Open Access

Functional roles of C/EBPα and SUMO‑modification in lung development

  • Authors:
    • Yuan-Dong Chen
    • Jiang-Yan Liu
    • Yan-Min Lu
    • Hai-Tao Zhu
    • Wei Tang
    • Qiu-Xia Wang
    • Hong-Yan Lu
  • View Affiliations

  • Published online on: August 29, 2017     https://doi.org/10.3892/ijmm.2017.3111
  • Pages: 1037-1046
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CCAAT enhancer binding protein alpha (C/EBPα) is a transcription factor regulating the core aspects of cell growth and differentiation. The present study investigated the level and functional role of C/EBPα during the development of the rat lung. C/EBPα protein exhibits a dynamic expression pattern. The correlation between the expression of C/EBPα protein and the content of glycogen during lung maturation was analyzed to understand the function of C/EBPα in lung differentiation. The high expression of C/EBPα coincides with the reduction of glycogen in the fetal lung. In addition, the authors identified that changes in the level of C/EBPα are associated with the secretion of pulmonary surfactant. C/EBPα is modified by small ubiquitin-related modifier (SUMO) post-translationally. The results of double immunofluorescence staining and immunoprecipitation demonstrated that SUMO-modified C/EBPα was present in the lung. The sumoylated C/EBPα gradually decreased during lung differentiation and was negatively correlated with pulmonary surfactant secretion, thereby suggesting that the SUMO modification may participate in C/EBPα-mediated lung growth and differentiation. These results indicated that C/EBPα played a role in lung development and provided the insight into the mechanism underlying SUMO-modification.
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October-2017
Volume 40 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Chen Y, Liu J, Lu Y, Zhu H, Tang W, Wang Q and Lu H: Functional roles of C/EBPα and SUMO‑modification in lung development. Int J Mol Med 40: 1037-1046, 2017
APA
Chen, Y., Liu, J., Lu, Y., Zhu, H., Tang, W., Wang, Q., & Lu, H. (2017). Functional roles of C/EBPα and SUMO‑modification in lung development. International Journal of Molecular Medicine, 40, 1037-1046. https://doi.org/10.3892/ijmm.2017.3111
MLA
Chen, Y., Liu, J., Lu, Y., Zhu, H., Tang, W., Wang, Q., Lu, H."Functional roles of C/EBPα and SUMO‑modification in lung development". International Journal of Molecular Medicine 40.4 (2017): 1037-1046.
Chicago
Chen, Y., Liu, J., Lu, Y., Zhu, H., Tang, W., Wang, Q., Lu, H."Functional roles of C/EBPα and SUMO‑modification in lung development". International Journal of Molecular Medicine 40, no. 4 (2017): 1037-1046. https://doi.org/10.3892/ijmm.2017.3111