|
1
|
Forno LS: Neuropathology of Parkinson's
disease. J Neuropathol Exp Neurol. 55:259–272. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Martin LJ: Biology of mitochondria in
neurodegenerative diseases. Prog Mol Biol Transl Sci. 107:355–415.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Trancikova A, Tsika E and Moore DJ:
Mitochondrial dysfunction in genetic animal models of Parkinson's
disease. Antioxid Redox Signal. 16:896–919. 2012. View Article : Google Scholar :
|
|
4
|
Ryan BJ, Hoek S, Fon EA and Wade-Martins
R: Mitochondrial dysfunction and mitophagy in Parkinson's: From
familial to sporadic disease. Trends Biochem Sci. 40:200–210. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Moon HE and Paek SH: Mitochondrial
dysfunction in Parkinson's disease. Exp Neurobiol. 24:103–116.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Exner N, Lutz AK, Haass C and Winklhofer
KF: Mitochondrial dysfunction in Parkinson's disease: Molecular
mechanisms and pathophysiological consequences. EMBO J.
31:3038–3062. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Mounsey RB and Teismann P: Mitochondrial
dysfunction in Parkinson's disease: Pathogenesis and
neuroprotection. Parkinsons Dis. 2010:6174722011.
|
|
8
|
Martin LJ: Mitochondrial and cell death
mechanisms in neurodegenerative diseases. Pharmaceuticals (Basel).
3:839–915. 2010. View Article : Google Scholar
|
|
9
|
Reddy PH and Reddy TP: Mitochondria as a
therapeutic target for aging and neurodegenerative diseases. Curr
Alzheimer Res. 8:393–409. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Reddy PH and Beal MF: Are mitochondria
critical in the pathogenesis of Alzheimer's disease? Brain Res
Brain Res Rev. 49:618–632. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Rostovtseva TK, Tan W and Colombini M: On
the role of VDAC in apoptosis: fact and fiction. J Bioenerg
Biomembr. 37:129–142. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Okada SF, O'Neal WK, Huang P, Nicholas RA,
Ostrowski LE, Craigen WJ, Lazarowski ER and Boucher RC:
Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP
release and cell volume regulation in murine cells. J Gen Physiol.
124:513–526. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Camara AK, Lesnefsky EJ and Stowe DF:
Potential therapeutic benefits of strategies directed to
mitochondria. Antioxid Redox Signal. 13:279–347. 2010. View Article : Google Scholar :
|
|
14
|
Bernardi P: Mitochondrial transport of
cations: Channels, exchangers, and permeability transition. Physiol
Rev. 79:1127–1155. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Teshima Y, Akao M, Jones SP and Marbán E:
Uncoupling protein-2 overexpression inhibits mitochondrial death
pathway in cardiomyocytes. Circ Res. 93:192–200. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
O'Rourke B: Mitochondrial ion channels.
Annu Rev Physiol. 69:19–49. 2007. View Article : Google Scholar
|
|
17
|
Wingrove DE and Gunter TE: Kinetics of
mitochondrial calcium transport. II A kinetic description of the
sodium-dependent calcium efflux mechanism of liver mitochondria and
inhibition by ruthenium red and by tetraphenylphosphonium. J Biol
Chem. 261:15166–15171. 1986.PubMed/NCBI
|
|
18
|
Bernardi P, Krauskopf A, Basso E,
Petronilli V, Blachly-Dyson E, Di Lisa F and Forte MA: The
mitochondrial permeability transition from in vitro artifact to
disease target. FEBS J. 273:2077–2099. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Leung AW and Halestrap AP: Recent progress
in elucidating the molecular mechanism of the mitochondrial
permeability transition pore. Biochim Biophys Acta. 1777:946–952.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Vyssokikh MY, Katz A, Rueck A, Wuensch C,
Dörner A, Zorov DB and Brdiczka D: Adenine nucleotide translocator
isoforms 1 and 2 are differently distributed in the mitochondrial
inner membrane and have distinct affinities to cyclophilin D.
Biochem J. 358:349–358. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Halestrap AP and Brenner C: The adenine
nucleotide translocase: A central component of the mitochondrial
permeability transition pore and key player in cell death. Curr Med
Chem. 10:1507–1525. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Ojala D, Montoya J and Attardi G: tRNA
punctuation model of RNA processing in human mitochondria. Nature.
290:470–474. 1981. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Reddy PH: Amyloid precursor
protein-mediated free radicals and oxidative damage: Implications
for the development and progression of Alzheimer's disease. J
Neurochem. 96:1–13. 2006. View Article : Google Scholar
|
|
24
|
Brookes PS, Levonen AL, Shiva S, Sarti P
and Darley-Usmar VM: Mitochondria: Regulators of signal
transduction by reactive oxygen and nitrogen species. Free Radic
Biol Med. 33:755–764. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Dröge W: Free radicals in the
physiological control of cell function. Physiol Rev. 82:47–95.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Kudin AP, Bimpong-Buta NY, Vielhaber S,
Elger CE and Kunz WS: Characterization of superoxide-producing
sites in isolated brain mitochondria. J Biol Chem. 279:4127–4135.
2004. View Article : Google Scholar
|
|
27
|
Brand MD, Affourtit C, Esteves TC, Green
K, Lambert AJ, Miwa S, Pakay JL and Parker N: Mitochondrial
superoxide: Production, biological effects, and activation of
uncoupling proteins. Free Radic Biol Med. 37:755–767. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Andreyev AY, Kushnareva YE and Starkov AA:
Mitochondrial metabolism of reactive oxygen species. Biochemistry
(Mosc). 70:200–214. 2005. View Article : Google Scholar
|
|
29
|
Cadenas E and Davies KJ: Mitochondrial
free radical generation, oxidative stress, and aging. Free Radic
Biol Med. 29:222–230. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Kudin AP, Debska-Vielhaber G and Kunz WS:
Characterization of superoxide production sites in isolated rat
brain and skeletal muscle mitochondria. Biomed Pharmacother.
59:163–168. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kussmaul L and Hirst J: The mechanism of
superoxide production by NADH:ubiquinone oxidoreductase (complex I)
from bovine heart mitochondria. Proc Natl Acad Sci USA.
103:7607–7612. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Rush JD and Koppenol WH: Oxidizing
intermediates in the reaction of ferrous EDTA with hydrogen
peroxide. Reactions with organic molecules and ferrocytochrome c. J
Biol Chem. 261:6730–6733. 1986.PubMed/NCBI
|
|
33
|
Antunes F, Han D and Cadenas E: Relative
contributions of heart mitochondria glutathione peroxidase and
catalase to H(2)O(2) detoxification in in vivo conditions. Free
Radic Biol Med. 33:1260–1267. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Morán M, Moreno-Lastres D, Marín-Buera L,
Arenas J, Martín MA and Ugalde C: Mitochondrial respiratory chain
dysfunction: Implications in neurodegeneration. Free Radic Biol
Med. 53:595–609. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Gutteridge JM: Superoxide-dependent
formation of hydroxyl radicals from ferric-complexes and hydrogen
peroxide: An evaluation of fourteen iron chelators. Free Radic Res
Commun. 9:119–125. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Hwang O: Role of oxidative stress in
Parkinson's disease. Exp Neurobiol. 22:11–17. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Dias V, Junn E and Mouradian MM: The role
of oxidative stress in Parkinson's disease. J Parkinsons Dis.
3:461–491. 2013.PubMed/NCBI
|
|
38
|
Jenner P: Oxidative stress in Parkinson's
disease. Ann Neurol. 53(Suppl 3): S26–S38. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Alam ZI, Jenner A, Daniel SE, Lees AJ,
Cairns N, Marsden CD, Jenner P and Halliwell B: Oxidative DNA
damage in the parkinsonian brain: An apparent selective increase in
8-hydroxyguanine levels in substantia nigra. J Neurochem.
69:1196–1203. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Yoritaka A, Hattori N, Uchida K, Tanaka M,
Stadtman ER and Mizuno Y: Immunohistochemical detection of
4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl
Acad Sci USA. 93:2696–2701. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Li DW, Yao M, Dong YH, Tang MN, Chen W, Li
GR and Sun BQ: Guanosine exerts neuroprotective effects by
reversing mitochondrial dysfunction in a cellular model of
Parkinson's disease. Int J Mol Med. 34:1358–1364. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Seet RC, Lee CY, Lim EC, Tan JJ, Quek AM,
Chong WL, Looi WF, Huang SH, Wang H and Chan YH: Oxidative damage
in Parkinson disease: Measurement using accurate biomarkers. Free
Radic Biol Med. 48:560–566. 2010. View Article : Google Scholar
|
|
43
|
Callio J, Oury TD and Chu CT: Manganese
superoxide dismutase protects against 6-hydroxydopamine injury in
mouse brains. J Biol Chem. 280:18536–18542. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Vila M and Przedborski S: Targeting
programmed cell death in neurodegenerative diseases. Nat Rev
Neurosci. 4:365–375. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Perier C, Bové J, Vila M and Przedborski
S: The rotenone model of Parkinson's disease. Trends Neurosci.
26:345–346. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Sun SY, An CN and Pu XP: DJ-1 protein
protects dopaminergic neurons against 6-OHDA/MG-132-induced
neurotoxicity in rats. Brain Res Bull. 88:609–616. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Heikkila RE, Hess A and Duvoisin RC:
Dopaminergic neurotoxicity of
1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science.
224:1451–1453. 1984. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Barzilai A and Yamamoto K: DNA damage
responses to oxidative stress. DNA Repair (Amst). 3:1109–1115.
2004. View Article : Google Scholar
|
|
49
|
Ruipérez V, Darios F and Davletov B:
Alpha-synuclein, lipids and Parkinson's disease. Prog Lipid Res.
49:420–428. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Mariani E, Polidori MC, Cherubini A and
Mecocci P: Oxidative stress in brain aging, neurodegenerative and
vascular diseases: An overview. J Chromatogr B Analyt Technol
Biomed Life Sci. 827:65–75. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Montine TJ, Neely MD, Quinn JF, Beal MF,
Markesbery WR, Roberts LJ II and Morrow JD: Lipid peroxidation in
aging brain and Alzheimer's disease. Free Radic Biol Med.
33:620–626. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Liu W, Kato M, Akhand AA, Hayakawa A,
Suzuki H, Miyata T, Kurokawa K, Hotta Y, Ishikawa N and Nakashima
I: 4-hydroxynonenal induces a cellular redox status-related
activation of the caspase cascade for apoptotic cell death. J Cell
Sci. 113:635–641. 2000.PubMed/NCBI
|
|
53
|
Schmidt H, Grune T, Müller R, Siems WG and
Wauer RR: Increased levels of lipid peroxidation products
malondialdehyde and 4-hydroxynonenal after perinatal hypoxia.
Pediatr Res. 40:15–20. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Montine KS, Quinn JF, Zhang J, Fessel JP,
Roberts LJ II, Morrow JD and Montine TJ: Isoprostanes and related
products of lipid peroxidation in neurodegenerative diseases. Chem
Phys Lipids. 128:117–124. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Lotharius J and Brundin P: Pathogenesis of
Parkinson's disease: Dopamine, vesicles and alpha-synuclein. Nat
Rev Neurosci. 3:932–942. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
56
|
Fornstedt B and Carlsson A: A marked rise
in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following
reserpine treatment. J Neural Transm. 76:155–161. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Youdim MB, Edmondson D and Tipton KF: The
therapeutic potential of monoamine oxidase inhibitors. Nat Rev
Neurosci. 7:295–309. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Fowler JS, Volkow ND, Wang GJ, Logan J,
Pappas N, Shea C and MacGregor R: Age-related increases in brain
monoamine oxidase B in living healthy human subjects. Neurobiol
Aging. 18:431–435. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Nagatsu T and Sawada M: Molecular
mechanism of the relation of monoamine oxidase B and its inhibitors
to Parkinson's disease: Possible implications of glial cells. J
Neural Transm Suppl. 71:53–65. 2006. View Article : Google Scholar
|
|
60
|
Kumar MJ and Andersen JK: Perspectives on
MAO-B in aging and neurological disease: Where do we go from here?
Mol Neurobiol. 30:77–89. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Norris EH, Giasson BI, Hodara R, Xu S,
Trojanowski JQ, Ischiropoulos H and Lee VM: Reversible inhibition
of alpha-synuclein fibrillization by dopaminochrome-mediated
conformational alterations. J Biol Chem. 280:21212–21219. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Zecca L, Wilms H, Geick S, Claasen JH,
Brandenburg LO, Holzknecht C, Panizza ML, Zucca FA, Deuschl G,
Sievers J, et al: Human neuromelanin induces neuroinflammation and
neurodegeneration in the rat substantia nigra: Implications for
Parkinson's disease. Acta Neuropathol. 116:47–55. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Jomova K and Valko M: Advances in
metal-induced oxidative stress and human disease. Toxicology.
283:65–87. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Núñez MT, Urrutia P, Mena N, Aguirre P,
Tapia V and Salazar J: Iron toxicity in neurodegeneration.
Biometals. 25:761–776. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Sadrzadeh SM and Saffari Y: Iron and brain
disorders. Am J Clin Pathol. 121(Suppl): S64–S70. 2004.PubMed/NCBI
|
|
66
|
Sian-Hülsmann J, Mandel S, Youdim MB and
Riederer P: The relevance of iron in the pathogenesis of
Parkinson's disease. J Neurochem. 118:939–957. 2011. View Article : Google Scholar
|
|
67
|
Sziráki I, Mohanakumar KP, Rauhala P, Kim
HG, Yeh KJ and Chiueh CC: Manganese: A transition metal protects
nigrostriatal neurons from oxidative stress in the iron-induced
animal model of parkinsonism. Neuroscience. 85:1101–1111. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Lan J and Jiang DH: Desferrioxamine and
vitamin E protect against iron and MPTP-induced neurodegeneration
in mice. J Neural Transm Vienna. 104:469–481. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Faucheux BA, Martin ME, Beaumont C, Hauw
JJ, Agid Y and Hirsch EC: Neuromelanin associated redox-active iron
is increased in the substantia nigra of patients with Parkinson's
disease. J Neurochem. 86:1142–1148. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Yokoyama H, Kuroiwa H, Yano R and Araki T:
Targeting reactive oxygen species, reactive nitrogen species and
inflammation in MPTP neurotoxicity and Parkinson's disease. Neurol
Sci. 29:293–301. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Duchen MR: Mitochondria in health and
disease: Perspectives on a new mitochondrial biology. Mol Aspects
Med. 25:365–451. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Henchcliffe C and Beal MF: Mitochondrial
biology and oxidative stress in Parkinson disease pathogenesis. Nat
Clin Pract Neurol. 4:600–609. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Mythri RB, Jagatha B, Pradhan N, Andersen
J and Bharath MM: Mitochondrial complex I inhibition in Parkinson's
disease: How can curcumin protect mitochondria? Antioxid Redox
Signal. 9:399–408. 2007. View Article : Google Scholar
|
|
74
|
Adams JM and Cory S: The Bcl-2 protein
family: Arbiters of cell survival. Science. 281:1322–1326. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Crompton M: The mitochondrial permeability
transition pore and its role in cell death. Biochem J. 341:233–249.
1999. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Burchell VS, Gandhi S, Deas E, Wood NW,
Abramov AY and Plun-Favreau H: Targeting mitochondrial dysfunction
in neurodegenerative disease: Part I. Expert Opin Ther Targets.
14:369–385. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Moon Y, Lee KH, Park JH, Geum D and Kim K:
Mitochondrial membrane depolarization and the selective death of
dopaminergic neurons by rotenone: Protective effect of coenzyme
Q10. J Neurochem. 93:1199–1208. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
McCarthy S, Somayajulu M, Sikorska M,
Borowy-Borowski H and Pandey S: Paraquat induces oxidative stress
and neuronal cell death; neuroprotection by water-soluble Coenzyme
Q10. Toxicol Appl Pharmacol. 201:21–31. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Cleren C, Yang L, Lorenzo B, Calingasan
NY, Schomer A, Sireci A, Wille EJ and Beal MF: Therapeutic effects
of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of
Parkinsonism. J Neurochem. 104:1613–1621. 2008. View Article : Google Scholar
|
|
80
|
Dubois C, Prevarskaya N and Vanden Abeele
F: The calcium-signaling toolkit: Updates needed. Biochim Biophys
Acta. 1863:1337–1343. 2016. View Article : Google Scholar
|
|
81
|
Santo-Domingo J, Wiederkehr A and De
Marchi U: Modulation of the matrix redox signaling by mitochondrial
Ca(2). World J Biol Chem. 6:310–323. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Nicholls DG: Mitochondrial function and
dysfunction in the cell: Its relevance to aging and aging-related
disease. Int J Biochem Cell Biol. 34:1372–1381. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Kirichok Y, Krapivinsky G and Clapham DE:
The mitochondrial calcium uniporter is a highly selective ion
channel. Nature. 427:360–364. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Gincel D, Zaid H and Shoshan-Barmatz V:
Calcium binding and translocation by the voltage-dependent anion
channel: A possible regulatory mechanism in mitochondrial function.
Biochem J. 358:147–155. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Takeuchi A, Kim B and Matsuoka S: The
destiny of Ca(2+) released by mitochondria. J Physiol Sci.
65:11–24. 2015. View Article : Google Scholar
|
|
86
|
Plovanich M, Bogorad RL, Sancak Y, Kamer
KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J,
Speciner L, et al: MICU2, a paralog of MICU1, resides within the
mitochondrial uniporter complex to regulate calcium handling. PLoS
One. 8:e557852013. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Perocchi F, Gohil VM, Girgis HS, Bao XR,
McCombs JE, Palmer AE and Mootha VK: MICU1 encodes a mitochondrial
EF hand protein required for Ca(2+) uptake. Nature. 467:291–296.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
McCormack JG and Denton RM: Mitochondrial
Ca2+ transport and the role of intramitochondrial
Ca2+ in the regulation of energy metabolism. Dev
Neurosci. 15:165–173. 1993. View Article : Google Scholar
|
|
89
|
Balaban RS: Cardiac energy metabolism
homeostasis: Role of cytosolic calcium. J Mol Cell Cardiol.
34:1259–1271. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Alderton WK, Cooper CE and Knowles RG:
Nitric oxide synthases: Structure, function and inhibition. Biochem
J. 357:593–615. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Jekabsone A, Ivanoviene L, Brown GC and
Borutaite V: Nitric oxide and calcium together inactivate
mitochondrial complex I and induce cytochrome c release. J Mol Cell
Cardiol. 35:803–809. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Brookes PS, Yoon Y, Robotham JL, Anders MW
and Sheu SS: Calcium, ATP, and ROS: A mitochondrial love-hate
triangle. Am J Physiol Cell Physiol. 287:C817–C833. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Muravchick S and Levy RJ: Clinical
implications of mitochondrial dysfunction. Anesthesiology.
105:819–837. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
O'Rourke B: Pathophysiological and
protective roles of mitochondrial ion channels. J Physiol.
529:23–36. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Di Lisa F and Bernardi P: A CaPful of
mechanisms regulating the mitochondrial permeability transition. J
Mol Cell Cardiol. 46:775–780. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Jones SP, Teshima Y, Akao M and Marbán E:
Simvastatin attenuates oxidant-induced mitochondrial dysfunction in
cardiac myocytes. Circ Res. 93:697–699. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Celardo I, Martins LM and Gandhi S:
Unravelling mitochondrial pathways to Parkinson's disease. Br J
Pharmacol. 171:1943–1957. 2014. View Article : Google Scholar :
|
|
98
|
Surmeier DJ, Guzman JN, Sanchez-Padilla J
and Goldberg JA: The origins of oxidant stress in Parkinson's
disease and therapeutic strategies. Antioxid Redox Signal.
14:1289–1301. 2011. View Article : Google Scholar :
|
|
99
|
Perier C, Tieu K, Guégan C, Caspersen C,
Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S
and Vila M: Complex I deficiency primes Bax-dependent neuronal
apoptosis through mitochondrial oxidative damage. Proc Natl Acad
Sci USA. 102:19126–19131. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Boatright KM and Salvesen GS: Mechanisms
of caspase activation. Curr Opin Cell Biol. 15:725–731. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Kumar S: Caspase function in programmed
cell death. Cell Death Differ. 14:32–43. 2007. View Article : Google Scholar
|
|
102
|
Javadov S, Choi A, Rajapurohitam V, Zeidan
A, Basnakian AG and Karmazyn M: NHE-1 inhibition-induced
cardioprotection against ischaemia/reperfusion is associated with
attenuation of the mitochondrial permeability transition.
Cardiovasc Res. 77:416–424. 2008. View Article : Google Scholar
|
|
103
|
Wallace DC: A mitochondrial paradigm of
metabolic and degenerative diseases, aging, and cancer: A dawn for
evolutionary medicine. Annu Rev Genet. 39:359–407. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Yang JL, Weissman L, Bohr VA and Mattson
MP: Mitochondrial DNA damage and repair in neurodegenerative
disorders. DNA Repair (Amst). 7:1110–1120. 2008. View Article : Google Scholar
|
|
105
|
Levy RJ and Deutschman CS: Deficient
mitochondrial biogenesis in critical illness: Cause, effect, or
epiphenomenon? Crit Care. 11:1582007. View
Article : Google Scholar : PubMed/NCBI
|
|
106
|
Elstner M, Müller SK, Leidolt L, Laub C,
Krieg L, Schlaudraff F, Liss B, Morris C, Turnbull DM, Masliah E,
et al: Neuromelanin, neurotransmitter status and brainstem location
determine the differential vulnerability of catecholaminergic
neurons to mitochondrial DNA deletions. Mol Brain. 4:432011.
View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Kraytsberg Y, Kudryavtseva E, McKee AC,
Geula C, Kowall NW and Khrapko K: Mitochondrial DNA deletions are
abundant and cause functional impairment in aged human substantia
nigra neurons. Nat Genet. 38:518–520. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Bender A, Krishnan KJ, Morris CM, Taylor
GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock
T, et al: High levels of mitochondrial DNA deletions in substantia
nigra neurons in aging and Parkinson disease. Nat Genet.
38:515–517. 2006. View
Article : Google Scholar : PubMed/NCBI
|
|
109
|
Ekstrand MI, Terzioglu M, Galter D, Zhu S,
Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS,
Trifunovic A, et al: Progressive parkinsonism in mice with
respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci
USA. 104:1325–1330. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Tanner CM, Kamel F, Ross GW, Hoppin JA,
Goldman SM, Korell M, Marras C, Bhudhikanok GS, Kasten M, Chade AR,
et al: Rotenone, paraquat, and Parkinson's disease. Environ Health
Perspect. 119:866–872. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Halliwell B: Role of free radicals in the
neurodegenerative diseases: Therapeutic implications for
antioxidant treatment. Drugs Aging. 18:685–716. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Reeve AK, Krishnan KJ and Turnbull D:
Mitochondrial DNA mutations in disease, aging, and
neurodegeneration. Ann NY Acad Sci. 1147:21–29. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Ropp PA and Copeland WC: Cloning and
characterization of the human mitochondrial DNA polymerase, DNA
polymerase gamma. Genomics. 36:449–458. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Luoma P, Melberg A, Rinne JO, Kaukonen JA,
Nupponen NN, Chalmers RM, Oldfors A, Rautakorpi I, Peltonen L,
Majamaa K, et al: Parkinsonism, premature menopause, and
mitochondrial DNA polymerase gamma mutations: Clinical and
molecular genetic study. Lancet. 364:875–882. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Wong LJ, Naviaux RK, Brunetti-Pierri N,
Zhang Q, Schmitt ES, Truong C, Milone M, Cohen BH, Wical B, Ganesh
J, et al: Molecular and clinical genetics of mitochondrial diseases
due to POLG mutations. Hum Mutat. 29:E150–E172. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Gui YX, Xu ZP, Lv W, Zhao JJ and Hu XY:
Evidence for polymerase gamma, POLG1 variation in reduced
mitochondrial DNA copy number in Parkinson's disease. Parkinsonism
Relat Disord. 21:282–286. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Hudson G and Chinnery PF: Mitochondrial
DNA polymerase-gamma and human disease. Hum Mol Genet.
15:R244–R252. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Sanders LH, McCoy J, Hu X, Mastroberardino
PG, Dickinson BC, Chang CJ, Chu CT, Van Houten B and Greenamyre JT:
Mitochondrial DNA damage: Molecular marker of vulnerable nigral
neurons in Parkinson's disease. Neurobiol Dis. 70:214–223. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Wilson DM III and Barsky D: The major
human abasic endonuclease: Formation, consequences and repair of
abasic lesions in DNA. Mutat Res. 485:283–307. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Benard G and Karbowski M: Mitochondrial
fusion and division: Regulation and role in cell viability. Semin
Cell Dev Biol. 20:365–374. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Soubannier V and McBride HM: Positioning
mitochondrial plasticity within cellular signaling cascades.
Biochim Biophys Acta. 1793:154–170. 2009. View Article : Google Scholar
|
|
122
|
Schrader M: Shared components of
mitochondrial and peroxisomal division. Biochim Biophys Acta.
1763:531–541. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Ishihara N, Jofuku A, Eura Y and Mihara K:
Regulation of mitochondrial morphology by membrane potential, and
DRP1-dependent division and FZO1-dependent fusion reaction in
mammalian cells. Biochem Biophys Res Commun. 301:891–898. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Cereghetti GM, Stangherlin A, Martins de
Brito O, Chang CR, Blackstone C, Bernardi P and Scorrano L:
Dephosphorylation by calcineurin regulates translocation of Drp1 to
mitochondria. Proc Natl Acad Sci USA. 105:15803–15808. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y,
Tomizawa K, Nairn AC, Takei K, Matsui H and Matsushita M: CaM
kinase I alpha-induced phosphorylation of Drp1 regulates
mitochondrial morphology. J Cell Biol. 182:573–585. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Reddy PH, Reddy TP, Manczak M, Calkins MJ,
Shirendeb U and Mao P: Dynamin-related protein 1 and mitochondrial
fragmentation in neurodegenerative diseases. Brain Res Brain Res
Rev. 67:103–118. 2011. View Article : Google Scholar
|
|
127
|
James DI, Parone PA, Mattenberger Y and
Martinou JC: hFis1, a novel component of the mammalian
mitochondrial fission machinery. J Biol Chem. 278:36373–36379.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Gomes LC and Scorrano L: High levels of
Fis1, a pro-fission mitochondrial protein, trigger autophagy.
Biochim Biophys Acta. 1777:860–866. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Santos D and Cardoso SM: Mitochondrial
dynamics and neuronal fate in Parkinson's disease. Mitochondrion.
12:428–437. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Reddy PH: Amyloid beta, mitochondrial
structural and functional dynamics in Alzheimer's disease. Exp
Neurol. 218:286–292. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Reddy PH: Mitochondrial dysfunction in
aging and Alzheimer's disease: Strategies to protect neurons.
Antioxid Redox Signal. 9:1647–1658. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Chen H, Chomyn A and Chan DC: Disruption
of fusion results in mitochondrial heterogeneity and dysfunction. J
Biol Chem. 280:26185–26192. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Ishihara N, Eura Y and Mihara K: Mitofusin
1 and 2 play distinct roles in mitochondrial fusion reactions via
GTPase activity. J Cell Sci. 117:6535–6546. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Züchner S, Mersiyanova IV, Muglia M,
Bissar-Tadmouri N, Rochelle J, Dadali EL, Zappia M, Nelis E,
Patitucci A, Senderek J, et al: Mutations in the mitochondrial
GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A.
Nat Genet. 36:449–451. 2004. View
Article : Google Scholar : PubMed/NCBI
|
|
135
|
Armstrong JS: Mitochondria-directed
therapeutics. Antioxid Redox Signal. 10:575–578. 2008. View Article : Google Scholar
|
|
136
|
Chan DC: Mitochondria: Dynamic organelles
in disease, aging, and development. Cell. 125:1241–1252. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
137
|
McBride HM, Neuspiel M and Wasiak S:
Mitochondria: More than just a powerhouse. Curr Biol. 16:R551–R560.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Barsoum MJ, Yuan H, Gerencser AA, Liot G,
Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, et al:
Nitric oxide-induced mitochondrial fission is regulated by
dynamin-related GTPases in neurons. EMBO J. 25:3900–3911. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Head B, Griparic L, Amiri M, Gandre-Babbe
S and van der Bliek AM: Inducible proteolytic inactivation of OPA1
mediated by the OMA1 protease in mammalian cells. J Cell Biol.
187:959–966. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Abou-Sleiman PM, Muqit MM and Wood NW:
Expanding insights of mitochondrial dysfunction in Parkinson's
disease. Nat Rev Neurosci. 7:207–219. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang
Y, Wang JW, Yang L, Beal MF, Vogel H and Lu B: Mitochondrial
pathology and muscle and dopaminergic neuron degeneration caused by
inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl
Acad Sci USA. 103:10793–10798. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Park J, Lee SB, Lee S, Kim Y, Song S, Kim
S, Bae E, Kim J, Shong M, Kim JM and Chung J: Mitochondrial
dysfunction in Drosophila PINK1 mutants is complemented by parkin.
Nature. 441:1157–1161. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Jin SM, Lazarou M, Wang C, Kane LA,
Narendra DP and Youle RJ: Mitochondrial membrane potential
regulates PINK1 import and proteolytic destabilization by PARL. J
Cell Biol. 191:933–942. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Narendra DP, Jin SM, Tanaka A, Suen DF,
Gautier CA, Shen J, Cookson MR and Youle RJ: PINK1 is selectively
stabilized on impaired mitochondria to activate Parkin. PLoS Biol.
8:e10002982010. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Kim Y, Park J, Kim S, Song S, Kwon SK, Lee
SH, Kitada T, Kim JM and Chung J: PINK1 controls mitochondrial
localization of Parkin through direct phosphorylation. Biochem
Biophys Res Commun. 377:975–980. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Sha D, Chin LS and Li L: Phosphorylation
of parkin by Parkinson disease-linked kinase PINK1 activates parkin
E3 ligase function and NF-kappaB signaling. Hum Mol Genet.
19:352–363. 2010. View Article : Google Scholar
|
|
147
|
Geisler S, Holmström KM, Skujat D, Fiesel
FC, Rothfuss OC, Kahle PJ and Springer W: PINK1/Parkin-mediated
mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol.
12:119–131. 2010. View Article : Google Scholar : PubMed/NCBI
|
