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Article Open Access

Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling

  • Authors:
    • Jie Zhou
    • Yan-Feng Zhu
    • Xiang-Yan Chen
    • Bin Han
    • Fei Li
    • Jing-Yao Chen
    • Xiao-Li Peng
    • Li-Ping Luo
    • Wei Chen
    • Xiao-Ping Yu
  • View Affiliations / Copyright

    Affiliations: Department of Public Health, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1649-1656
    |
    Published online on: October 11, 2017
       https://doi.org/10.3892/ijmm.2017.3183
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Abstract

This study aimed to investigate the role of focal adhesion kinase (FAK) signaling in the inhibitory effects of black rice anthocyanins (BRACs) on human epidermal growth factor receptor-2 (HER-2)-positive human breast cancer cell metastasis, using the MCF-10A, MCF-7 and MDA-MB-453 cells. BRACs exerted an anti-metastatic effect on the HER-2-positive breast cancer cells. The effects of BRACs on the proliferation of the MDA-MB-453 cells were examined by cell counting kit-8 assay. A wound-healing assay was used to examine the effects of BRACs on the migration of the breast cancer cells. BRACs interrupted migration and invasion. BRACs decreased the migration distance of the HER-2-positive human breast cancer cells, MDA-MB-453, by 37% compared with the cells in the untreated group. They also reduced the number of invading MDA-MB-453 cells by 68%. In addition, BRACs exerted an inhibitory effect on epithelial-mesenchymal transition. Western blot analysis revealed that BRACs decreased the phosphorylation of FAK, cSrc and p130Cas. The FAK inhibitor, Y15, was also used to further evaluate the role of FAK signaling in the anti-metastatic effects of BRACs on MDA-MB-453 cells. The results of western blot analysis revealed that BRACs increased the expression of the epithelial marker, E-cadherin, and decreased the expression of the mesenchymal markers, fibronectin and vimentin, in the MDA-MB‑453 cells. In addition, BRACs decreased the interaction between HER-2 and FAK, FAK and cSrc, cSrc and p130Cas, and between FAK and p130Cas. These results suggest that BRACs suppress the metastasis of HER-2-positive breast cancer in vitro, and that the cSrc/FAK/p130Cas pathway plays a vital role in this inhibitory effect.
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1 

Friedenreich CM: Physical activity and breast cancer: Review of the epidemiologic evidence and biologic mechanisms. Recent Results Cancer Res. 188:125–139. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zheng L, Zhou B, Meng X, Zhu W, Zuo A, Wang X, Jiang R and Yu S: A model of spontaneous mouse mammary tumor for human estrogen receptor- and progesterone receptor-negative breast cancer. Int J Oncol. 45:2241–2249. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Mendoza G, Portillo A and Olmos-Soto J: Accurate breast cancer diagnosis through real-time PCR her-2 gene quantification using immunohistochemically-identified biopsies. Oncol Lett. 5:295–298. 2013.

5 

Gutierrez C and Schiff R: HER2: Biology, detection, and clinical implications. Arch Pathol Lab Med. 135:55–62. 2011.PubMed/NCBI

6 

Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, et al: Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 244:707–712. 1989. View Article : Google Scholar : PubMed/NCBI

7 

Heerboth S, Housman G, Leary M, Longacre M, Byler S, Lapinska K, Willbanks A and Sarkar S: EMT and tumor metastasis. Clin Transl Med. 4:62015. View Article : Google Scholar : PubMed/NCBI

8 

Heffler M, Golubovskaya VM, Dunn KM and Cance W: Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. Cancer Biol Ther. 14:761–772. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Golubovskaya VM: Targeting FAK in human cancer: From finding to first clinical trials. Front Biosci (Landmark Ed). 19:687–706. 2014. View Article : Google Scholar

10 

Vadlamudi RK, Sahin AA, Adam L, Wang RA and Kumar R: Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215. FEBS Lett. 543:76–80. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Dolfi F, Garcia-Guzman M, Ojaniemi M, Nakamura H, Matsuda M and Vuori K: The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc Natl Acad Sci USA. 95:15394–15399. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Han C, Ding H, Casto B, Stoner GD and D'Ambrosio SM: Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer. 51:207–217. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Fayyaz S, Aydin T, Cakir A, Gasparri ML, Panici PB and Farooqi AA: Oleuropein mediated targeting of signaling network in cancer. Curr Top Med Chem. 16:2477–2483. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Farooqi AA, Wang Z, Hasnain S, Attar R, Aslam A, Mansoor Q and Ismail M: Citrus fruits and their bioactive ingredients: Leading four horsemen from front. Asian Pac J Cancer Prev. 16:2575–2580. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Lin X, Farooqi AA and Ismail M: Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells. Drug Des Devel Ther. 9:1797–1804. 2015.PubMed/NCBI

16 

Perk AA, Shatynska-Mytsyk I, Gerçek YC, Boztaş K, Yazgan M, Fayyaz S and Farooqi AA: Rutin mediated targeting of signaling machinery in cancer cells. Cancer Cell Int. 14:1242014. View Article : Google Scholar : PubMed/NCBI

17 

Attar R, Tabassum S, Fayyaz S, Ahmad MS, Nogueira DR, Yaylim I, Timirci-Kahraman O, Kucukhuseyin O, Cacina C, Farooqi AA, et al: Natural products are the future of anticancer therapy: Preclinical and clinical advancements of Viscum album phytometabolites. Cell Mol Biol (Noisy-le-grand). 61:62–68. 2015.

18 

Kong S, Kim DJ, Oh SK, Choi IS, Jeong HS and Lee J: Black rice bran as an ingredient in noodles: Chemical and functional evaluation. J Food Sci. 77:C303–C307. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Sehitoglu MH, Farooqi AA, Qureshi MZ, Butt G and Aras A: Anthocyanins: Targeting of signaling networks in cancer cells. Asian Pac J Cancer Prev. 15:2379–2381. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Hui C, Bin Y, Xiaoping Y, Long Y, Chunye C, Mantian M and Wenhua L: Anticancer activities of an anthocyanin-rich extract from black rice against breast cancer cells in vitro and in vivo. Nutr Cancer. 62:1128–1136. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Luo LP, Han B, Yu XP, Chen XY, Zhou J, Chen W, Zhu YF, Peng XL, Zou Q and Li SY: Anti-metastasis activity of black rice anthocyanins against breast cancer: Analyses using an ErbB2 positive breast cancer cell line and tumoral xenograft model. Asian Pac J Cancer Prev. 15:6219–6225. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Chen XY, Zhou J, Luo LP, Han B, Li F, Chen JY, Zhu YF, Chen W and Yu XP: Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway. Biomed Res Int. 2015:4142502015. View Article : Google Scholar : PubMed/NCBI

23 

Xu M, Bower KA, Wang S, Frank JA, Chen G, Ding M, Wang S, Shi X, Ke Z and Luo J: Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2. Mol Cancer. 9:2852010. View Article : Google Scholar : PubMed/NCBI

24 

Xu M, Bower KA, Chen G, Shi X, Dong Z, Ke Z and Luo J: Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin. Alcohol Clin Exp Res. 34:751–760. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Hou DX: Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med. 3:149–159. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Crozier A, Jaganath IB and Clifford MN: Dietary phenolics: Chemistry, bioavailability and effects on health. Nat Prod Rep. 26:1001–1043. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Scalbert A and Williamson G: Dietary intake and bioavailability of polyphenols. J Nutr. 130(Suppl 8): 2073S–2085S. 2000.PubMed/NCBI

28 

Manach C, Scalbert A, Morand C, Rémésy C and Jiménez L: Polyphenols: Food sources and bioavailability. Am J Clin Nutr. 79:727–747. 2004.PubMed/NCBI

29 

Kamiloglu S, Capanoglu E, Grootaert C and Van Camp J: Anthocyanin absorption and metabolism by human intestinal caco-2 cells - A review. Int J Mol Sci. 16:21555–21574. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Fang J: Bioavailability of anthocyanins. Drug Metab Rev. 46:508–520. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Chen PN, Kuo WH, Chiang CL, Chiou HL, Hsieh YS and Chu SC: Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chem Biol Interact. 163:218–229. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Wang LS and Stoner GD: Anthocyanins and their role in cancer prevention. Cancer Lett. 269:281–290. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Chen JS, Huang XH, Wang Q, Huang JQ, Zhang LJ, Chen XL, Lei J and Cheng ZX: Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer. Carcinogenesis. 34:10–19. 2013. View Article : Google Scholar

34 

Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D and Cance WG: A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem. 51:7405–7416. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Veeraraghavan J, Natarajan M, Lagisetty P, Awasthi V, Herman TS and Aravindan N: Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells. Pancreas. 40:1107–1119. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Singh N, Zaidi D, Shyam H, Sharma R and Balapure AK: Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman. PLoS One. 7:e377362012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Zhu Y, Chen X, Han B, Li F, Chen J, Peng X, Luo L, Chen W, Yu X, Yu X, et al: Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling. Int J Mol Med 40: 1649-1656, 2017.
APA
Zhou, J., Zhu, Y., Chen, X., Han, B., Li, F., Chen, J. ... Yu, X. (2017). Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling. International Journal of Molecular Medicine, 40, 1649-1656. https://doi.org/10.3892/ijmm.2017.3183
MLA
Zhou, J., Zhu, Y., Chen, X., Han, B., Li, F., Chen, J., Peng, X., Luo, L., Chen, W., Yu, X."Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling". International Journal of Molecular Medicine 40.6 (2017): 1649-1656.
Chicago
Zhou, J., Zhu, Y., Chen, X., Han, B., Li, F., Chen, J., Peng, X., Luo, L., Chen, W., Yu, X."Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling". International Journal of Molecular Medicine 40, no. 6 (2017): 1649-1656. https://doi.org/10.3892/ijmm.2017.3183
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Zhu Y, Chen X, Han B, Li F, Chen J, Peng X, Luo L, Chen W, Yu X, Yu X, et al: Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling. Int J Mol Med 40: 1649-1656, 2017.
APA
Zhou, J., Zhu, Y., Chen, X., Han, B., Li, F., Chen, J. ... Yu, X. (2017). Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling. International Journal of Molecular Medicine, 40, 1649-1656. https://doi.org/10.3892/ijmm.2017.3183
MLA
Zhou, J., Zhu, Y., Chen, X., Han, B., Li, F., Chen, J., Peng, X., Luo, L., Chen, W., Yu, X."Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling". International Journal of Molecular Medicine 40.6 (2017): 1649-1656.
Chicago
Zhou, J., Zhu, Y., Chen, X., Han, B., Li, F., Chen, J., Peng, X., Luo, L., Chen, W., Yu, X."Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling". International Journal of Molecular Medicine 40, no. 6 (2017): 1649-1656. https://doi.org/10.3892/ijmm.2017.3183
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