Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2018 Volume 41 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 41 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway

Corrigendum in: /10.3892/ijmm.2021.4953
  • Authors:
    • Li Luo
    • Wuhong Zheng
    • Guili Lian
    • Huaning Chen
    • Ling Li
    • Changsheng Xu
    • Liangdi Xie
  • View Affiliations / Copyright

    Affiliations: Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 51-60
    |
    Published online on: October 31, 2017
       https://doi.org/10.3892/ijmm.2017.3226
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to assess the effects of therapy with adiponectin (APN) gene-modified adipose-derived stem cells (ADSCs) on pulmonary arterial hypertension (PAH) in rats and the underlying cellular and molecular mechanisms. ADSCs were successfully isolated from the rats and characterized. ADSCs were effectively infected with the green fluorescent protein (GFP)-empty (ADSCs-V) or the APN-GFP (ADSCs-APN) lentivirus and the APN expression was evaluated by ELISA. Sprague-Dawley rats were administered monocrotaline (MCT) to develop PAH. The rats were treated with MCT, ADSCs, ADSCs-V and ADSCs-APN. Then ADSCs-APN in the lung were investigated by confocal laser scanning microscopy and western blot analysis. Engrafted ADSCs in the lung were located around the vessels. Mean pulmonary arterial pressure (mPAP) and the right ventricular hypertrophy index (RVHI) in the ADSCs-APN-treated mice were significantly decreased as compared with the ADSCs and ADSCs-V treatments. Pulmonary vascular remodeling was assessed. Right ventricular (RV) function was evaluated by echocardiography. We found that pulmonary vascular remodeling and the parameters of RV function were extensively improved after ADSCs-APN treatment when compared with ADSCs and ADSCs-V treatment. Pulmonary artery smooth muscle cells (PASMCs) were isolated from the PAH rats. The antiproliferative effect of APN on PASMCs was assayed by Cell Counting Kit-8. The influence of APN and specific inhibitors on the levels of bone morphogenetic protein (BMP), adenosine monophosphate activated protein kinase (AMPK), and small mothers against decapentaplegia (Smad) pathways was detected by western blot analysis. We found that APN suppressed the proliferation of PASMCs isolated from the PAH rats by regulating the AMPK/BMP/Smad pathway. This effect was weakened by addition of the AMPK inhibitor (compound C) and BMP2 inhibitor (noggin). Therefore, combination treatment with ADSCs and APN effectively attenuated PAH in rats by inhibiting PASMC proliferation and regulating the AMPK/BMP/Smad pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Liu K, Liu R, Cao G, Sun H, Wang X and Wu S: Adipose-derived stromal cell autologous transplantation ameliorates pulmonary arterial hypertension induced by shunt flow in rat models. Stem Cells Dev. 20:1001–1010. 2011. View Article : Google Scholar

2 

Baber SR, Deng W, Master RG, Bunnell BA, Taylor BK, Murthy SN, Hyman AL and Kadowitz PJ: Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 292:H1120–H1128. 2007. View Article : Google Scholar

3 

Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q and Stewart DJ: Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease. Circ Res. 96:442–450. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Luo L, Lin T, Zheng S, Xie Z, Chen M, Lian G, Xu C, Wang H and Xie L: Adipose-derived stem cells attenuate pulmonary arterial hypertension and ameliorate pulmonary arterial remodeling in monocrotaline-induced pulmonary hypertensive rats. Clin Exp Hypertens. 37:241–248. 2015. View Article : Google Scholar

5 

Takemiya K, Kai H, Yasukawa H, Tahara N, Kato S and Imaizumi T: Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats. Basic Res Cardiol. 105:409–417. 2010. View Article : Google Scholar

6 

Somanna NK, Wörner PM, Murthy SN, Pankey EA, Schächtele DJ, St Hilaire RC, Jansen D, Chaffin AE, Nossaman BD, Alt EU, et al: Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol. 307:H1187–H1195. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhao Q, Liu Z, Wang Z, Yang C, Liu J and Lu J: Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension. Ann Thorac Surg. 84:544–552. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Iwaguro H, Yamaguchi J, Kalka C, Murasawa S, Masuda H, Hayashi S, Silver M, Li T, Isner JM and Asahara T: Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation. 105:732–738. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Cao G, Liu C, Wan Z, Liu K, Sun H, Sun X, Tang M, Bing W, Wu S, Pang X, et al: Combined hypoxia inducible factor-1α and homogeneous endothelial progenitor cell therapy attenuates shunt flow-induced pulmonary arterial hypertension in rabbits. J Thorac Cardiovasc Surg. 150:621–632. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Granton J, Langleben D, Kutryk MB, Camack N, Galipeau J, Courtman DW and Stewart DJ: Endothelial NO-synthase gene-enhanced progenitor cell therapy for pulmonary arterial hypertension: The PHACeT trial. Circ Res. 117:645–654. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Antonopoulos AS, Margaritis M, Coutinho P, Shirodaria C, Psarros C, Herdman L, Sanna F, De Silva R, Petrou M, Sayeed R, et al: Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: The regulatory role of perivascular adipose tissue. Diabetes. 64:2207–2219. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, et al: Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation. 131:1861–1871. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ and Xu A: Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem. 280:18341–18347. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Summer R, Fiack CA, Ikeda Y, Sato K, Dwyer D, Ouchi N, Fine A, Farber HW and Walsh K: Adiponectin deficiency: A model of pulmonary hypertension associated with pulmonary vascular disease. Am J Physiol Lung Cell Mol Physiol. 297:L432–L438. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P and Luster AD: Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol. 41:397–406. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Weng M, Baron DM, Bloch KD, Luster AD, Lee JJ and Medoff BD: Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 301:L927–L936. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Nakagawa Y, Kishida K, Kihara S, Funahashi T and Shimomura I: Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling. Biochem Biophys Res Commun. 382:183–188. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Farber HW and Loscalzo J: Pulmonary arterial hypertension. N Engl J Med. 351:1655–1665. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Momose Y, Aimi Y, Hirayama T, Kataoka M, Ono M, Yoshino H, Satoh T and Gamou S: De novo mutations in the BMPR2 gene in patients with heritable pulmonary arterial hypertension. Ann Hum Genet. 79:85–91. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, et al: Genetics and genomics of pulmonary arterial hypertension. J Am Coll Cardiol. 62(Suppl 25): D13–D21. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M and Fukuchi Y: Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 290:L450–L458. 2006. View Article : Google Scholar

22 

Upton PD and Morrell NW: The transforming growth factor-β-bone morphogenetic protein type signalling pathway in pulmonary vascular homeostasis and disease. Exp Physiol. 98:1262–1266. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ and Yuan JX: Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 285:L740–L754. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Xie L, Lin P, Xie H and Xu C: Effects of atorvastatin and losartan on monocrotaline-induced pulmonary artery remodeling in rats. Clin Exp Hypertens. 32:547–554. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Weng M, Raher MJ, Leyton P, Combs TP, Scherer PE, Bloch KD and Medoff BD: Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension. Am J Respir Cell Mol Biol. 45:340–347. 2011. View Article : Google Scholar :

26 

Rabinovitch M: Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest. 122:4306–4313. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Farkas L and Kolb M: Vascular repair and regeneration as a therapeutic target for pulmonary arterial hypertension. Respiration. 85:355–364. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Foster WS, Suen CM and Stewart DJ: Regenerative cell and tissue-based therapies for pulmonary arterial hypertension. Can J Cardiol. 30:1350–1360. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Suen CM, Mei SH, Kugathasan L and Stewart DJ: Targeted delivery of genes to endothelial cells and cell- and gene-based therapy in pulmonary vascular diseases. Compr Physiol. 3:1749–1779. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Eguchi M, Ikeda S, Kusumoto S, Sato D, Koide Y, Kawano H and Maemura K: Adipose-derived regenerative cell therapy inhibits the progression of monocrotaline-induced pulmonary hypertension in rats. Life Sci. 118:306–312. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Salgado AJ, Reis RL, Sousa NJ and Gimble JM: Adipose tissue derived stem cells secretome: Soluble factors and their roles in regenerative medicine. Curr Stem Cell Res Ther. 5:103–110. 2010. View Article : Google Scholar

32 

Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV and March KL: Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 109:1292–1298. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Ii M, Horii M, Yokoyama A, Shoji T, Mifune Y, Kawamoto A, Asahi M and Asahara T: Synergistic effect of adipose-derived stem cell therapy and bone marrow progenitor recruitment in ischemic heart. Lab Invest. 91:539–552. 2011. View Article : Google Scholar

34 

Haque AK, Gadre S, Taylor J, Haque SA, Freeman D and Duarte A: Pulmonary and cardiovascular complications of obesity: An autopsy study of 76 obese subjects. Arch Pathol Lab Med. 132:1397–1404. 2008.PubMed/NCBI

35 

Burger CD, Foreman AJ, Miller DP, Safford RE, McGoon MD and Badesch DB: Comparison of body habitus in patients with pulmonary arterial hypertension enrolled in the Registry to Evaluate Early and Long-term PAH Disease Management with normative values from the National Health and Nutrition Examination Survey. Mayo Clin Proc. 86:105–112. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Okamoto Y, Kihara S, Funahashi T, Matsuzawa Y and Libby P: Adiponectin: A key adipocytokine in metabolic syndrome. Clin Sci (Lond). 110:267–278. 2006. View Article : Google Scholar

37 

Wang ZV and Scherer PE: Adiponectin, cardiovascular function, and hypertension. Hypertension. 51:8–14. 2008. View Article : Google Scholar

38 

García de Vinuesa A, Abdelilah-Seyfried S, Knaus P, Zwijsen A and Bailly S: BMP signaling in vascular biology and dysfunction. Cytokine Growth Factor Rev. 27:65–79. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC and Morrell NW: Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res. 96:1053–1063. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Zeng Y, Liu H, Kang K, Wang Z, Hui G, Zhang X, Zhong J, Peng W, Ramchandran R, Raj JU, et al: Hypoxia inducible factor-1 mediates expression of miR-322: Potential role in proliferation and migration of pulmonary arterial smooth muscle cells. Sci Rep. 5:120982015. View Article : Google Scholar : PubMed/NCBI

41 

Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, et al: Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 27:1072–1078. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Yang J, Li X, Al-Lamki RS, Wu C, Weiss A, Berk J, Schermuly RT and Morrell NW: Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol. 33:34–42. 2013. View Article : Google Scholar

43 

Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, Grimminger F, Schermuly RT and Morrell NW: Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Circ Res. 107:252–262. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Vakana E, Altman JK and Platanias LC: Targeting AMPK in the treatment of malignancies. J Cell Biochem. 113:404–409. 2012. View Article : Google Scholar

45 

Lévy J, Cacheux W, Bara MA, L'Hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, et al: Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. Nat Cell Biol. 17:1062–1073. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Lee KY, Lee DH and Choi HC: Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR. Clin Hypertens. 22:22016. View Article : Google Scholar : PubMed/NCBI

47 

Shimpo Lu J, Shimamoto H, Chong A, Hampton AJ, Spring CR, Yada DJ, Takao M, Onoda M, Yada KI, et al: Specific inhibition of 38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats. J Thorac Cardiovasc Surg. 128:850–859. 2004. View Article : Google Scholar

48 

Ma J, Zhang L, Han W, Shen T, Ma C, Liu Y, Nie X, Liu M, Ran Y and Zhu D: Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells. J Lipid Res. 53:1093–1105. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Yu MQ, Liu XS, Wu HX, Xiang M and Xu YJ: ERK1/2 promotes cigarette smoke-induced rat pulmonary artery smooth muscle cells proliferation and pulmonary vascular remodeling via up-regulating cycline1 expression. J Huazhong Univ Sci Technolog Med Sci. 33:315–322. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Chen XY, Dun JN, Miao QF and Zhang YJ: Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway. Pharmacology. 83:67–79. 2009. View Article : Google Scholar

51 

Havrda MC, Johnson MJ, O'Neill CF and Liaw L: A novel mechanism of transcriptional repression of 27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells. Thromb Haemost. 96:361–370. 2006.PubMed/NCBI

52 

Guo Z, Qi W, Yu Y, Du S, Wu J and Liu J: Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats. Diabetol Metab Syndr. 6:292014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Luo L, Zheng W, Lian G, Chen H, Li L, Xu C and Xie L: Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953. Int J Mol Med 41: 51-60, 2018.
APA
Luo, L., Zheng, W., Lian, G., Chen, H., Li, L., Xu, C., & Xie, L. (2018). Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953. International Journal of Molecular Medicine, 41, 51-60. https://doi.org/10.3892/ijmm.2017.3226
MLA
Luo, L., Zheng, W., Lian, G., Chen, H., Li, L., Xu, C., Xie, L."Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953". International Journal of Molecular Medicine 41.1 (2018): 51-60.
Chicago
Luo, L., Zheng, W., Lian, G., Chen, H., Li, L., Xu, C., Xie, L."Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953". International Journal of Molecular Medicine 41, no. 1 (2018): 51-60. https://doi.org/10.3892/ijmm.2017.3226
Copy and paste a formatted citation
x
Spandidos Publications style
Luo L, Zheng W, Lian G, Chen H, Li L, Xu C and Xie L: Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953. Int J Mol Med 41: 51-60, 2018.
APA
Luo, L., Zheng, W., Lian, G., Chen, H., Li, L., Xu, C., & Xie, L. (2018). Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953. International Journal of Molecular Medicine, 41, 51-60. https://doi.org/10.3892/ijmm.2017.3226
MLA
Luo, L., Zheng, W., Lian, G., Chen, H., Li, L., Xu, C., Xie, L."Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953". International Journal of Molecular Medicine 41.1 (2018): 51-60.
Chicago
Luo, L., Zheng, W., Lian, G., Chen, H., Li, L., Xu, C., Xie, L."Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953". International Journal of Molecular Medicine 41, no. 1 (2018): 51-60. https://doi.org/10.3892/ijmm.2017.3226
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team