Open Access

Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA

  • Authors:
    • Qian Zhang
    • Xiaofang Sun
    • Xinhua Xiao
    • Jia Zheng
    • Ming Li
    • Miao Yu
    • Fan Ping
    • Zhixin Wang
    • Cuijuan Qi
    • Tong Wang
    • Xiaojing Wang
  • View Affiliations

  • Published online on: December 18, 2017     https://doi.org/10.3892/ijmm.2017.3328
  • Pages: 1547-1559
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Increasing evidence suggests that undernutrition during the fetal period may lead to glucose intolerance, impair the insulin response and induce insulin resistance (IR). Considering the importance of chromium (Cr) in maintaining carbohydrate metabolism, the present study aimed to determine the effects of maternal low Cr (LC) on glucose metabolism in C57BL mice offspring, and the involved mechanisms. Weaned C57BL mice were born from mothers fed a control diet or LC diet, and were then fed a control or LC diet for 13 weeks. Subsequently, the liver microRNA (miRNA/miR) expression profile was analyzed by miRNA array analysis. A maternal LC diet increased fasting serum glucose (P<0.05) and insulin levels (P<0.05), homeostasis model assessment of IR index (P<0.01), and the area under curve for glucose concentration during oral glucose tolerance test (P<0.01). In addition, 8 upregulated and 6 downregulated miRNAs were identified in the maternal LC group (fold change ≥2, P<0.05). miRNA‑gene networks, Kyoto Encyclopedia of Genes and Genomes pathway analysis of differentially expressed miRNAs, and miRNA overexpression in HepG2 cells revealed the critical role of insulin signaling, via miR‑327, miR‑466f‑3p and miR‑223‑3p, in the effects of early life Cr restriction on glucose metabolism. In conclusion, maternal Cr restriction may irreversibly increase IR, which may involve a specific miRNA affecting the insulin signaling pathway.
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March 2018
Volume 41 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M. ... Wang, X. (2018). Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA. International Journal of Molecular Medicine, 41, 1547-1559. https://doi.org/10.3892/ijmm.2017.3328
MLA
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, Z., Qi, C., Wang, T., Wang, X."Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA". International Journal of Molecular Medicine 41.3 (2018): 1547-1559.
Chicago
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, Z., Qi, C., Wang, T., Wang, X."Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA". International Journal of Molecular Medicine 41, no. 3 (2018): 1547-1559. https://doi.org/10.3892/ijmm.2017.3328