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Article Open Access

Self-renewal molecular mechanisms of colorectal cancer stem cells

  • Authors:
    • Tianhui Pan
    • Jinghong Xu
    • Yongliang Zhu
  • View Affiliations / Copyright

    Affiliations: Laboratory of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9-20
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    Published online on: November 30, 2016
       https://doi.org/10.3892/ijmm.2016.2815
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Abstract

Colorectal cancer stem cells (CCSCs) represent a small fraction of the colorectal cancer cell population that possess self-renewal and multi-lineage differentiation potential and drive tumorigenicity. Self-renewal is essential for the malignant biological behaviors of colorectal cancer stem cells. While the self-renewal molecular mechanisms of colorectal cancer stem cells are not yet fully understood, the aberrant activation of signaling pathways, such as Wnt, Notch, transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) and Hedgehog-Gli (HH-GLI), specific roles mediated by cell surface markers and micro-environmental factors are involved in the regulation of self-renewal. The elucidation of the molecular mechanisms behind self-renewal may lead to the development of novel targeted interventions for the treatment of colorectal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Pan T, Xu J and Zhu Y: Self-renewal molecular mechanisms of colorectal cancer stem cells. Int J Mol Med 39: 9-20, 2017.
APA
Pan, T., Xu, J., & Zhu, Y. (2017). Self-renewal molecular mechanisms of colorectal cancer stem cells. International Journal of Molecular Medicine, 39, 9-20. https://doi.org/10.3892/ijmm.2016.2815
MLA
Pan, T., Xu, J., Zhu, Y."Self-renewal molecular mechanisms of colorectal cancer stem cells". International Journal of Molecular Medicine 39.1 (2017): 9-20.
Chicago
Pan, T., Xu, J., Zhu, Y."Self-renewal molecular mechanisms of colorectal cancer stem cells". International Journal of Molecular Medicine 39, no. 1 (2017): 9-20. https://doi.org/10.3892/ijmm.2016.2815
Copy and paste a formatted citation
x
Spandidos Publications style
Pan T, Xu J and Zhu Y: Self-renewal molecular mechanisms of colorectal cancer stem cells. Int J Mol Med 39: 9-20, 2017.
APA
Pan, T., Xu, J., & Zhu, Y. (2017). Self-renewal molecular mechanisms of colorectal cancer stem cells. International Journal of Molecular Medicine, 39, 9-20. https://doi.org/10.3892/ijmm.2016.2815
MLA
Pan, T., Xu, J., Zhu, Y."Self-renewal molecular mechanisms of colorectal cancer stem cells". International Journal of Molecular Medicine 39.1 (2017): 9-20.
Chicago
Pan, T., Xu, J., Zhu, Y."Self-renewal molecular mechanisms of colorectal cancer stem cells". International Journal of Molecular Medicine 39, no. 1 (2017): 9-20. https://doi.org/10.3892/ijmm.2016.2815
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