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Article Open Access

TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression

  • Authors:
    • Tianyong Hu
    • Xiaoqin Fan
    • Li Ma
    • Jiangqi Liu
    • Yunli Chang
    • Pingchang Yang
    • Shuqi Qiu
    • Tao Chen
    • Litao Yang
    • Zhiqiang Liu
  • View Affiliations / Copyright

    Affiliations: Immunology and Allergy Laboratory, Longgang ENT Hospital, Institute of ENT and Shenzhen Key Laboratory of ENT, Shenzhen, Guangdong 518172, P.R. China, Department of Gastroenterology, Shanghai Pudong New Area Zhoupu Hospital, Shanghai 201318, P.R. China, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen, Guangdong 518060, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1504-1510
    |
    Published online on: September 25, 2017
       https://doi.org/10.3892/ijmm.2017.3150
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Abstract

Skewed T helper 2 (Th2)‑cell polarization plays a critical role in the pathogenesis of allergic inflammations; however, the underlying mechanisms require further elucidation. The aim of the present study was to investigate the mechanisms through which the interaction between T‑cell immunoglobulin and mucin domain (TIM)4 and TIM1 regulates the expression of silent information regulator 1 (SIRT1) in Th2 cells, and the role of SIRT1 in Th2‑cell polarization during nasal allergic inflammation. The results demonstrated that TIM4 expression by splenic dendritic cells was increased in mice with allergic rhinitis, and the TIM4̸TIM1 interaction promoted CD4+ T cells to express SIRT1 during allergic inflammation via enhancing phosphoinositide 3‑kinase/Akt phosphorylation. SIRT1 then facilitated CD4+ T‑cell proliferation through downregulating the expression of Fas ligand, caspase-3 and p53 in mice with nasal allergic inflammation. In conclusion, the interaction of TIM4̸TIM1 was found to promote Th2‑cell proliferation through enhancing SIRT1 expression in mice with nasal allergic rhinitis.
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Copy and paste a formatted citation
Spandidos Publications style
Hu T, Fan X, Ma L, Liu J, Chang Y, Yang P, Qiu S, Chen T, Yang L, Liu Z, Liu Z, et al: TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. Int J Mol Med 40: 1504-1510, 2017.
APA
Hu, T., Fan, X., Ma, L., Liu, J., Chang, Y., Yang, P. ... Liu, Z. (2017). TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. International Journal of Molecular Medicine, 40, 1504-1510. https://doi.org/10.3892/ijmm.2017.3150
MLA
Hu, T., Fan, X., Ma, L., Liu, J., Chang, Y., Yang, P., Qiu, S., Chen, T., Yang, L., Liu, Z."TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression". International Journal of Molecular Medicine 40.5 (2017): 1504-1510.
Chicago
Hu, T., Fan, X., Ma, L., Liu, J., Chang, Y., Yang, P., Qiu, S., Chen, T., Yang, L., Liu, Z."TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression". International Journal of Molecular Medicine 40, no. 5 (2017): 1504-1510. https://doi.org/10.3892/ijmm.2017.3150
Copy and paste a formatted citation
x
Spandidos Publications style
Hu T, Fan X, Ma L, Liu J, Chang Y, Yang P, Qiu S, Chen T, Yang L, Liu Z, Liu Z, et al: TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. Int J Mol Med 40: 1504-1510, 2017.
APA
Hu, T., Fan, X., Ma, L., Liu, J., Chang, Y., Yang, P. ... Liu, Z. (2017). TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. International Journal of Molecular Medicine, 40, 1504-1510. https://doi.org/10.3892/ijmm.2017.3150
MLA
Hu, T., Fan, X., Ma, L., Liu, J., Chang, Y., Yang, P., Qiu, S., Chen, T., Yang, L., Liu, Z."TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression". International Journal of Molecular Medicine 40.5 (2017): 1504-1510.
Chicago
Hu, T., Fan, X., Ma, L., Liu, J., Chang, Y., Yang, P., Qiu, S., Chen, T., Yang, L., Liu, Z."TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression". International Journal of Molecular Medicine 40, no. 5 (2017): 1504-1510. https://doi.org/10.3892/ijmm.2017.3150
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