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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September-2017 Volume 40 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity

  • Authors:
    • Yi Jiang
    • Xinqing Ye
    • Yinan Ji
    • Xiao Zhou
    • Huawei Yang
    • Wei Wei
    • Qiuyun Li
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University, Guangxi, Nanning 530021, P.R. China, Department of Pathology, The Affiliated Tumor Hospital of Guangxi Medical University, Guangxi, Nanning 530021, P.R. China
  • Pages: 883-890
    |
    Published online on: July 17, 2017
       https://doi.org/10.3892/ijmm.2017.3069
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Abstract

Breast cancer is the most frequently diagnosed cancer in both more and less economically developed countries and remains the leading cause of cancer-related death in women worldwide. In this study, to explore the expression and pathological role of RSK4 in breast cancer progression, we demonstrated that RSK4 expression was significantly decreased in breast cancer cells and tissues, and the overexpression of RSK4 in MDA‑MB‑231 cells inhibited cell migration and invasion. In a mouse model experiment, overexpression of RSK4 in mice further confirmed its critical role in regulating breast cancer tumorigenicity. The regulatory role of RSK4 in breast cancer development was mediated by AKT and extracellular signal‑regulated kinase (ERK) signaling pathways and the expression of RSK4 was altered by DNA methylation in promoter regions. These results provide important insight into the role of RSK4 in cancerogenesis and may help to improve the prevention, diagnosis and treatment of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Ye X, Ji Y, Zhou X, Yang H, Wei W and Li Q: Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity. Int J Mol Med 40: 883-890, 2017.
APA
Jiang, Y., Ye, X., Ji, Y., Zhou, X., Yang, H., Wei, W., & Li, Q. (2017). Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity. International Journal of Molecular Medicine, 40, 883-890. https://doi.org/10.3892/ijmm.2017.3069
MLA
Jiang, Y., Ye, X., Ji, Y., Zhou, X., Yang, H., Wei, W., Li, Q."Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity". International Journal of Molecular Medicine 40.3 (2017): 883-890.
Chicago
Jiang, Y., Ye, X., Ji, Y., Zhou, X., Yang, H., Wei, W., Li, Q."Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity". International Journal of Molecular Medicine 40, no. 3 (2017): 883-890. https://doi.org/10.3892/ijmm.2017.3069
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Ye X, Ji Y, Zhou X, Yang H, Wei W and Li Q: Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity. Int J Mol Med 40: 883-890, 2017.
APA
Jiang, Y., Ye, X., Ji, Y., Zhou, X., Yang, H., Wei, W., & Li, Q. (2017). Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity. International Journal of Molecular Medicine, 40, 883-890. https://doi.org/10.3892/ijmm.2017.3069
MLA
Jiang, Y., Ye, X., Ji, Y., Zhou, X., Yang, H., Wei, W., Li, Q."Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity". International Journal of Molecular Medicine 40.3 (2017): 883-890.
Chicago
Jiang, Y., Ye, X., Ji, Y., Zhou, X., Yang, H., Wei, W., Li, Q."Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity". International Journal of Molecular Medicine 40, no. 3 (2017): 883-890. https://doi.org/10.3892/ijmm.2017.3069
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