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Article Open Access

Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes

  • Authors:
    • Qin Liu
    • Jianbo Wu
    • Jiquan Song
    • Pin Liang
    • Kaiping Zheng
    • Guifeng Xiao
    • Lanting Liu
    • Christos C. Zouboulis
    • Tiechi Lei
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Renmin Hospital of Wuhan University, Wuchang, Wuhan, Hubei 430060, P.R. China, Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, Hubei 430071, P.R. China, Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Theodore Fontane Medical University of Brandenburg, Dessau D-06847, Germany
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1029-1036
    |
    Published online on: August 25, 2017
       https://doi.org/10.3892/ijmm.2017.3109
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Abstract

A large body of evidence indicates that particulate matter (PM)2.5 is associated with various negative effects on human health. However, the impact and molecular mechanism of PM2.5 on the skin have not been elucidated. Therefore, the present study aimed to investigate the effects of two types of PM2.5 [water-soluble extracts (W-PM2.5) and non-water-soluble extracts (NW-PM2.5)] on cell proliferation, cell cycle progression, lipid synthesis, and inflammatory cytokine production of human SZ95 sebocytes. The results demonstrated that NW-PM2.5 and W-PM2.5 exposure dose-dependently inhibited SZ95 sebocyte proliferation by inducing G1 cell arrest. Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1α (IL-1α), IL-6 and IL-8 in SZ95 sebocytes. Additionally, the expression of aryl hydrocarbon (Ah) receptor (AhR), AhR nuclear translocator protein (ARNT), as well as cytochrome P450 1A1 were significantly increased following PM2.5 exposure. Thus, these findings indicate that PM2.5 exerts inhibitory effects on cell proliferation and lipid synthesis, and stimulatory effects on inflammatory cytokine production and AhR signaling activation in human SZ95 sebocytes.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Wu J, Song J, Liang P, Zheng K, Xiao G, Liu L, Zouboulis CC and Lei T: Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes. Int J Mol Med 40: 1029-1036, 2017.
APA
Liu, Q., Wu, J., Song, J., Liang, P., Zheng, K., Xiao, G. ... Lei, T. (2017). Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes. International Journal of Molecular Medicine, 40, 1029-1036. https://doi.org/10.3892/ijmm.2017.3109
MLA
Liu, Q., Wu, J., Song, J., Liang, P., Zheng, K., Xiao, G., Liu, L., Zouboulis, C. C., Lei, T."Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes". International Journal of Molecular Medicine 40.4 (2017): 1029-1036.
Chicago
Liu, Q., Wu, J., Song, J., Liang, P., Zheng, K., Xiao, G., Liu, L., Zouboulis, C. C., Lei, T."Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes". International Journal of Molecular Medicine 40, no. 4 (2017): 1029-1036. https://doi.org/10.3892/ijmm.2017.3109
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Wu J, Song J, Liang P, Zheng K, Xiao G, Liu L, Zouboulis CC and Lei T: Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes. Int J Mol Med 40: 1029-1036, 2017.
APA
Liu, Q., Wu, J., Song, J., Liang, P., Zheng, K., Xiao, G. ... Lei, T. (2017). Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes. International Journal of Molecular Medicine, 40, 1029-1036. https://doi.org/10.3892/ijmm.2017.3109
MLA
Liu, Q., Wu, J., Song, J., Liang, P., Zheng, K., Xiao, G., Liu, L., Zouboulis, C. C., Lei, T."Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes". International Journal of Molecular Medicine 40.4 (2017): 1029-1036.
Chicago
Liu, Q., Wu, J., Song, J., Liang, P., Zheng, K., Xiao, G., Liu, L., Zouboulis, C. C., Lei, T."Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes". International Journal of Molecular Medicine 40, no. 4 (2017): 1029-1036. https://doi.org/10.3892/ijmm.2017.3109
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