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Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity

  • Authors:
    • Simone Aparecida de Bessa Garcia
    • Ana Carolina Pavanelli
    • Natália Cruz e Melo
    • Maria Aparecida Nagai
  • View Affiliations / Copyright

    Affiliations: Discipline of Oncology, Department of Radiology and Oncology, Faculty of Medicine, University of São Paulo, São Paulo, SP 01246‑903, P.R. China
    Copyright: © de Bessa Garcia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 809-818
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    Published online on: February 21, 2017
       https://doi.org/10.3892/ijmm.2017.2900
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Abstract

Docetaxel is an effective drug for the treatment of metastatic breast cancer. However, the exact mechanisms and/or markers associated with chemosensitivity or resistance to docetaxel remain unclear. We previously showed that the expression of prostate apoptosis response 4 (PAR4) inhibits the growth of MCF7 breast cancer cells and increases their sensitivity to docetaxel. Using cDNA microarray analysis, we evaluated transcriptome changes in MCF7 cells expressing increased levels of PAR4 and control cells before and after docetaxel treatment. Some of the top gene networks generated from the differentially expressed genes were related to the wingless‑type MMTV integration 1 (WNT) canonical (WNT/β-catenin) and non‑canonical (β‑catenin‑independent) pathways. The Human WNT signaling pathway RT2 profiler™ PCR array was used to validate the effects of PAR4 on the expression pattern of genes involved in the WNT pathway. CACNAD2A3, GDF5 and IL6 were upregulated and NANOG was downregulated in the MCF7 breast cancer cells expressing increased levels of PAR4 after treatment with docetaxel, likely indicating inactivation of the WNT/β-catenin pathway. Upregulation of FGF7, LEF1 and TWIST1 indicated activation of the WNT/β‑catenin pathway. Although preliminary, our findings could be of particular interest for understanding the action of PAR4 in chemosensitivity, particularly to increase the specificity and effectiveness of drug treatment and overcome resistance to chemotherapy. Further studies are needed to better understand the biological roles of PAR4 in the regulation of WNT pathways in breast cancer cells in response to docetaxel and other chemotherapeutic agents.
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View References

1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

De Laurentiis M, Cancello G, D'Agostino D, Giuliano M, Giordano A, Montagna E, Lauria R, Forestieri V, Esposito A, Silvestro L, et al: Taxane-based combinations as adjuvant chemotherapy of early breast cancer: A meta-analysis of randomized trials. J Clin Oncol. 26:44–53. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, et al: Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010 a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380:2197–2223. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Zhao Y and Rangnekar VM: Apoptosis and tumor resistance conferred by Par-4. Cancer Biol Ther. 7:1867–1874. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Sells SF, Han SS, Muthukkumar S, Maddiwar N, Johnstone R, Boghaert E, Gillis D, Liu G, Nair P, Monnig S, et al: Expression and function of the leucine zipper protein Par-4 in apoptosis. Mol Cell Biol. 17:3823–3832. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Hebbar N, Wang C and Rangnekar VM: Mechanisms of apoptosis by the tumor suppressor Par-4. J Cell Physiol. 227:3715–3721. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Boehrer S, Chow KU, Beske F, Kukoc-Zivojnov N, Puccetti E, Ruthardt M, Baum C, Rangnekar VM, Hoelzer D, Mitrou PS, et al: In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation. Cancer Res. 62:1768–1775. 2002.PubMed/NCBI

8 

Chakraborty M, Qiu SG, Vasudevan KM and Rangnekar VM: Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Cancer Res. 61:7255–7263. 2001.PubMed/NCBI

9 

Gurumurthy S, Goswami A, Vasudevan KM and Rangnekar VM: Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Mol Cell Biol. 25:1146–1161. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Burikhanov R, Zhao Y, Goswami A, Qiu S, Schwarze SR and Rangnekar VM: The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell. 138:377–388. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Boghaert ER, Sells SF, Walid AJ, Malone P, Williams NM, Weinstein MH, Strange R and Rangnekar VM: Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues. Cell Growth Differ. 8:881–890. 1997.PubMed/NCBI

12 

Gurumurthy S and Rangnekar VM: Par-4 inducible apoptosis in prostate cancer cells. J Cell Biochem. 91:504–512. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Sells SF, Wood DP Jr, Joshi-Barve SS, Muthukumar S, Jacob RJ, Crist SA, Humphreys S and Rangnekar VM: Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ. 5:457–466. 1994.PubMed/NCBI

14 

Lucas T, Pratscher B, Krishnan S, Fink D, Günsberg P, Wolschek M, Wacheck V, Muster T, Romirer I, Wolff K, et al: Differential expression levels of Par-4 in melanoma. Melanoma Res. 11:379–383. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Cook J, Krishnan S, Ananth S, Sells SF, Shi Y, Walther MM, Linehan WM, Sukhatme VP, Weinstein MH and Rangnekar VM: Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene. 18:1205–1208. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Brieger A, Boehrer S, Schaaf S, Nowak D, Ruthardt M, Kim SZ, Atadja P, Hoelzer D, Mitrou PS, Weidmann E, et al: In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. Biochem Pharmacol. 68:85–93. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Kögel D, Reimertz C, Mech P, Poppe M, Frühwald MC, Engemann H, Scheidtmann KH and Prehn JH: Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: Requirement of the mitochondrial apoptosis pathway. Br J Cancer. 85:1801–1808. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Moreno-Bueno G, Fernandez-Marcos PJ, Collado M, Tendero MJ, Rodriguez-Pinilla SM, Garcia-Cao I, Hardisson D, Diaz-Meco MT, Moscat J, Serrano M, et al: Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Cancer Res. 67:1927–1934. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Ahmed MM, Sheldon D, Fruitwala MA, Venkatasubbarao K, Lee EY, Gupta S, Wood C, Mohiuddin M and Strodel WE: Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation. Int J Cancer. 122:63–70. 2008. View Article : Google Scholar

20 

Nagai MA, Gerhard R, Salaorni S, Fregnani JH, Nonogaki S, Netto MM and Soares FA: Downregulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer. Int J Oncol. 37:41–49. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Méndez-López LF, Zapata-Benavides P, Zavala-Pompa A, Aguado-Barrera ME, Pacheco-Calleros J, Rodríguez-Padilla C, Cerda-Flores RM, Cortés-Gutiérrez EI and Dávila-Rodríguez MI: Immunohistochemical analysis of prostate apoptosis response-4 (Par-4) in Mexican women with breast cancer: A preliminary study. Arch Med Res. 41:261–268. 2010. View Article : Google Scholar : PubMed/NCBI

22 

García-Cao I, Duran A, Collado M, Carrascosa MJ, Martín-Caballero J, Flores JM, Diaz-Meco MT, Moscat J and Serrano M: Tumour-suppression activity of the proapoptotic regulator Par4. EMBO Rep. 6:577–583. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Pereira MC, de Bessa-Garcia SA, Burikhanov R, Pavanelli AC, Antunes L, Rangnekar VM and Nagai MA: Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells. Int J Oncol. 43:531–538. 2013.PubMed/NCBI

24 

Jagtap JC, Parveen D, Shah RD, Desai A, Bhosale D, Chugh A, Ranade D, Karnik S, Khedkar B, Mathur A, et al: Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death. FEBS Open Bio. 5:8–19. 2014. View Article : Google Scholar

25 

Zhao Y, Burikhanov R, Qiu S, Lele SM, Jennings CD, Bondada S, Spear B and Rangnekar VM: Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res. 67:9276–9285. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Lee TJ, Lee JT, Kim SH, Choi YH, Song KS, Park JW and Kwon TK: Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells. J Cell Biochem. 103:358–368. 2008. View Article : Google Scholar

27 

Kline CL, Shanmugavelandy SS, Kester M and Irby RB: Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU. Cancer Biol Ther. 8:1831–1837. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Wang BD, Kline CL, Pastor DM, Olson TL, Frank B, Luu T, Sharma AK, Robertson G, Weirauch MT, Patierno SR, et al: Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network. Mol Cancer. 9:982010. View Article : Google Scholar : PubMed/NCBI

29 

Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou A, Pant D, Grimley JS, Wandless TJ, Demichele A and Chodosh LA; I-SPY 1 TRIAL Investigators: Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell. 24:30–44. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987. View Article : Google Scholar : PubMed/NCBI

31 

Edgar R, Domrachev M and Lash AE: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar :

32 

Michaelson JS and Leder P: beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene. 20:5093–5099. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Amin N and Vincan E: The Wnt signaling pathways and cell adhesion. Front Biosci (Landmark Ed). 17:784–804. 2012. View Article : Google Scholar

34 

Dijksterhuis JP, Petersen J and Schulte G: WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3. Br J Pharmacol. 171:1195–1209. 2014. View Article : Google Scholar :

35 

Mylona E, Vamvakaris I, Giannopoulou I, Theohari I, Papadimitriou C, Keramopoulos A and Nakopoulou L: An immunohistochemical evaluation of the proteins Wnt1 and glycogen synthase kinase (GSK)-3β in invasive breast carcinomas. Histopathology. 62:899–907. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Wang HQ, Xu ML, Ma J, Zhang Y and Xie CH: Frizzled-8 as a putative therapeutic target in human lung cancer. Biochem Biophys Res Commun. 417:62–66. 2012. View Article : Google Scholar

37 

Yin S, Xu L, Bonfil RD, Banerjee S, Sarkar FH, Sethi S and Reddy KB: Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer. Mol Cancer Ther. 12:491–498. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Niehrs C: The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol. 13:767–779. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Tice DA, Soloviev I and Polakis P: Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes. J Biol Chem. 277:6118–6123. 2002. View Article : Google Scholar

40 

Ji J, Wei X and Wang Y: Embryonic stem cell markers Sox-2 and OCT4 expression and their correlation with WNT signal pathway in cervical squamous cell carcinoma. Int J Clin Exp Pathol. 7:2470–2476. 2014.PubMed/NCBI

41 

Lam SP, Luk JM, Man K, Ng KT, Cheung CK, Rose-John S and Lo CM: Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration. Liver Transpl. 16:1195–1206. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Venkatesan B, Prabhu SD, Venkatachalam K, Mummidi S, Valente AJ, Clark RA, Delafontaine P and Chandrasekar B: WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death. Cell Signal. 22:809–820. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP, et al: Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci USA. 103:3799–3804. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Katoh M and Katoh M: FGF signaling network in the gastrointestinal tract (Review). Int J Oncol. 29:163–168. 2006.PubMed/NCBI

45 

Vadnais C, Shooshtarizadeh P, Rajadurai CV, Lesurf R, Hulea L, Davoudi S, Cadieux C, Hallett M, Park M and Nepveu A: Autocrine activation of the Wnt/β-catenin pathway by CUX1 and GLIS1 in breast cancers. Biol Open. 3:937–946. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Barreto RA, Walker FR, Dunkley PR, Day TA and Smith DW: Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression? BMC Neurosci. 13:1252012. View Article : Google Scholar : PubMed/NCBI

47 

Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR, et al: Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 18:1072–1087. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Wong AM, Kong KL, Chen L, Liu M, Wong AM, Zhu C, Tsang JW and Guan XY: Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma. Int J Cancer. 133:2284–2295. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Enochson L, Stenberg J, Brittberg M and Lindahl A: GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage. 22:566–577. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Yin D, Tian L, Ye Y, Li K, Wang J, Cheng P, Chen A, Guo F and Huang H: Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation. Int J Mol Med. 29:587–592. 2012.PubMed/NCBI

51 

Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL and Massagué J: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell. 138:51–62. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Je EC, Lca BS and Ga GA: The role of transcription factor TWIST in cancer cells. J Genet Syndr Gene Ther. 4:1242013.

53 

Loh YN, Hedditch EL, Baker LA, Jary E, Ward RL and Ford CE: The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC Cancer. 13:1742013. View Article : Google Scholar : PubMed/NCBI

54 

Ren J, Wang R, Song H, Huang G and Chen L: Secreted frizzled related protein 1 modulates taxane resistance of human lung adenocarcinoma. Mol Med. 20:164–178. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Lamb R, Ablett MP, Spence K, Landberg G, Sims AH and Clarke RB: Wnt pathway activity in breast cancer sub-types and stem-like cells. PLoS One. 8:e678112013. View Article : Google Scholar : PubMed/NCBI

56 

Zhang H, Zhang X, Wu X, Li W, Su P, Cheng H, Xiang L, Gao P and Zhou G: Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway. Cancer Lett. 323:106–113. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA and Rosen JM: WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci USA. 104:618–623. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D and Vadgama JV: Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastu-zumab-resistant HER2-overexpressing breast cancer cells. Mol Cancer Res. 10:1597–1606. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Ahmad A, Sarkar SH, Bitar B, Ali S, Aboukameel A, Sethi S, Li Y, Bao B, Kong D, Banerjee S, et al: Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol Cancer Ther. 11:2193–2201. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Zhao Z, Lu P, Zhang H, Xu H, Gao N, Li M and Liu C: Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells. Breast Cancer Res. 16:4082014. View Article : Google Scholar

61 

Mukherjee N, Bhattacharya N, Alam N, Roy A, Roychoudhury S and Panda CK: Subtype-specific alterations of the Wnt signaling pathway in breast cancer: clinical and prognostic significance. Cancer Sci. 103:210–220. 2012. View Article : Google Scholar

62 

Xiang T, Li L, Yin X, Zhong L, Peng W, Qiu Z, Ren G and Tao Q: Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells. J Cell Mol Med. 17:1236–1246. 2013. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
de Bessa Garcia SA, Pavanelli AC, Cruz e Melo N and Nagai MA: Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity. Int J Mol Med 39: 809-818, 2017.
APA
de Bessa Garcia, S.A., Pavanelli, A.C., Cruz e Melo, N., & Nagai, M.A. (2017). Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity. International Journal of Molecular Medicine, 39, 809-818. https://doi.org/10.3892/ijmm.2017.2900
MLA
de Bessa Garcia, S. A., Pavanelli, A. C., Cruz e Melo, N., Nagai, M. A."Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity". International Journal of Molecular Medicine 39.4 (2017): 809-818.
Chicago
de Bessa Garcia, S. A., Pavanelli, A. C., Cruz e Melo, N., Nagai, M. A."Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity". International Journal of Molecular Medicine 39, no. 4 (2017): 809-818. https://doi.org/10.3892/ijmm.2017.2900
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Spandidos Publications style
de Bessa Garcia SA, Pavanelli AC, Cruz e Melo N and Nagai MA: Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity. Int J Mol Med 39: 809-818, 2017.
APA
de Bessa Garcia, S.A., Pavanelli, A.C., Cruz e Melo, N., & Nagai, M.A. (2017). Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity. International Journal of Molecular Medicine, 39, 809-818. https://doi.org/10.3892/ijmm.2017.2900
MLA
de Bessa Garcia, S. A., Pavanelli, A. C., Cruz e Melo, N., Nagai, M. A."Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity". International Journal of Molecular Medicine 39.4 (2017): 809-818.
Chicago
de Bessa Garcia, S. A., Pavanelli, A. C., Cruz e Melo, N., Nagai, M. A."Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity". International Journal of Molecular Medicine 39, no. 4 (2017): 809-818. https://doi.org/10.3892/ijmm.2017.2900
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