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Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury

  • Authors:
    • Peng Song
    • Junbin Zhang
    • Yunwei Zhang
    • Zhiping Shu
    • Peng Xu
    • Long He
    • Chao Yang
    • Jinxiang Zhang
    • Hui Wang
    • Yiqing Li
    • Qin Li
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430033 P.R. China, Department of Emergency Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430033 P.R. China, Department of Nuclear Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430033 P.R. China, Department of Clinical Laboratory, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430033 P.R. China, Department of Genetics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430033 P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 935-945
    |
    Published online on: December 8, 2017
       https://doi.org/10.3892/ijmm.2017.3315
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Abstract

Monocytes infiltrate damaged liver tissue during noninfectious liver injury and often have dual roles, perpetuating inflammation and promoting resolution of inflammation and fibrosis. However, how monocyte subsets distribute and are differentially recruited in the liver remain unclear. In the current study, the subpopulations of infiltrating monocytes were examined following liver ischemia/reperfusion (I/R) injury in mice using flow cytometry. CD11b+Ly6C high (Ly6Chi) cells (inflammatory monocytes) and CD11b+Ly6C low cells (reparative monocytes) were recruited into the liver following I/R injury. Treatment with clodronate‑loaded liposomes, which transiently deplete systemic macrophages, alleviated hepatic damage. Mice genetically deficient in C‑C motif chemokine ligand 2 (CCL2), or its receptor C‑C chemokine receptor 2 (CCR2), exhibited diminished hepatic damage compared with wild‑type mice following I/R, by controlling intrahepatic inflammatory Ly6Chi monocyte accumulation. In addition, the CCR2 specific inhibitor RS504393 alleviated hepatic I/R injury. The results suggest that the CCR2/CCL2 axis has an important role in monocyte infiltration and may represent a novel target for the treatment of liver I/R injury.
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Copy and paste a formatted citation
Spandidos Publications style
Song P, Zhang J, Zhang Y, Shu Z, Xu P, He L, Yang C, Zhang J, Wang H, Li Y, Li Y, et al: Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury. Int J Mol Med 41: 935-945, 2018.
APA
Song, P., Zhang, J., Zhang, Y., Shu, Z., Xu, P., He, L. ... Li, Q. (2018). Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury. International Journal of Molecular Medicine, 41, 935-945. https://doi.org/10.3892/ijmm.2017.3315
MLA
Song, P., Zhang, J., Zhang, Y., Shu, Z., Xu, P., He, L., Yang, C., Zhang, J., Wang, H., Li, Y., Li, Q."Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury". International Journal of Molecular Medicine 41.2 (2018): 935-945.
Chicago
Song, P., Zhang, J., Zhang, Y., Shu, Z., Xu, P., He, L., Yang, C., Zhang, J., Wang, H., Li, Y., Li, Q."Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury". International Journal of Molecular Medicine 41, no. 2 (2018): 935-945. https://doi.org/10.3892/ijmm.2017.3315
Copy and paste a formatted citation
x
Spandidos Publications style
Song P, Zhang J, Zhang Y, Shu Z, Xu P, He L, Yang C, Zhang J, Wang H, Li Y, Li Y, et al: Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury. Int J Mol Med 41: 935-945, 2018.
APA
Song, P., Zhang, J., Zhang, Y., Shu, Z., Xu, P., He, L. ... Li, Q. (2018). Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury. International Journal of Molecular Medicine, 41, 935-945. https://doi.org/10.3892/ijmm.2017.3315
MLA
Song, P., Zhang, J., Zhang, Y., Shu, Z., Xu, P., He, L., Yang, C., Zhang, J., Wang, H., Li, Y., Li, Q."Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury". International Journal of Molecular Medicine 41.2 (2018): 935-945.
Chicago
Song, P., Zhang, J., Zhang, Y., Shu, Z., Xu, P., He, L., Yang, C., Zhang, J., Wang, H., Li, Y., Li, Q."Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury". International Journal of Molecular Medicine 41, no. 2 (2018): 935-945. https://doi.org/10.3892/ijmm.2017.3315
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