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Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation

  • Authors:
    • Xiaozhi Liu
    • Wenbo Ren
    • Zhongmin Jiang
    • Zhiguo Su
    • Xiaofang Ma
    • Yanxia Li
    • Rongcai Jiang
    • Jianning Zhang
    • Xinyu Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Neurology, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Department of Pathology, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Department of Neurosurgery, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Central Laboratory, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1631-1638
    |
    Published online on: September 29, 2017
       https://doi.org/10.3892/ijmm.2017.3167
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Abstract

Hypothermia therapy has a positive effect on patients with severe brain injury. Recent studies have shown that mild hypothermia increases the survival of bone marrow-derived mesenchymal stem cells (BMSCs) in a hypoxic environment; however, the underlying mechanisms are not yet fully understood. Small ubiquitin-like modifiers (SUMOs) are sensitive to temperature stress reactions and are considered to exert a protective effect. In this study, we examined the protective effects of hypothermia on BMSCs in terms of SUMO protein modification. First, we found that mild hypothermia inhibited the proliferation and differentiation of BMSCs and increased cell tolerance to a hypoxic environment. Second, hypothermia significantly increased the levels of SUMO modification of multiple proteins in BMSCs. The knockdown of SUMO1/2/3 induced the rapid aging of the BMSCs, while the inhibition of the SUMO-conjugating enzyme, Ubc9, reduced cell proliferation and increased the proportion of BMSCs differentiating into nerve cells. Moreover, the tolerance of BMSCs to the hypoxic environment was significantly decreased. Lastly, we investigated 4 reported SUMO target proteins, anti-proliferating cell nuclear antigen, octamer-binding transcription factor 4, p53 and hypoxia-inducible factor-1α, to confirm that SUMO modification was indeed involved in maintaining the proliferation, inhibiting differentiation and enhancing the resistance of BMSCs against adverse conditions. Taken together, our results indicate that the SUMO pathway is involved in the response to hypothermic stress, and that SUMOylation may be an important protective mechanism against hypothermia for the survival of BMSCs under unfavorable conditions.
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1 

Russo MV and McGavern DB: Inflammatory neuroprotection following traumatic brain injury. Science. 353:783–785. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Masoudi MS, Rezaee E, Hakiminejad H, Tavakoli M and Sadeghpoor T: Cisternostomy for management of intracranial hypertension in severe traumatic brain injury; case report and literature review. Bull Emerg Trauma. 4:161–164. 2016.PubMed/NCBI

3 

Limpastan K, Norasetthada T, Watcharasaksilp W and Vaniyapong T: Factors influencing the outcome of decompressive craniectomy used in the treatment of severe traumatic brain injury. J Med Assoc Thai. 96:678–682. 2013.PubMed/NCBI

4 

Shi J, Han P and Kuniyoshi SM: Cognitive impairment in neurological diseases: lessons from apolipoprotein E. J Alzheimers Dis. 38:1–9. 2014.

5 

Benarroch EE: Microglia: multiple roles in surveillance, circuit shaping, and response to injury. Neurology. 81:1079–1088. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Chang EH, Adorjan I, Mundim MV, Sun B, Dizon ML and Szele FG: Traumatic brain injury activation of the adult subventricular zone neurogenic niche. Front Neurosci. 10:3322016. View Article : Google Scholar : PubMed/NCBI

7 

Pietrini D, Piastra M, Luca E, Mancino A, Conti G, Cavaliere F and De Luca D: Neuroprotection and hypothermia in infants and children. Curr Drug Targets. 13:925–935. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Ahmed AI, Bullock MR and Dietrich WD: Hypothermia in traumatic brain injury. Neurosurg Clin N Am. 27:489–497. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Lazaridis C and Robertson CS: Hypothermia for increased intra-cranial pressure: is it dead? Curr Neurol Neurosci Rep. 16:782016. View Article : Google Scholar

10 

Leshnower BG, Myung RJ, Thourani VH, Halkos ME, Kilgo PD, Puskas JD and Chen EP: Hemiarch replacement at 28°C: an analysis of mild and moderate hypothermia in 500 patients. Ann Thorac Surg. 93:1910–1916. 2012. View Article : Google Scholar

11 

McAdams RM and Juul SE: Neonatal encephalopathy: update on therapeutic hypothermia and other novel therapeutics. Clin Perinatol. 43:485–500. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Dailey T, Mosley Y, Pabon M, Acosta S, Tajiri N, van Loveren H, Kaneko Y and Borlongan CV: Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy. Neuroreport. 24:1067–1071. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Wimmer P, Schreiner S and Dobner T: Human pathogens and the host cell SUMOylation system. J Virol. 86:642–654. 2012. View Article : Google Scholar :

14 

Kumar A and Zhang KY: Advances in the development of SUMO specific protease (SENP) inhibitors. Comput Struct Biotechnol J. 13:204–211. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wilson VG: Sumoylation at the host-pathogen interface. Biomolecules. 2:203–227. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Swatek KN and Komander D: Ubiquitin modifications. Cell Res. 26:399–422. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Ulrich HD: Ubiquitin and SUMO in DNA repair at a glance. J Cell Sci. 125:249–254. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Craig TJ and Henley JM: Protein SUMOylation in spine structure and function. Curr Opin Neurobiol. 22:480–487. 2012. View Article : Google Scholar :

19 

Chang E and Abe J: Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism. 65:623–633. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Yang W, Ma Q, Mackensen GB and Paschen W: Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. J Cereb Blood Flow Metab. 29:886–890. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Yang W and Paschen W: SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases. Proteomics. 15:1181–1191. 2015. View Article : Google Scholar :

22 

Wang L, Ma Q, Yang W, Mackensen GB and Paschen W: Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons. J Neurochem. 123:349–359. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Yamasaki S, Mera H, Itokazu M, Hashimoto Y and Wakitani S: Cartilage repair with autologous bone marrow mesenchymal stem cell transplantation: review of preclinical and clinical studies. Cartilage. 5:196–202. 2014. View Article : Google Scholar

24 

Mezey É and Nemeth K: Mesenchymal stem cells and infectious diseases: smarter than drugs. Immunol Lett. 168:208–214. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ross CL, Siriwardane M, Almeida-Porada G, Porada CD, Brink P, Christ GJ and Harrison BS: The effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell differentiation. Stem Cell Res (Amst). 15:96–108. 2015. View Article : Google Scholar

26 

Lynch K and Pei M: Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies. Organogenesis. 10:289–298. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Błogowski W, Bodnarczuk T and Starzyńska T: Concise review: pancreatic cancer and bone marrow-derived stem cells. Stem Cells Transl Med. 5:938–945. 2016. View Article : Google Scholar :

28 

Yang Z, Zhu L, Li F, Wang J, Wan H and Pan Y: Bone marrow stromal cells as a therapeutic treatment for ischemic stroke. Neurosci Bull. 30:524–534. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Liu Z, Jiang Z, Huang J, Huang S, Li Y, Yu S, Yu S and Liu X: miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways. Int J Oncol. 44:1571–1580. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Parker JL and Ulrich HD: A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA. Nucleic Acids Res. 40:11380–11388. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Tahmasebi S, Ghorbani M, Savage P, Gocevski G and Yang XJ: The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency. Stem Cells. 32:1012–1020. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Stehmeier P and Muller S: Regulation of p53 family members by the ubiquitin-like SUMO system. DNA Repair (Amst). 8:491–498. 2009. View Article : Google Scholar

33 

Lee YJ, Bernstock JD, Nagaraja N, Ko B and Hallenbeck JM: Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose. J Neurochem. 138:101–116. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Sadaka F and Veremakis C: Therapeutic hypothermia for the management of intracranial hypertension in severe traumatic brain injury: a systematic review. Brain Inj. 26:899–908. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Shankaran S: Current status of hypothermia for hypoxemic ischemia of the newborn. Indian J Pediatr. 81:578–584. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Lee YJ and Hallenbeck JM: SUMO and ischemic tolerance. Neuromolecular Med. 15:771–781. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Hirohama M, Kumar A, Fukuda I, Matsuoka S, Igarashi Y, Saitoh H, Takagi M, Shin-ya K, Honda K, Kondoh Y, et al: Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chem Biol. 8:2635–2642. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Dieckman LM, Freudenthal BD and Washington MT: PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. Subcell Biochem. 62:281–299. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Parker JL and Ulrich HD: In vitro PCNA modification assays. Methods Mol Biol. 920:569–589. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Wei F, Schöler HR and Atchison ML: Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem. 282:21551–21560. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Yang F, Yao Y, Jiang Y, Lu L, Ma Y and Dai W: Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor. J Biol Chem. 287:38600–38608. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Laura MV, de la Cruz-Herrera CF, Ferreirós A, Baz-Martínez M, Lang V, Vidal A, Muñoz-Fontela C, Rodríguez MS, Collado M and Rivas C: KSHV latent protein LANA2 inhibits sumo2 modification of p53. Cell Cycle. 14:277–282. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Wang F, Cai F, Shi R, Wei JN and Wu XT: Hypoxia regulates sumoylation pathways in intervertebral disc cells: implications for hypoxic adaptations. Osteoarthritis Cartilage. 24:1113–1124. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Ren W, Jiang Z, Su Z, Ma X, Li Y, Jiang R, Zhang J and Yang X: Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation. Int J Mol Med 40: 1631-1638, 2017.
APA
Liu, X., Ren, W., Jiang, Z., Su, Z., Ma, X., Li, Y. ... Yang, X. (2017). Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation. International Journal of Molecular Medicine, 40, 1631-1638. https://doi.org/10.3892/ijmm.2017.3167
MLA
Liu, X., Ren, W., Jiang, Z., Su, Z., Ma, X., Li, Y., Jiang, R., Zhang, J., Yang, X."Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation". International Journal of Molecular Medicine 40.6 (2017): 1631-1638.
Chicago
Liu, X., Ren, W., Jiang, Z., Su, Z., Ma, X., Li, Y., Jiang, R., Zhang, J., Yang, X."Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation". International Journal of Molecular Medicine 40, no. 6 (2017): 1631-1638. https://doi.org/10.3892/ijmm.2017.3167
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Ren W, Jiang Z, Su Z, Ma X, Li Y, Jiang R, Zhang J and Yang X: Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation. Int J Mol Med 40: 1631-1638, 2017.
APA
Liu, X., Ren, W., Jiang, Z., Su, Z., Ma, X., Li, Y. ... Yang, X. (2017). Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation. International Journal of Molecular Medicine, 40, 1631-1638. https://doi.org/10.3892/ijmm.2017.3167
MLA
Liu, X., Ren, W., Jiang, Z., Su, Z., Ma, X., Li, Y., Jiang, R., Zhang, J., Yang, X."Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation". International Journal of Molecular Medicine 40.6 (2017): 1631-1638.
Chicago
Liu, X., Ren, W., Jiang, Z., Su, Z., Ma, X., Li, Y., Jiang, R., Zhang, J., Yang, X."Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation". International Journal of Molecular Medicine 40, no. 6 (2017): 1631-1638. https://doi.org/10.3892/ijmm.2017.3167
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