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Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2

  • Authors:
    • Yue Tian
    • Xiuying Wu
    • Shanbin Guo
    • Ling Ma
    • Wei Huang
    • Xiaochun Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 869-878
    |
    Published online on: February 28, 2017
       https://doi.org/10.3892/ijmm.2017.2908
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Abstract

Minocycline has been demonstrated to exert neuroprotective effects in various experimental models. In the present study, we investigated the mechanisms underlying the protective effects of minocycline on cell injury induced by the inhalation of the anesthetic, sevoflurane. In our in vivo experiments using rats, minocycline attenuated sevoflurane-induced neuronal degeneration and apoptosis in the rat hippocampus, and this effect was associated with the minocycline-mediated suppression of oxidative stress in the hippocampus. In in vitro experiments, minocycline inhibited sevoflurane-induced apoptosis and the production of reactive oxygen species (ROS) in H4 human neuroglioma cells. In addition, minocycline suppressed the sevoflurane-induced upregulation of interleukin (IL)-6 and the activation of the nuclear factor-κB (NF-κB) signaling pathway in H4 cells. Furthermore, we found that nuclear factor E2-related factor 2 (Nrf2), an activator of the stress response, was upregulated and activated upon sevoflurane treatment both in the rat hippocampus and in H4 cells. In addition, minocycline further augmented the upregulation and activation of Nrf2 when used in conjunction with sevoflurane. Moreover, the knockdown of Nrf2 in H4 cells by small interfering RNA (siRNA) diminished the cytoprotective effect of minocycline, and attenuated the inhibitory effect of minocycline on ROS production, IL-6 upregulation and the activation of the NF-κB signaling pathway. On the whole, our findings indicate that minocycline may exert protective effects against sevoflurane-induced cell injury via the Nrf2-modulated antioxidant response and the inhibition of the activation of the NF-κB signaling pathway.
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View References

1 

Bittner EA, Yue Y and Xie Z: Brief review: anesthetic neurotoxicity in the elderly, cognitive dysfunction and Alzheimer's disease. Can J Anaesth. 58:216–223. 2011. View Article : Google Scholar

2 

Xiong WX, Zhou GX, Wang B, Xue ZG, Wang L, Sun HC and Ge SJ: Impaired spatial learning and memory after sevoflurane-nitrous oxide anesthesia in aged rats is associated with down-regulated cAMP/CREB signaling. PLoS One. 8:e794082013. View Article : Google Scholar : PubMed/NCBI

3 

Zhang L, Zhang J, Yang L, Dong Y, Zhang Y and Xie Z: Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells. Br J Anaesth. 110(Suppl 1): i82–i91. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yang LP, Zhu XA and Tso MO: Minocycline and sulforaphane inhibited lipopolysaccharide-mediated retinal microglial activation. Mol Vis. 13:1083–1093. 2007.PubMed/NCBI

5 

Choi Y, Kim HS, Shin KY, Kim EM, Kim M, Kim HS, Park CH, Jeong YH, Yoo J, Lee JP, et al: Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models. Neuropsychopharmacology. 32:2393–2404. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Yrjänheikki J, Tikka T, Keinänen R, Goldsteins G, Chan PH and Koistinaho J: A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA. 96:13496–13500. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Desjarlais M, Pratt J, Lounis A, Mounier C, Haidara K and Annabi B: Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-a-activated human hepatoma cells. Gene Regul Syst Bio. 8:63–73. 2014.PubMed/NCBI

8 

Yoon SY, Patel D and Dougherty PM: Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes. Neuroscience. 221:214–224. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Kuang X, Scofield VL, Yan M, Stoica G, Liu N and Wong PK: Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice. Brain Res. 1286:174–184. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Tian Y, Guo S, Wu X, Ma L and Zhao X: Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats. Cell Mol Neurobiol. 35:585–594. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S and Yamamoto M: Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 275:16023–16029. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Lyu JH, Kim KH, Kim HW, Cho SI, Ha KT, Choi JY, Han CW, Jeong HS, Lee HK, Ahn KS, et al: Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-kappaB. J Ethnopharmacol. 140:107–116. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Cuadrado A, Martín-Moldes Z, Ye J and Lastres-Becker I: Transcription factors NRF2 and NF-kappaB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation. J Biol Chem. 289:15244–15258. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Mahmoud-Awny M, Attia AS, Abd-Ellah MF and El-Abhar HS: Mangiferin mitigates gastric ulcer in ischemia/reperfused rats: involvement of PPAR-gamma, NF-kappaB and Nrf2/HO-1 signaling pathways. PLoS One. 10:e01324972015. View Article : Google Scholar

15 

Franks NP and Lieb WR: Temperature dependence of the potency of volatile general anesthetics: implications for in vitro experiments. Anesthesiology. 84:716–720. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Jacobson MD: Reactive oxygen species and programmed cell death. Trends Biochem Sci. 21:83–86. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 5:415–418. 2000. View Article : Google Scholar

18 

Heo K, Cho YJ, Cho KJ, Kim HW, Kim HJ, Shin HY, Lee BI and Kim GW: Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice. Neurosci Lett. 398:195–200. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Wang J, Wei Q, Wang CY, Hill WD, Hess DC and Dong Z: Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem. 279:19948–19954. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Huang C, Li R, Zeng Q, Ding Y, Zou Y, Mao X, Hu W, Xiong R and Li M: Effect of minocycline postconditioning and ischemic postconditioning on myocardial ischemia-reperfusion injury in atherosclerosis rabbits. J Huazhong Univ Sci Technolog Med Sci. 32:524–529. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, et al: Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 6:797–801. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Jiang BP, Le L, Xu LJ and Xiao PG: Minocycline inhibits ICAD degradation and the NF-kappaB activation induced by 6-OHDA in PC12 cells. Brain Res. 1586:1–11. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Schmitz T, Endesfelder S, Chew LJ, Zaak I and Bührer C: Minocycline protects oligodendroglial precursor cells against injury caused by oxygen-glucose deprivation. J Neurosci Res. 90:933–944. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, Piao JH, Yagita H, Okumura K, Doi T, et al: NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 22:3898–3909. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Xiao W, Hodge DR, Wang L, Yang X, Zhang X and Farrar WL: Co-operative functions between nuclear factors NF-kappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate. 61:354–370. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Dutta J, Fan Y, Gupta N, Fan G and Gélinas C: Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene. 25:6800–6816. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Nakano H, Nakajima A, Sakon-Komazawa S, Piao JH, Xue X and Okumura K: Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ. 13:730–737. 2006. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tian Y, Wu X, Guo S, Ma L, Huang W and Zhao X: Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. Int J Mol Med 39: 869-878, 2017.
APA
Tian, Y., Wu, X., Guo, S., Ma, L., Huang, W., & Zhao, X. (2017). Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. International Journal of Molecular Medicine, 39, 869-878. https://doi.org/10.3892/ijmm.2017.2908
MLA
Tian, Y., Wu, X., Guo, S., Ma, L., Huang, W., Zhao, X."Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2". International Journal of Molecular Medicine 39.4 (2017): 869-878.
Chicago
Tian, Y., Wu, X., Guo, S., Ma, L., Huang, W., Zhao, X."Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2". International Journal of Molecular Medicine 39, no. 4 (2017): 869-878. https://doi.org/10.3892/ijmm.2017.2908
Copy and paste a formatted citation
x
Spandidos Publications style
Tian Y, Wu X, Guo S, Ma L, Huang W and Zhao X: Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. Int J Mol Med 39: 869-878, 2017.
APA
Tian, Y., Wu, X., Guo, S., Ma, L., Huang, W., & Zhao, X. (2017). Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. International Journal of Molecular Medicine, 39, 869-878. https://doi.org/10.3892/ijmm.2017.2908
MLA
Tian, Y., Wu, X., Guo, S., Ma, L., Huang, W., Zhao, X."Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2". International Journal of Molecular Medicine 39.4 (2017): 869-878.
Chicago
Tian, Y., Wu, X., Guo, S., Ma, L., Huang, W., Zhao, X."Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2". International Journal of Molecular Medicine 39, no. 4 (2017): 869-878. https://doi.org/10.3892/ijmm.2017.2908
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