Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2018 Volume 41 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 41 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells

  • Authors:
    • Xiao Yin
    • Zhaobin Zeng
    • Jinliang Xing
    • Ansheng Zhang
    • Wenkai Jiang
    • Wei Wang
    • Hantang Sun
    • Longxing Ni
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Stomatology, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110015, P.R. China, Preclinical Medical Teaching Experimental Center, School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 331-339
    |
    Published online on: November 13, 2017
       https://doi.org/10.3892/ijmm.2017.3254
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Substantial evidence has indicated that Notch and bone morphogenetic protein (BMP) signaling may regulate odontoblastic differentiation. Hairy/enhancer‑of‑split related with YRPW motif 1 (Hey1), a downstream target gene of Notch and BMP signaling, is expressed in dental pulp tissues and has been demonstrated to be responsible for osteoblast mineralization. The aim of this study was to investigate the effects of Hey1 on odontoblast differentiation. The results of the study demonstrated that Hey1 expression in odontoblast‑lineage cells (OLCs) was upregulated by stimulation of osteoblastic/odontoblastic differentiation medium containing ascorbic acid, β‑glycerol phosphate and dexamethasone. Furthermore, stable Hey1‑overexpressing cells expressed higher levels of dentin sialophosphoprotein (DSPP) and exhibited higher mineralization capabilities following stimulation by differentiation medium. Furthermore, RNA interference‑mediated knockdown of Hey1 downregulated the expression levels of DSPP in OLCs stimulated by differentiation medium. Taken together, the findings indicate that Hey1 may be a positive regulator of odontoblastic differentiation. The present study broadens the understanding of odontoblast differentiation and biomineralization.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ruch JV, Lesot H and Bègue-Kirn C: Odontoblast differentiation. Int J Dev Biol. 39:51–68. 1995.PubMed/NCBI

2 

Artavanis-Tsakonas S, Rand MD and Lake RJ: Notch signaling: Cell fate control and signal integration in development. Science. 284:770–776. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Mitsiadis TA, Lardelli M, Lendahl U and Thesleff I: Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J Cell Biol. 130:407–418. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Cai X, Gong P, Huang Y and Lin Y: Notch signalling pathway in tooth development and adult dental cells. Cell Prolif. 44:495–507. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Løvschall H, Tummers M, Thesleff I, Füchtbauer EM and Poulsen K: Activation of the Notch signaling pathway in response to pulp capping of rat molars. Eur J Oral Sci. 113:312–317. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Mitsiadis TA, Fried K and Goridis C: Reactivation of Delta-Notch signaling after injury: Complementary expression patterns of ligand and receptor in dental pulp. Exp Cell Res. 246:312–318. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Wang X, He F, Tan Y, Tian W and Qiu S: Inhibition of Delta1 promotes differentiation of odontoblasts and inhibits proliferation of human dental pulp stem cell in vitro. Arch Oral Biol. 56:837–845. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Zhang C, Chang J, Sonoyama W, Shi S and Wang CY: Inhibition of human dental pulp stem cell differentiation by Notch signaling. J Dent Res. 87:250–255. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Yang W, Harris MA, Cui Y, Mishina Y, Harris SE and Gluhak-Heinrich J: Bmp2 is required for odontoblast differentiation and pulp vasculogenesis. J Dent Res. 91:58–64. 2012. View Article : Google Scholar :

10 

Cho YD, Yoon WJ, Woo KM, Baek JH, Park JC and Ryoo HM: The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. J Biol Chem. 285:36369–36376. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Washio A, Kitamura C, Morotomi T, Terashita M and Nishihara T: Possible involvement of Smad signaling pathways ininduction of odontoblastic properties in KN-3 cells by bone morphogenetic protein-2: A growth factor to induce dentin regeneration. Int J Dent. 2012:2584692012. View Article : Google Scholar

12 

Zhang W, Zhang X, Ling J, Liu W, Zhang X, Ma J and Zheng J: Proliferation and odontogenic differentiation of BMP2 gene transfected stem cells from human tooth apical papilla: An in vitro study. Int J Mol Med. 34:1004–1012. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yang X, van der Kraan PM, van den Dolder J, Walboomers XF, Bian Z, Fan M and Jansen JA: STRO-1 selected rat dental pulp stem cells transfected with adenoviral-mediated human bone morphogenetic protein 2 gene show enhanced odontogenic differentiation. Tissue Eng. 13:2803–2812. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Iso T, Kedes L and Hamamori Y: HES and HERP families: Multiple effectors of the Notch signaling pathway. J Cell Physiol. 194:237–255. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Zavadil J, Cermak L, Soto-Nieves N and Böttinger EP: Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J. 23:1155–1165. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Wöltje K, Jabs M and Fischer A: Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS One. 10:e01205472015. View Article : Google Scholar : PubMed/NCBI

17 

Salie R, Kneissel M, Vukevic M, Zamurovic N, Kramer I, Evans G, Gerwin N, Mueller M, Kinzel B and Susa M: Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone. Bone. 46:680–694. 2010. View Article : Google Scholar

18 

Sakamoto M, Hirata H, Ohtsuka T, Bessho Y and Kageyama R: The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem. 278:44808–44815. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Kokubo H, Tomita-Miyagawa S, Hamada Y and Saga Y: Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development. 134:747–755. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Buas MF, Kabak S and Kadesch T: The Notch effector Hey1 associates with myogenic target genes to repress myogenesis. J Biol Chem. 285:1249–1258. 2010. View Article : Google Scholar :

21 

Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, Hamamori Y, Kedes L, Kato M and ten Dijke Pt P: Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 23:541–551. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Sun H, Kawashima N, Xu J, Takahashi S and Suda H: Expression of Notch signalling-related genes in normal and differentiating rat dental pulp cells. Aust Endod J. 36:54–58. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Sharff KA, Song WX, Luo X, Tang N, Luo J, Chen J, Bi Y, He BC, Huang J, Li X, et al: Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J Biol Chem. 284:649–659. 2009. View Article : Google Scholar :

24 

Zamurovic N, Cappellen D, Rohner D and Susa M: Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. J Biol Chem. 279:37704–37715. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Arany S, Nakata A, Kameda T, Koyota S, Ueno Y and Sugiyama T: Phenotype properties of a novel spontaneously immortalized odontoblast-lineage cell line. Biochem Biophys Res Commun. 342:718–724. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Wang H, Kawashima N, Iwata T, Xu J, Takahashi S, Sugiyama T and Suda H: Differentiation of odontoblasts is negatively regulated by MEPE via its C-terminal fragment. Biochem Biophys Res Commun. 398:406–412. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Han N, Zheng Y, Li R, Li X, Zhou M, Niu Y and Zhang Q: β-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2. PLoS One. 9:e888902014. View Article : Google Scholar

28 

Salmon B, Bardet C, Khaddam M, Naji J, Coyac BR, Baroukh B, Letourneur F, Lesieur J, Decup F, Le Denmat D, et al: MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemia. PLoS One. 8:e567492013. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

30 

Zeng Z, Yin X, Zhang X, Jing D and Feng X: Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1. Int J Mol Med. 36:1273–1281. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Xu J, Yu B, Hong C and Wang CY: KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells. Int J Oral Sci. 5:200–205. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Chen Z, Li W, Wang H, Wan C, Luo D, Deng S, Chen H and Chen S: Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes. Cell Tissue Res. 363:385–398. 2016. View Article : Google Scholar :

33 

Wang X, He H, Wu X, Hu J and Tan Y: Promotion of dentin regeneration via CCN3 modulation on Notch and BMP signaling pathways. Biomaterials. 35:2720–2729. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Prasad M, Butler WT and Qin C: Dentin sialophosphoprotein in biomineralization. Connect Tissue Res. 51:404–417. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Yamakoshi Y: Dentinogenesis and dentin sialophosphoprotein (DSPP). J Oral Biosci. 51:134–142. 2009. View Article : Google Scholar

36 

Weber D, Wiese C and Gessler M: Hey bHLH transcription factors. Curr Top Dev Biol. 110:285–315. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL and Gessler M: Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 8:e10027282012. View Article : Google Scholar : PubMed/NCBI

38 

Aranguren XL, Agirre X, Beerens M, Coppiello G, Uriz M, Vandersmissen I, Benkheil M, Panadero J, Aguado N, Pascual-Montano A, et al: Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature. Blood. 122:3982–3992. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Lavery K, Hawley S, Swain P, Rooney R, Falb D and Alaoui-Ismaili MH: New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells. Bone. 45:27–41. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Jacob A, Zhang Y and George A: Transcriptional regulation of dentin matrix protein 1 (DMP1) in odontoblasts and osteoblasts. Connect Tissue Res. 55(Suppl 1): 107–112. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Li S, Kong H, Yao N, Yu Q, Wang P, Lin Y, Wang J, Kuang R, Zhao X, Xu J, et al: The role of runt-related transcription factor 2 (Runx2) in the late stage of odontoblast differentiation and dentin formation. Biochem Biophys Res Commun. 410:698–704. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Fuke S, Minami N, Kokubo H, Yoshikawa A, Yasumatsu H, Sasagawa N, Saga Y, Tsukahara T and Ishiura S: Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system. J Neurosci Res. 84:1555–1563. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Belyea BC, Naini S, Bentley RC and Linardic CM: Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. Clin Cancer Res. 17:7324–7336. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yin X, Zeng Z, Xing J, Zhang A, Jiang W, Wang W, Sun H and Ni L: Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells. Int J Mol Med 41: 331-339, 2018.
APA
Yin, X., Zeng, Z., Xing, J., Zhang, A., Jiang, W., Wang, W. ... Ni, L. (2018). Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells. International Journal of Molecular Medicine, 41, 331-339. https://doi.org/10.3892/ijmm.2017.3254
MLA
Yin, X., Zeng, Z., Xing, J., Zhang, A., Jiang, W., Wang, W., Sun, H., Ni, L."Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells". International Journal of Molecular Medicine 41.1 (2018): 331-339.
Chicago
Yin, X., Zeng, Z., Xing, J., Zhang, A., Jiang, W., Wang, W., Sun, H., Ni, L."Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells". International Journal of Molecular Medicine 41, no. 1 (2018): 331-339. https://doi.org/10.3892/ijmm.2017.3254
Copy and paste a formatted citation
x
Spandidos Publications style
Yin X, Zeng Z, Xing J, Zhang A, Jiang W, Wang W, Sun H and Ni L: Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells. Int J Mol Med 41: 331-339, 2018.
APA
Yin, X., Zeng, Z., Xing, J., Zhang, A., Jiang, W., Wang, W. ... Ni, L. (2018). Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells. International Journal of Molecular Medicine, 41, 331-339. https://doi.org/10.3892/ijmm.2017.3254
MLA
Yin, X., Zeng, Z., Xing, J., Zhang, A., Jiang, W., Wang, W., Sun, H., Ni, L."Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells". International Journal of Molecular Medicine 41.1 (2018): 331-339.
Chicago
Yin, X., Zeng, Z., Xing, J., Zhang, A., Jiang, W., Wang, W., Sun, H., Ni, L."Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells". International Journal of Molecular Medicine 41, no. 1 (2018): 331-339. https://doi.org/10.3892/ijmm.2017.3254
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team