Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
September-2017 Volume 40 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 40 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice

  • Authors:
    • Lingyu Hao
    • Jiayao Fu
    • Yawen Tian
    • Junhua Wu
  • View Affiliations / Copyright

    Affiliations: Department of Prosthodontics, School and Hospital of Stomatology, Tongji University and Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 689-702
    |
    Published online on: July 10, 2017
       https://doi.org/10.3892/ijmm.2017.3062
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoporosis is a complex and multifactorial disease caused by an imbalance between bone formation and resorption. Post‑menopausal women with endogenous estrogen deficiency suffer from systemic bone loss and osteoporosis, and are at high risk of this affecting the jaw bones. MicroRNAs (miRNAs or miRs) have been implicated in the mechanisms of metabolic bone diseases and are expressed at differential levels in alveolar bone following ovariectomy. In the present study, we systematically analyzed the expression profiles of miRNAs, mRNAs and long non‑coding RNA (lncRNAs) in the mandible of ovariectomized (OVX) mice. A complex miRNA‑mRNA‑lncRNA regulatory network was constructed based on differentially expressed RNAs. Two core differentially expressed genes (DEGs), namely, LRP2 binding protein (Lrp2bp) and perilipin 4 (Plin4), significantly influenced the network targeted by differentially expressed miRNAs. Moreover, peroxisome proliferator-activated receptor (PPAR) and insulin signaling pathways were significantly dysregulated in the mandible of OVX mice. Several differentially expressed lncRNAs were also implicated in the two signaling pathways, which influenced mandible development by forming competing endogenous RNA. On the whole, our data indicate that the comprehensive analysis of miRNAs, mRNAs and lncRNAs provides insight into the pathogenesis of estrogen deficiency‑induced osteoporosis in the mandible. This study proposes potential biomarkers for diagnosis or therapeutic targets for osteoporosis which may aid in the development of novel drugs for the treatment of osteoporosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

View References

1 

Simsek G, Uzun H, Karter Y, Aydin S and Yigit G: Effects of osteoporotic cytokines in ovary-intact and ovariectomised rats with induced hyperthyroidism; is skeletal responsiveness to thyroid hormone altered in estrogen deficiency? Tohoku J Exp Med. 201:81–89. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Zhao L, Mao Z, Schneider LS and Brinton RD: Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause. Menopause. 18:1131–1142. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Mawatari T, Miura H, Higaki H, Kurata K, Moro-oka T, Murakami T and Iwamoto Y: Quantitative analysis of three-dimensional complexity and connectivity changes in trabecular microarchitecture in relation to aging, menopause, and inflammation. J Orthop Sci. 4:431–438. 1999. View Article : Google Scholar

4 

Liang H, Ma Y, Pun S, Stimpel M and Jee WS: Aging- and ovariectomy-related skeletal changes in spontaneously hypertensive rats. Anat Rec. 249:173–180. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Zhao Q, Liu X, Zhang L, Shen X, Qi J, Wang J, Qian N and Deng L: Bone selective protective effect of a novel bone-seeking estrogen on trabecular bone in ovariectomized rats. Calcif Tissue Int. 93:172–183. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Manolagas SC, O'Brien CA and Almeida M: The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol. 9:699–712. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wronski TJ, Dann LM, Scott KS and Cintrón M: Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int. 45:360–366. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Sharma D, Ciani C, Marin PA, Levy JD, Doty SB and Fritton SP: Alterations in the osteocyte lacunar-canalicular microenvironment due to estrogen deficiency. Bone. 51:488–497. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Xu T, Yan M, Wang Y, Wang Z, Xie L, Tang C, Zhang G and Yu J: Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors. J Mol Histol. 45:11–19. 2014. View Article : Google Scholar

10 

Liu X, Zhang R, Zhou Y, Yang Y, Si H, Li X and Liu L: The effect of Astragalus extractive on alveolar bone rebuilding progress of tooth extracted socket of ovariectomied rats. Afr J Tradit Complement Altern Med. 11:91–98. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Zhang R, Liu ZG, Li C, Hu SJ, Liu L, Wang JP and Mei QB: Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats. Bone. 45:553–559. 2009. View Article : Google Scholar

12 

Tewari D, Khan MP, Sagar N, China SP, Singh AK, Kheruka SC, Barai S, Tewari MC, Nagar GK, Vishwakarma AL, et al: Ovariectomized rats with established osteopenia have diminished mesenchymal stem cells in the bone marrow and impaired homing, osteoinduction and bone regeneration at the fracture site. Stem Cell Rev. 11:309–321. 2015. View Article : Google Scholar

13 

Bhatnagar S, Krishnamurthy V and Pagare SS: Diagnostic efficacy of panoramic radiography in detection of osteoporosis in post-menopausal women with low bone mineral density. J Clin Imaging Sci. 3:232013. View Article : Google Scholar : PubMed/NCBI

14 

Aguilera-Barreirode LA, Dáva los-Vázquez KF, Jiménez-Méndez C, Jiménez-Mendoza D, Olivarez-Padrón LA and Rodríguez-García ME: The relationship of nutritional status, body and mandibular bone mineral density, tooth loss and fracture risk (FRAX) in pre-and postmenopausal women with periodontitis. Nutr Hosp. 29:1419–1426. 2014.In Spanish.

15 

Nackaerts O, Jacobs R, Devlin H, Pavitt S, Bleyen E, Yan B, Borghs H, Lindh C, Karayianni K, van der Stelt P, et al: Osteoporosis detection using intraoral densitometry. Dentomaxillofac Rad. 37:282–287. 2008. View Article : Google Scholar

16 

Barngkgei I, Al Haffar I and Khattab R: Osteoporosis prediction from the mandible using cone-beam computed tomography. Imaging Sci Dent. 44:263–271. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Chen J, Qiu M, Dou C, Cao Z and Dong S: MicroRNAs in bone balance and osteoporosis. Drug Dev Res. 76:235–245. 2015. View Article : Google Scholar : PubMed/NCBI

18 

An JH, Ohn JH, Song JA, Yang JY, Park H, Choi HJ, Kim SW, Kim SY, Park WY and Shin CS: Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice. J Bone Miner Res. 29:644–56. 2014. View Article : Google Scholar

19 

Lv H, Sun Y and Zhang Y: MiR-133 is involved in estrogen deficiency-induced osteoporosis through modulating osteogenic differentiation of mesenchymal stem cells. Med Sci Monit. 21:1527–1534. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Sun M, Zhou X, Chen L, Huang S, Leung V, Wu N, Pan H, Zhen W, Lu W and Peng S: The regulatory roles of microRNAs in bone remodeling and perspectives as biomarkers in osteoporosis. Biomed Res Int. 2016:16524172016. View Article : Google Scholar : PubMed/NCBI

21 

Liao L, Yang X, Su X, Hu C, Zhu X, Yang N, Chen X, Shi S, Shi S and Jin Y: Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow. Cell Death Dis. 4:e6002013. View Article : Google Scholar : PubMed/NCBI

22 

Krzeszinski JY, Wei W, Huynh H, Jin Z, Wang X, Chang TC, Xie XJ, He L, Mangala LS, Lopez-Berestein G, et al: miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature. 512:431–435. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Li Y, Fan L, Hu J, Zhang L, Liao L, Liu S, Wu D, Yang P, Shen L, Chen J and Jin Y: MiR-26a rescues bone regeneration deficiency of mesenchymal stem cells derived from osteoporotic mice. Mol Ther. 23:1349–1357. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Tong X, Gu PC, Xu SZ and Lin XJ: Long non-coding RNA-DANCR in human circulating monocytes: A potential biomarker associated with postmenopausal osteoporosis. Biosci Biotechnol Biochem. 79:732–737. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kang DM, Yoon KH, Kim JY, Oh JM, Lee M, Jung ST, Juhng SK and Lee YH: CT imaging biomarker for evaluation of emodin as a potential drug on LPS-mediated osteoporosis mice. Acad Radiol. 21:457–462. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Cao J, Ou G, Yang N, Ding K, Kream BE, Hamrick MW, Isales CM and Shi XM: Impact of targeted PPARγ disruption on bone remodeling. Mol Cell Endocrinol. 410:27–34. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Liu Q, Liu H, Yu X, Wang Y, Yang C and Xu H: Analysis of the role of insulin signaling in bone turnover induced by fluoride. Biol Trace Elem Res. 171:380–390. 2016. View Article : Google Scholar

28 

Aydin A, Kenar H, Atmaca H, Alici T, Gacar G, Müezzinoğlu ÜS and Karaöz E: The short- and long- term effects of estrogen deficiency on apoptosis in musculoskeletal tissues: an experimental animal model study. Arch Iran Med. 16:271–276. 2013.PubMed/NCBI

29 

Väänänen HK and Härkönen PL: Estrogen and bone metabolism. Maturitas. 23(Suppl): S65–S69. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Darcey J, Horner K, Walsh T, Southern H, Marjanovic EJ and Devlin H: Tooth loss and osteoporosis: To assess the association between osteoporosis status and tooth number. Br Dent J. 214:E102013. View Article : Google Scholar : PubMed/NCBI

31 

Jang KM, Cho KH, Lee SH, Han SB, Han KD and Kim YH: Tooth loss and bone mineral density in postmenopausal South Korean women: The 2008–2010 Korea National Health and Nutrition Examination Survey. Maturitas. 82:360–364. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Numoto Y, Mori T, Maeda S, Tomoyasu Y, Higuchi H, Egusa M and Miyawaki T: Low bone mass is a risk factor in periodontal disease-related tooth loss in patients with intellectual disability. Open Dent J. 7:157–161. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Guiglia R, Di Fede O, Lo Russo L, Sprini D, Rini GB and Campisi G: Osteoporosis, jawbones and periodontal disease. Med Oral Patol Oral Cir Bucal. 18:e93–e99. 2013. View Article : Google Scholar :

34 

Khojastehpour L, Mogharrabi S, Dabbaghmanesh MH and Iraji Nasrabadi N: Comparison of the mandibular bone densitometry measurement between normal, osteopenic and osteoporotic postmenopausal women. J Dent (Tehran). 10:203–209. 2013.

35 

Ejiri S, Tanaka M, Watanabe N, Anwar RB, Yamashita E, Yamada K and Ikegame M: Estrogen deficiency and its effect on the jaw bones. J Bone Miner Metab. 26:409–415. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Mavropoulos A, Rizzoli R and Ammann P: Different responsiveness of alveolar and tibial bone to bone loss stimuli. J Bone Miner Res. 22:403–410. 2007. View Article : Google Scholar

37 

Zhang Y, Li Y, Gao Q, Shao B, Xiao J, Zhou H, Niu Q, Shen M, Liu B, Hu K and Kong L: The variation of cancellous bones at lumbar vertebra, femoral neck, mandibular angle and rib in ovariectomized sheep. Arch Oral Biol. 59:663–669. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Elovic RP, Hipp JA and Hayes WC: Ovariectomy decreases the bone area fraction of the rat mandible. Calcif Tissue Int. 56:305–310. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Nagi R: Relationship between femur bone mineral density, body mass index and dental panoramic mandibular cortical width in diagnosis of elderly postmenopausal women with osteoporosis. J Clin Diagn Res. 8:ZC36–ZC40. 2014.PubMed/NCBI

40 

Hekmatin E, Ahmadi SS, Ataiekhorasgani M, Feizianfard M, Jafaripozve S and Jafaripozve N: Prediction of lumbar spine bone mineral density from the mandibular cortical width in postmenopausal women. J Res Med Sci. 18:951–955. 2013.

41 

Srinivasan S, Selvan ST, Archunan G, Gulyas B and Padmanabhan P: MicroRNAs - the next generation therapeutic targets in human diseases. Theranostics. 3:930–942. 2013. View Article : Google Scholar

42 

Zhao X, Xu D, Li Y, Zhang J, Liu T, Ji Y, Wang J, Zhou G and Xie X: MicroRNAs regulate bone metabolism. J Bone Miner Metab. 32:221–231. 2014. View Article : Google Scholar

43 

Khosravi R, Sodek KL, Xu WP, Bais MV, Saxena D, Faibish M and Trackman PC: A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia. PLoS One. 9:e1006692014. View Article : Google Scholar : PubMed/NCBI

44 

Cusano NE, Kiel DP, Demissie S, Karasik D, Cupples LA, Corella D, Gao Q, Richardson K, Yiannakouris N and Ordovas JM: A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study. Calcif Tissue Int. 90:96–107. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Yamada Y, Ando F and Shimokata H: Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals. Int J Mol Med. 18:119–127. 2006.PubMed/NCBI

46 

Surve VV, Andersson N, Alatalo S, Lehto-Axtelius D, Halleen J, Väänänen K and Håkanson R: Does combined gastrectomy and ovariectomy induce greater osteopenia in young female rats than gastrectomy alone? Calcif Tissue Int. 69:274–280. 2001. View Article : Google Scholar

47 

Reinwald S, Mayer LP, Hoyer PB, Turner CH, Barnes S and Weaver CM: A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity. J Osteoporos. 2010: View Article : Google Scholar : 2009.

48 

Tontonoz P, Hu E and Spiegelman BM: Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 79:1147–1156. 1994. View Article : Google Scholar : PubMed/NCBI

49 

Lecka-Czernik B, Gubrij I, Moerman EJ, Kajkenova O, Lipschitz DA, Manolagas SC and Jilka RL: Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2. J Cell Biochem. 74:357–371. 1999. View Article : Google Scholar : PubMed/NCBI

50 

Cho SW, Yang JY, Her SJ, Choi HJ, Jung JY, Sun HJ, An JH, Cho HY, Kim SW, Park KS, et al: Osteoblast-targeted overexpression of PPARγ inhibited bone mass gain in male mice and accelerated ovariectomy-induced bone loss in female mice. J Bone Miner Res. 26:1939–1952. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Hassumi MY, Silva-Filho VJ, Campos-Júnior JC, Vieira SM, Cunha FQ, Alves PM, Alves JB, Kawai T, Gonçalves RB and Napimoga MH: PPAR-gamma agonist rosiglitazone prevents inflammatory periodontal bone loss by inhibiting osteoclastogenesis. Int Immunopharmacol. 9:1150–1158. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Fujita K, Taya Y, Shimazu Y, Aoba T and Soeno Y: Molecular signaling at the fusion stage of the mouse mandibular arch: Involvement of insulin-like growth factor family. Int J Dev Biol. 57:399–406. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Li F, Xing WH, Yang XJ, Jiang HY and Xia H: Influence of polymorphisms in insulin-like growth factor-1 on the risk of osteoporosis in a Chinese postmenopausal female population. Int J Clin Exp Pathol. 8:5727–5732. 2015.PubMed/NCBI

54 

Yun-Kai L, Hui W, Xin-Wei Z, Liang G and Jin-Liang Z: The polymorphism of Insulin-like growth factor-I (IGF-I) is related to osteoporosis and bone mineral density in postmenopausal population. Pak J Med Sci. 30:131–135. 2014.PubMed/NCBI

55 

Zhuang J, Gao R, Wu H, Wu X and Pan F: Signal transducer and activator of transcription 3 regulates CCAAT-enhancer-binding homologous protein expression in osteoblasts through upregulation of microRNA-205. Exp Ther Med. 10:295–299. 2015.PubMed/NCBI

56 

Paci P, Colombo T and Farina L: Computational analysis identifies a sponge interaction network between long non-coding RNAs and messenger RNAs in human breast cancer. BMC Syst Biol. 8:832014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hao L, Fu J, Tian Y and Wu J: Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice. Int J Mol Med 40: 689-702, 2017.
APA
Hao, L., Fu, J., Tian, Y., & Wu, J. (2017). Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice. International Journal of Molecular Medicine, 40, 689-702. https://doi.org/10.3892/ijmm.2017.3062
MLA
Hao, L., Fu, J., Tian, Y., Wu, J."Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice". International Journal of Molecular Medicine 40.3 (2017): 689-702.
Chicago
Hao, L., Fu, J., Tian, Y., Wu, J."Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice". International Journal of Molecular Medicine 40, no. 3 (2017): 689-702. https://doi.org/10.3892/ijmm.2017.3062
Copy and paste a formatted citation
x
Spandidos Publications style
Hao L, Fu J, Tian Y and Wu J: Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice. Int J Mol Med 40: 689-702, 2017.
APA
Hao, L., Fu, J., Tian, Y., & Wu, J. (2017). Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice. International Journal of Molecular Medicine, 40, 689-702. https://doi.org/10.3892/ijmm.2017.3062
MLA
Hao, L., Fu, J., Tian, Y., Wu, J."Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice". International Journal of Molecular Medicine 40.3 (2017): 689-702.
Chicago
Hao, L., Fu, J., Tian, Y., Wu, J."Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice". International Journal of Molecular Medicine 40, no. 3 (2017): 689-702. https://doi.org/10.3892/ijmm.2017.3062
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team