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Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model

  • Authors:
    • Tae-Shin Park
    • Young-Kyoung Ryu
    • Hye-Yeon Park
    • Jae Yun Kim
    • Jun Go
    • Jung-Ran Noh
    • Yong-Hoon Kim
    • Jung Hwan Hwang
    • Dong-Hee Choi
    • Won-Keun Oh
    • Chul-Ho Lee
    • Kyoung-Shim Kim
  • View Affiliations / Copyright

    Affiliations: Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Republic of Korea, Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 21-30
    |
    Published online on: November 16, 2016
       https://doi.org/10.3892/ijmm.2016.2804
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Abstract

Humulus japonicus Siebold & Zucc. (HJ) has traditionally been administered to patients with pulmonary disease, skin disease and hypertension in Korea, and it is considered to exert anti-inflammatory, antioxidant, antimicrobial and antimycobacterial effects. However, its effects against Alzheimer's disease (AD) have yet to be explored. Thus, this study was carried out to investigate whether HJ has a beneficial effect on the progression of AD in an animal model. A methanolic extract of HJ (500 mg/kg/day) was intragastrically administered to 5-month-old APP/PS1 transgenic (Tg-APP/PS1) mice for 2.5 months. Novel object recognition and Y-maze alteration tests were used to assess cognitive function, and an immunohistochemical assay was performed to assess amyloid β (Aβ)deposition, tau phosphorylation and gliosis. An in vitro assay using a microglial cell line was also performed to investigate the anti-inflammatory effects of HJ. Our results revealed that HJ significantly decreased the mRNA and protein expression levels of tumor necrosis factor-α (TNF‑α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide in the microglial cell line. The administration of HJ for 2 months improved the cognitive function of Tg-APP/PS1 mice. HJ notably reduced the area occupied by Aβ and neurofibrillary tangles, and the number of activated astrocytes and microglia in the cortex of Tg-APP/PS1 mice. The findings of our study suggest that HJ has the therapeutic potential to inhibit the progression of AD and to improve cognitive deterioration in Tg-APP/PS1 mice.
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1 

Ali FEA, Barnham KJ, Barrow CJ and Separovic F: Metal-catalyzed oxidative damage and oligomerization of the amyloid-peptide of Alzheimer's disease. Aust J Chem. 57:511–518. 2004. View Article : Google Scholar

2 

Baldeiras I, Santana I, Proença MT, Garrucho MH, Pascoal R, Rodrigues A, Duro D and Oliveira CR: Oxidative damage and progression to Alzheimer's disease in patients with mild cognitive impairment. J Alzheimers Dis. 21:1165–1177. 2010.PubMed/NCBI

3 

Zhang F and Jiang L: Neuroinflammation in Alzheimer's disease. Neuropsychiatr Dis Treat. 11:243–256. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Birch AM, Katsouri L and Sastre M: Modulation of inflammation in transgenic models of Alzheimer's disease. J Neuroinflammation. 11:252014. View Article : Google Scholar : PubMed/NCBI

5 

Finch CE and Morgan TE: Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr Alzheimer Res. 4:185–189. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Frank B and Gupta S: A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry. 17:269–286. 2005. View Article : Google Scholar

7 

Zhu X, Su B, Wang X, Smith MA and Perry G: Causes of oxidative stress in Alzheimer disease. Cell Mol Life Sci. 64:2202–2210. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Heneka MT and O'Banion MK: Inflammatory processes in Alzheimer's disease. J Neuroimmunol. 184:69–91. 2007. View Article : Google Scholar : PubMed/NCBI

9 

El Khoury J and Luster AD: Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci. 29:626–632. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Mandrekar-Colucci S, Karlo JC and Landreth GE: Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci. 32:10117–10128. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP and Anderton BH: Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB J. 23:739–750. 2009. View Article : Google Scholar

12 

Sastre M and Gentleman SM: NSAIDs: how they work and their prospects as therapeutics in Alzheimer's disease. Front Aging Neurosci. 2:202010.PubMed/NCBI

13 

Seabrook TJ, Jiang L, Maier M and Lemere CA: Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia. 53:776–782. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Tweedie D, Ferguson RA, Fishman K, Frankola KA, Van Praag H, Holloway HW, Luo W, Li Y, Caracciolo L, Russo I, et al: Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflammation. 9:1062012. View Article : Google Scholar

15 

Chan MM, Huang HI, Fenton MR and Fong D: In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem Pharmacol. 55:1955–1962. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB and Pasinetti GM: Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci. 28:6388–6392. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Xia EQ, Deng GF, Guo YJ and Li HB: Biological activities of polyphenols from grapes. Int J Mol Sci. 11:622–646. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA and Cole GM: Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 280:5892–5901. 2005. View Article : Google Scholar

19 

Jeong KY, Han IS, Choi SY, Lee JH, Lee JS, Hong CS and Park JW: Allergenicity of recombinant profilins from Japanese hop, Humulus japonicus. J Investig Allergol Clin Immunol. 23:345–350. 2013.PubMed/NCBI

20 

Lee YR, Kim KY, Lee SH, Kim MY, Park HJ and Jeong HS: Antioxidant and antitumor activities of methanolic extracts from Humulus japonicus. Korean J Food Nutr. 25:357–361. 2012. View Article : Google Scholar

21 

Park SW, Woo CJ, Chung SK and Chung KT: Antimicrobial and antioxidative activities of solvent fraction from Humulus japonicus. Korean J Food Sci Technol. 26:464–470. 1994.

22 

Hwang SY, Jo MJ, Kim SC and Jee SY: Anti-inflammaory effects of the MeOH extract of Humulus japonicus in vivo. J Korean Orient Med Ophthalmol Otolaryngol Derm. 22:92–103. 2009.

23 

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, et al: Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 13:159–170. 2004. View Article : Google Scholar

24 

Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG and Borchelt DR: Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng. 17:157–165. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Park HY, Kang YM, Kang Y, Park TS, Ryu YK, Hwang JH, Kim YH, Chung BH, Nam KH, Kim MR, et al: Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease. J Neurosci. 34:11744–11753. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Akkerman S, Blokland A, Reneerkens O, van Goethem NP, Bollen E, Gijselaers HJ, Lieben CK, Steinbusch HW and Prickaerts J: Object recognition testing: methodological considerations on exploration and discrimination measures. Behav Brain Res. 232:335–347. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Antunes M and Biala G: The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process. 13:93–110. 2012. View Article : Google Scholar :

28 

Wasilewska-Sampaio AP, Santos TG, Lopes MH, Cammarota M and Martins VR: The growth of glioblastoma orthotopic xenografts in nude mice is directly correlated with impaired object recognition memory. Physiol Behav. 123:55–61. 2014. View Article : Google Scholar

29 

Belforte JE, Zsiros V, Sklar ER, Jiang Z, Yu G, Li Y, Quinlan EM and Nakazawa K: Postnatal NMDA receptor ablation in cortico-limbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci. 13:76–83. 2010. View Article : Google Scholar

30 

Kim KS, Kang YM, Kang Y, Park TS, Park HY, Kim YJ, Han BS, Kim CH, Lee CH, Ardayfio PA, et al: Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism. Brain Res. 1552:72–81. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Sierksma AS, Prickaerts J, Chouliaras L, Rostamian S, Delbroek L, Rutten BP, Steinbusch HW and van den Hove DL: Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice. Neurobiol Aging. 34:319–337. 2013. View Article : Google Scholar

32 

Hafez D, Huang JY, Huynh AM, Valtierra S, Rockenstein E, Bruno AM, Lu B, DesGroseillers L, Masliah E and Marr RA: Neprilysin-2 is an important β-amyloid degrading enzyme. Am J Pathol. 178:306–312. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB and Selkoe DJ: Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 273:32730–32738. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Sastre M, Klockgether T and Heneka MT: Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int J Dev Neurosci. 24:167–176. 2006. View Article : Google Scholar : PubMed/NCBI

35 

McGeer PL and McGeer EG: The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev. 21:195–218. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Rubio-Perez JM: A review: inflammatory process in Alzheimer's disease, role of cytokines. ScientificWord Journal. 2012:7563572012.

37 

Town T, Nikolic V and Tan J: The microglial 'activation' continuum: from innate to adaptive responses. J Neuroinflammation. 2:242005. View Article : Google Scholar

38 

Brown GC and Bal-Price A: Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol. 27:325–355. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Halliday G, Robinson SR, Shepherd C and Kril J: Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms. Clin Exp Pharmacol Physiol. 27:1–8. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, et al: GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease. Nat Med. 20:886–896. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, et al: Inflammation and Alzheimer's disease. Neurobiol Aging. 21:383–421. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Guo HB, Cheng YF, Wu JG, Wang CM, Wang HT, Zhang C, Qiu ZK and Xu JP: Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation. Neuroscience. 290:530–542. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H and Haass C: Reconstitution of gamma-secretase activity. Nat Cell Biol. 5:486–488. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, et al: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:735–741. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y and Saido TC: Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med. 6:143–150. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP and Selkoe DJ: Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 40:1087–1093. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR and Selkoe DJ: Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 20:1657–1665. 2000.PubMed/NCBI

48 

Leal MC, Dorfman VB, Gamba AF, Frangione B, Wisniewski T, Castaño EM, Sigurdsson EM and Morelli L: Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology. J Neuropathol Exp Neurol. 65:976–987. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Cook DG, Leverenz JB, McMillan PJ, Kulstad JJ, Ericksen S, Roth RA, Schellenberg GD, Jin LW, Kovacina KS and Craft S: Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. Am J Pathol. 162:313–319. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Hong MS, Son ES, Lee SJ, Lee SK, Lee YJ, Song SD, Cho SN, Barry CE III and Eum SY: Anti-mycobacterial Effects of the Extract of Humulus japonicas. Korean J Food Sci Technol. 46:94–99. 2014. View Article : Google Scholar

51 

Park SW, Kim SH and Chung SK: Antimutagenic effects and isolation of flavonoids from HJ extract. Korean J Food Sci Technol. 27:897–901. 1995.

52 

Di Bona D, Scapagnini G, Candore G, Castiglia L, Colonna-Romano G, Duro G, Nuzzo D, Iemolo F, Lio D, Pellicanò M, et al: Immune-inflammatory responses and oxidative stress in Alzheimer's disease: therapeutic implications. Curr Pharm Des. 16:684–691. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park T, Ryu Y, Park H, Kim JY, Go J, Noh J, Kim Y, Hwang JH, Choi D, Oh W, Oh W, et al: Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med 39: 21-30, 2017.
APA
Park, T., Ryu, Y., Park, H., Kim, J.Y., Go, J., Noh, J. ... Kim, K. (2017). Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. International Journal of Molecular Medicine, 39, 21-30. https://doi.org/10.3892/ijmm.2016.2804
MLA
Park, T., Ryu, Y., Park, H., Kim, J. Y., Go, J., Noh, J., Kim, Y., Hwang, J. H., Choi, D., Oh, W., Lee, C., Kim, K."Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model". International Journal of Molecular Medicine 39.1 (2017): 21-30.
Chicago
Park, T., Ryu, Y., Park, H., Kim, J. Y., Go, J., Noh, J., Kim, Y., Hwang, J. H., Choi, D., Oh, W., Lee, C., Kim, K."Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model". International Journal of Molecular Medicine 39, no. 1 (2017): 21-30. https://doi.org/10.3892/ijmm.2016.2804
Copy and paste a formatted citation
x
Spandidos Publications style
Park T, Ryu Y, Park H, Kim JY, Go J, Noh J, Kim Y, Hwang JH, Choi D, Oh W, Oh W, et al: Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med 39: 21-30, 2017.
APA
Park, T., Ryu, Y., Park, H., Kim, J.Y., Go, J., Noh, J. ... Kim, K. (2017). Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. International Journal of Molecular Medicine, 39, 21-30. https://doi.org/10.3892/ijmm.2016.2804
MLA
Park, T., Ryu, Y., Park, H., Kim, J. Y., Go, J., Noh, J., Kim, Y., Hwang, J. H., Choi, D., Oh, W., Lee, C., Kim, K."Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model". International Journal of Molecular Medicine 39.1 (2017): 21-30.
Chicago
Park, T., Ryu, Y., Park, H., Kim, J. Y., Go, J., Noh, J., Kim, Y., Hwang, J. H., Choi, D., Oh, W., Lee, C., Kim, K."Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model". International Journal of Molecular Medicine 39, no. 1 (2017): 21-30. https://doi.org/10.3892/ijmm.2016.2804
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