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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2017 Volume 39 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

PINK1 signaling in mitochondrial homeostasis and in aging (Review)

Yasuko Kitagishi, Noriko Nakano, Mako Ogino, Mayuko Ichimura, Akari Minami, Satoru Matsuda
Pages: 3-8
Published online on: 12 December 2016

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Article Open Access

Self-renewal molecular mechanisms of colorectal cancer stem cells

Tianhui Pan, Jinghong Xu, Yongliang Zhu
Pages: 9-20
Published online on: 30 November 2016

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Article Open Access

Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model

Tae-Shin Park, Young-Kyoung Ryu, Hye-Yeon Park, Jae Yun Kim, Jun Go, Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Won-Keun Oh, Chul-Ho Lee, Kyoung-Shim Kim
Pages: 21-30
Published online on: 16 November 2016

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Article Open Access

Pyropia yezoensis peptide promotes collagen synthesis by activating the TGF-β/Smad signaling pathway in the human dermal fibroblast cell line Hs27

Cho-Rong Kim, Young-Min Kim, Min-Kyeong Lee, In-Hye Kim, Youn-Hee Choi, Taek-Jeong Nam
Pages: 31-38
Published online on: 18 November 2016

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Article Open Access

Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling

Lixiang Zheng, Yujian Cai, Li Zhou, Ping Huang, Xiaoying Ren, Airen Zuo, Xianming Meng, Minjuan Xu, Xiangru Liao
Pages: 39-46
Published online on: 22 November 2016

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Article Open Access

Klf4 inhibits tumor growth and metastasis by targeting microRNA-31 in human hepatocellular carcinoma

Chuan Tian, Shanshan Yao, Li Liu, Youcheng Ding, Qingwang Ye, Xiao Dong, Yong Gao, Ning Yang, Qi Li
Pages: 47-56
Published online on: 24 November 2016

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Article Open Access

Microarray expression profiles of genes in lung tissues of rats subjected to focal cerebral ischemia-induced lung injury following bone marrow-derived mesenchymal stem cell transplantation

Yue Hu, Liu-Lin Xiong, Piao Zhang, Ting-Hua Wang
Pages: 57-70
Published online on: 06 December 2016

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Article Open Access

miR-214 suppresses the osteogenic differentiation of bone marrow-derived mesenchymal stem cells and these effects are mediated through the inhibition of the JNK and p38 pathways

Yongzhi Guo, Lianhua Li, Jie Gao, Xiaobin Chen, Qinghua Sang
Pages: 71-80
Published online on: 12 December 2016

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Article Open Access

Sequencing and bioinformatics analysis of the differentially expressed genes in herniated discs with or without calcification

Jia Shao, Miao Yu, Liang Jiang, Fengliang Wu, Xiaoguang Liu
Pages: 81-90
Published online on: 07 December 2016

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Article Open Access

Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice

Yuan Liu, Yi Zheng
Pages: 91-100
Published online on: 08 December 2016

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Article Open Access

A tryptophan derivative, ITE, enhances liver cell metabolic functions in vitro

Xiaoqian Zhang, Juan Lu, Bin He, Lingling Tang, Xiaoli Liu, Danhua Zhu, Hongcui Cao, Yingjie Wang, Lanjuan Li
Pages: 101-112
Published online on: 09 December 2016

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Article Open Access

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Pages: 113-125
Published online on: 22 November 2016

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Article Open Access

UHRF2 decreases H3K9ac expression by interacting with it through the PHD and SRA/YDG domain in HepG2 hepatocellular carcinoma cells

Ting Zhang, Linglin Zhao, Shengyuan Zeng, Lu Bai, Junxia Chen, Zheng Zhang, Yalan Wang, Changzhu Duan
Pages: 126-134
Published online on: 17 November 2016

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Article Open Access

Genetic differences in osteogenic differentiation potency in the thoracic ossification of the ligamentum flavum under cyclic mechanical stress

Shanglong Ning, Zhongqiang Chen, Dongwei Fan, Chuiguo Sun, Chi Zhang, Yan Zeng, Weishi Li, Xiaofei Hou, Xiaochen Qu, Yunlong Ma, Huilei Yu
Pages: 135-143
Published online on: 16 November 2016

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Article Open Access

Immunomodulatory effects of OX40Ig gene-modified adipose tissue-derived mesenchymal stem cells on rat kidney transplantation

Tao Liu, Yue Zhang, Zhongyang Shen, Xunfeng Zou, Xiaobo Chen, Li Chen, Yuliang Wang
Pages: 144-152
Published online on: 21 November 2016

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Article Open Access

Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway Corrigendum in /10.3892/ijmm.2019.4403

Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu
Pages: 153-159
Published online on: 01 December 2016

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Article Open Access

Protective effect of VK2 on glucocorticoid-treated MC3T3-E1 cells

Yue-Lei Zhang, Jun-Hui Yin, Hao Ding, Wei Zhang, Chang-Qing Zhang, You-Shui Gao
Pages: 160-166
Published online on: 01 December 2016

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Article Open Access

A new scaffold containing small intestinal submucosa and mesenchymal stem cells improves pancreatic islet function and survival in vitro and in vivo

Dan Wang, Xiaoming Ding, Wujun Xue, Jin Zheng, Xiaohui Tian, Yang Li, Xiaohong Wang, Huanjin Song, Hua Liu, Xiaohui Luo
Pages: 167-173
Published online on: 29 November 2016

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Article Open Access

Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms Corrigendum in /10.3892/ijmm.2019.4422

Thanasekaran Jayakumar, Kao-Chang Lin, Wan-Jung Lu, Chia-Ying Lin, Geraldine Pitchairaj, Jiun-Yi Li, Joen-Rong Sheu
Pages: 174-182
Published online on: 07 December 2016

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Article

HSP27 regulates TGF-β mediated lung fibroblast differentiation through the Smad3 and ERK pathways

Gang Wang, Hao Jiao, Jun-Nian Zheng, Xia Sun
Pages: 183-190
Published online on: 28 November 2016

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Article

2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells

Young-Hee Jin, Soo-A Kim
Pages: 191-198
Published online on: 06 December 2016

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Article

Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy Expression of Concern in /10.3892/ijmm.2026.5784

Fangfang Li, Ning Zhang, Qingqing Wu, Yuan Yuan, Zheng Yang, Mengqiao Zhou, Jinxiu Zhu, Qizhu Tang
Pages: 199-207
Published online on: 08 December 2016

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Article

SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22

Hui Lu, Bincheng Wang
Pages: 208-216
Published online on: 18 November 2016

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Article

SN38 increases IL-8 expression through the MAPK pathways in HCT8 cells

Lei Zhang, Wen-Hui Lou, Xue-Feng Xu, Wenchuan Wu, Ye-Fei Rong, Da-Yong Jin
Pages: 217-222
Published online on: 22 November 2016

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Article

Bone marrow-derived mesenchymal stem cells modified with IGFBP-3 inhibit the proliferation of pulmonary artery smooth muscle cells

Ge Sheng Cheng, Yu Shun Zhang, Ting Ting Zhang, Lu He, Xing Ye Wang
Pages: 223-230
Published online on: 07 December 2016

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Article

Resveratrol upregulates SOCS1 production by lipopolysaccharide-stimulated RAW264.7 macrophages by inhibiting miR-155 Corrigendum in /10.3892/ijmm.2024.5386

Chunfang Ma, Yin Wang, Aijuan Shen, Wanru Cai
Pages: 231-237
Published online on: 16 November 2016

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Journal Cover
June-2026 Volume 57 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression

Hang Guo, Yaoji Li, Chengyan Jin, Xiao Qi, Jincheng Wang, Baofeng Li, Chunguang Wang
Article Number: 168
Published online on: 28 April 2026

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Retraction Open Access

[Retracted] Metformin‑induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16

Biao Hao, Yan Xiao, Fang Song, Xiangshu Long, Jing Huang, Maobo Tian, Shiyan Deng, Qiang Wu
Article Number: 167
Published online on: 22 April 2026

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Review Open Access

Dysregulation of the DNA repair‑immune axis: Targeted therapeutic strategies for autoimmune diseases (Review)

Ke Wan, Miao Wang, Qingqing Xia, Hui Fang, Ying Chen, Tongsheng Zhou, Xue Yang, Lu Wang, Jianwen Ye, Han Shu, Xiao-Feng Li, Jun Li
Article Number: 166
Published online on: 22 April 2026

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Retraction Open Access

[Retracted] Puerarin attenuates glucocorticoid‑induced apoptosis of hFOB1.19 cells through the JNK‑ and Akt‑mediated mitochondrial apoptotic pathways

Dongdong Yu, Shuai Mu, Danyang Zhao, Guangbin Wang, Zhiguang Chen, Hongfei Ren, Qin Fu
Article Number: 165
Published online on: 20 April 2026

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Review Open Access

High‑altitude polycythemia: Unveiling the molecular landscape beyond erythropoietin (Review)

Haiyan Li, Hongjuan Zhang, Hujun Zhang, Yujie Li, Yigang He, Jia Luan
Article Number: 164
Published online on: 17 April 2026

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Review

Mechanistic roles of interleukin‑18 in colonic immunity across infection, inflammatory bowel disease, and colorectal cancer (Review)

Jingwen Zhang, Lili Bao, Xia Li, Jiaxi Li, Jiaxian Cui, Lu Qiao, Xiaoxia He, Mingyu Zhang, Jingkun Lu, Xuan Zhang, Jing Dong, Gesi Tao, Tuya Bai, Yun Peng Tian, Pengwei Zhao, Ya Tuo
Article Number: 163
Published online on: 17 April 2026

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Article Open Access

IDH2 lactylation regulates mitochondrial dysfunction injury induced by myocardial ischemia‑reperfusion via the AMPK signaling pathway

Changsen Wang, Siman Shen, Suyun Chen, Jinda Lin, Simeng Li, Jianning Chen, Shuyun Cai, Xiaodong Yuan, Ziqiang Yang, Kun Ding, Li Xu, Liangqing Zhang
Article Number: 162
Published online on: 17 April 2026

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Review Open Access

Context‑dependent duality of the apelin/elabela‑APJ system in diabetes and its complications (Review)

Zhenyuan Han, Jiale Zhang, Min Shi, Juan Chen, Anni Li, Yuxuan Ye, Hong Zhang
Article Number: 161
Published online on: 17 April 2026

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Review Open Access

Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review)

Taimin Zhang, Xizhe Zhang, Yaru Xie, Yue Liu, Siyu Xia, Xiaodie Yin, Tian Li, Libin Liao
Article Number: 160
Published online on: 16 April 2026

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Retraction Open Access

[Retracted] Quercetin promotes the apoptosis of fibroblast‑like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1

Fang Pan, Lihua Zhu, Haozhe Lv, Chunpeng Pei
Article Number: 159
Published online on: 15 April 2026

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Article Open Access

Triptolide exerts antiviral effects and alleviates influenza A‑induced pneumonia by inhibiting the overactivation of absent in melanoma 2 signaling in immune cells

Yeyang Chen, Hua Wu, Xiangjian Wu, Likun Che, Xiaoyan Fu, Ruihan Qi, Dan Jia, Minfang Li, Wei Xie, Wenxiang Zhu
Article Number: 158
Published online on: 15 April 2026

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Review Open Access

ETS‑1/ETS‑2 transcription factors in CVD (Review)

Shasha Yang, Jing Zhang, Ying Yang, Yunbo Lv, Jian Yang, Huibo Wang
Article Number: 157
Published online on: 15 April 2026

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Review Open Access

RNA‑binding proteins as epithelial transcriptome orchestrators in gastric cancer: Immune‑metabolic crosstalk and therapeutic vulnerability (Review)

Shuhui Liu, Zhiyuan Ma, Bei Ji, Jiaxing Zhu, Shun Yao, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 156
Published online on: 14 April 2026

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Retraction Open Access

[Retracted] Role of miR‑146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro  

Lei Jin, Jian Zhao, Wensen Jing, Shiju Yan, Xin Wang, Chun Xiao, Baoan Ma
Article Number: 155
Published online on: 07 April 2026

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Review Open Access

A tale of dual role: HECT‑type E3 ubiquitin ligase mechanisms in liver diseases (Review)

Tongxi Li, Hao Chen, Peng Zhao, Chuanzheng Yin, Zifang Song
Article Number: 154
Published online on: 07 April 2026

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Correction Open Access

[Corrigendum] Macrophage‑derived foam cells impair endothelial barrier function by inducing endothelial‑mesenchymal transition via CCL‑4 

Ying Yang, Nian-Sang Luo, Ru Ying, Yong Xie, Jia-Yuan Chen, Xiao-Qiao Wang, Zhen-Jie Gu, Jing-Ting Mai, Wen-Hao Liu, Mao-Xiong Wu, Zhi-Teng Chen, Yong-Biao Fang, Hai-Feng Zhang, Zhi-Yi Zuo, Jing-Feng Wang, Yang-Xin Chen
Article Number: 153
Published online on: 03 April 2026

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Review Open Access

Macrophage metabolism reprogramming in sepsis: Pathogenesis and therapeutic implications (Review)

Tong Zhao, Wenzhe Zhang, Zixuan Ren, Xiujing Feng
Article Number: 152
Published online on: 03 April 2026

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Article Open Access

Astragaloside IV targets TUBB4B to inhibit proliferation and promote apoptosis of pituitary tumor cells via the STMN1/ERK pathway

Jiale Li, Yufei Qu, Wenge Zhang, Zexu Yang, Yangdong Zeng, Jisheng Xu, Kuncen Xie, Qi Liu
Article Number: 151
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation

Keng Wu, Wenming Xu, Qiong You, Runmin Guo, Jianqiang Feng, Changran Zhang, Wen Wu
Article Number: 150
Published online on: 01 April 2026

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Review Open Access

Animal models accurately representing acute liver failure (Review)

Sang Luo, Fang Wu, Yiran Jin, Xiaofen Huang, Dan Liu, Bingren Tian
Article Number: 149
Published online on: 01 April 2026

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Correction Open Access

[Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism 

Zhirong Zhang, Weiji Yang, Rongbiao Ying, Ying Shi, Huifang Jiang, Danli Cai, Jing Kuang, Ruhui Yang, Lingcong Wang
Article Number: 148
Published online on: 31 March 2026

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Review Open Access

Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)

Jing Mao, Mandi Luo, Lei Ruan, Cuntai Zhang
Article Number: 147
Published online on: 31 March 2026

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Review Open Access

Role of aging‑related cytokines in neurodegenerative disease (Review)

Xinke Dai, Xinran Rao, Yuandi Wang, Weijiang Zhao
Article Number: 146
Published online on: 31 March 2026

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Expression of Concern Open Access

[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

Peng Xu, Xuelei Tao, Chengjin Zhao, Qingfeng Huang, Hao Chang, Na Ban, Yuanqi Bei, Xiaojie Xia, Chaoyan Shen, Kun Wang, Li Xu, Peizhang Wu, Jianbing Ren, Donglin Wang
Article Number: 145
Published online on: 30 March 2026

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Review Open Access

Role of itaconate in intestinal disease (Review)

Xin Li, Qian Liu, Jiajia Li, Li Zhang, Shun Yao, Lulu Tang, Bingqi Yang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 144
Published online on: 27 March 2026

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Review Open Access

Unveiling lactylation: A novel frontier in the pathogenesis of diabetic nephropathy (Review)

Yuanyuan Xiao, Niansong Wang, Dingkun Gui, Youhua Xu
Article Number: 143
Published online on: 27 March 2026

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Review Open Access

Crosstalk between autophagy and ferroptosis in liver diseases (Review)

Yanming Wei, Kun Zhou, Yuerui Su, Zhihua Luan, Pengcheng Li, Yinxia Chang, Bo Han, Huifang Li, Yuanbiao Qiao, Jinhong Ren
Article Number: 142
Published online on: 26 March 2026

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Article Open Access

circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance

Qing Rao, Dimin Zhu, Zongming Wang, Shaolin Zhang, Xueli Li, Shashikiran Tagilapalli, Nan Wang, Weiyu Hu, Wenli Chen, Yonghong Zhu
Article Number: 141
Published online on: 26 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Article Open Access

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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