Evodiamine promotes differentiation and inhibits proliferation of C2C12 muscle cells

  • Authors:
    • Xiangping Yao
    • Taiyong Yu
    • Chen Zhao
    • Youlei Li
    • Ying Peng
    • Fengxue Xi
    • Gongshe Yang
  • View Affiliations

  • Published online on: December 13, 2017     https://doi.org/10.3892/ijmm.2017.3321
  • Pages: 1627-1634
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Abstract

Evodiamine is a botanical alkaloid compound extracted from Tetradium plants. Previous studies have reported that evodiamine (Evo) treatment can reduce food uptake and improve insulin resistance in animals . The skeletal muscle comprises about 40% of the body mass of adults and has a vital role in regulating whole body glucose metabolism and energy metabolism. However, the effect of Evo on skeletal muscle is unclear. The main aim of the present study was to investigate the effect of Evo on the differentiation and proliferation of the mouse C2C12 muscle cell line. The results demonstrated that Evo promoted the expression of myogenic marker genes (Myogenin and muscle myosin heavy chain) and increased myoblast differentiation, potentially via activation of the Wnt/β‑catenin pathway. Furthermore, Evo increased mRNA expression of p21, reduced mRNA expression of Cyclin B, Cyclin D and Cyclin E and reduced the percentage of proliferating cells. Also, phosphorylation of ERK1/2 was decreased by Evo treatment during cell proliferation. In conclusion, these findings indicated that Evo has marked effects on skeletal muscle development.
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February 2018
Volume 41 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Yao, X., Yu, T., Zhao, C., Li, Y., Peng, Y., Xi, F., & Yang, G. (2018). Evodiamine promotes differentiation and inhibits proliferation of C2C12 muscle cells. International Journal of Molecular Medicine, 41, 1627-1634. https://doi.org/10.3892/ijmm.2017.3321
MLA
Yao, X., Yu, T., Zhao, C., Li, Y., Peng, Y., Xi, F., Yang, G."Evodiamine promotes differentiation and inhibits proliferation of C2C12 muscle cells". International Journal of Molecular Medicine 41.3 (2018): 1627-1634.
Chicago
Yao, X., Yu, T., Zhao, C., Li, Y., Peng, Y., Xi, F., Yang, G."Evodiamine promotes differentiation and inhibits proliferation of C2C12 muscle cells". International Journal of Molecular Medicine 41, no. 3 (2018): 1627-1634. https://doi.org/10.3892/ijmm.2017.3321