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Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death

  • Authors:
    • Jie Yuan
    • Xin Guo
    • Zhengang Liu
    • Xiuqin Zhao
    • Yan Feng
    • Sixin Song
    • Changmeng Cui
    • Pei Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Institute of Mental Health, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China, Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China, Department of Neurosurgery, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China, Department of Neurology, Weixian People's Hospital, Xingtai, Hebei 054700, P.R. China, Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Neurosurgery, Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, P.R. China, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China, Department of Clinical Pharmacy and Pharmacology, Jining First People's Hospital, Jining Medical University, Jining, Shandong 272000, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 364-372
    |
    Published online on: November 9, 2017
       https://doi.org/10.3892/ijmm.2017.3249
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Abstract

Previous studies have demonstrated that global cerebral ischemia (GCI) causes neurological deficits and neuronal cell apoptosis. Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear vitamin D receptor. It is being assessed as an emerging therapeutic strategy in models of various medical conditions, including acute brain injury. The purpose of the present study was to investigate the neuroprotective effects of calcitriol on GCI and further refine the potential underlying mechanisms. A total of 145 male rats were assigned to 5 groups as follows: Sham group, GCI group, calcitriol treatment group, PD98059 treatment group and vehicle-treated group. Brain water content and neurologic severity score were assessed to evaluate the brain edema and neurological deficits of rats. Histopathological changes and ultrastructures of cells were observed via hematoxylin and eosin stain and transmission electron microscopy, respectively. Immunofluorescent staining and western blot analysis were used to assess the expression of proteins and their co-localization at the molecular level. The results demonstrated that post-GCI administration of calcitriol attenuated brain edema and improved neurological function in rats. Calcitriol also caused marked extracellular signal-regulated kinase 1/2 pathway activation, and thereby attenuated neuronal apoptosis. The present study provided novel clues for understanding the mechanisms by which calcitriol exerts its neuroprotective activity in a rat model of GCI.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan J, Guo X, Liu Z, Zhao X, Feng Y, Song S, Cui C and Jiang P: Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death. Int J Mol Med 41: 364-372, 2018.
APA
Yuan, J., Guo, X., Liu, Z., Zhao, X., Feng, Y., Song, S. ... Jiang, P. (2018). Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death. International Journal of Molecular Medicine, 41, 364-372. https://doi.org/10.3892/ijmm.2017.3249
MLA
Yuan, J., Guo, X., Liu, Z., Zhao, X., Feng, Y., Song, S., Cui, C., Jiang, P."Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death". International Journal of Molecular Medicine 41.1 (2018): 364-372.
Chicago
Yuan, J., Guo, X., Liu, Z., Zhao, X., Feng, Y., Song, S., Cui, C., Jiang, P."Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death". International Journal of Molecular Medicine 41, no. 1 (2018): 364-372. https://doi.org/10.3892/ijmm.2017.3249
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan J, Guo X, Liu Z, Zhao X, Feng Y, Song S, Cui C and Jiang P: Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death. Int J Mol Med 41: 364-372, 2018.
APA
Yuan, J., Guo, X., Liu, Z., Zhao, X., Feng, Y., Song, S. ... Jiang, P. (2018). Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death. International Journal of Molecular Medicine, 41, 364-372. https://doi.org/10.3892/ijmm.2017.3249
MLA
Yuan, J., Guo, X., Liu, Z., Zhao, X., Feng, Y., Song, S., Cui, C., Jiang, P."Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death". International Journal of Molecular Medicine 41.1 (2018): 364-372.
Chicago
Yuan, J., Guo, X., Liu, Z., Zhao, X., Feng, Y., Song, S., Cui, C., Jiang, P."Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death". International Journal of Molecular Medicine 41, no. 1 (2018): 364-372. https://doi.org/10.3892/ijmm.2017.3249
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