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Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice

  • Authors:
    • Jong‑Min Lim
    • Young Joon Lee
    • Hyung‑Rae Cho
    • Dong‑Chan Park
    • Go‑Woon Jung
    • Sae Kwang Ku
    • Jae‑Suk Choi
  • View Affiliations / Copyright

    Affiliations: Glucan Corporation, #305 Marine Bio‑Industry Development Center, Busan 46048, Republic of Korea, Department of Preventive Medicine, College of Korean Medicine, Daegu Haany University, Gyeongsan‑si, Gyeongsangbuk‑do 38610, Republic of Korea, Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan‑si, Gyeongsangbuk‑do 38610, Republic of Korea, Major in Food Biotechnology, Division of Bioindustry, College of Medical and Life Sciences, Silla University, Busan 46958, Republic of Korea
    Copyright: © Lim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1245-1264
    |
    Published online on: November 10, 2017
       https://doi.org/10.3892/ijmm.2017.3251
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Abstract

The present study assessed the beneficial skeletal muscle‑preserving effects of extracellular polysaccharides from Aureobasidium pullulans SM‑2001 (Polycan) (EAP) on dexamethasone (DEXA)‑induced catabolic muscle atrophy in mice. To investigate whether EAP prevented catabolic DEXA‑induced muscle atrophy, and to examine its mechanisms of action, EAP (100, 200 and 400 mg/kg) was administered orally, once a day for 24 days. EAP treatment was initiated 2 weeks prior to DEXA treatment (1 mg/kg, once a day for 10 days) in mice. Body weight alterations, serum biochemistry, calf thickness, calf muscle strength, gastrocnemius muscle thickness and weight, gastrocnemius muscle antioxidant defense parameters, gastrocnemius muscle mRNA expression, histology and histomorphometry were subsequently assessed. After 24 days, DEXA control mice exhibited muscle atrophy according to all criteria indices. However, these muscle atrophy symptoms were significantly inhibited by oral treatment with all three doses of EAP. Regarding possible mechanisms of action, EAP exhibited favorable ameliorating effects on DEXA‑induced catabolic muscle atrophy via antioxidant and anti‑inflammatory effects; these effects were mediated by modulation of the expression of genes involved in muscle protein synthesis (AKT serine/threonine kinase 1, phosphatidylinositol 3‑kinase, adenosine A1 receptor and transient receptor potential cation channel subfamily V member 4) and degradation (atrogin‑1, muscle RING‑finger protein‑1, myostatin and sirtuin 1). Therefore, these results indicated that EAP may be helpful in improving muscle atrophies of various etiologies. EAP at 400 mg/kg exhibited favorable muscle protective effects against DEXA‑induced catabolic muscle atrophy, comparable with the effects of oxymetholone (50 mg/kg), which has been used to treat various muscle disorders.
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1 

Brooks SV and Faulkner JA: Skeletal muscle weakness in old age: Underlying mechanisms. Med Sci Sports Exerc. 26:432–439. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ and Roubenoff R: Aging of skeletal muscle: A 12-yr longitudinal study. J Appl Physiol. 88:1321–1326. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Metter EJ, Talbot LA, Schrager M and Conwit R: Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 57:B359–B365. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Glass DJ: Molecular mechanisms modulating muscle mass. Trends Mol Med. 9:344–350. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, et al: Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 294:1704–1708. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Glass DJ: Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol. 37:1974–1984. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Ramírez C, Russo TL, Sandoval MC, Dentillo AA, Couto MA, Durigan JL and Salvini TF: Joint inflammation alters gene and protein expression and leads to atrophy in the tibialis anterior muscle in rats. Am J Phys Med Rehabil. 90:930–939. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Hofer T, Marzetti E, Xu J, Seo AY, Gulec S, Knutson MD, Leeuwenburgh C and Dupont-Versteegden EE: Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Exp Gerontol. 43:563–570. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Onda A, Jiao Q, Nagano Y, Akimoto T, Miyamoto T, Minamisawa S and Fukubayashi T: Acupuncture ameliorated skeletal muscle atrophy induced by hindlimb suspension in mice. Biochem Biophys Res Commun. 410:434–439. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Booth FW: Physiologic and biochemical effects of immobilization on muscle. Clin orthop Relat Res. 219:15–20. 1987.

11 

Thomas DR: Loss of skeletal muscle mass in aging: Examining the relationship of starvation, sarcopenia and cachexia. Clin Nutr. 26:389–399. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Léger B, Senese R, Al-Khodairy AW, Dériaz O, Gobelet C, Giacobino JP and Russell AP: Atrogin-1, MuRF1, and FoXo, as well as phosphorylated GSK-3beta and 4EBP1 are reduced in skeletal muscle of chronic spinal cord-injured patients. Muscle Nerve. 40:69–78. 2009. View Article : Google Scholar

13 

Kawano F, Tanihata J, Sato S, Nomura S, Shiraishi A, Tachiyashiki K and Imaizumi K: Effects of dexamethasone on the expression of beta(1)-, beta (2)- and beta (3)-adrenoceptor mRNAs in skeletal and left ventricle muscles in rats. J Physiol Sci. 59:383–390. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Dardevet D, Sornet C, Savary I, Debras E, Patureau-Mirand P and Grizard J: Glucocorticoid effects on insulin- and IGF-I-regulated muscle protein metabolism during aging. J Endocrinol. 156:83–89. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Kanda F, Takatani K, Okuda S, Matsushita T and Chihara K: Preventive effects of insulinlike growth factor-I on steroid-induced muscle atrophy. Muscle Nerve. 22:213–217. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Gilson H, Schakman O, Combaret L, Lause P, Grobet L, Attaix D, Ketelslegers JM and Thissen JP: Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology. 148:452–460. 2007. View Article : Google Scholar

17 

Auclair D, Garrel DR, Chaouki Zerouala A and Ferland LH: Activation of the ubiquitin pathway in rat skeletal muscle by catabolic doses of glucocorticoids. Am J Physiol. 272:C1007–C1016. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Hasselgren PO: Glucocorticoids and muscle catabolism. Curr Opin Clin Nutr Metab Care. 2:201–205. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Komamura K, Shirotani-Ikejima H, Tatsumi R, Tsujita-Kuroda Y, Kitakaze M, Miyatake K, Sunagawa K and Miyata T: Differential gene expression in the rat skeletal and heart muscle in glucocorticoid-induced myopathy: Analysis by microarray. Cardiovasc Drugs Ther. 17:303–310. 2003. View Article : Google Scholar : PubMed/NCBI

20 

McPherron AC, Lawler AM and Lee SJ: Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature. 387:83–90. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Qin J, Du R, Yang YQ, Zhang HQ, Li Q, Liu L, Guan H, Hou J and An XR: Dexamethasone-induced skeletal muscle atrophy was associated with upregulation of myostatin promoter activity. Res Vet Sci. 94:84–89. 2013. View Article : Google Scholar

22 

Allen DL, Bandstra ER, Harrison BC, Thorng S, Stodieck LS, Kostenuik PJ, Morony S, Lacey DL, Hammond TG, Leinwand LL, et al: Effects of spaceflight on murine skeletal muscle gene expression. J Appl Physiol 1985. 106:582–595. 2009. View Article : Google Scholar :

23 

Dirks-Naylor AJ and Griffiths CL: Glucocorticoid-induced apoptosis and cellular mechanisms of myopathy. J Steroid Biochem Mol Biol. 117:1–7. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Orzechowski A, Ostaszewski P, Wilczak J, Jank M, Bałasińska B, Wareski P and Fuller J Jr: Rats with a glucocorticoid-induced catabolic state show symptoms of oxidative stress and spleen atrophy: The effects of age and recovery. J Vet Med A Physiol Pathol Clin Med. 49:256–263. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Alamdari N, Aversa Z, Castillero E, Gurav A, Petkova V, Tizio S and Hasselgren PO: Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Biochem Biophys Res Commun. 417:528–533. 2012. View Article : Google Scholar :

26 

Kim JW, Ku SK, Han MH, Kim KY, Kim SG, Kim GY, Hwang HJ, Kim BW, Kim CM and Choi YH: The administration of Fructus Schisandrae attenuates dexamethasone-induced muscle atrophy in mice. Int J Mol Med. 36:29–42. 2015a. View Article : Google Scholar

27 

Benveniste O, Jacobson L, Farrugia ME, Clover L and Vincent A: MuSK antibody positive myasthenia gravis plasma modifies MURF-1 expression in C2C12 cultures and mouse muscle in vivo. J Neuroimmunol. 170:41–48. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Jones A, Hwang DJ, Narayanan R, Miller DD and Dalton JT: Effects of a novel selective androgen receptor modulator on dexa-methasone-induced and hypogonadism-induced muscle atrophy. Endocrinology. 151:3706–3719. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Yang Z, Nakagawa K, Sarkar A, Maruyama J, Iwasa H, Bao Y, Ishigami-Yuasa M, Ito S, Kagechika H, Hata S, et al: Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol Cell Biol. 34:1607–1621. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Ringold HJ, Batres E, Halpern O and Necoechea E: Steroids. CV. 12-Methyl and 2-hydroxymethylene-androstane derivatives. J Am Chem Soc. 81:427–432. 1959. View Article : Google Scholar

31 

Lennon HD: Effects of various 17-alpha-alkyl substitutions and structural modifications of steroids on sulfobromophthalein (BSP) retention in rabbits. Steroids. 7:157–170. 1966. View Article : Google Scholar : PubMed/NCBI

32 

Dorfman RI and Kincl FA: Relative potency of steroids in an anabolic-androgenic assay using the castrated rat. Endocrinology. 72:259–266. 1963. View Article : Google Scholar

33 

Pavlatos AM, Fultz O, Monberg MJ and Vootkur A: Review of oxymetholone: A 17alpha-alkylated anabolic-androgenic steroid. Clin Ther. 23:789–801; discussion 771. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Isaacs J, Loveland K, Mallu S, Adams S and Wodicka R: The use of anabolic steroids as a strategy in reversing denervation atrophy after delayed nerve repair. Hand (NY). 6:142–148. 2011. View Article : Google Scholar

35 

Kim JW, Ku SK, Kim KY, Kim SG, Han MH, Kim GY, Hwang HJ, Kim BW, Kim CM and Choi YH: Schisandrae Fructus supplementation ameliorates sciatic neurectomy-induced muscle atrophy in mice. Oxid Med Cell Longev. 2015:8724282015. View Article : Google Scholar : PubMed/NCBI

36 

Young GP, Bhathal PS, Sullivan JR, Wall AJ, Fone DJ and Hurley TH: Fatal hepatic coma complicating oxymetholone therapy in multiple myeloma. Aust N Z J Med. 7:47–51. 1977. View Article : Google Scholar : PubMed/NCBI

37 

Wood P and Yin JA: Oxymetholone hepatotoxicity enhanced by concomitant use of cyclosporin A in a bone marrow transplant patient. Clin Lab Haematol. 16:201–204. 1994. View Article : Google Scholar : PubMed/NCBI

38 

Walker ID, Davidson JF, Young P and Conkie JA: Plasma fibrinolytic activity following oral anabolic steroid therapy. Thromb Diath Haemorrh. 34:236–245. 1975.PubMed/NCBI

39 

Tzianabos AO: Polysaccharide immunomodulators as therapeutic agents: Structural aspects and biologic function. Clin Microbiol Rev. 13:523–533. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Estrada A, Yun CH, Van Kessel A, Li B, Hauta S and Laarveld B: Immunomodulatory activities of oat beta-glucan in vitro and in vivo. Microbiol Immunol. 41:991–998. 1997. View Article : Google Scholar : PubMed/NCBI

41 

Lotzová E and Gutterman JU: Effect of glucan on natural killer (NK) cells: Further comparison between NK cell and bone marrow effector cell activities. J Immunol. 123:607–611. 1979.PubMed/NCBI

42 

Hofer M and Pospísil M: Glucan as stimulator of hematopoiesis in normal and gamma-irradiated mice. A survey of the authors’ results. Int J Immunopharmacol. 19:607–609. 1997. View Article : Google Scholar

43 

Lee JN, Lee DY, Ji IH, Kim GE, Kim HN, Sohn J, Kim S and Kim CW: Purification of soluble beta-glucan with immune-enhancing activity from the cell wall of yeast. Biosci Biotechnol Biochem. 65:837–841. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Benach JL, Habicht GS, Holbrook TW and Cook JA: Glucan as an adjuvant for a murine Babesia microti immunization trial. Infect Immun. 35:947–951. 1982.PubMed/NCBI

45 

Yoon HS, Kim JW, Cho HR, Moon SB, Shin HD, Yang KJ, Lee HS, Kwon YS and Ku SK: Immunomodulatory effects of Aureobasidium pullulans SM-2001 exopolymers on the cyclo-phosphamide-treated mice. J Microbiol Biotechnol. 20:438–445. 2010.PubMed/NCBI

46 

Jung MY, Kim JW, Kim KY, Choi SH and Ku SK: Polycan, a β-glucan from Aureobasidium pullulans SM-2001, mitigates ovariectomy-induced osteoporosis in rats. Exp Ther Med. 12:1251–1262. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Kim HD, Cho HR, Moon SB, Shin HD, Yang KJ, Park BR, Jang HJ, Kim LS, Lee HS and Ku SK: Effects of β-glucan from Aureobasidium pullulans on acute inflammation in mice. Arch Pharm Res. 30:323–328. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Kim HD, Cho HR, Moon SB, Shin HD, Yang KJ, Park BR, Jang HJ, Kim LS, Lee HS and Ku SK: Effect of Exopolymers from Aureobasidum pullulans on formalin-induced chronic paw inflammation in mice. J Microbiol Biotechnol. 16:1954–1960. 2006.

49 

Ku SK, Lee YJ, Lee SD, Cho HR, Moon SB, Kim KY, Kwon YS and Kim JW: Nephroprotective effect of Polycan on acute renal failure induced by cisplatin in rats. ISRN Vet Sci. 2012:8621042012. View Article : Google Scholar : PubMed/NCBI

50 

Ku SK, Kim JW, Cho HR, Kim KY, Min YH, Park JH, Kim JS, Park JH, Seo BI and Roh SS: Effect of β-glucan originated from Aureobasidium pullulans on asthma induced by ovalbumin in mouse. Arch Pharm Res. 35:1073–1081. 2012a. View Article : Google Scholar

51 

Kim JW, Cho HR and Ku SK: Efficacy test of Polycan, a beta-glucan originated from Aureobasidium pullulans SM-2001, on anterior cruciate ligament transection and partial medial meniscectomy-induced-osteoarthritis rats. J Microbiol Biotechnol. 22:274–282. 2012a. View Article : Google Scholar

52 

Kim YS, Kang SJ, Kim JW, Cho HR, Moon SB, Kim KY, Lee HS, Han CH, Ku SK and Lee YJ: Effects of Polycan, a β-glucan, on experimental periodontitis and alveolar bone loss in Sprague-Dawley rats. J Periodontal Res. 47:800–810. 2012b. View Article : Google Scholar

53 

Seo HP, Kim JM, Shin HD, Kim TK, Chang HJ, Park BR and Lee JW: Production of β-1,3/1,6-glucan by Aureobasidium pullulans SM-2001. Korean J Bitechnol Bioeng. 17:376–380. 2002.

54 

Del Rio D, Stewart AJ and Pellegrini N: A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 15:316–328. 2005. View Article : Google Scholar : PubMed/NCBI

55 

Jamall IS and Smith JC: Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: A possible mechanism of cadmium cardiotoxicity. Toxicol Appl Pharmacol. 80:33–42. 1985. View Article : Google Scholar : PubMed/NCBI

56 

Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–275. 1951.PubMed/NCBI

57 

He HJ, Wang GY, Gao Y, Ling WH, Yu ZW and Jin TR: Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice. World J Diabetes. 3:94–104. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Sedlak J and Lindsay RH: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem. 25:192–205. 1968. View Article : Google Scholar : PubMed/NCBI

59 

Aebi H: Catalase. Methods in Enzymatic Analysis. Bergmeyer HU: Academic Press; New York, NY: pp. 673–686. 1974, View Article : Google Scholar

60 

Sun Y, Oberley LW and Li Y: A simple method for clinical assay of superoxide dismutase. Clin Chem. 34:497–500. 1988.PubMed/NCBI

61 

Yokoyama U, Minamisawa S, Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, et al: Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A. J Biol Chem. 283:28702–28709. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the the 2−ΔΔCt method. Methods. 25:402–408. 2001. View Article : Google Scholar

63 

Ogawa T, Nikawa T, Furochi H, Kosyoji M, Hirasaka K, Suzue N, Sairyo K, Nakano S, Yamaoka T, Itakura M, et al: Osteoactivin upregulates expression of MMP-3 and MMP-9 in fibroblasts infiltrated into denervated skeletal muscle in mice. Am J Physiol Cell Physiol. 289:C697–C707. 2005. View Article : Google Scholar : PubMed/NCBI

64 

Tipoe GL, Leung TM, Liong EC, Lau TY, Fung ML and Nanji AA: Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology. 273:45–52. 2010. View Article : Google Scholar : PubMed/NCBI

65 

Shi SR, Chaiwun B, Young L, Cote RJ and Taylor CR: Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections. J Histochem Cytochem. 41:1599–1604. 1993. View Article : Google Scholar : PubMed/NCBI

66 

Levene A: Pathological factors influencing excision of tumours in the head and neck. Part I. Clin Otolaryngol Allied Sci. 6:145–151. 1981. View Article : Google Scholar : PubMed/NCBI

67 

Ludbrook J: Update: Microcomputer statistics packages. A personal view. Clin Exp Pharmacol Physiol. 24:294–296. 1997. View Article : Google Scholar : PubMed/NCBI

68 

Jackman RW and Kandarian SC: The molecular basis of skeletal muscle atrophy. Am J Physiol Cell Physiol. 287:C834–C843. 2004. View Article : Google Scholar : PubMed/NCBI

69 

Sandri M: Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda). 23:160–170. 2008.

70 

Glass DJ: Signaling pathways perturbing muscle mass. Curr Opin Clin Nutr Metab Care. 13:225–229. 2010. View Article : Google Scholar : PubMed/NCBI

71 

Powers SK, Kavazis AN and McClung JM: Oxidative stress and disuse muscle atrophy. J Appl Physiol 1985. 102:2389–2397. 2007. View Article : Google Scholar : PubMed/NCBI

72 

Arakawa T, Katada A, Shigyo H, Kishibe K, Adachi M, Nonaka S and Harabuchi Y: Electrical stimulation prevents apoptosis in denervated skeletal muscle. NeuroRehabilitation. 27:147–154. 2010.PubMed/NCBI

73 

Lim JY and Han TR: Effect of electromyostimulation on apoptosis-related factors in denervation and reinnervation of rat skeletal muscles. Muscle Nerve. 42:422–430. 2010. View Article : Google Scholar : PubMed/NCBI

74 

Mastagllia FL: Drug induced myopathies. Pract Neurol. 6:4–13. 2006. View Article : Google Scholar

75 

Seale JP and Compton MR: Side-effects of corticosteroid agents. Med J Aust. 144:139–142. 1986.PubMed/NCBI

76 

Zoorob RJ and Cender D: A different look at corticosteroids. Am Fam Physician. 58:443–450. 1998.PubMed/NCBI

77 

Bowyer SL, LaMothe MP and Hollister JR: Steroid myopathy: Incidence and detection in a population with asthma. J Allergy Clin Immunol. 76:234–242. 1985. View Article : Google Scholar : PubMed/NCBI

78 

Covar RA, Leung DY, McCormick D, Steelman J, Zeitler P and Spahn JD: Risk factors associated with glucocorticoid-induced adverse effects in children with severe asthma. J Allergy Clin Immunol. 106:651–659. 2000. View Article : Google Scholar : PubMed/NCBI

79 

Owczarek J, Jasińska M and Orszulak-Michalak D: Drug-induced myopathies. An overview of the possible mechanisms. Pharmacol Rep. 57:23–34. 2005.PubMed/NCBI

80 

Fox JG, Cohen BJ and Loew FM: Laboratory animal medicine. Academic Press Inc.; Orlando, Fl: 1984

81 

Tajima Y: Biological reference data book on experimental animals. Soft Science Inc.; Tokyo: 1989

82 

Gupta AK and Chow M: Prednicarbate (Dermatop): Profile of a corticosteroid. J Cutan Med Surg. 8:244–247. 2004. View Article : Google Scholar

83 

Cho YH, Chung IK, Cheon WH, Lee HS and Ku SK: Effect of DHU001, a polyherbal formula on formalin-induced paw chronic inflammation of mice. Toxicol Res. 27:95–102. 2011. View Article : Google Scholar : PubMed/NCBI

84 

Lee HS, Yang KJ, Shin HD, Park BR, Son CW, Jang HJ, Park DC, Jung YM and Ku SK: Single oral dose toxicity studies of Polycan, β-glucan originated from Aureobasidium in mice. Toxicol Res. 21:361–365. 2005.

85 

Duarte CG, dos Santos GL, Azzolini AE and de Assis Pandochi AI: The effect of the antithyroid drug propylthiouracil on the alternative pathway of complement in rats. Int J Immunopharmacol. 22:25–33. 2000. View Article : Google Scholar : PubMed/NCBI

86 

Pinzone JJ, Fox ML, Sastry MK, Parenti DM and Simon GL: Plasma leptin concentration increases early during highly active antiretroviral therapy for acquired immunodeficiency syndrome, independent of body weight. J Endocrinol Invest. 28:RC1–RC3. 2005. View Article : Google Scholar : PubMed/NCBI

87 

Hengge UR, Baumann M, Maleba R, Brockmeyer NH and Goos M: Oxymetholone promotes weight gain in patients with advanced human immunodeficiency virus (HIV-1) infection. Br J Nutr. 75:129–138. 1996. View Article : Google Scholar : PubMed/NCBI

88 

Hengge UR, Stocks K, Faulkner S, Wiehler H, Lorenz C, Jentzen W, Hengge D and Ringham G: Oxymetholone for the treatment of HIV-wasting: A double-blind, randomized, placebo-controlled phase III trial in eugonadal men and women. HIV Clin Trials. 4:150–163. 2003.PubMed/NCBI

89 

Hengge UR, Stocks K, Wiehler H, Faulkner S, Esser S, Lorenz C, Jentzen W, Hengge D, Goos M, Dudley RE, et al: Double-blind, randomized, placebo-controlled phase III trial of oxymetholone for the treatment of HIV wasting. AIDS. 17:699–710. 2003. View Article : Google Scholar : PubMed/NCBI

90 

Wyss M and Kaddurah-Daouk R: Creatine and creatinine metabolism. Physiol Rev. 80:1107–1213. 2000. View Article : Google Scholar : PubMed/NCBI

91 

Hunter A: The biological distribution of creatine and creatinine. Creatine and Creatinine. Longmans; Green, London: pp. 73–113. 1928

92 

Balsom PD, Söderlund K and Ekblom B: Creatine in humans with special reference to creatine supplementation. Sports Med. 18:268–280. 1994. View Article : Google Scholar : PubMed/NCBI

93 

Fitch CD, Lucy DD, Bornhofen JH and Dalrymple GV: Creatine metabolism in skeletal muscle. II. Creatine kinetics in man. Neurology. 18:32–42. 1968. View Article : Google Scholar : PubMed/NCBI

94 

Bloch K and Schoenheimer R: Studies in protein metabolism. XI. The metabolic relation of creatine and creatinine studies with isotopic nitrogen. J Biol Chem. 131:111–119. 1939.

95 

Heymsfield SB, Arteaga C, McManus C, Smith J and Moffitt S: Measurement of muscle mass in humans: Validity of the 24-hour urinary creatinine method. Am J Clin Nutr. 37:478–494. 1983. View Article : Google Scholar : PubMed/NCBI

96 

Sala A, Tarnopolsky M, Webber C, Norman G and Barr R: Serum creatinine: A surrogate measurement of lean body mass in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 45:16–19. 2005. View Article : Google Scholar : PubMed/NCBI

97 

Stimpson SA, Turner SM, Clifton LG, Poole JC, Mohammed HA, Shearer TW, Waitt GM, Hagerty LL, Remlinger KS, Hellerstein MK, et al: Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats. J Appl Physiol 1985. 112:1940–1948. 2012. View Article : Google Scholar : PubMed/NCBI

98 

Zhang Y, Huang JJ, Wang ZQ, Wang N and Wu ZY: Value of muscle enzyme measurement in evaluating different neuro-muscular diseases. Clin Chim Acta. 413:520–524. 2012. View Article : Google Scholar

99 

Choi M, Park H, Cho S and Lee M: Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats. Cytokine. 63:27–35. 2013. View Article : Google Scholar : PubMed/NCBI

100 

Cohen I, Bogin E, Chechick A and Rzetelny V: Biochemical alterations secondary to disuse atrophy in the rat’s serum and limb tissues. Arch Orthop Trauma Surg. 119:410–417. 1999. View Article : Google Scholar

101 

Pellegrino MA, D’Antona G, Bortolotto S, Boschi F, Pastoris O, Bottinelli R, Polla B and Reggiani C: Clenbuterol antagonizes glucocorticoid-induced atrophy and fibre type transformation in mice. Exp Physiol. 89:89–100. 2004. View Article : Google Scholar : PubMed/NCBI

102 

Comporti M: Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest. 53:599–623. 1985.PubMed/NCBI

103 

Gore M, Fiebig R, Hollander J, Leeuwenburgh C, Ohno H and Ji LL: Endurance training alters antioxidant enzyme gene expression in rat skeletal muscle. Can J Physiol Pharmacol. 76:1139–1145. 1998. View Article : Google Scholar

104 

Süleyman H, Cadirci E, Albayrak A, Polat B, Halici Z, Koc F, Hacimuftuoglu A and Bayir Y: Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats. Chem Biol Interact. 180:318–324. 2009. View Article : Google Scholar : PubMed/NCBI

105 

Chen JH, Tipoe GL, Liong EC, So HS, Leung KM, Tom WM, Fung PC and Nanji AA: Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants. Am J Clin Nutr. 80:742–751. 2004. View Article : Google Scholar : PubMed/NCBI

106 

Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q and Chen C: Nitrotyrosine and chlorotyrosine: Clinical significance and biological functions in the vascular system. J Surg Res. 133:143–149. 2006. View Article : Google Scholar

107 

Pacher P, Beckman JS and Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 87:315–424. 2007. View Article : Google Scholar : PubMed/NCBI

108 

Salvini TF, Durigan JL, Peviani SM and Russo TL: Effects of electrical stimulation and stretching on the adaptation of denervated skeletal muscle: Implications for physical therapy. Rev Bras Fisioter. 16:175–183. 2012. View Article : Google Scholar : PubMed/NCBI

109 

Delgado J, Saborido A and Megías A: Prolonged treatment with the anabolic-androgenic steroid stanozolol increases antioxidant defences in rat skeletal muscle. J Physiol Biochem. 66:63–71. 2010. View Article : Google Scholar : PubMed/NCBI

110 

Yoo YE and Ko CP: Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice. PLoS One. 7:e372582012. View Article : Google Scholar : PubMed/NCBI

111 

Nuñez G, Benedict MA, Hu Y and Inohara N: Caspases: The proteases of the apoptotic pathway. Oncogene. 17:3237–3245. 1998. View Article : Google Scholar

112 

Barrett KL, Willingham JM, Garvin AJ and Willingham MC: Advances in cytochemical methods for detection of apoptosis. J Histochem Cytochem. 49:821–832. 2001. View Article : Google Scholar : PubMed/NCBI

113 

Dam AD, Mitchell AS, Rush JW and Quadrilatero J: Elevated skeletal muscle apoptotic signaling following glutathione depletion. Apoptosis. 17:48–60. 2012. View Article : Google Scholar

114 

Yen YP, Tsai KS, Chen YW, Huang CF, Yang RS and Liu SH: Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Arch Toxicol. 86:923–933. 2012. View Article : Google Scholar : PubMed/NCBI

115 

Gomes MD, Lecker SH, Jagoe RT, Navon A and Goldberg AL: Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci USA. 98:14440–14445. 2001. View Article : Google Scholar : PubMed/NCBI

116 

Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E and Goldberg AL: During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 185:1083–1095. 2009. View Article : Google Scholar : PubMed/NCBI

117 

Berne RM, Knabb RM, Ely SW and Rubio R: Adenosine in the local regulation of blood flow: A brief overview. Fed Proc. 42:3136–3142. 1983.PubMed/NCBI

118 

Segal SS and Kurjiaka DT: Coordination of blood flow control in the resistance vasculature of skeletal muscle. Med Sci Sports Exerc. 27:1158–1164. 1995. View Article : Google Scholar : PubMed/NCBI

119 

Hespel P and Richter EA: Role of adenosine in regulation of carbohydrate metabolism in contracting muscle. Skeletal Muscle Metabolism in Exercise and Diabetes. Richter EA, Kiens B, Galbo H and Saltin B: Plenum Press; New York, NY: pp. 97–106. 1998, View Article : Google Scholar

120 

Dobson JG Jr, Rubio R and Berne RM: Role of adenine nucleotides, adenosine, and inorganic phosphate in the regulation of skeletal muscle blood flow. Circ Res. 29:375–384. 1971. View Article : Google Scholar : PubMed/NCBI

121 

Vergauwen L, Hespel P and Richter EA: Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J Clin Invest. 93:974–981. 1994. View Article : Google Scholar : PubMed/NCBI

122 

Lynge J and Hellsten Y: Distribution of adenosine A1, A2A and A2B receptors in human skeletal muscle. Acta Physiol Scand. 169:283–290. 2000. View Article : Google Scholar : PubMed/NCBI

123 

Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD and Julius D: The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature. 389:816–824. 1997. View Article : Google Scholar : PubMed/NCBI

124 

Guilak F, Leddy HA and Liedtke W: Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Ann N Y Acad Sci. 1192:404–409. 2010. View Article : Google Scholar : PubMed/NCBI

125 

Mizoguchi F, Mizuno A, Hayata T, Nakashima K, Heller S, Ushida T, Sokabe M, Miyasaka N, Suzuki M, Ezura Y, et al: Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss. J Cell Physiol. 216:47–53. 2008. View Article : Google Scholar : PubMed/NCBI

126 

Michishita E, Park JY, Burneskis JM, Barrett JC and Horikawa I: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 16:4623–4635. 2005. View Article : Google Scholar : PubMed/NCBI

127 

Haigis MC and Guarente LP: Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20:2913–2921. 2006. View Article : Google Scholar : PubMed/NCBI

128 

Amat R, Planavila A, Chen SL, Iglesias R, Giralt M and Villarroya F: SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD. J Biol Chem. 284:21872–21880. 2009. View Article : Google Scholar : PubMed/NCBI

129 

Toledo M, Busquets S, Ametller E, López-Soriano FJ and Argilés JM: Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats: A role in impaired regeneration? J Cachexia Sarcopenia Muscle. 2:57–62. 2011. View Article : Google Scholar : PubMed/NCBI

130 

Amat R, Solanes G, Giralt M and Villarroya F: SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription. J Biol Chem. 282:34066–34076. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lim JM, Lee Y, Cho HR, Park DC, Jung GW, Ku S and Choi JS: Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice. Int J Mol Med 41: 1245-1264, 2018.
APA
Lim, J., Lee, Y., Cho, H., Park, D., Jung, G., Ku, S., & Choi, J. (2018). Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice. International Journal of Molecular Medicine, 41, 1245-1264. https://doi.org/10.3892/ijmm.2017.3251
MLA
Lim, J., Lee, Y., Cho, H., Park, D., Jung, G., Ku, S., Choi, J."Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice". International Journal of Molecular Medicine 41.3 (2018): 1245-1264.
Chicago
Lim, J., Lee, Y., Cho, H., Park, D., Jung, G., Ku, S., Choi, J."Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice". International Journal of Molecular Medicine 41, no. 3 (2018): 1245-1264. https://doi.org/10.3892/ijmm.2017.3251
Copy and paste a formatted citation
x
Spandidos Publications style
Lim JM, Lee Y, Cho HR, Park DC, Jung GW, Ku S and Choi JS: Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice. Int J Mol Med 41: 1245-1264, 2018.
APA
Lim, J., Lee, Y., Cho, H., Park, D., Jung, G., Ku, S., & Choi, J. (2018). Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice. International Journal of Molecular Medicine, 41, 1245-1264. https://doi.org/10.3892/ijmm.2017.3251
MLA
Lim, J., Lee, Y., Cho, H., Park, D., Jung, G., Ku, S., Choi, J."Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice". International Journal of Molecular Medicine 41.3 (2018): 1245-1264.
Chicago
Lim, J., Lee, Y., Cho, H., Park, D., Jung, G., Ku, S., Choi, J."Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice". International Journal of Molecular Medicine 41, no. 3 (2018): 1245-1264. https://doi.org/10.3892/ijmm.2017.3251
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