioresour Technol. 96:1709–1712. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Wagner C, Fachinetto R, Dalla Corte CL, Brito VB, Severo D, de Oliveira Costa Dias G, Morel AF, Nogueira CW and Rocha JB: Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro. Brain Res. 1107:192–198. 2006. View Article : Google Scholar : PubMed/NCBI

8 

La Casa C, Villegas I, Alarcón de la Lastra C, Motilva V and Martín Calero MJ: Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol. 71:45–53. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Kamalakkannan N and Prince PS: Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic Wistar rats. Basic Clin Pharmacol Toxicol. 98:97–103. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Bishnoi M, Chopra K and Kulkarni SK: Protective effect of rutin, a polyphenolic flavonoid against haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes. Fundam Clin Pharmacol. 21:521–529. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Makino T, Kanemaru M, Okuyama S, Shimizu R, Tanaka H and Mizukami H: Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. J Nat Med. 67:881–886. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Han Y, Ding Y, Xie D, Hu D, Li P, Li X, Xue W, Jin L and Song B: Design, synthesis, and antiviral activity of novel rutin derivatives containing 1, 4-pentadien-3-one moiety. Eur J Med Chem. 92:732–737. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Perk AA, Shatynska-Mytsyk I, Gerçek YC, Boztaş K, Yazgan M, Fayyaz S and Farooqi AA: Rutin mediated targeting of signaling machinery in cancer cells. Cancer Cell Int. 14:1242014. View Article : Google Scholar : PubMed/NCBI

14 

Sheu JR, Hsiao G, Chou PH, Shen MY and Chou DS: Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. J Agric Food Chem. 52:4414–4418. 2004. View Article : Google Scholar : PubMed/NCBI

15 

MacLean AL and Brambel CE: Dicumarol and rutin in vascular disorders. Trans Am Ophthalmol Soc. 44:194–213. 1946.

16 

Kuntić V, Filipović I and Vujić Z: Effects of rutin and hesperidin and their Al(III) and Cu(II) complexes on in vitro plasma coagulation assays. Molecules. 16:1378–1388. 2011. View Article : Google Scholar

17 

Choi JH, Kim DW, Park SE, Lee HJ, Kim KM, Kim KJ, Kim MK, Kim SJ and Kim S: Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille. J Biosci Bioeng. 120:181–186. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Jing Y, Dai J, Chalmers-Redman RM, Tatton WG and Waxman S: Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood. 94:2102–2111. 1999.PubMed/NCBI

19 

Jabs T: Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem Pharmacol. 57:231–245. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Woessner JF Jr: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5:2145–2154. 1991.PubMed/NCBI

21 

Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E and Seiki M: A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature. 370:61–65. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Will H and Hinzmann B: cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. Eur J Biochem. 231:602–608. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Matrisian LM: The matrix-degrading metalloproteinases. BioEssays. 14:455–463. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Matrisian LM: Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet. 6:121–125. 1990. View Article : Google Scholar : PubMed/NCBI

25 

Burke EM, Horton WE, Pearson JD, Crow MT and Martin GR: Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors. Exp Gerontol. 29:37–53. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Bizot-Foulon V, Bouchard B, Hornebeck W, Dubertret L and Bertaux B: Uncoordinate expressions of type I and III collagens, collagenase and tissue inhibitor of matrix metalloproteinase 1 along in vitro proliferative life span of human skin fibroblasts. Regulation by all-trans retinoic acid. Cell Biol Int. 19:129–135. 1995. View Article : Google Scholar : PubMed/NCBI

27 

Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S and Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 337:1419–1428. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Vincenti MP, White LA, Schroen DJ, Benbow U and Brinckerhoff CE: Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability. Crit Rev Eukaryot Gene Expr. 6:391–411. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Westermarck J and Kähäri VM: Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 13:781–792. 1999.PubMed/NCBI

30 

White LA and Brinckerhoff CE: Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have different effects on transcription and bind Jun D, c-Fos, and Fra-2. Matrix Biol. 14:715–725. 1995. View Article : Google Scholar : PubMed/NCBI

31 

White LA, Maute C and Brinckerhoff CE: ETS sites in the promoters of the matrix metalloproteinases collagenase (MMP-1) and stromelysin (MMP-3) are auxiliary elements that regulate basal and phorbol-induced transcription. Connect Tissue Res. 36:321–335. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Karin M, Liu Z and Zandi E: AP-1 function and regulation. Curr Opin Cell Biol. 9:240–246. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Angel P, Szabowski A and Schorpp-Kistner M: Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene. 20:2413–2423. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Lim JY, Kim OK, Lee J, Lee MJ, Kang N and Hwang JK: Protective effect of the standardized green tea seed extract on UVB-induced skin photoaging in hairless mice. Nutr Res Pract. 8:398–403. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Nwomeh BC, Liang HX, Diegelmann RF, Cohen IK and Yager DR: Dynamics of the matrix metalloproteinases MMP-1 and MMP-8 in acute open human dermal wounds. Wound Repair Regen. 6:127–134. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Parrado J, Bougria M, Ayala A, Castaño A and Machado A: Effects of aging on the various steps of protein synthesis: fragmentation of elongation factor 2. Free Radic Biol Med. 26:362–370. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S and Voorhees JJ: Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 138:1462–1470. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Berneburg M and Krutmann J: Photoaging-associated large-scale deletions of mitochondrial DNA. Methods Enzymol. 319:366–376. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Rossetti D, Kielmanowicz MG, Vigodman S, Hu YP, Chen N, Nkengne A, Oddos T, Fischer D, Seiberg M and Lin CB: A novel anti-ageing mechanism for retinol: induction of dermal elastin synthesis and elastin fibre formation. Int J Cosmet Sci. 33:62–69. 2011. View Article : Google Scholar

40 

Hachiya A, Sriwiriyanont P, Fujimura T, Ohuchi A, Kitahara T, Takema Y, Kitzmiller WJ, Visscher MO, Tsuboi R and Boissy RE: Mechanistic effects of long-term ultraviolet B irradiation induce epidermal and dermal changes in human skin xenografts. Am J Pathol. 174:401–413. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Sherratt MJ: Tissue elasticity and the ageing elastic fibre. Age (Dordr). 31:305–325. 2009. View Article : Google Scholar

42 

Tracy LE, Minasian RA and Caterson EJ: Extracellular matrix and dermal fibroblast function in the healing wound. Adv Wound Care (New Rochelle). 5:119–136. 2016. View Article : Google Scholar

43 

Inomata S, Matsunaga Y, Amano S, Takada K, Kobayashi K, Tsunenaga M, Nishiyama T, Kohno Y and Fukuda M: Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse. J Invest Dermatol. 120:128–134. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Cho S, Won CH, Lee DH, Lee MJ, Lee S, So SH, Lee SK, Koo BS, Kim NM and Chung JH: Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study. J Med Food. 12:1252–1259. 2009. View Article : Google Scholar

45 

Manosroi A, Chutoprapat R, Abe M, Manosroi W and Manosroi J: Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds. Pharm Biol. 50:208–224. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Kligman LH and Kligman AM: The nature of photoaging: its prevention and repair. Photodermatol. 3:215–227. 1986.PubMed/NCBI

47 

Hussain SH, Limthongkul B and Humphreys TR: The biomechanical properties of the skin. Dermatol Surg. 39:193–203. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Roh E, Kim JE, Kwon JY, Park JS, Bode AM, Dong Z and Lee KW: Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging. Crit Rev Food Sci Nutr. Jun 26–2015.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

49 

Talwar HS, Griffiths CE, Fisher GJ, Hamilton TA and Voorhees JJ: Reduced type I and type III procollagens in photodamaged adult human skin. J Invest Dermatol. 105:285–290. 1995. View Article : Google Scholar : PubMed/NCBI

50 

Fisher GJ and Voorhees JJ: Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc. 3:61–68. 1998.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Choi SJ, Lee S, Kim K, Joo DH, Shin S, Lee J, Lee HK, Kim J, Kwon SB, Kim MJ, Kim MJ, et al: Biological effects of rutin on skin aging. Int J Mol Med 38: 357-363, 2016.
APA
Choi, S.J., Lee, S., Kim, K., Joo, D.H., Shin, S., Lee, J. ... Cha, H.J. (2016). Biological effects of rutin on skin aging. International Journal of Molecular Medicine, 38, 357-363. https://doi.org/10.3892/ijmm.2016.2604
MLA
Choi, S. J., Lee, S., Kim, K., Joo, D. H., Shin, S., Lee, J., Lee, H. K., Kim, J., Kwon, S. B., Kim, M. J., Ahn, K. J., An, I., An, S., Cha, H. J."Biological effects of rutin on skin aging". International Journal of Molecular Medicine 38.1 (2016): 357-363.
Chicago
Choi, S. J., Lee, S., Kim, K., Joo, D. H., Shin, S., Lee, J., Lee, H. K., Kim, J., Kwon, S. B., Kim, M. J., Ahn, K. J., An, I., An, S., Cha, H. J."Biological effects of rutin on skin aging". International Journal of Molecular Medicine 38, no. 1 (2016): 357-363. https://doi.org/10.3892/ijmm.2016.2604
Copy and paste a formatted citation
x
Spandidos Publications style
Choi SJ, Lee S, Kim K, Joo DH, Shin S, Lee J, Lee HK, Kim J, Kwon SB, Kim MJ, Kim MJ, et al: Biological effects of rutin on skin aging. Int J Mol Med 38: 357-363, 2016.
APA
Choi, S.J., Lee, S., Kim, K., Joo, D.H., Shin, S., Lee, J. ... Cha, H.J. (2016). Biological effects of rutin on skin aging. International Journal of Molecular Medicine, 38, 357-363. https://doi.org/10.3892/ijmm.2016.2604
MLA
Choi, S. J., Lee, S., Kim, K., Joo, D. H., Shin, S., Lee, J., Lee, H. K., Kim, J., Kwon, S. B., Kim, M. J., Ahn, K. J., An, I., An, S., Cha, H. J."Biological effects of rutin on skin aging". International Journal of Molecular Medicine 38.1 (2016): 357-363.
Chicago
Choi, S. J., Lee, S., Kim, K., Joo, D. H., Shin, S., Lee, J., Lee, H. K., Kim, J., Kwon, S. B., Kim, M. J., Ahn, K. J., An, I., An, S., Cha, H. J."Biological effects of rutin on skin aging". International Journal of Molecular Medicine 38, no. 1 (2016): 357-363. https://doi.org/10.3892/ijmm.2016.2604
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