1
|
Liu K, Liu R, Cao G, Sun H, Wang X and Wu
S: Adipose-derived stromal cell autologous transplantation
ameliorates pulmonary arterial hypertension induced by shunt flow
in rat models. Stem Cells Dev. 20:1001–1010. 2011. View Article : Google Scholar
|
2
|
Baber SR, Deng W, Master RG, Bunnell BA,
Taylor BK, Murthy SN, Hyman AL and Kadowitz PJ: Intratracheal
mesenchymal stem cell administration attenuates
monocrotaline-induced pulmonary hypertension and endothelial
dysfunction. Am J Physiol Heart Circ Physiol. 292:H1120–H1128.
2007. View Article : Google Scholar
|
3
|
Zhao YD, Courtman DW, Deng Y, Kugathasan
L, Zhang Q and Stewart DJ: Rescue of monocrotaline-induced
pulmonary arterial hypertension using bone marrow-derived
endothelial-like progenitor cells: Efficacy of combined cell and
eNOS gene therapy in established disease. Circ Res. 96:442–450.
2005. View Article : Google Scholar : PubMed/NCBI
|
4
|
Luo L, Lin T, Zheng S, Xie Z, Chen M, Lian
G, Xu C, Wang H and Xie L: Adipose-derived stem cells attenuate
pulmonary arterial hypertension and ameliorate pulmonary arterial
remodeling in monocrotaline-induced pulmonary hypertensive rats.
Clin Exp Hypertens. 37:241–248. 2015. View Article : Google Scholar
|
5
|
Takemiya K, Kai H, Yasukawa H, Tahara N,
Kato S and Imaizumi T: Mesenchymal stem cell-based prostacyclin
synthase gene therapy for pulmonary hypertension rats. Basic Res
Cardiol. 105:409–417. 2010. View Article : Google Scholar
|
6
|
Somanna NK, Wörner PM, Murthy SN, Pankey
EA, Schächtele DJ, St Hilaire RC, Jansen D, Chaffin AE, Nossaman
BD, Alt EU, et al: Intratracheal administration of
cyclooxygenase-1-transduced adipose tissue-derived stem cells
ameliorates monocrotaline-induced pulmonary hypertension in rats.
Am J Physiol Heart Circ Physiol. 307:H1187–H1195. 2014. View Article : Google Scholar : PubMed/NCBI
|
7
|
Zhao Q, Liu Z, Wang Z, Yang C, Liu J and
Lu J: Effect of prepro-calcitonin gene-related peptide-expressing
endothelial progenitor cells on pulmonary hypertension. Ann Thorac
Surg. 84:544–552. 2007. View Article : Google Scholar : PubMed/NCBI
|
8
|
Iwaguro H, Yamaguchi J, Kalka C, Murasawa
S, Masuda H, Hayashi S, Silver M, Li T, Isner JM and Asahara T:
Endothelial progenitor cell vascular endothelial growth factor gene
transfer for vascular regeneration. Circulation. 105:732–738. 2002.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Cao G, Liu C, Wan Z, Liu K, Sun H, Sun X,
Tang M, Bing W, Wu S, Pang X, et al: Combined hypoxia inducible
factor-1α and homogeneous endothelial progenitor cell therapy
attenuates shunt flow-induced pulmonary arterial hypertension in
rabbits. J Thorac Cardiovasc Surg. 150:621–632. 2015. View Article : Google Scholar : PubMed/NCBI
|
10
|
Granton J, Langleben D, Kutryk MB, Camack
N, Galipeau J, Courtman DW and Stewart DJ: Endothelial NO-synthase
gene-enhanced progenitor cell therapy for pulmonary arterial
hypertension: The PHACeT trial. Circ Res. 117:645–654. 2015.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Antonopoulos AS, Margaritis M, Coutinho P,
Shirodaria C, Psarros C, Herdman L, Sanna F, De Silva R, Petrou M,
Sayeed R, et al: Adiponectin as a link between type 2 diabetes and
vascular NADPH oxidase activity in the human arterial wall: The
regulatory role of perivascular adipose tissue. Diabetes.
64:2207–2219. 2015. View Article : Google Scholar : PubMed/NCBI
|
12
|
Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y,
Jin L, Lian Q, Huang Y, Ding H, et al: Fibroblast growth factor 21
prevents atherosclerosis by suppression of hepatic sterol
regulatory element-binding protein-2 and induction of adiponectin
in mice. Circulation. 131:1861–1871. 2015. View Article : Google Scholar : PubMed/NCBI
|
13
|
Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper
GJ and Xu A: Adiponectin inhibits cell proliferation by interacting
with several growth factors in an oligomerization-dependent manner.
J Biol Chem. 280:18341–18347. 2005. View Article : Google Scholar : PubMed/NCBI
|
14
|
Summer R, Fiack CA, Ikeda Y, Sato K, Dwyer
D, Ouchi N, Fine A, Farber HW and Walsh K: Adiponectin deficiency:
A model of pulmonary hypertension associated with pulmonary
vascular disease. Am J Physiol Lung Cell Mol Physiol.
297:L432–L438. 2009. View Article : Google Scholar : PubMed/NCBI
|
15
|
Medoff BD, Okamoto Y, Leyton P, Weng M,
Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P and Luster AD:
Adiponectin deficiency increases allergic airway inflammation and
pulmonary vascular remodeling. Am J Respir Cell Mol Biol.
41:397–406. 2009. View Article : Google Scholar : PubMed/NCBI
|
16
|
Weng M, Baron DM, Bloch KD, Luster AD, Lee
JJ and Medoff BD: Eosinophils are necessary for pulmonary arterial
remodeling in a mouse model of eosinophilic inflammation-induced
pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol.
301:L927–L936. 2011. View Article : Google Scholar : PubMed/NCBI
|
17
|
Nakagawa Y, Kishida K, Kihara S, Funahashi
T and Shimomura I: Adiponectin ameliorates hypoxia-induced
pulmonary arterial remodeling. Biochem Biophys Res Commun.
382:183–188. 2009. View Article : Google Scholar : PubMed/NCBI
|
18
|
Farber HW and Loscalzo J: Pulmonary
arterial hypertension. N Engl J Med. 351:1655–1665. 2004.
View Article : Google Scholar : PubMed/NCBI
|
19
|
Momose Y, Aimi Y, Hirayama T, Kataoka M,
Ono M, Yoshino H, Satoh T and Gamou S: De novo mutations in the
BMPR2 gene in patients with heritable pulmonary arterial
hypertension. Ann Hum Genet. 79:85–91. 2015. View Article : Google Scholar : PubMed/NCBI
|
20
|
Soubrier F, Chung WK, Machado R, Grünig E,
Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, et
al: Genetics and genomics of pulmonary arterial hypertension. J Am
Coll Cardiol. 62(Suppl 25): D13–D21. 2013. View Article : Google Scholar : PubMed/NCBI
|
21
|
Takahashi H, Goto N, Kojima Y, Tsuda Y,
Morio Y, Muramatsu M and Fukuchi Y: Downregulation of type II bone
morphogenetic protein receptor in hypoxic pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol. 290:L450–L458. 2006. View Article : Google Scholar
|
22
|
Upton PD and Morrell NW: The transforming
growth factor-β-bone morphogenetic protein type signalling pathway
in pulmonary vascular homeostasis and disease. Exp Physiol.
98:1262–1266. 2013. View Article : Google Scholar : PubMed/NCBI
|
23
|
Zhang S, Fantozzi I, Tigno DD, Yi ES,
Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ and
Yuan JX: Bone morphogenetic proteins induce apoptosis in human
pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol
Physiol. 285:L740–L754. 2003. View Article : Google Scholar : PubMed/NCBI
|
24
|
Xie L, Lin P, Xie H and Xu C: Effects of
atorvastatin and losartan on monocrotaline-induced pulmonary artery
remodeling in rats. Clin Exp Hypertens. 32:547–554. 2010.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Weng M, Raher MJ, Leyton P, Combs TP,
Scherer PE, Bloch KD and Medoff BD: Adiponectin decreases pulmonary
arterial remodeling in murine models of pulmonary hypertension. Am
J Respir Cell Mol Biol. 45:340–347. 2011. View Article : Google Scholar :
|
26
|
Rabinovitch M: Molecular pathogenesis of
pulmonary arterial hypertension. J Clin Invest. 122:4306–4313.
2012. View
Article : Google Scholar : PubMed/NCBI
|
27
|
Farkas L and Kolb M: Vascular repair and
regeneration as a therapeutic target for pulmonary arterial
hypertension. Respiration. 85:355–364. 2013. View Article : Google Scholar : PubMed/NCBI
|
28
|
Foster WS, Suen CM and Stewart DJ:
Regenerative cell and tissue-based therapies for pulmonary arterial
hypertension. Can J Cardiol. 30:1350–1360. 2014. View Article : Google Scholar : PubMed/NCBI
|
29
|
Suen CM, Mei SH, Kugathasan L and Stewart
DJ: Targeted delivery of genes to endothelial cells and cell- and
gene-based therapy in pulmonary vascular diseases. Compr Physiol.
3:1749–1779. 2013. View Article : Google Scholar : PubMed/NCBI
|
30
|
Eguchi M, Ikeda S, Kusumoto S, Sato D,
Koide Y, Kawano H and Maemura K: Adipose-derived regenerative cell
therapy inhibits the progression of monocrotaline-induced pulmonary
hypertension in rats. Life Sci. 118:306–312. 2014. View Article : Google Scholar : PubMed/NCBI
|
31
|
Salgado AJ, Reis RL, Sousa NJ and Gimble
JM: Adipose tissue derived stem cells secretome: Soluble factors
and their roles in regenerative medicine. Curr Stem Cell Res Ther.
5:103–110. 2010. View Article : Google Scholar
|
32
|
Rehman J, Traktuev D, Li J, Merfeld-Clauss
S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV
and March KL: Secretion of angiogenic and antiapoptotic factors by
human adipose stromal cells. Circulation. 109:1292–1298. 2004.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Ii M, Horii M, Yokoyama A, Shoji T, Mifune
Y, Kawamoto A, Asahi M and Asahara T: Synergistic effect of
adipose-derived stem cell therapy and bone marrow progenitor
recruitment in ischemic heart. Lab Invest. 91:539–552. 2011.
View Article : Google Scholar
|
34
|
Haque AK, Gadre S, Taylor J, Haque SA,
Freeman D and Duarte A: Pulmonary and cardiovascular complications
of obesity: An autopsy study of 76 obese subjects. Arch Pathol Lab
Med. 132:1397–1404. 2008.PubMed/NCBI
|
35
|
Burger CD, Foreman AJ, Miller DP, Safford
RE, McGoon MD and Badesch DB: Comparison of body habitus in
patients with pulmonary arterial hypertension enrolled in the
Registry to Evaluate Early and Long-term PAH Disease Management
with normative values from the National Health and Nutrition
Examination Survey. Mayo Clin Proc. 86:105–112. 2011. View Article : Google Scholar : PubMed/NCBI
|
36
|
Okamoto Y, Kihara S, Funahashi T,
Matsuzawa Y and Libby P: Adiponectin: A key adipocytokine in
metabolic syndrome. Clin Sci (Lond). 110:267–278. 2006. View Article : Google Scholar
|
37
|
Wang ZV and Scherer PE: Adiponectin,
cardiovascular function, and hypertension. Hypertension. 51:8–14.
2008. View Article : Google Scholar
|
38
|
García de Vinuesa A, Abdelilah-Seyfried S,
Knaus P, Zwijsen A and Bailly S: BMP signaling in vascular biology
and dysfunction. Cytokine Growth Factor Rev. 27:65–79. 2016.
View Article : Google Scholar : PubMed/NCBI
|
39
|
Yang X, Long L, Southwood M,
Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H,
Trembath RC and Morrell NW: Dysfunctional Smad signaling
contributes to abnormal smooth muscle cell proliferation in
familial pulmonary arterial hypertension. Circ Res. 96:1053–1063.
2005. View Article : Google Scholar : PubMed/NCBI
|
40
|
Zeng Y, Liu H, Kang K, Wang Z, Hui G,
Zhang X, Zhong J, Peng W, Ramchandran R, Raj JU, et al: Hypoxia
inducible factor-1 mediates expression of miR-322: Potential role
in proliferation and migration of pulmonary arterial smooth muscle
cells. Sci Rep. 5:120982015. View Article : Google Scholar : PubMed/NCBI
|
41
|
Morty RE, Nejman B, Kwapiszewska G, Hecker
M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus
P, et al: Dysregulated bone morphogenetic protein signaling in
monocrotaline-induced pulmonary arterial hypertension. Arterioscler
Thromb Vasc Biol. 27:1072–1078. 2007. View Article : Google Scholar : PubMed/NCBI
|
42
|
Yang J, Li X, Al-Lamki RS, Wu C, Weiss A,
Berk J, Schermuly RT and Morrell NW: Sildenafil potentiates bone
morphogenetic protein signaling in pulmonary arterial smooth muscle
cells and in experimental pulmonary hypertension. Arterioscler
Thromb Vasc Biol. 33:34–42. 2013. View Article : Google Scholar
|
43
|
Yang J, Li X, Al-Lamki RS, Southwood M,
Zhao J, Lever AM, Grimminger F, Schermuly RT and Morrell NW:
Smad-dependent and smad-independent induction of id1 by
prostacyclin analogues inhibits proliferation of pulmonary artery
smooth muscle cells in vitro and in vivo. Circ Res. 107:252–262.
2010. View Article : Google Scholar : PubMed/NCBI
|
44
|
Vakana E, Altman JK and Platanias LC:
Targeting AMPK in the treatment of malignancies. J Cell Biochem.
113:404–409. 2012. View Article : Google Scholar
|
45
|
Lévy J, Cacheux W, Bara MA, L'Hermitte A,
Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain
AM, et al: Intestinal inhibition of Atg7 prevents tumour initiation
through a microbiome-influenced immune response and suppresses
tumour growth. Nat Cell Biol. 17:1062–1073. 2015. View Article : Google Scholar : PubMed/NCBI
|
46
|
Lee KY, Lee DH and Choi HC: Mesoglycan
attenuates VSMC proliferation through activation of AMP-activated
protein kinase and mTOR. Clin Hypertens. 22:22016. View Article : Google Scholar : PubMed/NCBI
|
47
|
Shimpo Lu J, Shimamoto H, Chong A, Hampton
AJ, Spring CR, Yada DJ, Takao M, Onoda M, Yada KI, et al: Specific
inhibition of 38 mitogen-activated protein kinase with FR167653
attenuates vascular proliferation in monocrotaline-induced
pulmonary hypertension in rats. J Thorac Cardiovasc Surg.
128:850–859. 2004. View Article : Google Scholar
|
48
|
Ma J, Zhang L, Han W, Shen T, Ma C, Liu Y,
Nie X, Liu M, Ran Y and Zhu D: Activation of JNK/c-Jun is required
for the proliferation, survival, and angiogenesis induced by EET in
pulmonary artery endothelial cells. J Lipid Res. 53:1093–1105.
2012. View Article : Google Scholar : PubMed/NCBI
|
49
|
Yu MQ, Liu XS, Wu HX, Xiang M and Xu YJ:
ERK1/2 promotes cigarette smoke-induced rat pulmonary artery smooth
muscle cells proliferation and pulmonary vascular remodeling via
up-regulating cycline1 expression. J Huazhong Univ Sci Technolog
Med Sci. 33:315–322. 2013. View Article : Google Scholar : PubMed/NCBI
|
50
|
Chen XY, Dun JN, Miao QF and Zhang YJ:
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses
5-hydroxytryptamine-induced pulmonary artery smooth muscle cell
proliferation via JNK and ERK1/2 pathway. Pharmacology. 83:67–79.
2009. View Article : Google Scholar
|
51
|
Havrda MC, Johnson MJ, O'Neill CF and Liaw
L: A novel mechanism of transcriptional repression of 27kip1
through Notch/HRT2 signaling in vascular smooth muscle cells.
Thromb Haemost. 96:361–370. 2006.PubMed/NCBI
|
52
|
Guo Z, Qi W, Yu Y, Du S, Wu J and Liu J:
Effect of exenatide on the cardiac expression of adiponectin
receptor 1 and NADPH oxidase subunits and heart function in
streptozotocin-induced diabetic rats. Diabetol Metab Syndr.
6:292014. View Article : Google Scholar : PubMed/NCBI
|