Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1

  • Authors:
    • Hyun Ah Park
    • Jae-Won Lee
    • Ok-Kyoung Kwon
    • Gilhye Lee
    • Yourim Lim
    • Jung Hee Kim
    • Jin-Hyub Paik
    • Sangho Choi
    • Imam Paryanto
    • Prasetyawan Yuniato
    • Doo-Young Kim
    • Hyung Won Ryu
    • Sei-Ryang Oh
    • Seung Jin Lee
    • Kyung-Seop Ahn
  • View Affiliations

  • Published online on: September 15, 2017     https://doi.org/10.3892/ijmm.2017.3139
  • Pages: 1557-1565
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Abstract

Physalis peruviana L. (PP) is a medicinal herb that has been confirmed to have several biological activities, including anticancer, antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of PP on cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with PP significantly reduced the influx of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung of mice with CS- and LPS-induced pulmonary inflammation. PP also decreased the levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the BALF. PP effectively attenuated the expression of monocyte chemoattractant protein-1 (MCP-1) and the activation of extracellular signal-regulated kinase (ERK) in the lung. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression were increased by PP treatment. In an in vitro experiment, PP reduced the mRNA expression of TNF-α and MCP-1, and the activation of ERK in CS extract-stimulated A549 epithelial cells. Furthermore, PP increased the activation of Nrf2 and the expression of HO-1 in A549 cells. These findings suggest that PP has a therapeutic potential for the treatment of pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease.
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November-2017
Volume 40 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Park H, Lee J, Kwon O, Lee G, Lim Y, Kim J, Paik J, Choi S, Paryanto I, Yuniato P, Yuniato P, et al: Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1. Int J Mol Med 40: 1557-1565, 2017.
APA
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J. ... Ahn, K. (2017). Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1. International Journal of Molecular Medicine, 40, 1557-1565. https://doi.org/10.3892/ijmm.2017.3139
MLA
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J., Paik, J., Choi, S., Paryanto, I., Yuniato, P., Kim, D., Ryu, H., Oh, S., Lee, S., Ahn, K."Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1". International Journal of Molecular Medicine 40.5 (2017): 1557-1565.
Chicago
Park, H., Lee, J., Kwon, O., Lee, G., Lim, Y., Kim, J., Paik, J., Choi, S., Paryanto, I., Yuniato, P., Kim, D., Ryu, H., Oh, S., Lee, S., Ahn, K."Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1". International Journal of Molecular Medicine 40, no. 5 (2017): 1557-1565. https://doi.org/10.3892/ijmm.2017.3139