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Article

Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1

  • Authors:
    • Hyun Ah Park
    • Jae-Won Lee
    • Ok-Kyoung Kwon
    • Gilhye Lee
    • Yourim Lim
    • Jung Hee Kim
    • Jin-Hyub Paik
    • Sangho Choi
    • Imam Paryanto
    • Prasetyawan Yuniato
    • Doo-Young Kim
    • Hyung Won Ryu
    • Sei-Ryang Oh
    • Seung Jin Lee
    • Kyung-Seop Ahn
  • View Affiliations / Copyright

    Affiliations: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea, International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea, Center for Pharmaceutical and Medical Technology, The Agency for the Assessment and Application of Technology (BPPT), Tangerang, Banten 15314, Indonesia, College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea
  • Pages: 1557-1565
    |
    Published online on: September 15, 2017
       https://doi.org/10.3892/ijmm.2017.3139
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Abstract

Physalis peruviana L. (PP) is a medicinal herb that has been confirmed to have several biological activities, including anticancer, antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of PP on cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with PP significantly reduced the influx of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung of mice with CS- and LPS-induced pulmonary inflammation. PP also decreased the levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the BALF. PP effectively attenuated the expression of monocyte chemoattractant protein-1 (MCP-1) and the activation of extracellular signal-regulated kinase (ERK) in the lung. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression were increased by PP treatment. In an in vitro experiment, PP reduced the mRNA expression of TNF-α and MCP-1, and the activation of ERK in CS extract-stimulated A549 epithelial cells. Furthermore, PP increased the activation of Nrf2 and the expression of HO-1 in A549 cells. These findings suggest that PP has a therapeutic potential for the treatment of pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease.
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1 

Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, et al: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 187:347–365. 2013. View Article : Google Scholar

2 

Wei J, Fan G, Zhao H and Li J: Heme oxygenase-1 attenuates inflammation and oxidative damage in a rat model of smoke-induced emphysema. Int J Mol Med. 36:1384–1392. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Tamimi A, Serdarevic D and Hanania NA: The effects of cigarette smoke on airway inflammation in asthma and COPD: Therapeutic implications. Respir Med. 106:319–328. 2012. View Article : Google Scholar

4 

Lee J, Taneja V and Vassallo R: Cigarette smoking and inflammation: Cellular and molecular mechanisms. J Dent Res. 91:142–149. 2012. View Article : Google Scholar :

5 

Afonso AS, Verhamme KM, Sturkenboom MC and Brusselle GG: COPD in the general population: Prevalence, incidence and survival. Respir Med. 105:1872–1884. 2011. View Article : Google Scholar : PubMed/NCBI

6 

O'Donnell R, Breen D, Wilson S and Djukanovic R: Inflammatory cells in the airways in COPD. Thorax. 61:448–454. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Lee JW, Shin NR, Park JW, Park SY, Kwon OK, Lee HS, Hee Kim J, Lee HJ, Lee J, Zhang ZY, et al: Callicarpa japonica Thunb. attenuates cigarette smoke-induced neutrophil inflammation and mucus secretion. J Ethnopharmacol. 175:1–8. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Lee E, Yun N, Jang YP and Kim J: Lilium lancifolium Thunb. extract attenuates pulmonary inflammation and air space enlargement in a cigarette smoke-exposed mouse model. J Ethnopharmacol. 149:148–156. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Garcia-Rio F, Miravitlles M, Soriano JB, Muñoz L, Duran- Tauleria E, Sánchez G, Sobradillo V and Ancochea J; EPI-SCAN Steering Committee: Systemic inflammation in chronic obstructive pulmonary disease: A population-based study. Respir Res. 11:632010. View Article : Google Scholar : PubMed/NCBI

10 

Zhou R, Luo F, Lei H, Zhang K, Liu J, He H, Gao J, Chang X, He L, Ji H, et al: Liujunzi Tang, a famous traditional Chinese medicine, ameliorates cigarette smoke-induced mouse model of COPD. J Ethnopharmacol. 193:643–651. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Jung KH, Beak H, Park S, Shin D, Jung J, Park S, Kim J and Bae H: The therapeutic effects of tuberostemonine against cigarette smoke-induced acute lung inflammation in mice. Eur J Pharmacol. 774:80–86. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valença S, Porto LC, Lagente V and Boichot E: Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells. PLoS One. 9:e852432014. View Article : Google Scholar : PubMed/NCBI

13 

Lee JW, Park HA, Kwon OK, Jang YG, Kim JY, Choi BK, Lee HJ, Lee S, Paik JH, Oh SR, et al: Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke. Int Immunopharmacol. 39:208–217. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Ge LT, Liu YN, Lin XX, Shen HJ, Jia YL, Dong XW, Sun Y and Xie QM: Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway. Int Immunopharmacol. 33:90–98. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Li J, Tong D, Liu J, Chen F and Shen Y: Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2. Int Immunopharmacol. 40:524–529. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Cheng L, Li F, Ma R and Hu X: Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-κB. Int Immunopharmacol. 28:494–499. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Osorio-Guarín JA, Enciso-Rodríguez FE, González C, Fernández-Pozo N, Mueller LA and Barrero LS: Association analysis for disease resistance to Fusarium oxysporum in cape gooseberry (Physalis peruviana L). BMC Genomics. 17:2482016. View Article : Google Scholar : PubMed/NCBI

18 

Wu SJ, Tsai JY, Chang SP, Lin DL, Wang SS, Huang SN and Ng LT: Supercritical carbon dioxide extract exhibits enhanced antioxidant and anti-inflammatory activities of Physalis peruviana. J Ethnopharmacol. 108:407–413. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Abdel Moneim AE: Prevention of carbon tetrachloride (CCl4)-induced toxicity in testes of rats treated with Physalis peruviana L. fruit. Toxicol Ind Health. 32:1064–1073. 2016. View Article : Google Scholar

20 

Al-Olayan EM, El-Khadragy MF, Omer SA, Shata MT, Kassab RB and Abdel Moneim AE: The beneficial effect of cape gooseberry juice on carbon tetrachloride-induced neuronal damage. CNS Neurol Disord Drug Targets. 15:344–350. 2016. View Article : Google Scholar

21 

Lee JW, Park JW, Shin NR, Park SY, Kwon OK, Park HA, Lim Y, Ryu HW, Yuk HJ, Kim JH, et al: Picrasma quassiodes (D. Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury. Int J Mol Med. 38:834–844. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Lee JW, Park JW, Kwon OK, et al: NPS2143 inhibits MUC5AC and proinflammatory mediators in cigarette smoke extract (CSE)-stimulated human airway epithelial cells. Inflammation. 2016.PubMed/NCBI

23 

Sutherland ER and Martin RJ: Airway inflammation in chronic obstructive pulmonary disease: Comparisons with asthma. J Allergy Clin Immunol. 112:819–827; quiz 828. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Kirkham PA and Barnes PJ: Oxidative stress in COPD. Chest. 144:266–273. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Rahman I: The role of oxidative stress in the pathogenesis of COPD: Implications for therapy. Treat Respir Med. 4:175–200. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Barnes PJ: Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 138:16–27. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Ng DS, Liao W, Tan WS, Chan TK, Loh XY and Wong WS: Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice. Phytomedicine. 21:1638–1644. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Bodas M, Silverberg D, Walworth K, Brucia K and Vij N: Augmentation of S-nitrosoglutathione controls cigarette smoke-induced inflammatory-oxidative stress and chronic obstructive pulmonary disease-emphysema pathogenesis by restoring cystic fibrosis transmembrane conductance regulator function. Antioxid Redox Signal. 27:433–451. 2017. View Article : Google Scholar

29 

Gupta I, Ganguly S, Rozanas CR, Stuehr DJ and Panda K: Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. Proc Natl Acad Sci USA. 113:E4208–E4217. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Chen B, You WJ, Xue S, Qin H, Zhao XJ, Zhang M, Liu XQ, Zhu SY and Jiang HD: Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease. J Thorac Dis. 8:3063–3074. 2016. View Article : Google Scholar

31 

Li D, Hu J, Wang T, Zhang X, Liu L, Wang H, Wu Y, Xu D and Wen F: Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells. Sci Rep. 6:377512016. View Article : Google Scholar : PubMed/NCBI

32 

Li D, Xu D, Wang T, Shen Y, Guo S, Zhang X, Guo L, Li X, Liu L and Wen F: Silymarin attenuates airway inflammation induced by cigarette smoke in mice. Inflammation. 38:871–878. 2015. View Article : Google Scholar

33 

Wu X, Song M, Rakariyatham K, Zheng J, Guo S, Tang Z, Zhou S and Xiao H: Anti-inflammatory effects of 4′-demethylnobiletin, a major metabolite of nobiletin. J Funct Foods. 19:278–287. 2015. View Article : Google Scholar

34 

Yao W, Luo G, Zhu G, Chi X, Zhang A, Xia Z and Hei Z: Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model. Oxid Med Cell Longev. 2014:2585672014. View Article : Google Scholar : PubMed/NCBI

35 

Lee JW, Bae CJ, Choi YJ, Kim SI, Kwon YS, Lee HJ, Kim SS and Chun W: 3,4,5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo. Mol Cell Biochem. 390:143–153. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Li RJ, Gao CY, Guo C, Zhou MM, Luo J and Kong LY: The Anti-inflammatory activities of two major withanolides from Physalis minima via acting on NF-κB, STAT3, and HO-1 in LPS-stimulated RAW264.7 cells. Inflammation. 40:401–413. 2017. View Article : Google Scholar

37 

Domej W, Oettl K and Renner W: Oxidative stress and free radicals in COPD - implications and relevance for treatment. Int J Chron Obstruct Pulmon Dis. 9:1207–1224. 2014. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Park H, Lee J, Kwon O, Lee G, Lim Y, Kim J, Paik J, Choi S, Paryanto I, Yuniato P, Yuniato P, et al: Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1. Int J Mol Med 40: 1557-1565, 2017.
APA
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J. ... Ahn, K. (2017). Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1. International Journal of Molecular Medicine, 40, 1557-1565. https://doi.org/10.3892/ijmm.2017.3139
MLA
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J., Paik, J., Choi, S., Paryanto, I., Yuniato, P., Kim, D., Ryu, H., Oh, S., Lee, S., Ahn, K."Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1". International Journal of Molecular Medicine 40.5 (2017): 1557-1565.
Chicago
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J., Paik, J., Choi, S., Paryanto, I., Yuniato, P., Kim, D., Ryu, H., Oh, S., Lee, S., Ahn, K."Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1". International Journal of Molecular Medicine 40, no. 5 (2017): 1557-1565. https://doi.org/10.3892/ijmm.2017.3139
Copy and paste a formatted citation
x
Spandidos Publications style
Park H, Lee J, Kwon O, Lee G, Lim Y, Kim J, Paik J, Choi S, Paryanto I, Yuniato P, Yuniato P, et al: Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1. Int J Mol Med 40: 1557-1565, 2017.
APA
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J. ... Ahn, K. (2017). Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1. International Journal of Molecular Medicine, 40, 1557-1565. https://doi.org/10.3892/ijmm.2017.3139
MLA
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J., Paik, J., Choi, S., Paryanto, I., Yuniato, P., Kim, D., Ryu, H., Oh, S., Lee, S., Ahn, K."Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1". International Journal of Molecular Medicine 40.5 (2017): 1557-1565.
Chicago
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J., Paik, J., Choi, S., Paryanto, I., Yuniato, P., Kim, D., Ryu, H., Oh, S., Lee, S., Ahn, K."Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1". International Journal of Molecular Medicine 40, no. 5 (2017): 1557-1565. https://doi.org/10.3892/ijmm.2017.3139
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