Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October-2017 Volume 40 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 40 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles

  • Authors:
    • Yonghee Lee
    • Su Na Kim
    • Yong Deog Hong
    • Byung Cheol Park
    • Yongjoo Na
  • View Affiliations / Copyright

    Affiliations: Amorepacific R&D Center, Yongin-si, Gyeonggi-do 446-729, Republic of Korea, Department of Dermatology, Dankook Medical College, Cheonan, Chungcheongnam-do 31116, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1194-1200
    |
    Published online on: August 25, 2017
       https://doi.org/10.3892/ijmm.2017.3107
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

It is well known that Panax ginseng (PG) has various pharmacological effects such as anti-aging and anti-inflammation. In a previous study, the authors identified that PG extract induced hair growth by means of a mechanism similar to that of minoxidil. In the present study, the inhibitory effect of PG extract on Dickkopf-1 (DKK-1)-induced catagen-like changes in hair follicles (HFs) was investigated in addition to the underlying mechanism of action. The effects of PG extract on cell proliferation, anti-apoptotic effect, and hair growth were observed using cultured outer root sheath (ORS) keratinocytes and human HFs with or without DKK-1 treatment. The PG extract significantly stimulated proliferation and inhibited apoptosis, respectively, in ORS keratinocytes. PG extract treatment affected the expression of apoptosis-related genes Bcl-2 and Bax. DKK-1 inhibited hair growth, and PG extract dramatically reversed the effect of DKK-1 on ex vivo human hair organ culture. PG extract antagonizes DKK-1-induced catagen-like changes, in part, through the regulation of apoptosis-related gene expression in HFs. These findings suggested that PG extract may reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Inui S, Fukuzato Y, Nakajima T, Yoshikawa K and Itami S: Androgen-inducible TGF-beta1 from balding dermal papilla cells inhibits epithelial cell growth: A clue to understand paradoxical effects of androgen on human hair growth. FASEB J. 16:1967–1969. 2002.PubMed/NCBI

2 

Li L, Mignone J, Yang M, Matic M, Penman S, Enikolopov G and Hoffman RM: Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci USA. 100:9958–9961. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Reynolds AJ and Jahoda CA: Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development. 115:587–593. 1992.PubMed/NCBI

4 

Millar SE: Molecular mechanisms regulating hair follicle development. J Invest Dermatol. 118:216–225. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Botchkarev VA and Paus R: Molecular biology of hair morphogenesis: Development and cycling. J Exp Zoolog B Mol Dev Evol. 298:164–180. 2003. View Article : Google Scholar

6 

Botchkareva NV, Ahluwalia G and Shander D: Apoptosis in the hair follicle. J Invest Dermatol. 126:258–264. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Sawaya ME, Blume-Peytavi U, Mullins DL, Nusbaum BP, Whiting D, Nicholson DW, Lotocki G and Keane RW: Effects of finasteride on apoptosis and regulation of the human hair cycle. J Cutan Med Surg. 6:1–9. 2002. View Article : Google Scholar : PubMed/NCBI

8 

El-Domyati M, Attia S, Saleh F, Bassyouni M, Barakat M and Abdel-Wahab H: Evaluation of apoptosis regulatory markers in androgenetic alopecia. J Cosmet Dermatol. 9:267–275. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:609–619. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Müller-Röver S, Rossiter H, Lindner G, Peters EM, Kupper TS and Paus R: Hair follicle apoptosis and Bcl-2. J Investig Dermatol Symp Proc. 4:272–277. 1999. View Article : Google Scholar

11 

Kwack MH, Ahn JS, Kim MK, Kim JC and Sung YK: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells. BMB Rep. 43:688–692. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kwack MH, Sung YK, Chung EJ, Im SU, Ahn JS, Kim MK and Kim JC: Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes. J Invest Dermatol. 128:262–269. 2008. View Article : Google Scholar

13 

Kwack MH, Kim MK, Kim JC and Sung YK: Dickkopf 1 promotes regression of hair follicles. J Invest Dermatol. 132:1554–1560. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Hu S, Concha C, Lin F and Persson Waller K: Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle. Vet Immunol Immunopathol. 91:29–37. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Na HS, Lim YJ, Yun YS, Kweon MN and Lee HC: Ginsan enhances humoral antibody response to orally delivered antigen. Immune Netw. 10:5–14. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Hong CE and Lyu SY: Anti-inflammatory and anti-oxidative effects of korean red ginseng extract in human keratinocytes. Immune Netw. 11:42–49. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Yun TK and Choi SY: Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev. 4:401–408. 1995.PubMed/NCBI

18 

Cho S, Won CH, Lee DH, Lee MJ, Lee S, So SH, Lee SK, Koo BS, Kim NM and Chung JH: Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: A randomized, double-blind, placebo-controlled study. J Med Food. 12:1252–1259. 2009. View Article : Google Scholar

19 

Kang TH, Park HM, Kim YB, Kim H, Kim N, Do JH, Kang C, Cho Y and Kim SY: Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J Ethnopharmacol. 123:446–451. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kim S, Kang BY, Cho SY, Sung DS, Chang HK, Yeom MH, Kim DH, Sim YC and Lee YS: Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin. Biochem Biophys Res Commun. 316:348–355. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Kwok HH, Yue PY, Mak NK and Wong RN: Ginsenoside Rb(1) induces type I collagen expression through peroxisome proliferator-activated receptor-delta. Biochem Pharmacol. 84:532–539. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Lee J, Jung E, Lee J, Huh S, Kim J, Park M, So J, Ham Y, Jung K, Hyun CG, et al: Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. J Ethnopharmacol. 109:29–34. 2007. View Article : Google Scholar

23 

Matsuda H, Yamazaki M, Asanuma Y and Kubo M: Promotion of hair growth by ginseng radix on cultured mouse vibrissal hair follicles. Phytother Res. 17:797–800. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Kim SH, Jeong KS, Ryu SY and Kim TH: Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice. In Vivo. 12:219–222. 1998.PubMed/NCBI

25 

Attele AS, Wu JA and Yuan CS: Ginseng pharmacology: Multiple constituents and multiple actions. Biochem Pharmacol. 58:1685–1693. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Leung KW and Wong AS: Pharmacology of ginsenosides: A literature review. Chin Med. 5:202010. View Article : Google Scholar : PubMed/NCBI

27 

Kim SN, Kim S, Hong YD, Park H, Shin SH, Kim AR, Park BC, Shin SS, Park JS, Park M, et al: The ginsenosides of Panax ginseng promote hair growth via similar mechanism of minoxidil. J Dermatol Sci. 77:132–134. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Magerl M, Kauser S, Paus R and Tobin DJ: Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles. Exp Dermatol. 11:381–385. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Philpott MP, Sanders DA and Kealey T: Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro. J Invest Dermatol. 102:857–861. 1994. View Article : Google Scholar : PubMed/NCBI

30 

Philpott MP, Green MR and Kealey T: Human hair growth in vitro. J Cell Sci. 97:463–471. 1990.PubMed/NCBI

31 

Philpott MP, Sanders D, Westgate GE and Kealey T: Human hair growth in vitro: A model for the study of hair follicle biology. J Dermatol Sci. 7(Suppl): S55–S72. 1994. View Article : Google Scholar : PubMed/NCBI

32 

Kim SN, Ha YW, Shin H, Son SH, Wu SJ and Kim YS: Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. J Pharm Biomed Anal. 45:164–170. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Hall CL, Zhang H, Baile S, Ljungman M, Kuhstoss S and Keller ET: P21CIP-1/WAF-1 induction is required to inhibit prostate cancer growth elicited by deficient expression of the Wnt inhibitor Dickkopf-1. Cancer Res. 70:9916–9926. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Ueno K, Yamamura S, Zaman MS, Khatri G, Chen Y, et al: Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Int J Cancer. 128:1793–1803. 2011. View Article : Google Scholar

35 

Lindner G, Botchkarev VA, Botchkareva NV, Ling G, van der Veen C and Paus R: Analysis of apoptosis during hair follicle regression (catagen). Am J Pathol. 151:1601–1617. 1997.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lee Y, Kim SN, Hong YD, Park BC and Na Y: Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles. Int J Mol Med 40: 1194-1200, 2017.
APA
Lee, Y., Kim, S.N., Hong, Y.D., Park, B.C., & Na, Y. (2017). Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles. International Journal of Molecular Medicine, 40, 1194-1200. https://doi.org/10.3892/ijmm.2017.3107
MLA
Lee, Y., Kim, S. N., Hong, Y. D., Park, B. C., Na, Y."Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles". International Journal of Molecular Medicine 40.4 (2017): 1194-1200.
Chicago
Lee, Y., Kim, S. N., Hong, Y. D., Park, B. C., Na, Y."Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles". International Journal of Molecular Medicine 40, no. 4 (2017): 1194-1200. https://doi.org/10.3892/ijmm.2017.3107
Copy and paste a formatted citation
x
Spandidos Publications style
Lee Y, Kim SN, Hong YD, Park BC and Na Y: Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles. Int J Mol Med 40: 1194-1200, 2017.
APA
Lee, Y., Kim, S.N., Hong, Y.D., Park, B.C., & Na, Y. (2017). Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles. International Journal of Molecular Medicine, 40, 1194-1200. https://doi.org/10.3892/ijmm.2017.3107
MLA
Lee, Y., Kim, S. N., Hong, Y. D., Park, B. C., Na, Y."Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles". International Journal of Molecular Medicine 40.4 (2017): 1194-1200.
Chicago
Lee, Y., Kim, S. N., Hong, Y. D., Park, B. C., Na, Y."Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles". International Journal of Molecular Medicine 40, no. 4 (2017): 1194-1200. https://doi.org/10.3892/ijmm.2017.3107
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team