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Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling

  • Authors:
    • Lixiang Zheng
    • Yujian Cai
    • Li Zhou
    • Ping Huang
    • Xiaoying Ren
    • Airen Zuo
    • Xianming Meng
    • Minjuan Xu
    • Xiangru Liao
  • View Affiliations / Copyright

    Affiliations: College of Biology Engineering, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, School of Computer Science, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, P.R. China, School of Basic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 39-46
    |
    Published online on: November 22, 2016
       https://doi.org/10.3892/ijmm.2016.2811
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Abstract

Natural pigments are known for possessing a wide range of pharmacological and health-promoting properties. The pigments, produced by a new strain Fusarium (Fusarium sp. JN158) previously identified in our laboratory, were found to have 6 peaks (representing 6 compounds) by high-performance liquid chromatography with a diode-array detector (HPLC-DAD) separation. The 6th peak compound (compound VI) is a benzoquinone compound. In this study, we examined the effects of compound VI on the proliferation of breast cancer cells and aimed to elucidate the underlying mechamisms. Compound VI exerted anti-proliferative effects on MCF‑7 estrogen receptor (ER)+ cells in a dose-dependent manner (IC25, 7 µM; IC50, 11 µM), whereas it had no effect on MDA‑MB‑231 ER- cells and normal cells. The cell index (CI) began to decrease at 24 h following treatment with benzoquinone. Mechanistically, the results from molecular analysis revealed that compound VI inhibited the expression of ERα, progesterone receptor (PR), vascular endothelial growth factor (VEGF), Bcl-2, cyclin D1 and nuclear factor-κB (NF-κB) p65, while it increased the expression of cleaved caspase-3 and Bax in the MCF‑7 cells. Taken together, our findings indicate that compound VI exerts anti-proliferative effects on MCF‑7 cells through the NF-κB pathway via the regulation of ER signaling. Our data may indicate that benzoquinone from Fusarium pigment may have potential for use as an anti-proliferative agent in the treatment of breast cancer.
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View References

1 

Mata-Gómez LC, Montañez JC, Méndez-Zavala A and Aguilar CN: Biotechnological production of carotenoids by yeasts: An overview. Microb Cell Fact. 13:122014. View Article : Google Scholar : PubMed/NCBI

2 

Jackson H, Braun CL and Ernst H: The chemistry of novel xanthophyll carotenoids. Am J Cardiol. 101:50D–57D. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Kang B, Zhang X, Wu Z, Wang Z and Park S: Production of citrinin-free Monascus pigments by submerged culture at low pH. Enzyme Microb Technol. 55:50–57. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Jomova K and Valko M: Health protective effects of carotenoids and their interactions with other biological antioxidants. Eur J Med Chem. 70:102–110. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Hu W, Gao Q, Hamada MS, Dawood DH, Zheng J, Chen Y and Ma Z: Potential of pseudomonas chlororaphis subsp. aurantiaca strain Pcho10 as a biocontrol agent against Fusarium graminearum. Phytopathology. 104:1289–1297. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Zeng XL, Cai YJ, Liao XR, Zeng XK, Li ZH and Zhang DB: Extraction and physico-chemical properties of pigments from liquid-cultured mycelia of Fusarium sp. B158. Food Science. 33:131–135. 2012.In Chinese.

7 

Reigan P, David S, Guo WC and Ross D: A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins. Mol Pharmacol. 79:823–832. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Pedrini N, Ortiz-Urquiza A, Huarte-Bonnet C, Fan Y, Juárez MP and Keyhani NO: Tenebrionid secretions and a fungal benzoquinone oxidoreductase form competing components of an arms race between a host and pathogen. Proc Natl Acad Sci USA. 112:231–240. 2015. View Article : Google Scholar

9 

Gaascht F, Dicato M and Diederich M: Venus flytrap (Dionaea muscipula Solander ex Ellis) contains powerful compounds that prevent and cure cancer. Front Oncol. 3:202–210. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Boopalan T, Arumugam A, Parada J, Saltzstein E and Lakshmanaswamy R: Receptor activator for nuclear factor-κB ligand signaling promotes progesterone-mediated estrogen-induced mammary carcinogenesis. Cancer Sci. 106:25–33. 2015. View Article : Google Scholar :

11 

King AE, Collins F, Klonisch T, Sallenave JM, Critchley HO and Saunders PT: An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells. Hum Reprod. 25:510–518. 2010. View Article : Google Scholar

12 

Ashcroft KJ, Syed F and Bayat A: Site-specific keloid fibroblasts alter the behaviour of normal skin and normal scar fibroblasts through paracrine signalling. PLoS One. 8:e756002013. View Article : Google Scholar : PubMed/NCBI

13 

Kim JH, Jekarl DW, Kim M, Oh EJ, Kim Y, Park IY and Shin JC: Effects of ECM protein mimetics on adhesion and proliferation of chorion derived mesenchymal stem cells. Int J Med Sci. 11:298–308. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF and Firestone GL: Indole-3-Carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)α protein degradation in breast cancer cells disrupting an ERα-GATA3 transcriptional cross-regulatory loop. Mol Biol Cell. 21:1166–1177. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Mezzanotte L, An N, Mol IM, Löwik CW and Kaijzel EL: A new multicolor bioluminescence imaging platform to investigate NF-κB activity and apoptosis in human breast cancer cells. PLoS One. 9:e855502014. View Article : Google Scholar

16 

Tozawa K, Sagawa M and Kizaki M: Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway. Int J Oncol. 39:1117–1122. 2011.PubMed/NCBI

17 

Kruk J: Overweight, obesity, oxidative stress and the risk of breast cancer. Asian Pac J Cancer Prev. 15:9579–9586. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Schiavano GF, De Santi M, Brandi G, Fanelli M, Bucchini A, Giamperi L and Giomaro G: Inhibition of breast cancer cell proliferation and in vitro tumorigenesis by a new red apple cultivar. PLoS One. 10:e01358402015. View Article : Google Scholar : PubMed/NCBI

19 

Ahmadian M and Samah AA: Application of health behavior theories to breast cancer screening among Asian women. Asian Pac J Cancer Prev. 14:4005–4013. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Gordaliza M: Synthetic strategies to terpene quinones/hydroquinones. Mar Drugs. 10:358–402. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Bertanha CS, Januário AH, Alvarenga TA, Pimenta LP, Silva ML, Cunha WR and Pauletti PM: Quinone and hydroquinone metabolites from the ascidians of the genus Aplidium. Mar Drugs. 12:3608–3633. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Magnani L, Ballantyne EB, Zhang X and Lupien M: PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer. PLoS Genet. 7:e10023682011. View Article : Google Scholar

23 

Shanle EK and Xu W: Endocrine disrupting chemicals targeting estrogen receptor signaling: Identification and mechanisms of action. Chem Res Toxicol. 24:6–19. 2011. View Article : Google Scholar :

24 

Condon JC, Hardy DB, Kovaric K and Mendelson CR: Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Mol Endocrinol. 20:764–775. 2006. View Article : Google Scholar

25 

Dai XL, Zhou SL, Qiu J, Liu YF and Hua H: Correlated expression of Fas, NF-kappaB, and VEGF-C in infiltrating ductal carcinoma of the breast. Eur J Gynaecol Oncol. 33:633–639. 2012.

26 

Reuter S, Prasad S, Phromnoi K, Ravindran J, Sung B, Yadav VR, Kannappan R, Chaturvedi MM and Aggarwal BB: Thiocolchicoside exhibits anticancer effects through down-regulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer. Cancer Prev Res (Phila). 3:1462–1472. 2010. View Article : Google Scholar

27 

Miller Susanne C, Huang RL and Sakamuru S: Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Biochem Pharmacol. 9:1272–1280. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zheng L, Cai Y, Zhou L, Huang P, Ren X, Zuo A, Meng X, Xu M and Liao X: Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling. Int J Mol Med 39: 39-46, 2017.
APA
Zheng, L., Cai, Y., Zhou, L., Huang, P., Ren, X., Zuo, A. ... Liao, X. (2017). Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling. International Journal of Molecular Medicine, 39, 39-46. https://doi.org/10.3892/ijmm.2016.2811
MLA
Zheng, L., Cai, Y., Zhou, L., Huang, P., Ren, X., Zuo, A., Meng, X., Xu, M., Liao, X."Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling". International Journal of Molecular Medicine 39.1 (2017): 39-46.
Chicago
Zheng, L., Cai, Y., Zhou, L., Huang, P., Ren, X., Zuo, A., Meng, X., Xu, M., Liao, X."Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling". International Journal of Molecular Medicine 39, no. 1 (2017): 39-46. https://doi.org/10.3892/ijmm.2016.2811
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng L, Cai Y, Zhou L, Huang P, Ren X, Zuo A, Meng X, Xu M and Liao X: Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling. Int J Mol Med 39: 39-46, 2017.
APA
Zheng, L., Cai, Y., Zhou, L., Huang, P., Ren, X., Zuo, A. ... Liao, X. (2017). Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling. International Journal of Molecular Medicine, 39, 39-46. https://doi.org/10.3892/ijmm.2016.2811
MLA
Zheng, L., Cai, Y., Zhou, L., Huang, P., Ren, X., Zuo, A., Meng, X., Xu, M., Liao, X."Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling". International Journal of Molecular Medicine 39.1 (2017): 39-46.
Chicago
Zheng, L., Cai, Y., Zhou, L., Huang, P., Ren, X., Zuo, A., Meng, X., Xu, M., Liao, X."Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling". International Journal of Molecular Medicine 39, no. 1 (2017): 39-46. https://doi.org/10.3892/ijmm.2016.2811
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