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Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3

  • Authors:
    • Cunshu Li
    • Ye Chang
    • Yuan Li
    • Shuang Chen
    • Yintao Chen
    • Ning Ye
    • Dongxue Dai
    • Yingxian Sun
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1242-1254
    |
    Published online on: March 28, 2017
       https://doi.org/10.3892/ijmm.2017.2938
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Abstract

The present study was aimed to investigate the role of reactive oxygen species (ROS) on advanced glycation end product (AGE)-induced proliferation and migration of vascular smooth muscle cells (VSMCs) and whether Bcl-2‑associated athanogene 3 (BAG3) is involved in the process. Primary rat VSMCs were extracted and cultured in vitro. Cell viability was detected by MTT assay and cell proliferation was detected by EdU incorporation assay. Cell migration was detected by wound healing and Transwell assays. BAG3 was detected using qPCR and western blot analysis. Transcriptional and translational inhibitors (actinomycin D and cycloheximide, respectively) were used to study the effect of AGEs on the expression of BAG3 in VSMCs. Lentiviral plasmids containing short hairpin RNA (shRNA) against rat BAG3 or control shRNA were transduced into VSMCs. Cellular ROS were detected by 2',7'-dichlorofluorescein diacetate (DCFH-DA) staining. Mitochondrial membrane potential was detected by tetramethylrhodamine methyl ester (TMRE) staining. AGEs significantly increased the expression of BAG3 in a dose-and time-dependent manner. Furthermore, AGEs mainly increased the expression of BAG3 mRNA by increasing the RNA synthesis rather than inhibiting the RNA translation. BAG3 knockdown reduced the proliferation and migration of VSMCs induced by AGEs. BAG3 knockdown reduced the generation of ROS and sustained the mitochondrial membrane potential of VSMCs. Reduction of ROS production by N-acetylcysteine (NAC), a potent antioxidant, also reduced the proliferation and migration of VSMCs. On the whole, the present study demonstrated for the first time that AGEs could increase ROS production and promote the proliferation and migration of VSMCs by upregulating BAG3 expression. This study indicated that BAG3 should be considered as a potential target for the prevention and/or treatment of vascular complications of diabetes.
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1 

Kudryavtseva O, Aalkjaer C and Matchkov VV: Vascular smooth muscle cell phenotype is defined by Ca2+-dependent transcription factors. FEBS J. 280:5488–5499. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Tang DD and Anfinogenova Y: Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther. 13:130–140. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Owens GK, Kumar MS and Wamhoff BR: Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 84:767–801. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Bochaton-Piallat ML and Gabbiani G: Modulation of smooth muscle cell proliferation and migration: Role of smooth muscle cell heterogeneity. Handb Exp Pharmacol. 170:645–663. 2005. View Article : Google Scholar

5 

Orr AW, Hastings NE, Blackman BR and Wamhoff BR: Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J Vasc Res. 47:168–180. 2010. View Article : Google Scholar :

6 

Rzucidlo EM, Martin KA and Powell RJ: Regulation of vascular smooth muscle cell differentiation. J Vasc Surg. 45(Suppl A): A25–A32. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Davis-Dusenbery BN, Wu C, Hata A and Sessa WC: Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 31:2370–2377. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Zhao LM, Su XL, Wang Y, Li GR and Deng XL: KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells. Lab Invest. 93:159–167. 2013. View Article : Google Scholar

9 

Yuan X, Zhang Z, Gong K, Zhao P, Qin J and Liu N: Inhibition of reactive oxygen species/extracellular signal-regulated kinases pathway by pioglitazone attenuates advanced glycation end products-induced proliferation of vascular smooth muscle cells in rats. Biol Pharm Bull. 34:618–623. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Nam MH, Son WR, Lee YS and Lee KW: Glycolaldehyde-derived advanced glycation end products (glycol-AGEs)-induced vascular smooth muscle cell dysfunction is regulated by the AGES-receptor (RAGE) axis in endothelium. Cell Commun Adhes. 22:67–78. 2015. View Article : Google Scholar

11 

Simard E, Söllradl T, Maltais JS, Boucher J, D'Orléans-Juste P and Grandbois M: Receptor for advanced glycation end-products signaling interferes with the vascular smooth muscle cell contractile phenotype and function. PLoS One. 10:e01288812015. View Article : Google Scholar : PubMed/NCBI

12 

Singh R, Barden A, Mori T and Beilin L: Advanced glycation end-products: A review. Diabetologia. 44:129–146. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Goldin A, Beckman JA, Schmidt AM and Creager MA: Advanced glycation end products: Sparking the development of diabetic vascular injury. Circulation. 114:597–605. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Ma M, Guo X, Chang Y, Li C, Meng X, Li S, Du ZX, Wang HQ and Sun Y: Advanced glycation end products promote proliferation and suppress autophagy via reduction of Cathepsin D in rat vascular smooth muscle cells. Mol Cell Biochem. 403:73–83. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wu L, Li X, Li Y, Wang L, Tang Y and Xue M: Proliferative inhibition of danxiongfang and its active ingredients on rat vascular smooth muscle cell and protective effect on the VSMC damage induced by hydrogen peroxide. J Ethnopharmacol. 126:197–206. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Panchenko MP, Silva N and Stone JR: Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia. Cardiovasc Pathol. 18:167–172. 2009. View Article : Google Scholar

17 

Zhou Y, Zhang MJ, Li BH, Chen L, Pi Y, Yin YW, Long CY, Wang X, Sun MJ, Chen X, et al: PPARγ inhibits VSMC proliferation and migration via attenuating oxidative stress through upregulating UCP2. PLoS One. 11:e01547202016. View Article : Google Scholar

18 

Iwasaki M, Homma S, Hishiya A, Dolezal SJ, Reed JC and Takayama S: BAG3 regulates motility and adhesion of epithelial cancer cells. Cancer Res. 67:10252–10259. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Liu BQ, Du ZX, Zong ZH, Li C, Li N, Zhang Q, Kong DH and Wang HQ: BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells. Autophagy. 9:905–916. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Rosati A, Graziano V, De Laurenzi V, Pascale M and Turco MC: BAG3: A multifaceted protein that regulates major cell pathways. Cell Death Dis. 2:e1412011. View Article : Google Scholar : PubMed/NCBI

21 

Shi H, Xu H, Li Z, Zhen Y, Wang B, Huo S, Xiao R and Xu Z: BAG3 regulates cell proliferation, migration, and invasion in human colorectal cancer. Tumour Biol. 37:5591–5597. 2016. View Article : Google Scholar

22 

Hishiya A, Kitazawa T and Takayama S: BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. Circ Res. 107:1220–1231. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Falco A, Festa M, Basile A, Rosati A, Pascale M, Florenzano F, Nori SL, Nicolin V, Di Benedetto M, Vecchione ML, et al: BAG3 controls angiogenesis through regulation of ERK phosphorylation. Oncogene. 31:5153–5161. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Norton N, Li D, Rieder MJ, Siegfried JD, Rampersaud E, Züchner S, Mangos S, Gonzalez-Quintana J, Wang L, McGee S, et al: Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. Am J Hum Genet. 88:273–282. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Citro R, d'Avenia M, De Marco M, Giudice R, Mirra M, Ravera A, Silverio A, Farina R, Silvestri F, Gravina P, et al: Polymorphisms of the antiapoptotic protein bag3 may play a role in the pathogenesis of tako-tsubo cardiomyopathy. Int J Cardiol. 168:1663–1665. 2013. View Article : Google Scholar : PubMed/NCBI

26 

De Marco M, Falco A, Basile A, Rosati A, Festa M, d'Avenia M, Pascale M, Dal Piaz F, Bisogni R, Barcaroli D, et al: Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure. Cell Death Dis. 4:e4952013. View Article : Google Scholar : PubMed/NCBI

27 

Salabei JK, Cummins TD, Singh M, Jones SP, Bhatnagar A and Hill BG: PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem J. 451:375–388. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Li C, Li S, Kong DH, Meng X, Zong ZH, Liu BQ, Guan Y, Du ZX and Wang HQ: BAG3 is upregulated by c-Jun and stabilizes JunD. Biochim Biophys Acta. 1833:3346–3354. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Guo L, Guo X, Chang Y, Li Z, Yu S, Yang H and Sun Y: Modified ideal cardiovascular health status is associated with lower prevalence of stroke in rural northeast China. Int J Environ Res Public Health. 13:2072016. View Article : Google Scholar : PubMed/NCBI

30 

Chen S, Liu B, Kong D, Li S, Li C, Wang H and Sun Y: Atorvastatin calcium inhibits phenotypic modulation of PDGF-BB-induced VSMCs via down-regulation the Akt signaling pathway. PLoS One. 10:e01225772015. View Article : Google Scholar : PubMed/NCBI

31 

Chang Y, Li Y, Ye N, Guo X, Li Z, Sun G and Sun Y: Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis. Apoptosis. 21:977–996. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Di Pietro M, Filardo S, De Santis F, Mastromarino P and Sessa R: Chlamydia pneumoniae and oxidative stress in cardiovascular disease: State of the art and prevention strategies. Int J Mol Sci. 16:724–735. 2014. View Article : Google Scholar

33 

Crauwels HM, Herman AG and Bult H: Local application of advanced glycation end products and intimal hyperplasia in the rabbit collared carotid artery. Cardiovasc Res. 47:173–182. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Zhou Z, Wang K, Penn MS, Marso SP, Lauer MA, Forudi F, Zhou X, Qu W, Lu Y, Stern DM, et al: Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury. Circulation. 107:2238–2243. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Coughlan MT, Thorburn DR, Penfold SA, Laskowski A, Harcourt BE, Sourris KC, Tan AL, Fukami K, Thallas-Bonke V, Nawroth PP, et al: RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol. 20:742–752. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Kay AM, Simpson CL and Stewart JA Jr: The role of AGE/RAGE signaling in diabetes-mediated vascular calcification. J Diabetes Res. 2016:68097032016. View Article : Google Scholar : PubMed/NCBI

37 

Liu X, Liu K, Wang Z, Liu C, Han Z, Tao J, Lu P, Wang J, Wu B, Huang Z, et al: Advanced glycation end products accelerate arteriosclerosis after renal transplantation through the AGE/RAGE/ILK pathway. Exp Mol Pathol. 99:312–319. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Wei Q, Ren X, Jiang Y, Jin H, Liu N and Li J: Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress. BMC Cardiovasc Disord. 13:132013. View Article : Google Scholar : PubMed/NCBI

39 

Bloemberg D, McDonald E, Dulay D and Quadrilatero J: Autophagy is altered in skeletal and cardiac muscle of spontaneously hypertensive rats. Acta Physiol (Oxf). 210:381–391. 2014. View Article : Google Scholar

40 

Gentilella A and Khalili K: BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem. 286:9205–9215. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Zhu H, Wu W, Fu Y, Shen W, Miao K, Hong M, Xu W, Young KH, Liu P and Li J: Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia. Ann Hematol. 93:425–435. 2014. View Article : Google Scholar

42 

Staibano S, Mascolo M, Di Benedetto M, Vecchione ML, Ilardi G, Di Lorenzo G, Autorino R, Salerno V, Morena A, Rocco A, et al: BAG3 protein delocalisation in prostate carcinoma. Tumour Biol. 31:461–469. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Gentilella A, Passiatore G, Deshmane S, Turco MC and Khalili K: Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells. Oncogene. 27:5011–5018. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Franceschelli S, Rosati A, Lerose R, De Nicola S, Turco MC and Pascale M: Bag3 gene expression is regulated by heat shock factor 1. J Cell Physiol. 215:575–577. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Du ZX, Meng X, Zhang HY, Guan Y and Wang HQ: Caspase-dependent cleavage of BAG3 in proteasome inhibitors-induced apoptosis in thyroid cancer cells. Biochem Biophys Res Commun. 369:894–898. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Liao Q, Ozawa F, Friess H, Zimmermann A, Takayama S, Reed JC, Kleeff J and Büchler MW: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Lett. 503:151–157. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Pagliuca MG, Lerose R, Cigliano S and Leone A: Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. FEBS Lett. 541:11–15. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Fiorentino TV, Prioletta A, Zuo P and Folli F: Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des. 19:5695–5703. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Adamopoulos C, Mihailidou C, Grivaki C, Papavassiliou KA, Kiaris H, Piperi C and Papavassiliou AG: Systemic effects of AGEs in ER stress induction in vivo. Glycoconj J. 33:537–544. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU and Behl C: Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J. 28:889–901. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Ma Y, Gai Y, Yan J, Li J and Zhang Y: Puerarin attenuates anoxia/reoxygenation injury through enhancing Bcl-2 associated athanogene 3 expression, a modulator of apoptosis and autophagy. Med Sci Monit. 22:977–983. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Kunsch C and Medford RM: Oxidative stress as a regulator of gene expression in the vasculature. Circ Res. 85:753–766. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li C, Chang Y, Li Y, Chen S, Chen Y, Ye N, Dai D and Sun Y: Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3. Int J Mol Med 39: 1242-1254, 2017.
APA
Li, C., Chang, Y., Li, Y., Chen, S., Chen, Y., Ye, N. ... Sun, Y. (2017). Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3. International Journal of Molecular Medicine, 39, 1242-1254. https://doi.org/10.3892/ijmm.2017.2938
MLA
Li, C., Chang, Y., Li, Y., Chen, S., Chen, Y., Ye, N., Dai, D., Sun, Y."Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3". International Journal of Molecular Medicine 39.5 (2017): 1242-1254.
Chicago
Li, C., Chang, Y., Li, Y., Chen, S., Chen, Y., Ye, N., Dai, D., Sun, Y."Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3". International Journal of Molecular Medicine 39, no. 5 (2017): 1242-1254. https://doi.org/10.3892/ijmm.2017.2938
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Chang Y, Li Y, Chen S, Chen Y, Ye N, Dai D and Sun Y: Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3. Int J Mol Med 39: 1242-1254, 2017.
APA
Li, C., Chang, Y., Li, Y., Chen, S., Chen, Y., Ye, N. ... Sun, Y. (2017). Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3. International Journal of Molecular Medicine, 39, 1242-1254. https://doi.org/10.3892/ijmm.2017.2938
MLA
Li, C., Chang, Y., Li, Y., Chen, S., Chen, Y., Ye, N., Dai, D., Sun, Y."Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3". International Journal of Molecular Medicine 39.5 (2017): 1242-1254.
Chicago
Li, C., Chang, Y., Li, Y., Chen, S., Chen, Y., Ye, N., Dai, D., Sun, Y."Advanced glycation end products promote the proliferation and migration of primary rat vascular smooth muscle cells via the upregulation of BAG3". International Journal of Molecular Medicine 39, no. 5 (2017): 1242-1254. https://doi.org/10.3892/ijmm.2017.2938
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