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Article Open Access

Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells

  • Authors:
    • Cong Wang
    • Liubin Guo
    • Saiqi Wang
    • Junwei Wang
    • Yongmei Li
    • Yinhui Dou
    • Ran Wang
    • Hongge Shi
    • Yu Ke
    • Hongmin Liu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, Henan 450001, P.R. China, Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 645-653
    |
    Published online on: January 24, 2017
       https://doi.org/10.3892/ijmm.2017.2867
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Abstract

Chemoresistance to anticancer drugs is a major obstacle in the efforts to develop a successful treatment strategy for esophageal squamous carcinoma (ESCC). Thus, the exploration of new drugs and treatment strategies for combating resistance are of utmost importance. In this study, we investigated the antitumor drug resistance activity of Jesridonin, a new ent-kaurene diterpenoid, and its possible mechanisms of action using the resistant cancer cell line, EC109/Taxol. MTT assay revealed that Jesridonin had similar IC50 values against EC109 paclitaxel-sensitive cells and drug-resistant EC109/Taxol cells in vitro. In mice, Jesridonin effectively prevented the growth of EC109/Taxol tumor xenografts without exerting any significant toxicity. In addition, Jesridonin significantly inhibited the proliferation of EC109/Taxol cells, induced apoptosis and arrested the cell cycle at the G2/M phase. Furthermore, western blot analysis revealed that Jesridonin upregulated the expression of p53, p53 upregulated modulator of apoptosis (PUMA), cleaved-caspase-9 and cleaved-caspase-3 in EC109/Taxol cells, and downregulated the expression of procaspase-3, procaspase-9 and Bcl-2 in the EC109/Taxol cells in a concentration-dependent manner. Overall, our results demonstrate that Jesridonin may have potential for use in the treatment of paclitaxel-resistant ESCC. The data of the present study may lead to the development of novel treatment strategies for paclitaxel-resistant tumors.
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1 

Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, Lou F, Yang J, Zhang Q, et al: Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 4:e8382013. View Article : Google Scholar : PubMed/NCBI

2 

Lu HP and Chao CC: Cancer cells acquire resistance to anticancer drugs: an update. Biomed J. 35:464–472. 2012. View Article : Google Scholar

3 

Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I and Gottesman MM: Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol. 39:361–398. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Baguley BC: Multidrug resistance in cancer. Methods Mol Biol. 596:1–14. 2010. View Article : Google Scholar

5 

Zhou Q, Li Y, Jin J, Lang L, Zhu Z, Fang W and Chen X: Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo. Biol Pharm Bull. 35:2170–2179. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Mor G, Montagna MK and Alvero AB: Modulation of apoptosis to reverse chemoresistance. Methods Mol Biol. 414:1–12. 2008.PubMed/NCBI

7 

Hsu PC, Hung HC, Liao YF, Liu CC, Tsay GJ and Liu GY: Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells. Leuk Res. 32:1530–1540. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Wang C, Guo LB, Ma JY, Li YM and Liu HM: Establishment and characterization of a paclitaxel resistant human esophageal carcinoma cell line. Int J Oncol. 43:1607–1617. 2013.PubMed/NCBI

9 

Liu Z, Ouyang L, Peng H and Zhang WZ: Oridonin: Targeting programmed cell death pathways as an anti-tumour agent. Cell Prolif. 45:499–507. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Li CY, Wang EQ, Cheng Y and Bao JK: Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. Int J Biochem Cell Biol. 43:701–704. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Wang C, Jiang L, Wang S, Shi H, Wang J, Wang R, Li Y, Dou Y, Liu Y, Hou G, et al: The antitumor activity of the novel compound Jesridonin on human esophageal carcinoma cells. PLoS One. 10:e01302842015. View Article : Google Scholar : PubMed/NCBI

12 

Tian QE, Li HD, Yan M, Cai HL, Tan QY and Zhang WY: Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice. World J Gastroenterol. 18:7079–7086. 2012. View Article : Google Scholar

13 

Wacheck V and Zangemeister-Wittke U: Antisense molecules for targeted cancer therapy. Crit Rev Oncol Hematol. 59:65–73. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Uchiyama-Kokubu N and Watanabe T: Establishment and characterization of adriamycin-resistant human colorectal adenocarcinoma HCT-15 cell lines with multidrug resistance. Anticancer Drugs. 12:769–779. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Fulda S and Debatin KM: Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene. 25:4798–4811. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Zhang J, Zhu X, Li H, Li B, Sun L, Xie T, Zhu T, Zhou H and Ye Z: Piperine inhibits proliferation of human osteosarcoma cells via G2/M phase arrest and metastasis by suppressing MMP-2/-9 expression. Int Immunopharmacol. 24:50–58. 2015. View Article : Google Scholar

17 

Hafezi F, Steinbach JP, Marti A, Munz K, Wang ZQ, Wagner EF, Aguzzi A and Remé CE: The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med. 3:346–349. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Cao B, Chen H, Gao Y, Niu C, Zhang Y and Li L: CIP-36, a novel topoisomerase II-targeting agent, induces the apoptosis of multidrug-resistant cancer cells in vitro. Int J Mol Med. 35:771–776. 2015.PubMed/NCBI

19 

Uboldi S, Bernasconi S, Romano M, Marchini S, Fuso Nerini I, Damia G, Ganzinelli M, Marangon E, Sala F, Clivio L, et al: Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents. Int J Cancer. 131:59–69. 2012. View Article : Google Scholar

20 

Bai HW, Badaboina S, Park CH, Choi BY, Na YH and Chung BY: Centipedegrass extract induces apoptosis through the activation of caspases and the downregulation of I3K/Akt and MAPK phosphorylation in leukemia cells. Int J Mol Med. 35:511–518. 2015.

21 

Kroemer G and Reed JC: Mitochondrial control of cell death. Nat Med. 6:513–519. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Fares M, Abedi-Valugerdi M, Hassan M and Potácová Z: DNA damage, lysosomal degradation and Bcl-xL deamidation in doxycycline- and minocycline-induced cell death in the K562 leukemic cell line. Biochem Biophys Res Commun. 463:268–274. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Peng J, Ding J, Tan C, Baggenstoss B, Zhang Z, Lapolla SM and Lin J: Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid. Apoptosis. 14:1145–1153. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 275:1132–1136. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Degli Esposti M and Dive C: Mitochondrial membrane permeabilisation by Bax/Bak. Biochem Biophys Res Commun. 304:455–461. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M and Green DR: Direct activation of Bax by 53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 303:1010–1014. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Kang MH and Reynolds CP: Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 15:1126–1132. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Bodur C and Basaga H: Bcl-2 inhibitors: Emerging drugs in cancer therapy. Curr Med Chem. 19:1804–1820. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Nikoletopoulou V, Markaki M, Palikaras K and Tavernarakis N: Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta. 1833:3448–3459. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Seervi M, Sobhan PK, Joseph J, Ann Mathew K and Santhoshkumar TR: ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 4:e9682013. View Article : Google Scholar

31 

Culmsee C and Mattson MP: 53 in neuronal apoptosis. Biochem Biophys Res Commun. 331:761–777. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Tacar O and Dass CR: Doxorubicin-induced death in tumour cells and cardiomyocytes: Is autophagy the key to improving future clinical outcomes? J Pharm Pharmacol. 65:1577–1589. 2013. View Article : Google Scholar : PubMed/NCBI

33 

West KA, Castillo SS and Dennis PA: Activation of the I3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat. 5:234–248. 2002. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Guo L, Wang S, Wang J, Li Y, Dou Y, Wang R, Shi H, Ke Y, Liu H, Liu H, et al: Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells. Int J Mol Med 39: 645-653, 2017.
APA
Wang, C., Guo, L., Wang, S., Wang, J., Li, Y., Dou, Y. ... Liu, H. (2017). Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells. International Journal of Molecular Medicine, 39, 645-653. https://doi.org/10.3892/ijmm.2017.2867
MLA
Wang, C., Guo, L., Wang, S., Wang, J., Li, Y., Dou, Y., Wang, R., Shi, H., Ke, Y., Liu, H."Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells". International Journal of Molecular Medicine 39.3 (2017): 645-653.
Chicago
Wang, C., Guo, L., Wang, S., Wang, J., Li, Y., Dou, Y., Wang, R., Shi, H., Ke, Y., Liu, H."Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells". International Journal of Molecular Medicine 39, no. 3 (2017): 645-653. https://doi.org/10.3892/ijmm.2017.2867
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Guo L, Wang S, Wang J, Li Y, Dou Y, Wang R, Shi H, Ke Y, Liu H, Liu H, et al: Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells. Int J Mol Med 39: 645-653, 2017.
APA
Wang, C., Guo, L., Wang, S., Wang, J., Li, Y., Dou, Y. ... Liu, H. (2017). Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells. International Journal of Molecular Medicine, 39, 645-653. https://doi.org/10.3892/ijmm.2017.2867
MLA
Wang, C., Guo, L., Wang, S., Wang, J., Li, Y., Dou, Y., Wang, R., Shi, H., Ke, Y., Liu, H."Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells". International Journal of Molecular Medicine 39.3 (2017): 645-653.
Chicago
Wang, C., Guo, L., Wang, S., Wang, J., Li, Y., Dou, Y., Wang, R., Shi, H., Ke, Y., Liu, H."Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells". International Journal of Molecular Medicine 39, no. 3 (2017): 645-653. https://doi.org/10.3892/ijmm.2017.2867
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