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International Journal of Molecular Medicine
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July-2016 Volume 38 Issue 1

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Article Open Access

Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma

Corrigendum in: /10.3892/ijmm.2016.2682
Retraction in: /10.3892/ijmm.2024.5425
  • Authors:
    • Liping Fang
    • Jiuhan Zhao
    • Dan Wang
    • Liyu Zhu
    • Jian Wang
    • Kui Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology 5, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Neurology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110001, P.R. China, Department of Cardiothoracic Surgery, Dalian Friendship Hospital, Zhongshan, Dalian, Liaoning 116100, P.R. China, Department of Neurology, Liaoning Provincial People's Hospital, Shenyang, Liaoning 110016, P.R. China
    Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 172-182
    |
    Published online on: May 30, 2016
       https://doi.org/10.3892/ijmm.2016.2614
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Abstract

Previous studies have suggested that jumonji AT-rich interactive domain 1B (JARID1B) plays an important role in the genesis of some types of cancer, and it is therefore considered to be an important drug target protein. Although the expression of JARID1B has been researched in some types of cancer, little is known about JARID1B expression in glioma and its function in the tumorigenesis of gliomas. In the present study, we examined the expression of JARID1B in glioma. In addition, RT-PCR, western blot analysis and immunohistochemical analysis were performed using glioma tissue samples and the results revealed that JARID1B expression increased according to the histological grade of glioma. However, in the normal brain tissue samples JARID1B expression was barely detected. Kaplan‑Meier analysis revealed that higher JARID1B expression in patients with glioma was associated with a poorer prognosis. The overexpression of JARID1B stimulated the proliferation and migration of glioma cells as well as sphere formation, whereas suppressing the expression of JARID1B produced opposite effects. The overexpression of JARID1B increased the tumorigenicity of glioma cells in vivo in a nude mouse xenograft model of glioma. Moreover, the activation of phosphorylated (p-)Smad2 contributes to JARID1B-induced oncogenic activities. These findings suggest that JARID1B is involved in the pathogenesis of glioma, and that the downregulation of JARID1B in glioma cells may be a therapeutic target for the treatment of patients with glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Fang L, Zhao J, Wang D, Zhu L, Wang J and Jiang K: Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425. Int J Mol Med 38: 172-182, 2016.
APA
Fang, L., Zhao, J., Wang, D., Zhu, L., Wang, J., & Jiang, K. (2016). Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425. International Journal of Molecular Medicine, 38, 172-182. https://doi.org/10.3892/ijmm.2016.2614
MLA
Fang, L., Zhao, J., Wang, D., Zhu, L., Wang, J., Jiang, K."Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425". International Journal of Molecular Medicine 38.1 (2016): 172-182.
Chicago
Fang, L., Zhao, J., Wang, D., Zhu, L., Wang, J., Jiang, K."Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425". International Journal of Molecular Medicine 38, no. 1 (2016): 172-182. https://doi.org/10.3892/ijmm.2016.2614
Copy and paste a formatted citation
x
Spandidos Publications style
Fang L, Zhao J, Wang D, Zhu L, Wang J and Jiang K: Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425. Int J Mol Med 38: 172-182, 2016.
APA
Fang, L., Zhao, J., Wang, D., Zhu, L., Wang, J., & Jiang, K. (2016). Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425. International Journal of Molecular Medicine, 38, 172-182. https://doi.org/10.3892/ijmm.2016.2614
MLA
Fang, L., Zhao, J., Wang, D., Zhu, L., Wang, J., Jiang, K."Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425". International Journal of Molecular Medicine 38.1 (2016): 172-182.
Chicago
Fang, L., Zhao, J., Wang, D., Zhu, L., Wang, J., Jiang, K."Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma Corrigendum in /10.3892/ijmm.2016.2682 Retraction in /10.3892/ijmm.2024.5425". International Journal of Molecular Medicine 38, no. 1 (2016): 172-182. https://doi.org/10.3892/ijmm.2016.2614
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