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Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)

  • Authors:
    • Li-Li Fang
    • Xing-Hui Wang
    • Bao-Fei Sun
    • Xiao-Dong Zhang
    • Xu-Hui Zhu
    • Zi-Jiang Yu
    • Heng Luo
  • View Affiliations / Copyright

    Affiliations: Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, Guizhou 550004, P.R. China, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P.R. China
    Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1624-1630
    |
    Published online on: September 29, 2017
       https://doi.org/10.3892/ijmm.2017.3164
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Abstract

MicroRNAs (miRNAs), a class of short, single‑stranded non‑coding RNAs, regulate and control gene expression in eukaryotes by degrading mRNA at the post‑transcriptional level. Regulation by miRNAs involves a plethora of biological processes, such as cell differentiation, proliferation, metastasis, metabolism, apoptosis, tumorigenesis and others. miRNAs also represent a powerful tool in disease diagnosis and prognosis. The miR‑17‑92 cluster, one of the most extensively investigated microRNA clusters, comprises six mature miRNA members, including miR‑17, miR‑18a, miR‑19a, miR‑19b, miR‑20a and miR‑92a. Originally identified as being involved in tumorigenesis, it is currently evident that the expression of the miR‑17‑92 cluster is upregulated in a wide range of tumor cells and cancer types; thus, this cluster has been identified as a potential oncogene. Considering the growing interest in the field of miR‑17‑92 research, we herein review recent advances in the expression and regulation of this cluster in various cancer cells, discuss the proposed mechanism of action for tumorigenesis and tumor development, and propose clinical and therapeutic applications for miR‑17‑92 cluster members, such as potential cancer biomarkers.
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Fang L, Wang X, Sun B, Zhang X, Zhu X, Yu Z and Luo H: Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review). Int J Mol Med 40: 1624-1630, 2017.
APA
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., & Luo, H. (2017). Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review). International Journal of Molecular Medicine, 40, 1624-1630. https://doi.org/10.3892/ijmm.2017.3164
MLA
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., Luo, H."Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)". International Journal of Molecular Medicine 40.6 (2017): 1624-1630.
Chicago
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., Luo, H."Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)". International Journal of Molecular Medicine 40, no. 6 (2017): 1624-1630. https://doi.org/10.3892/ijmm.2017.3164
Copy and paste a formatted citation
x
Spandidos Publications style
Fang L, Wang X, Sun B, Zhang X, Zhu X, Yu Z and Luo H: Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review). Int J Mol Med 40: 1624-1630, 2017.
APA
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., & Luo, H. (2017). Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review). International Journal of Molecular Medicine, 40, 1624-1630. https://doi.org/10.3892/ijmm.2017.3164
MLA
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., Luo, H."Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)". International Journal of Molecular Medicine 40.6 (2017): 1624-1630.
Chicago
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., Luo, H."Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)". International Journal of Molecular Medicine 40, no. 6 (2017): 1624-1630. https://doi.org/10.3892/ijmm.2017.3164
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