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Article

Effects of ginger and its pungent constituents on transient receptor potential channels

  • Authors:
    • Young-Soo Kim
    • Chan Sik Hong
    • Sang Weon Lee
    • Joo Hyun Nam
    • Byung Joo Kim
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, College of Medicine, Pusan National University, Yangsan Hospital, Yangsan, Republic of Korea, Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Physiology, Dongguk University, College of Medicine, Kyungju, Republic of Korea, Healthy Aging Korean Medical Research Center (HAKMRC), Pusan National University, School of Korean Medicine, Yangsan, Republic of Korea
  • Pages: 1905-1914
    |
    Published online on: October 26, 2016
       https://doi.org/10.3892/ijmm.2016.2791
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Abstract

Ginger extract is used as an analeptic in herbal medicine and has been reported to exert antioxidant effects. Transient receptor potential (TRP) canonical 5 (TRPC5), TRP cation channel, subfamily M, member 7 (TRPM7; melastatin 7), and TRP cation channel, subfamily A, member 1 (TRPA1; ankyrin 1) are non-selective cation channels that are modulated by reactive oxygen/nitrogen species (ROS/RNS) and subsequently control various cellular processes. The aim of this study was to evaluate whether ginger and its pungent constituents modulate these channels and exert antioxidant effects. It was found that TRPC5 and TRPA1 currents were modulated by ginger extract and by its pungent constituents, [6]-gingerol, zingerone and [6]-shogaol. In particular, [6]-shogaol markedly and dose-dependently inhibited TRPC5 currents with an IC50 of value of ~18.3 µM. Furthermore, the strong dose-dependent activation of TRPA1 currents by [6]-shogaol was abolished by A‑967079 (a selective TRPA1 inhibitor). However, ginger extract and its pungent constituents had no effect on TRPM7 currents. These results suggest the antioxidant effects of ginger extract and its pungent constituents are mediated through TRPC5 and TRPA1, and that [6]-shogaol is predominantly responsible for the regulation of TRPC5 and TRPA1 currents by ginger extract.
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Copy and paste a formatted citation
Spandidos Publications style
Kim Y, Hong CS, Lee SW, Nam JH and Kim BJ: Effects of ginger and its pungent constituents on transient receptor potential channels. Int J Mol Med 38: 1905-1914, 2016.
APA
Kim, Y., Hong, C.S., Lee, S.W., Nam, J.H., & Kim, B.J. (2016). Effects of ginger and its pungent constituents on transient receptor potential channels. International Journal of Molecular Medicine, 38, 1905-1914. https://doi.org/10.3892/ijmm.2016.2791
MLA
Kim, Y., Hong, C. S., Lee, S. W., Nam, J. H., Kim, B. J."Effects of ginger and its pungent constituents on transient receptor potential channels". International Journal of Molecular Medicine 38.6 (2016): 1905-1914.
Chicago
Kim, Y., Hong, C. S., Lee, S. W., Nam, J. H., Kim, B. J."Effects of ginger and its pungent constituents on transient receptor potential channels". International Journal of Molecular Medicine 38, no. 6 (2016): 1905-1914. https://doi.org/10.3892/ijmm.2016.2791
Copy and paste a formatted citation
x
Spandidos Publications style
Kim Y, Hong CS, Lee SW, Nam JH and Kim BJ: Effects of ginger and its pungent constituents on transient receptor potential channels. Int J Mol Med 38: 1905-1914, 2016.
APA
Kim, Y., Hong, C.S., Lee, S.W., Nam, J.H., & Kim, B.J. (2016). Effects of ginger and its pungent constituents on transient receptor potential channels. International Journal of Molecular Medicine, 38, 1905-1914. https://doi.org/10.3892/ijmm.2016.2791
MLA
Kim, Y., Hong, C. S., Lee, S. W., Nam, J. H., Kim, B. J."Effects of ginger and its pungent constituents on transient receptor potential channels". International Journal of Molecular Medicine 38.6 (2016): 1905-1914.
Chicago
Kim, Y., Hong, C. S., Lee, S. W., Nam, J. H., Kim, B. J."Effects of ginger and its pungent constituents on transient receptor potential channels". International Journal of Molecular Medicine 38, no. 6 (2016): 1905-1914. https://doi.org/10.3892/ijmm.2016.2791
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