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Article

Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice

  • Authors:
    • Qiang Wang
    • Yunrong Zhang
    • De Li
    • Yan Zhang
    • Bing Tang
    • Gang Li
    • Yongjian Yang
    • Dachun Yang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Chengdu Military General Hospital, Jinniu, Chengdu, Sichuan 610083, P.R. China
  • Pages: 601-609
    |
    Published online on: June 16, 2016
       https://doi.org/10.3892/ijmm.2016.2648
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Abstract

Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel with high permeability to Ca2+. Intracellular Ca2+ signaling is an essential regulator of endothelial nitric oxide (NO) synthase (eNOS) that plays a beneficial role in myocardial fibrosis. The aim of the present study was to determine the role of TRPV1 in isoproterenol-induced myocardial fibrosis. Transgenic mice overexpressing TRPV1 were generated on a C57BL/6J genetic background. An animal model of myocardial fibrosis was created by subcutaneously injecting the mice with isoproterenol. We found that the wild-type mice exhibited a significant increase in heart/body weight ratio, left ventricle/body weight ratio, left ventricular end-diastolic pressure (LVEDP), the cardiac fibrotic lesion area and collagen content, as well as a marked decrease in eNOS phosphorylation and NO/cyclic guanosine monophosphate (cGMP) levels at 2 weeks after the administration of isoproterenol (all p<0.01). However, these changes were significantly attenuated in the TRPV1 transgenic mice (p<0.05 or p<0.01). Moreover, the beneficial effects on myocardial fibrosis exerted by the overexpression of TRPV1 were attenuated by the administration of the eNOS inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME) (all p<0.05). Similar anti-fibrotic effects were observed in in vitro experiments with primary cultured cardiac fibroblasts. The findings of our study suggest that TRPV1 overexpression attenuates isoproterenol‑induced myocardial fibrosis.
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1 

Cohn JN, Ferrari R and Sharpe N: Cardiac remodeling - concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 35:569–582. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Biernacka A and Frangogiannis NG: aging and cardiac fibrosis. Aging Dis. 2:158–173. 2011.PubMed/NCBI

3 

Leask A: Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res. 106:1675–1680. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Osadchii OE: Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects. Heart Fail Rev. 12:66–86. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Nichtova Z, Novotova M, Kralova E and Stankovicova T: Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol. Gen Physiol Biophys. 31:141–151. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ozaki M, Kawashima S, Yamashita T, Hirase T, Ohashi Y, Inoue N, Hirata K and Yokoyama M: Overexpression of endothelial nitric oxide synthase attenuates cardiac hypertrophy induced by chronic isoproterenol infusion. Circ J. 66:851–856. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Smith RS Jr, Agata J, Xia CF, Chao L and Chao J: Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction. Life Sci. 76:2457–2471. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Park JY, Shin HK, Choi YW, Lee YJ, Bae SS, Han J and Kim CD: Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells. J Ethnopharmacol. 125:291–296. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Park JH, Lee S, Cho DH, Park YM, Kang DH and Jo I: Far-infrared radiation acutely increases nitric oxide production by increasing Ca(2+) mobilization and Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphorylation of endothelial nitric oxide synthase at serine 1179. Biochem Biophys Res Commun. 436:601–606. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Gail MH, Boone CW and Thompson CS: A calcium requirement for fibroblast motility and prolifertion. Exp Cell Res. 79:386–390. 1973. View Article : Google Scholar : PubMed/NCBI

11 

Gees M, Colsoul B and Nilius B: The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol. 2:a0039622010. View Article : Google Scholar

12 

Thilo F, Liu Y, Schulz N, Gergs U, Neumann J, Loddenkemper C, Gollasch M and Tepel M: Increased transient receptor potential vanilloid type 1 (TRPV1) channel expression in hypertrophic heart. Biochem Biophys Res Commun. 401:98–103. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Marshall NJ, Liang L, Bodkin J, Dessapt-Baradez C, Nandi M, Collot-Teixeira S, Smillie SJ, Lalgi K, Fernandes ES, Gnudi L and Brain SD: A role for TRPV1 in influencing the onset of cardiovascular disease in obesity. Hypertension. 61:246–252. 2013. View Article : Google Scholar

14 

Ma S, Li D, Yang D, Tan Y, Tang B, Jin F, Jiang S, Li X and Yang Y: Establishment of a conditional transgenic mouse model expressing human uncoupling protein 2 in vascular smooth muscle cells. Exp Ther Med. 4:545–547. 2012.PubMed/NCBI

15 

Ma S, Yang D, Wang K, Tang B, Li D and Yang Y: Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in mice associated with upregulation and activation of matrix metal-loproteinase-2. Mol Med Rep. 6:145–150. 2012.PubMed/NCBI

16 

Mukai Y, Rikitake Y, Shiojima I, Wolfrum S, Satoh M, Takeshita K, Hiroi Y, Salomone S, Kim HH, Benjamin LE, et al: Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt. J Clin Invest. 116:334–343. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Yang D, Luo Z, Ma S, Wong WT, Ma L, Zhong J, He H, Zhao Z, Cao T, Yan Z, et al: Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab. 12:130–141. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Ma S, Yang D, Li D, Tang B, Sun M and Yang Y: Cardiac extracellular matrix tenascin-C deposition during fibronectin degradation. Biochem Biophys Res Commun. 409:321–327. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Wang Q, Ma S, Li D, Zhang Y, Tang B, Qiu C, Yang Y and Yang D: Dietary capsaicin ameliorates pressure overload-induced cardiac hypertrophy and fibrosis through the transient receptor potential vanilloid type 1. Am J Hypertens. 27:1521–1529. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Andresen MC and Peters JH: TRPV1, hypertension, and cardiovascular regulation. Cell Metab. 12:421author reply 422. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Zhao JF, Ching LC, Kou YR, Lin SJ, Wei J, Shyue SK and Lee TS: Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: role of liver X receptor α. Mediators Inflamm. 2013:9251712013. View Article : Google Scholar

22 

Ohanyan VA, Guarini G, Thodeti CK, Talasila PK, Raman P, Haney RM, Meszaros JG, Damron DS and Bratz IN: Endothelin-mediated in vivo pressor responses following TRPV1 activation. Am J Physiol Heart Circ Physiol. 301:H1135–H1142. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Suri A and Szallasi A: The emerging role of TRPV1 in diabetes and obesity. Trends Pharmacol Sci. 29:29–36. 2008. View Article : Google Scholar

24 

Motter AL and Ahern GP: TRPV1-null mice are protected from diet-induced obesity. FEBS Lett. 582:2257–2262. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Wang L and Wang DH: TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice. Circulation. 112:3617–3623. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Zhong B and Wang DH: TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice. Am J Physiol Heart Circ Physiol. 293:H1791–H1798. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Huang W, Rubinstein J, Prieto AR, Thang LV and Wang DH: Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction. Hypertension. 53:243–250. 2009. View Article : Google Scholar

28 

Huang W, Rubinstein J, Prieto AR and Wang DH: Enhanced postmyocardial infarction fibrosis via stimulation of the transforming growth factor-beta-Smad2 signaling pathway: role of transient receptor potential vanilloid type 1 channels. J Hypertens. 28:367–376. 2010. View Article : Google Scholar

29 

Ren JY, Song JX, Lu MY and Chen H: Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P. Regul Pept. 169:49–57. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Zhang Y, Li L, Hua Y, Nunn JM, Dong F, Yanagisawa M and Ren J: Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Biol. 4:97–107. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Gao F, Liang Y, Wang X, Lu Z, Li L, Zhu S, Liu D, Yan Z and Zhu Z: TRPV1 activation attenuates high-salt diet-induced cardiac hypertrophy and fibrosis through PPAR-δ upregulation. PPAR Res. 2014:4919632014. View Article : Google Scholar

32 

Buckley CL and Stokes AJ: Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy. Channels (Austin). 5:367–374. 2011. View Article : Google Scholar :

33 

Horton JS, Buckley CL and Stokes AJ: Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice. Channels (Austin). 7:17–22. 2013. View Article : Google Scholar

34 

Ge W, Yuan M, Ceylan AF, Wang X and Ren J: Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. Biochim Biophys Acta. 1862:622–634. 2016. View Article : Google Scholar

35 

Bhuiyan MS, Shioda N and Fukunaga K: Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats. Expert Opin Ther Targets. 13:275–286. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Belge C, Hammond J, Dubois-Deruy E, Manoury B, Hamelet J, Beauloye C, Markl A, Pouleur AC, Bertrand L, Esfahani H, et al: Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase. Circulation. 129:451–462. 2014. View Article : Google Scholar

37 

Savergnini SQ, Ianzer D, Carvalho MB, Ferreira AJ, Silva GA, Marques FD, Peluso AA, Beiman M, Cojocaru G, Cohen Y, et al: The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats. PLoS One. 8:e577572013. View Article : Google Scholar : PubMed/NCBI

38 

Bharti S, Singh R, Chauhan SS, Hussain T, Al-Attas OS and Arya DS: Phosphorylation of Akt/GSK-3β/eNOS amplifies 5-HT2B receptor blockade mediated anti-hypertrophic effect in rats. FEBS Lett. 586:180–185. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Liao Y, Asakura M, Takashima S, Ogai A, Asano Y, Shintani Y, Minamino T, Asanuma H, Sanada S, Kim J, et al: Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice. Circulation. 110:692–699. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Ching LC, Kou YR, Shyue SK, Su KH, Wei J, Cheng LC, Yu YB, Pan CC and Lee TS: Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type s1. Cardiovasc Res. 91:492–501. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Ching LC, Chen CY, Su KH, Hou HH, Shyue SK, Kou YR and Lee TS: Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase. Mol Med. 18:805–815. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Su KH, Lin SJ, Wei J, Lee KI, Zhao JF, Shyue SK and Lee TS: The essential role of transient receptor potential vanilloid s1 in simvastatin-induced activation of endothelial nitric oxide synthase and angiogenesis. Acta Physiol (Oxf). 212:191–204. 2014. View Article : Google Scholar

43 

Guarini G, Ohanyan VA, Kmetz JG, DelloStritto DJ, Thoppil RJ, Thodeti CK, Meszaros JG, Damron DS and Bratz IN: Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels. Am J Physiol Heart Circ Physiol. 303:H216–H223. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Kazakov A, Hall R, Jagoda P, Bachelier K, Müller-Best P, Semenov A, Lammert F, Böhm M and Laufs U: Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis. Cardiovasc Res. 100:211–221. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Zhang Y, Li D, Zhang Y, Tang B, Li G, Yang Y and Yang D: Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice. Int J Mol Med 38: 601-609, 2016.
APA
Wang, Q., Zhang, Y., Li, D., Zhang, Y., Tang, B., Li, G. ... Yang, D. (2016). Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice. International Journal of Molecular Medicine, 38, 601-609. https://doi.org/10.3892/ijmm.2016.2648
MLA
Wang, Q., Zhang, Y., Li, D., Zhang, Y., Tang, B., Li, G., Yang, Y., Yang, D."Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice". International Journal of Molecular Medicine 38.2 (2016): 601-609.
Chicago
Wang, Q., Zhang, Y., Li, D., Zhang, Y., Tang, B., Li, G., Yang, Y., Yang, D."Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice". International Journal of Molecular Medicine 38, no. 2 (2016): 601-609. https://doi.org/10.3892/ijmm.2016.2648
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Zhang Y, Li D, Zhang Y, Tang B, Li G, Yang Y and Yang D: Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice. Int J Mol Med 38: 601-609, 2016.
APA
Wang, Q., Zhang, Y., Li, D., Zhang, Y., Tang, B., Li, G. ... Yang, D. (2016). Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice. International Journal of Molecular Medicine, 38, 601-609. https://doi.org/10.3892/ijmm.2016.2648
MLA
Wang, Q., Zhang, Y., Li, D., Zhang, Y., Tang, B., Li, G., Yang, Y., Yang, D."Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice". International Journal of Molecular Medicine 38.2 (2016): 601-609.
Chicago
Wang, Q., Zhang, Y., Li, D., Zhang, Y., Tang, B., Li, G., Yang, Y., Yang, D."Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice". International Journal of Molecular Medicine 38, no. 2 (2016): 601-609. https://doi.org/10.3892/ijmm.2016.2648
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