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Article

Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling

  • Authors:
    • Zhi-Guo Zhang
    • Yan-Jing Chen
    • Li-Hua Xiang
    • Jing-Hua Pan
    • Zhen Wang
    • Gary Guishan Xiao
    • Da-Hong Ju
  • View Affiliations / Copyright

    Affiliations: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China, School of Pharmaceutical Science, Dalian University of Technology, Dalian, Liaoning 116024, P.R. China
  • Pages: 1602-1610
    |
    Published online on: September 8, 2017
       https://doi.org/10.3892/ijmm.2017.3130
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Abstract

The aim of the present study was to assess the effectiveness of Rhizoma Dioscoreae extract (RDE) on preventing rat alveolar bone loss induced by ovariectomy (OVX), and to determine the role of interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in this effect. Female Wistar rats were subjected to OVX or sham surgery. The rats that had undergone OVX were treated with RDE (RDE group), vehicle (OVX group) or 17β-estradiol subcutaneous injection (E2 group). Subsequently, bone metabolic activity was assessed by analyzing 3-D alveolar bone construction, bone mineral density, as well as the plasma biomarkers of bone turnover. The gene expression of alveolar bone in the OVX and RDE groups was evaluated by IL-6/STAT3 signaling pathway polymerase chain reaction (PCR) arrays, and differentially expressed genes were determined through reverse transcription-quantitative PCR. The inhibitory effect of RDE on alveolar bone loss in the OVX group was demonstrated in the study. In comparison with the OVX group, the RDE group exhibited 19 downregulated genes and 1 upregulated gene associated with the IL-6/STAT3 signaling pathway in alveolar bone. Thus, RDE was shown to relieve OVX-induced alveolar bone loss in rats, an effect which was likely associated with decreased abnormal bone remodeling via regulation of the IL-6/STAT3 signaling pathway.
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1 

Gallagher JC and Levine JP: Preventing osteoporosis in symptomatic postmenopausal women. Menopause. 18:109–118. 2011. View Article : Google Scholar

2 

Sultan N and Rao J: Association between periodontal disease and bone mineral density in postmenopausal women: A cross sectional study. Med Oral Patol Oral Cir Bucal. 16:e440–e447. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Lee BD and White SC: Age and trabecular features of alveolar bone associated with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100:92–98. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Streckfus CF, Johnson RB, Nick T, Tsao A and Tucci M: Comparison of alveolar bone loss, alveolar bone density and second metacarpal bone density, salivary and gingival crevicular fluid interleukin-6 concentrations in healthy premenopausal and postmenopausal women on estrogen therapy. J Gerontol A Biol Sci Med Sci. 52:M343–M351. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Tezal M, Wactawski-Wende J, Grossi SG, Dmochowski J and Genco RJ: Periodontal disease and the incidence of tooth loss in postmenopausal women. J Periodontol. 76:1123–1128. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Civitelli R, Pilgram TK, Dotson M, Muckerman J, Lewandowski N, Armamento-Villareal R, Yokoyama-Crothers N, Kardaris EE, Hauser J, Cohen S, et al: Alveolar and postcranial bone density in postmenopausal women receiving hormone/estrogen replacement therapy: A randomized, double-blind, placebo-controlled trial. Arch Intern Med. 162:1409–1415. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Liu J, Cao Z and Li C: Intermittent PTH administration: A novel therapy method for periodontitis-associated alveolar bone loss. Med Hypotheses. 72:294–296. 2009. View Article : Google Scholar

8 

Palomo L, Bissada NF and Liu J: Periodontal assessment of postmenopausal women receiving risedronate. Menopause. 12:685–690. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Strom BL, Schinnar R, Weber AL, Bunin G, Berlin JA, Baumgarten M, DeMichele A, Rubin SC, Berlin M, Troxel AB, et al: Case-control study of postmenopausal hormone replacement therapy and endometrial cancer. Am J Epidemiol. 164:775–786. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Rossing MA, Cushing-Haugen KL, Wicklund KG, Doherty JA and Weiss NS: Menopausal hormone therapy and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 16:2548–2556. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Rizzoli R, Reginster JY, Boonen S, Bréart G, Diez-Perez A, Felsenberg D, Kaufman JM, Kanis JA and Cooper C: Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcif Tissue Int. 89:91–104. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Woo SB, Hellstein JW and Kalmar JR: Narrative [corrected] review: Bisphosphonates and osteonecrosis of the jaws. Ann Intern Med. 144:753–761. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Clemett D and Spencer CM: Raloxifene: A review of its use in postmenopausal osteoporosis. Drugs. 60:379–411. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Sugimoto H1, Watanabe K, Toyama T, Takahashi SS, Sugiyama S, Lee MC and Hamada N: Inhibitory effects of French pine bark extract, Pycnogenol®, on alveolar bone resorption and on the osteoclast differentiation. Phytother Res. 29:251–259. 2015. View Article : Google Scholar

15 

Sağlam M, Köseoğlu S, Hatipoğlu M, Esen HH and Köksal E: Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats. J Appl Oral Sci. 23:33–41. 2015. View Article : Google Scholar

16 

Guimarães MV, Melo IM, Adriano Araújo VM, Tenazoa Wong DV, Roriz Fonteles CS, Moreira Leal LK, Ribeiro RA and Lima V: Dry extract of Matricaria recutita L. (Chamomile) prevents ligature-induced alveolar bone resorption in rats via inhibition of tumor necrosis factor-α and interleukin-1β. J Periodontol. 87:706–715. 2016. View Article : Google Scholar

17 

Feng XF, Huang LQ, Ge XG, Yang LJ and Yang JY: Textual research on origin and development of genuine medicinal herbs of Shanyao. Zhongguo Zhong Yao Za Zhi. 33:859–862. 2008.In Chinese. PubMed/NCBI

18 

Zhang Z, Xiang L, Bai D, Wang W, Li Y, Pan J, Liu H, Wang S, Xiao GG and Ju D: The protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulating Wnt and p38 MAPK signaling. Nutrients. 6:5853–5870. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Blanchard F, Duplomb L, Baud' huin M and Brounais B: The dual role of IL-6-type cytokines on bone remodeling and bone tumors. Cytokine Growth Factor Rev. 20:19–28. 2009. View Article : Google Scholar

20 

Sims NA and Walsh NC: GP130 cytokines and bone remodelling in health and disease. BMB Rep. 43:513–523. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Z, Song C, Zhang F, Xiang L, Chen Y, Li Y, Pan J, Liu H, Xiao GG and Ju D: Rhizoma Dioscoreae extract protects against alveolar bone loss in ovariectomized rats via microRNAs regulation. Nutrients. 7:1333–1351. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Z, Xiang L, Bai D, Fu X, Wang W, Li Y, Liu H, Pan J, Li Y, Xiao GG, et al: Treatment with Rhizoma Dioscoreae extract has protective effect on osteopenia in ovariectomized rats. ScientificWorldJournal. 2014:6459752014.PubMed/NCBI

23 

Hidaka S, Okamoto Y, Yamada Y, Kon Y and Kimura T: A Japanese herbal medicine, Chujo-to, has a beneficial effect on osteoporosis in rats. Phytother Res. 13:14–19. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Yang J, Pham SM and Crabbe DL: High-resolution micro-CT evaluation of mid- to long-term effects of estrogen deficiency on rat trabecular bone. Acad Radiol. 10:1153–1158. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ and Müller R: Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 25:1468–1486. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S and Scheller J: Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev. 23:85–97. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Grant SL and Begley CG: The oncostatin M signalling pathway: Reversing the neoplastic phenotype? Mol Med Today. 5:406–412. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G and Schaper F: Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 374:1–20. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS and Cosman D: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem. 271:32635–32643. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Lindberg RA, Juan TS, Welcher AA, Sun Y, Cupples R, Guthrie B and Fletcher FA: Cloning and characterization of a specific receptor for mouse oncostatin M. Mol Cell Biol. 18:3357–3367. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Bellido T, Borba VZ, Roberson P and Manolagas SC: Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation. Endocrinology. 138:3666–3676. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Itoh S, Udagawa N, Takahashi N, Yoshitake F, Narita H, Ebisu S and Ishihara K: A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation. Bone. 39:505–512. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Bellido T, O' Brien CA, Roberson PK and Manolagas SC: Transcriptional activation of the p21(WAF1, CIP1, SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. J Biol Chem. 273:21137–21144. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Jilka RL, Weinstein RS, Bellido T, Parfitt AM and Manolagas SC: Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res. 13:793–802. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Palmqvist P, Persson E, Conaway HH and Lerner UH: IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae. J Immunol. 169:3353–3362. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Kim S, Yamazaki M, Shevde NK and Pike JW: Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers. Mol Endocrinol. 21:197–214. 2007. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Chen Y, Xiang L, Pan J, Wang Z, Xiao GG and Ju D: Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling. Int J Mol Med 40: 1602-1610, 2017.
APA
Zhang, Z., Chen, Y., Xiang, L., Pan, J., Wang, Z., Xiao, G.G., & Ju, D. (2017). Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling. International Journal of Molecular Medicine, 40, 1602-1610. https://doi.org/10.3892/ijmm.2017.3130
MLA
Zhang, Z., Chen, Y., Xiang, L., Pan, J., Wang, Z., Xiao, G. G., Ju, D."Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling". International Journal of Molecular Medicine 40.5 (2017): 1602-1610.
Chicago
Zhang, Z., Chen, Y., Xiang, L., Pan, J., Wang, Z., Xiao, G. G., Ju, D."Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling". International Journal of Molecular Medicine 40, no. 5 (2017): 1602-1610. https://doi.org/10.3892/ijmm.2017.3130
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Chen Y, Xiang L, Pan J, Wang Z, Xiao GG and Ju D: Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling. Int J Mol Med 40: 1602-1610, 2017.
APA
Zhang, Z., Chen, Y., Xiang, L., Pan, J., Wang, Z., Xiao, G.G., & Ju, D. (2017). Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling. International Journal of Molecular Medicine, 40, 1602-1610. https://doi.org/10.3892/ijmm.2017.3130
MLA
Zhang, Z., Chen, Y., Xiang, L., Pan, J., Wang, Z., Xiao, G. G., Ju, D."Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling". International Journal of Molecular Medicine 40.5 (2017): 1602-1610.
Chicago
Zhang, Z., Chen, Y., Xiang, L., Pan, J., Wang, Z., Xiao, G. G., Ju, D."Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling". International Journal of Molecular Medicine 40, no. 5 (2017): 1602-1610. https://doi.org/10.3892/ijmm.2017.3130
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