|
1
|
Rini BI, Melichar B, Fishman MN, Oya M,
Pithavala YK, Chen Y, Bair AH and Grünwald V: Axitinib dose
titration: Analyses of exposure, blood pressure and clinical
response from a randomized phase II study in metastatic renal cell
carcinoma. Ann Oncol. 26:1372–1377. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Voss MH, Chen D, Marker M, Hakimi AA, Lee
CH, Hsieh JJ, Knox JJ, Voi M and Motzer RJ: Circulating biomarkers
and outcome from a randomised phase II trial of sunitinib vs
everolimus for patients with metastatic renal cell carcinoma. Br J
Cancer. 114:642–649. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Huijts CM, Santegoets SJ, van den Eertwegh
AJ, Pijpers LS, Haanen JB, de Gruijl TD, Verheul HM and van der
Vliet HJ: Phase I-II study of everolimus and low-dose oral
cyclophosphamide in patients with metastatic renal cell cancer. BMC
Cancer. 11:5052011. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Molina AM, Hutson TE, Larkin J, Gold AM,
Wood K, Carter D, Motzer R and Michaelson MD: A phase 1b clinical
trial of the multi-targeted tyrosine kinase inhibitor lenvatinib
(E7080) in combination with everolimus for treatment of metastatic
renal cell carcinoma (RCC). Cancer Chemother Pharmacol. 73:181–189.
2014. View Article : Google Scholar :
|
|
5
|
Li Z, Chen Y, Hu S, Zhang J, Wu J, Ren W,
Shao N and Ying X: Integrative analysis of protein-coding and
non-coding RNAs identifies clinically relevant subtypes of clear
cell renal cell carcinoma. Oncotarget. 7:82671–82685.
2016.PubMed/NCBI
|
|
6
|
Zhang L, Xul B, Chen S, Lu K, Liu C, Wang
Y, Zhao Y, Zhang X, Liu D and Chen M: The complex roles of
microRNAs in the metastasis of renal cell carcinoma. J Nanosci
Nanotechnol. 13:3195–3203. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wang P, Yin B, Shan L, Zhang H, Cui J,
Zhang M and Song Y: RNA interference-mediated knockdown of
astrocyte elevated gene-1 inhibits growth, induces apoptosis, and
increases the chemosensitivity to 5-fluorouracil in renal cancer
Caki-1 cells. Mol Cells. 37:857–864. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Tutar Y: miRNA and cancer; computational
and experimental approaches. Curr Pharm Biotechnol. 15:4292014.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Al-Ali BM, Ress AL, Gerger A and Pichler
M: MicroRNAs in renal cell carcinoma: Implications for
pathogenesis, diagnosis, prognosis and therapy. Anticancer Res.
32:3727–3732. 2012.PubMed/NCBI
|
|
10
|
Mlcochova H, Machackova T, Rabien A,
Radova L, Fabian P, Iliev R, Slaba K, Poprach A, Kilic E, Stanik M,
et al: Epithelial-mesenchymal transition-associated microRNA/mRNA
signature is linked to metastasis and prognosis in clear-cell renal
cell carcinoma. Sci Rep. 6:318522016. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Luo Z, Hu X, Xiong H, Qiu H, Yuan X, Zhu
F, Wang Y and Zou Y: A polysaccharide from Huaier induced apoptosis
in MCF-7 breast cancer cells via downregulation of MTDH protein.
Carbohydr Polym. 151:1027–1033. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Du C, Yi X, Liu W, Han T, Liu Z, Ding Z,
Zheng Z, Piao Y, Yuan J, Han Y, et al: MTDH mediates trastuzumab
resistance in HER2 positive breast cancer by decreasing PTEN
expression through an NFκB-dependent pathway. BMC Cancer.
14:8692014. View Article : Google Scholar
|
|
13
|
Lee SG, Su ZZ, Emdad L, Sarkar D, Franke
TF and Fisher PB: Astrocyte elevated gene-1 activates cell survival
pathways through PI3K-Akt signaling. Oncogene. 27:1114–1121. 2008.
View Article : Google Scholar
|
|
14
|
Seo BR, Min KJ, Cho IJ, Kim SC and Kwon
TK: Curcumin significantly enhances dual PI3K/Akt and mTOR
inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma
Caki cells through downregulation of p53-dependent Bcl-2 expression
and inhibition of Mcl-1 protein stability. PLoS One. 9:e955882014.
View Article : Google Scholar
|
|
15
|
Lim W, Jeong W and Song G: Delphinidin
suppresses proliferation and migration of human ovarian clear cell
carcinoma cells through blocking AKT and ERK1/2 MAPK signaling
pathways. Mol Cell Endocrinol. 422:172–181. 2016. View Article : Google Scholar
|
|
16
|
Ribback S, Cigliano A, Kroeger N, Pilo MG,
Terracciano L, Burchardt M, Bannasch P, Calvisi DF and Dombrowski
F: PI3K/AKT/mTOR pathway plays a major pathogenetic role in
glycogen accumulation and tumor development in renal distal tubules
of rats and men. Oncotarget. 6:13036–13048. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
18
|
Fournier LS, Oudard S, Thiam R, Trinquart
L, Banu E, Medioni J, Balvay D, Chatellier G, Frija G and Cuenod
CA: Metastatic renal carcinoma: Evaluation of antiangiogenic
therapy with dynamic contrast-enhanced CT. Radiology. 256:511–518.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Bracarda S, Porta C, Boni C, Santoro A,
Mucciarini C, Pazzola A, Cortesi E, Gasparro D, Labianca R, Di
Costanzo F, et al: Could interferon still play a role in metastatic
renal cell carcinoma? A randomized study of two schedules of
sorafenib plus interferon-alpha 2a (RAPSODY). Eur Urol. 63:254–261.
2013. View Article : Google Scholar
|
|
20
|
Li HC, Li JP, Wang ZM, Fu DL, Li ZL, Zhang
D, Gan WM and Chong T: Identification of angiogenesis-related
miRNAs in a population of patients with renal clear cell carcinoma.
Oncol Rep. 32:2061–2069. 2014.PubMed/NCBI
|
|
21
|
Su Z, Ni L, Yu W, Yu Z, Chen D, Zhang E,
Li Y, Wang Y, Li X, Yang S, et al: MicroRNA-451a is associated with
cell proliferation, migration and apoptosis in renal cell
carcinoma. Mol Med Rep. 11:2248–2254. 2015. View Article : Google Scholar
|
|
22
|
Zheng J, Qin W, Jiao D, Ren J, Wei M, Shi
S, Xi W, Wang H, Yang AG, Huan Y, et al: Knockdown of COUP-TFII
inhibits cell proliferation and induces apoptosis through
upregulating BRCA1 in renal cell carcinoma cells. Int J Cancer.
139:1574–1585. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Liang T, Hu XY, Li YH, Tian BQ, Li ZW and
Fu Q: MicroRNA-21 regulates the proliferation, differentiation, and
apoptosis of human renal cell carcinoma cells by the mTOR-STAT3
signaling pathway. Oncol Res. 24:371–380. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Yamada T, Horinaka M, Shinnoh M, Yoshioka
T, Miki T and Sakai T: A novel HDAC inhibitor OBP-801 and a PI3K
inhibitor LY294002 synergistically induce apoptosis via the
suppression of survivin and XIAP in renal cell carcinoma. Int J
Oncol. 43:1080–1086. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhou J, Zhu G, Huang J, Li L, Du Y, Gao Y,
Wu D, Wang X, Hsieh JT, He D, et al: Non-canonical GLI1/2
activation by PI3K/AKT signaling in renal cell carcinoma: A novel
potential therapeutic target. Cancer Lett. 370:313–323. 2016.
View Article : Google Scholar
|
|
26
|
Han X, Yang J, Jia Z, Wei P, Zhang H, Lv
W, Sun J and Huo Q: Knockdown of serine-arginine protein kinase 1
inhibits the growth and migration in 6 renal cell carcinoma cells.
Oncol Res. 25:389–395. 2017. View Article : Google Scholar
|
|
27
|
Papadopoulos EI, Yousef GM and Scorilas A:
Gemcitabine impacts differentially on bladder and kidney cancer
cells: Distinct modulations in the expression patterns of
apoptosis-related microRNAs and BCL2 family genes. Tumour Biol.
36:3197–3207. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Burke MT, Morais C, Oliver KA, Lambie DL,
Gobe GC, Carroll RP, Staatz CE, Sinnya S, Soyer HP, Winterford C,
et al: Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin
cancers of renal transplant recipients. Am J Clin Pathol.
143:514–526. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Zhong WF, Wang XH, Pan B, Li F, Kuang L
and Su ZX: Eupatilin induces human renal cancer cell apoptosis via
ROS-mediated MAPK and PI3K/AKT signaling pathways. Oncol Lett.
12:2894–2899. 2016.PubMed/NCBI
|
|
30
|
Zhu GC, Yu CY, She L, Tan HL, Li G, Ren
SL, Su ZW, Wei M, Huang DH, Tian YQ, et al: Metadherin regulation
of vascular endothelial growth factor expression is dependent upon
the PI3K/Akt pathway in squamous cell carcinoma of the head and
neck. Medicine (Baltimore). 94:e5022015. View Article : Google Scholar
|
|
31
|
Li WF, Ou Q, Dai H and Liu CA:
Lentiviral-mediated short hairpin RNA knockdown of MTDH inhibits
cell growth and induces apoptosis by regulating the PTEN/AKT
pathway in hepatocellular carcinoma. Int J Mol Sci. 16:19419–19432.
2015. View Article : Google Scholar : PubMed/NCBI
|
