Open Access

Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review)

  • Authors:
    • Henrieta Škovierová
    • Terézia Okajčeková
    • Ján Strnádel
    • Eva Vidomanová
    • Erika Halašová
  • View Affiliations

  • Published online on: December 13, 2017     https://doi.org/10.3892/ijmm.2017.3320
  • Pages: 1187-1200
  • Copyright: © Škovierová et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Numerous studies over the past two decades have focused on the epithelial‑to‑mesenchymal transition (EMT) and its role in the development of metastasis. Certain studies highlighted the importance of EMT in the dissemination of tumor cells and metastasis of epithelium‑derived carcinomas. Tumor metastasis is a multistep process during which tumor cells change their morphology, and start to migrate and invade distant sites. The present review discusses the current understanding of the molecular mechanisms contributing to EMT in embryogenesis, fibrosis and tumorigenesis. Additionally, the signaling pathways that initiate EMT through transcriptional factors responsible for the activation and suppression of various genes associated with cancer cell migration were investigated. Furthermore, the important role of the epigenetic modifications that regulate EMT and the reverse process, mesenchymal‑to‑epithelial transition (MET) are discussed. MicroRNAs are key regulators of various intracellular processes and current knowledge of EMT has significantly improved due to microRNA characterization. Their effect on signaling pathways and the ensuing events that occur during EMT at the molecular level is becoming increasingly recognized. The current review also highlights the role of circulating tumor cells (CTCs) and CTC clusters, and their ability to form metastases. In addition, the biological properties of different types of circulating cells based on their tumor‑forming potential are compared.
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March 2018
Volume 41 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Škovierová, H., Okajčeková, T., Strnádel, J., Vidomanová, E., & Halašová, E. (2018). Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review). International Journal of Molecular Medicine, 41, 1187-1200. https://doi.org/10.3892/ijmm.2017.3320
MLA
Škovierová, H., Okajčeková, T., Strnádel, J., Vidomanová, E., Halašová, E."Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review)". International Journal of Molecular Medicine 41.3 (2018): 1187-1200.
Chicago
Škovierová, H., Okajčeková, T., Strnádel, J., Vidomanová, E., Halašová, E."Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review)". International Journal of Molecular Medicine 41, no. 3 (2018): 1187-1200. https://doi.org/10.3892/ijmm.2017.3320