|
1
|
Ding S, Li L, Liu X, Yang G, Zhou G and
Zhou S: A nano-micro alternating multilayer scaffold loading with
rBMSCs and BMP-2 for bone tissue engineering. Colloids Surf B
Biointerfaces. 133:286–295. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Rahman CV, Ben-David D, Dhillon A, Kuhn G,
Gould TW, Müller R, Rose FR, Shakesheff KM and Livne E: Controlled
release of BMP-2 from a sintered polymer scaffold enhances bone
repair in a mouse calvarial defect model. J Tissue Eng Regen Med.
8:59–66. 2014. View Article : Google Scholar
|
|
3
|
Su J, Xu H, Sun J, Gong X and Zhao H: Dual
delivery of BMP-2 and bFGF from a new nano-composite scaffold,
loaded with vascular stents for large-size mandibular defect
regeneration. Int J Mol Sci. 14:12714–12728. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Wong E, Sangadala S, Boden SD, Yoshioka K,
Hutton WC, Oliver C and Titus L: A novel low-molecular-weight
compound enhances ectopic bone formation and fracture repair. J
Bone Joint Surg Am. 95:454–461. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hu ZM, Peel SA, Sandor GK and Clokie CM:
The osteoinductive activity of bone morphogenetic protein (BMP)
purified by repeated extracts of bovine bone. Growth Factors.
22:29–33. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Okada M, Sangadala S, Liu Y, Yoshida M,
Reddy BV, Titus L and Boden SD: Development and optimization of a
cell-based assay for the selection of synthetic compounds that
potentiate bone morphogenetic protein-2 activity. Cell Biochem
Funct. 27:526–534. 2009. View
Article : Google Scholar : PubMed/NCBI
|
|
7
|
Fan JJ, Cao LG, Wu T, Wang DX, Jin D,
Jiang S, Zhang ZY, Bi L and Pei GX: The dose-effect of icariin on
the proliferation and osteogenic differentiation of human bone
mesenchymal stem cells. Molecules. 16:10123–10133. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Franceschi RT, Yang S, Rutherford RB,
Krebsbach PH, Zhao M and Wang D: Gene therapy approaches for bone
regeneration. Cells Tissues Organs. 176:95–108. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Wutzl A, Brozek W, Lernbass I, Rauner M,
Hofbauer G, Schopper C, Watzinger F, Peterlik M and Pietschmann P:
Bone morphogenetic proteins 5 and 6 stimulate osteoclast
generation. J Biomed Mater Res A. 77:75–83. 2006. View Article : Google Scholar
|
|
10
|
Kim RY, Oh JH, Lee BS, Seo YK, Hwang SJ
and Kim IS: The effect of dose on rhBMP-2 signaling, delivered via
collagen sponge, on osteoclast activation and in vivo bone
resorption. Biomaterials. 35:1869–1881. 2014. View Article : Google Scholar
|
|
11
|
Zhang J, Zhao Y, Hou X, Chen B, Xiao Z,
Han J, Shi C, Liu J, Miao Q and Dai J: The inhibition effects of
insulin on BMP2-induced muscle heterotopic ossification.
Biomaterials. 35:9322–9331. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Wu T, Xu JC and Nan KH: Icariin enhances
proliferation and osteogenic differentiation of goat bone marrow
mesenchymal stem cells. J Clin Rehabilitative Tissue Eng Res.
13:3725–3729. 2009.
|
|
13
|
Fan J, Bi L, Wu T, Cao L, Wang D, Nan K,
Chen J, Jin D, Jiang S and Pei G: A combined chitosan/nano-size
hydroxyapatite system for the controlled release of icariin. J
Mater Sci Mater Med. 23:399–407. 2012. View Article : Google Scholar
|
|
14
|
Wu T, Nan KH, Chen JD, Jin D, Jiang S,
Zhao PR, Xu JC, Du H, Zhang XQ, Li JW and Pei GX: A new bone repair
scaffold combined with chitosan/hydroxyapatite and sustained
releasing icariin. Chin Sci Bull. 54:2953–2961. 2009. View Article : Google Scholar
|
|
15
|
Ye LH, Xiao BX, Cao FR, Zheng Y, Pan RL
and Chang Q: Identification of icaritin metabolites in rats by
LC-MS/MS. Chin Herb Med. 7:296–302. 2015. View Article : Google Scholar
|
|
16
|
Yao ZH, Liu MY, Dai Y, Zhang Y, Qin ZF, Tu
FJ and Yao XS: Metabolism of Epimedium-derived flavonoid glycosides
in intestinal flora of rabbits and its inhibition by
gluconolactone. Chin J Nat Med. 9:461–465. 2011.
|
|
17
|
Wang ZQ and Lou YJ:
Proliferation-stimulating effects of icaritin and desmethylicaritin
in MCF-7 cells. Eur J Pharmacol. 504:147–153. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Kang HK, Choi YH, Kwon H, Lee SB, Kim DH,
Sung CK, Park YI and Dong MS: Estrogenic/antiestrogenic activities
of a Epimedium koreanum extract and its major components: In vitro
and in vivo studies. Food Chem Toxicol. 50:2751–2759. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Ye HY and Lou YJ: Estrogenic effects of
two derivatives of icariin on human breast cancer MCF-7 cells.
Phytomedicine. 12:735–741. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Wong SP, Shen P, Lee L, Li J and Yong EL:
Pharmacokinetics of prenylflavonoids and correlations with the
dynamics of estrogen action in sera following ingestion of a
standardized Epimedium extract. J Pharm Biomed Anal. 50:216–223.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Liu YQ, Yang QX, Cheng MC and Xiao HB:
Synergistic inhibitory effect of Icariside II with Icaritin from
Herba Epimedii on pre-osteoclastic RAW264.7 cell growth.
Phytomedicine. 21:1633–1637. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Yao D, Wang X, Xie X, Zhang G and Qin L:
Icaritin promotes osteogenic differentiation while inhibits
osteoclastic differentiation in vitro. Can Nurse. 76:510–519.
1980.
|
|
23
|
Long J, Zhou Q, Li D, Wang X, Cao H and
Qin L: Phytoestrogenic molecule icaritin prevents OVX-induced
osteoporosis in mice. J Orthop Transl. 2:224–225. 2014.
|
|
24
|
Sheng H, Rui XF, Sheng CJ, Li WJ, Cheng
XY, Jhummon NP, Yu YC, Qu S, Zhang G and Qin L: A novel
semisynthetic molecule icaritin stimulates osteogenic
differentiation and inhibits adipogenesis of mesenchymal stem
cells. Int J Med Sci. 10:782–789. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Qin L, Yao D, Zheng L, Liu WC, Liu Z, Lei
M, Huang L, Xie X, Wang X, Chen Y, et al: Phytomolecule icaritin
incorporated PLGA/TCP scaffold for steroid-associated
osteonecrosis: Proof-of-concept for prevention of hip joint
collapse in bipedal emus and mechanistic study in quadrupedal
rabbits. Biomaterials. 59:125–143. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Chen SH, Wang XL, Xie XH, Zheng LZ, Yao D,
Wang DP, Leng Y, Zhang G and Qin L: Comparative study of osteogenic
potential of a composite scaffold incorporating either endogenous
bone morphogenetic protein-2 or exogenous phytomolecule icaritin:
An in vitro efficacy study. Acta Biomater. 8:3128–3137. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhang G, Qin L, Sheng H, Wang XL, Wang YX,
Yeung DK, Griffith JF, Yao XS, Xie XH, Li ZR, et al: A novel
semisynthesized small molecule icaritin reduces incidence of
steroid-associated osteonecrosis with inhibition of both thrombosis
and lipid-deposition in a dose-dependent manner. Bone. 44:345–356.
2009. View Article : Google Scholar
|
|
28
|
Wang XL, Xie XH, Zhang G, Chen SH, Yao D
and Qin L: An innovative porous scaffold incorporating exogenous
phytoestrogenic molecule icaritin for enhancement of bone defect
repair. Bone. 47:S4182010. View Article : Google Scholar
|
|
29
|
Kyllönen L, D'Este M, Alini M and Eglin D:
Local drug delivery for enhancing fracture healing in osteoporotic
bone. Acta Biomater. 11:412–434. 2015. View Article : Google Scholar
|
|
30
|
Zhang X, Liu T, Huang Y, Wismeijer D and
Liu Y: Icariin: Does it have an osteoinductive potential for bone
tissue engineering? Phytother Res. 28:498–509. 2014. View Article : Google Scholar
|
|
31
|
Zhao J, Ohba S, Komiyama Y, Shinkai M,
Chung UI and Nagamune T: Icariin: A potential osteoinductive
compound for bone tissue engineering. Tissue Eng Part A.
16:233–243. 2010. View Article : Google Scholar
|
|
32
|
Zhang SQ: Ultra-high performance liquid
chromatography-tandem mass spectrometry for the quantification of
icaritin in mouse bone. J Chromatogr B Analyt Technol Biomed Life
Sci. 978–979:24–28. 2015. View Article : Google Scholar
|
|
33
|
Huang J, Yuan L, Wang X, Zhang TL and Wang
K: Icaritin and its glycosides enhance osteoblastic, but suppress
osteoclastic, differentiation and activity in vitro. Life Sci.
81:832–840. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zhu RQ, Li ZZ, Zhou J, Han GQ, Cheng GZ
and Zhai YK: Estrogenic activities of icariin and its possible
metabolites in vitro. Acta Chin Med Pharmacol. 40:15–20. 2012.
|
|
35
|
Zhai YK, Li ZZ, Chen KM, Zhang N, Cheng GZ
and Zhu RQ: Comparative study on the effects of the osteogenic
differentiation of rat bone marrow stromal cells by icaritin and
dehydrated icaritin. J Chin Pharm Sci. 46:837–842. 2011.
|
|
36
|
Guo B, Zhang G, He Y, Wang X, Xie X, Hung
L and Qin L: Icaritin with dual action prevents ovariectomy-induced
osteoporosis in mice: Beneficial effect on bone and muscle via
estrogen-receptor-dependent and independent pathway, respectively.
Bone. 47:S3592010. View Article : Google Scholar
|
|
37
|
He Y, Zhang G, Wang X, Guo B, Xie X, Hung
L and Qin L: Icaritin, as secondary metabolites of
bone-strengthening herb epimedium, dose-dependently prevents
estrogen-depletion-induced bone loss in ovariectomized rats. Bone.
47:S404–S405. 2010. View Article : Google Scholar
|
|
38
|
Yao D, Xie XH, Wang XL, Wan C, Lee YW,
Chen SH, Pei DQ, Wang YX, Li G and Qin L: Icaritin, an exogenous
phytomolecule, enhances osteogenesis but not angiogenesis - an in
vitro efficacy study. PLoS One. 7:e412642012. View Article : Google Scholar
|
|
39
|
Aubin JE: Regulation of osteoblast
formation and function. Rev Endocr Metab Disord. 2:81–94. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wagner ER, Luther G, Zhu G, Luo Q, Shi Q,
Kim SH, Gao JL, Huang E, Gao Y, Yang K, et al: Defective osteogenic
differentiation in the development of osteosarcoma. Sarcoma.
2011:3252382011. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Ryoo HM, Lee MH and Kim YJ: Critical
molecular switches involved in BMP-2-induced osteogenic
differentiation of mesenchymal cells. Gene. 366:51–57. 2006.
View Article : Google Scholar
|
|
42
|
Ulsamer A, Ortuño MJ, Ruiz S, Susperregui
AR, Osses N, Rosa JL and Ventura F: BMP-2 induces Osterix
expression through up-regulation of Dlx5 and its phosphorylation by
p38. J Biol Chem. 283:3816–3826. 2008. View Article : Google Scholar
|
|
43
|
Wang RY and Jing YI: Signaling mechanism
of osteoblastic differentiation of bone morphogenetic proteins
Chin. Bull Life Sci. 17:34–39. 2005.
|
|
44
|
Choi MH, Noh WC, Park JW, Lee JM and Suh
JY: Gene expression pattern during osteogenic differentiation of
human periodontal ligament cells in vitro. J Periodontal Implant
Sci. 41:167–175. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Zhao J, Ohba S, Shinkai M, Chung UI and
Nagamune T: Icariin induces osteogenic differentiation in vitro in
a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun.
369:444–448. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Qian G, Zhang X, Lu L, Wu X, Li S and Meng
J: Regulation of Cbfa1 expression by total flavonoids of Herba
epimedii. Endocr J. 53:87–94. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Yin XX, Chen ZQ, Liu ZJ, Ma QJ and Dang
GT: Icariine stimulates proliferation and differentiation of human
osteoblasts by increasing production of bone morphogenetic protein
2. Chin Med J (Engl). 120:204–210. 2007.
|
|
48
|
He W, Li Z, Yi B, Liang C and Wang X, Li Y
and Wang X: Icariin upregulated Cbfa1, bone morphogenetic protein 2
and bone morphogenetic protein 4 mRNA expression of rat osteoblast.
Int J Oral Max Surg. 38:4592009. View Article : Google Scholar
|
|
49
|
Xiao Q, Chen A and Guo F: Effects of
Icariin on expression of OPN mRNA and type I collagen in rat
osteoblasts in vitro. J Huazhong Univ Sci Technolog Med Sci.
25:690–692. 2005. View Article : Google Scholar
|
|
50
|
Shen P, Guo BL, Gong Y, Hong DY, Hong Y
and Yong EL: Taxonomic, genetic, chemical and estrogenic
characteristics of Epimedium species. Phytochemistry. 68:1448–1458.
2007. View Article : Google Scholar : PubMed/NCBI
|
