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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2016 Volume 38 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review)

Bjorn Baselet, Charlotte Rombouts, Abderrafi Mohammed Benotmane, Sarah Baatout, An Aerts
Pages: 1623-1641
Published online on: 17 October 2016

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Review

Overlapping molecular pathways between cannabinoid receptors type 1 and 2 and estrogens/androgens on the periphery and their involvement in the pathogenesis of common diseases (Review)

Luka Dobovišek, Marko Hojnik, Polonca Ferk
Pages: 1642-1651
Published online on: 17 October 2016

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Article Open Access

Impact of vitamin E-blended UHMWPE wear particles on the osseous microenvironment in polyethylene particle-induced osteolysis

Carl Neuerburg, Theresa Loer, Lena Mittlmeier, Christina Polan, Zsuzsanna Farkas, Lesca Miriam Holdt, Sandra Utzschneider, Jens Schwiesau, Thomas M. Grupp, Wolfgang Böcker, Attila Aszodi, Christian Wedemeyer, Christian Kammerlander
Pages: 1652-1660
Published online on: 18 October 2016

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Article Open Access

Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice

Xue-Ju Li, Zhe Zhu, Si-Lin Han, Zi-Long Zhang
Pages: 1661-1672
Published online on: 02 November 2016

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Article Open Access

Heparin-binding epidermal growth factor-like growth factor and hepatocyte growth factor inhibit cholestatic liver injury in mice through different mechanisms

Kouichi Sakamoto, Ngin Cin Khai, Yuqing Wang, Rie Irie, Hideo Takamatsu, Hiroshi Matsufuji, Ken-Ichiro Kosai
Pages: 1673-1682
Published online on: 20 October 2016

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Article Open Access

Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase

Akbar Ahmad, Domokos Gerö, Gabor Olah, Csaba Szabo
Pages: 1683-1692
Published online on: 14 October 2016

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Article Open Access

All-trans retinoic acid shifts rosiglitazone-induced adipogenic differentiation to osteogenic differentiation in mouse embryonic fibroblasts

Ying Shao, Qian-Zhao Chen, Yu-Hua Zeng, Yang Li, Wen-Yan Ren, Lin-Yun Zhou, Rong-Xin Liu, Ke Wu, Jun-Qing Yang, Zhong-Liang Deng, Yu Yu, Wen-Juan Sun, Bai-Cheng He
Pages: 1693-1702
Published online on: 19 October 2016

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Article Open Access

Seven novel and six de novo PHEX gene mutations in patients with hypophosphatemic rickets

Shan-Shan Li, Jie-Mei Gu, Wei-Jia Yu, Jin-Wei He, Wen-Zhen Fu, Zhen-Lin Zhang
Pages: 1703-1714
Published online on: 07 November 2016

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Article Open Access

Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice

Qin Kong, Haojun Zhang, Tingting Zhao, Weiku Zhang, Meihua Yan, Xi Dong, Ping Li
Pages: 1715-1726
Published online on: 10 November 2016

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Article Open Access

Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells

Qiang Liu, Yunyan Wu, Tadashi Yoshizawa, Xu Yan, Satoko Morohashi, Hiroko Seino, Yukio Kato, Hiroshi Kijima
Pages: 1727-1733
Published online on: 08 November 2016

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Article Open Access

TRIM16 suppresses the progression of prostate tumors by inhibiting the Snail signaling pathway Retraction in /10.3892/ijmm.2023.5262

Li Qi, Zhong Lu, Yong-Hong Sun, Hai-Tao Song, Wei-Kang Xu
Pages: 1734-1742
Published online on: 17 October 2016

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Article Open Access

Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis

Magdy El-Salhy, Tarek Mazzawi, Kazuo Umezawa, Odd Helge Gilja
Pages: 1743-1751
Published online on: 24 October 2016

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Article Open Access

Aquaporin 1 contributes to chondrocyte apoptosis in a rat model of osteoarthritis

Hangfei Gao, Jiancao Gui, Liming Wang, Yan Xu, Yiqiu Jiang, Mingyue Xiong, Yongguang Cui
Pages: 1752-1758
Published online on: 24 October 2016

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Article Open Access

Amentoflavone protects against high fat-induced metabolic dysfunction: Possible role of the regulation of adipogenic differentiation

Guangyong Chen, Yangdong Han, Wang He, Feng Liang
Pages: 1759-1767
Published online on: 14 October 2016

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Article

MicroRNA-16 inhibits the proliferation, migration and invasion of glioma cells by targeting Sal-like protein 4

Yu Zhou, Yang Liu, Chao Hu, Yugang Jiang
Pages: 1768-1776
Published online on: 17 October 2016

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Article Open Access

Low concentrations of human neutrophil peptide ameliorate experimental murine colitis

Takuro Maeda, Toshio Sakiyama, Shuji Kanmura, Shinichi Hashimoto, Kazunari Ibusuki, Shiroh Tanoue, Yuga Komaki, Shiho Arima, Yuichiro Nasu, Fumisato Sasaki, Hiroki Taguchi, Masatsugu Numata, Hirofumi Uto, Hirohito Tsubouchi, Akio Ido
Pages: 1777-1785
Published online on: 03 November 2016

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Article Open Access

Suppression of the expression of hypoxia-inducible factor-1α by RNA interference alleviates hypoxia-induced pulmonary hypertension in adult rats

Ying Li, Bo Shi, Liping Huang, Xin Wang, Xiaona Yu, Baosheng Guo, Weidong Ren
Pages: 1786-1794
Published online on: 14 October 2016

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Article Open Access

Molecular cloning, expression, IgE binding activities and in silico epitope prediction of Per a 9 allergens of the American cockroach

Haiwei Yang, Hao Chen, Min Jin, Hua Xie, Shaoheng He, Ji-Fu Wei
Pages: 1795-1805
Published online on: 27 October 2016

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Article Open Access

In silico epitope prediction, expression and functional analysis of Per a 10 allergen from the American cockroach

Xunliang Tong, Miao Guo, Min Jin, Hao Chen, Yanming Li, Ji-Fu Wei
Pages: 1806-1814
Published online on: 26 October 2016

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Article

High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells

Di Che, Ti Zhou, Yuqing Lan, Jinye Xie, Haijun Gong, Chaoyang Li, Juan Feng, Honghai Hong, Weiwei Qi, Caiqi Ma, Qiyuan Wu, Xia Yang, Guoquan Gao
Pages: 1815-1822
Published online on: 06 October 2016

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Article

Asiatic acid inhibits lactate-induced cardiomyocyte apoptosis through the regulation of the lactate signaling cascade

Changzheng Gao, Fen Wang, Zhiqiang Wang, Jing Zhang, Xiangjun Yang
Pages: 1823-1830
Published online on: 20 October 2016

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Article

Role of urotensin II in advanced glycation end product-induced extracellular matrix synthesis in rat proximal tubular epithelial cells

Lin Tian, Peng Fu, Min Zhou, Yunhe Gu, Yunqian Li, Jiping Qi
Pages: 1831-1838
Published online on: 26 October 2016

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Article

Screening for genes, transcription factors and miRNAs associated with the myogenic and osteogenic differentiation of human adipose tissue-derived stem cells

Liangliang Quan, Yang Wang, Jiulong Liang, Tao Qiu, Hongyi Wang, Ye Zhang, Yu Zhang, Qiang Hui, Kai Tao
Pages: 1839-1849
Published online on: 25 October 2016

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Article

Deregulated WWOX is involved in a negative feedback loop with microRNA-214-3p in osteosarcoma

Kaituo Gao, Jijuan Yin, Jian Dong
Pages: 1850-1856
Published online on: 10 November 2016

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Article

Sevoflurane inhibits the migration and invasion of glioma cells by upregulating microRNA-637

Wenbo Yi, Dongliang Li, Yongmin Guo, Yan Zhang, Bin Huang, Xingang Li
Pages: 1857-1863
Published online on: 08 November 2016

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Article

Anti-inflammatory effect of salidroside on phorbol-12-myristate-13-acetate plus A23187-mediated inflammation in HMC-1 cells

Da-Wun Yang, Ok-Hwa Kang, Young-Seob Lee, Sin-Hee Han, Sang-Won Lee, Seon‑Woo Cha, Yun-Soo Seo, Su-Hyun Mun, Ryong Gong, Dong-Won Shin, Dong-Yeul Kwon
Pages: 1864-1870
Published online on: 18 October 2016

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Article

Paeonol promotes microRNA-126 expression to inhibit monocyte adhesion to ox-LDL-injured vascular endothelial cells and block the activation of the PI3K/Akt/NF-κB pathway

Xusheng Yuan, Junjun Chen, Min Dai
Pages: 1871-1878
Published online on: 17 October 2016

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Article

Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells

Estelle R. Simo-Cheyou, George Vardatsikos, Ashok K. Srivastava
Pages: 1879-1886
Published online on: 06 October 2016

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Article

Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature

Dominika Labochka, Barbara Moszczuk, Wojciech Kukwa, Cezary Szczylik, Anna M. Czarnecka
Pages: 1887-1894
Published online on: 17 October 2016

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Article

The phytogestrogenic stilbenes, arachidin-1 and resveratrol, modulate regulatory T cell functions responsible for successful aging in aged ICR mice

Brian Bor-Chun Weng, Wen-Shin Lin, Ju-Chun Chang, Robin Yih-Yuan Chiou
Pages: 1895-1904
Published online on: 27 October 2016

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Article

Effects of ginger and its pungent constituents on transient receptor potential channels

Young-Soo Kim, Chan Sik Hong, Sang Weon Lee, Joo Hyun Nam, Byung Joo Kim
Pages: 1905-1914
Published online on: 26 October 2016

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Article

CNTF protects neurons from hypoxic injury through the activation of STAT3pTyr705

Ying Li Gu, Guan Qun Gao, Ning Ma, Lin Lin Ye, Li Wei Zhang, Xu Gao, Zhuo Bo Zhang
Pages: 1915-1921
Published online on: 13 October 2016

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Article

Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis

Hongbo Hu, Baohui Yang, Yumin Li, Subin Zhang, Zheng Li
Pages: 1922-1932
Published online on: 13 October 2016

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Article

Expression of β1- and β2-adrenergic receptors in the lungs and changes in the levels of corresponding autoantibodies in an aged rat model of heart failure

Xiang-Yang Fang, Zhe Chen, Guo-Bin Miao, Lin Zhang
Pages: 1933-1939
Published online on: 24 October 2016

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Article

The combination of β-caryophyllene, baicalin and catechin synergistically suppresses the proliferation and promotes the death of RAW267.4 macrophages in vitro

Masayoshi Yamaguchi, Robert M. Levy
Pages: 1940-1946
Published online on: 14 November 2016

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Retraction Open Access

[Retracted] Slit-miR-218-Robo axis regulates retinal neovascularization

Yichun Kong, Bei Sun, Quanhong Han, Shuang Han, Yuchuan Wang, Ying Chen
Pages: 1947-1947
Published online on: 23 September 2016

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Review Open Access

Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Article Open Access

Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Article Open Access

Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Article

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Review Open Access

Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Article Open Access

Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Review Open Access

Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Review Open Access

Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Review Open Access

Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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