Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March-2018 Volume 41 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 41 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA

  • Authors:
    • Qian Zhang
    • Xiaofang Sun
    • Xinhua Xiao
    • Jia Zheng
    • Ming Li
    • Miao Yu
    • Fan Ping
    • Zhixin Wang
    • Cuijuan Qi
    • Tong Wang
    • Xiaojing Wang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1547-1559
    |
    Published online on: December 18, 2017
       https://doi.org/10.3892/ijmm.2017.3328
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Increasing evidence suggests that undernutrition during the fetal period may lead to glucose intolerance, impair the insulin response and induce insulin resistance (IR). Considering the importance of chromium (Cr) in maintaining carbohydrate metabolism, the present study aimed to determine the effects of maternal low Cr (LC) on glucose metabolism in C57BL mice offspring, and the involved mechanisms. Weaned C57BL mice were born from mothers fed a control diet or LC diet, and were then fed a control or LC diet for 13 weeks. Subsequently, the liver microRNA (miRNA/miR) expression profile was analyzed by miRNA array analysis. A maternal LC diet increased fasting serum glucose (P<0.05) and insulin levels (P<0.05), homeostasis model assessment of IR index (P<0.01), and the area under curve for glucose concentration during oral glucose tolerance test (P<0.01). In addition, 8 upregulated and 6 downregulated miRNAs were identified in the maternal LC group (fold change ≥2, P<0.05). miRNA‑gene networks, Kyoto Encyclopedia of Genes and Genomes pathway analysis of differentially expressed miRNAs, and miRNA overexpression in HepG2 cells revealed the critical role of insulin signaling, via miR‑327, miR‑466f‑3p and miR‑223‑3p, in the effects of early life Cr restriction on glucose metabolism. In conclusion, maternal Cr restriction may irreversibly increase IR, which may involve a specific miRNA affecting the insulin signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Diabetes Atlas IDF. 7th edition. International Diabetes Federation; 2015

2 

Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C and Winter PD: Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 303:1019–1022. 1991. View Article : Google Scholar : PubMed/NCBI

3 

Hales CN and Barker DJ: Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia. 35:595–601. 1992. View Article : Google Scholar : PubMed/NCBI

4 

de Rooij SR, Painter RC, Phillips DI, Osmond C, Michels RP, Godsland IF, Bossuyt PM, Bleker OP and Roseboom TJ: Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care. 29:1897–1901. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Food and Nutrition Board Recommended Dietary Allowances. National Research Council, National Academy of Sciences; Washington DC: 2000

6 

Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg GR and Bruce-Robertson A: Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition. Am J Clin Nutr. 30:531–538. 1977. View Article : Google Scholar : PubMed/NCBI

7 

Anderson RA: Chromium, glucose intolerance and diabetes. J Am Coll Nutr. 17:548–555. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Freund H, Atamian S and Fischer JE: Chromium deficiency during total parenteral nutrition. JAMA. 241:496–498. 1979. View Article : Google Scholar : PubMed/NCBI

9 

Padmavathi IJ, Rao KR and Raghunath M: Impact of maternal chromium restriction on glucose tolerance, plasma insulin and oxidative stress in WNIN rat offspring. J Mol Endocrinol. 47:261–271. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Waterland RA and Jirtle RL: Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition. 20:63–68. 2004. View Article : Google Scholar

11 

Zhang Q, Xiao XH, Zheng J, Li M, Yu M, Ping F, Wang Z, Qi C, Wang T and Wang X: Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring. Exp Biol Med (Maywood). 242:1444–1452. 2017. View Article : Google Scholar

12 

Herrera BM, Lockstone HE, Taylor JM, Wills QF, Kaisaki PJ, Barrett A, Camps C, Fernandez C, Ragoussis J, Gauguier D, et al: MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes. BMC Med Genomics. 2:542009. View Article : Google Scholar : PubMed/NCBI

13 

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, et al: Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol. 13:434–446. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Zhou B, Li C, Qi W, Zhang Y, Zhang F, Wu JX, Hu YN, Wu DM, Liu Y, Yan TT, et al: Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia. 55:2032–2043. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Ryu HS, Park SY, Ma D, Zhang J and Lee W: The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS One. 6:e173432011. View Article : Google Scholar : PubMed/NCBI

16 

Jeong HJ, Park SY, Yang WM and Lee W: The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational repression of IRS-1 in SK-Hep1 cells. Biochem Biophys Res Commun. 434:503–508. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Dou L, Zhao T, Wang L, Huang X, Jiao J, Gao D, Zhang H, Shen T, Man Y, Wang S, et al: miR-200s contribute to interleukin-6 (IL-6)-induced insulin resistance in hepatocytes. J Biol Chem. 288:22596–22606. 2013. View Article : Google Scholar : PubMed/NCBI

18 

National Research Council Committee for the Update of the Guide for the C and Use of Laboratory A: The National Academies Collection: Reports funded by National Institutes of Health Guide for the Care and Use of Laboratory Animals. 8th (ed). National Academies Press (US) National Academy of Sciences; Washington (DC): 2011

19 

Yokomizo H, Inoguchi T, Sonoda N, Sakaki Y, Maeda Y, Inoue T, Hirata E, Takei R, Ikeda N, Fujii M, et al: Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice. Am J Physiol Endocrinol Metab. 306:E1163–E1175. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Chou CH, Chang NW, Shrestha S, Hsu SD, Lin YL, Lee WH, Yang CD, Hong HC, Wei TY, Tu SJ, et al: miRTarBase 2016: Updates to the experimentally validated miRNA-target interactions database. Nucleic Acids Res. 44:D239–D247. 2016. View Article : Google Scholar :

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

22 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4:32003. View Article : Google Scholar

23 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Król E and Krejpcio Z: Chromium(III) propionate complex supplementation improves carbohydrate metabolism in insulin-resistance rat model. Food Chem Toxicol. 48:2791–2796. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Hao C, Hao J, Wang W, Han Z, Li G, Zhang L, Zhao X and Yu G: Insulin sensitizing effects of oligomannuronate-chromium (III) complexes in C2C12 skeletal muscle cells. PLoS One. 6:e245982011. View Article : Google Scholar : PubMed/NCBI

26 

Feng W, Zhao T, Mao G, Wang W, Feng Y, Li F, Zheng D, Wu H, Jin D, Yang L, et al: Type 2 diabetic rats on diet supplemented with chromium malate show improved glycometabolism, glycometabolism-related enzyme levels and lipid metabolism. PLoS One. 10:e01259522015. View Article : Google Scholar : PubMed/NCBI

27 

Feng W, Mao G, Li Q, Wang W, Chen Y, Zhao T, Li F, Zou Y, Wu H, Yang L, et al: Effects of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose-response and curative effects study. J Diabetes Investig. 6:396–407. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Racek J, Sindberg CD, Moesgaard S, Mainz J, Fabry J, Müller L and Rácová K: Effect of chromium-enriched yeast on fasting plasma glucose, glycated haemoglobin and serum lipid levels in patients with type 2 diabetes mellitus treated with insulin. Biol Trace Elem Res. 155:1–4. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Intapad S, Dasinger JH, Brown AD, Fahling JM, Esters J and Alexander BT: Glucose intolerance develops prior to increased adiposity and accelerated cessation of estrous cyclicity in female growth-restricted rats. Pediatr Res. 79:962–970. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Venu L, Kishore YD and Raghunath M: Maternal and perinatal magnesium restriction predisposes rat pups to insulin resistance and glucose intolerance. J Nutr. 135:1353–1358. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Bringhenti I, Schultz A, Rachid T, Bomfim MA, Mandarim- de-Lacerda CA and Aguila MB: An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice. J Nutr Biochem. 22:1009–1014. 2011. View Article : Google Scholar

32 

Takaya J, Yamanouchi S and Kaneko K: A calcium-deficient diet in rat dams during gestation and nursing affects hepatic 11β-hydroxysteroid dehydrogenase-1 expression in the offspring. PLoS One. 9:e841252014. View Article : Google Scholar

33 

Zeng LQ, Wei SB, Sun YM, Qin WY, Cheng J, Mitchelson K and Xie L: Systematic profiling of mRNA and miRNA expression in the pancreatic islets of spontaneously diabetic Goto-Kakizaki rats. Mol Med Rep. 11:67–74. 2015. View Article : Google Scholar

34 

Tang X, Muniappan L, Tang G and Ozcan S: Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription. RNA. 15:287–293. 2009. View Article : Google Scholar :

35 

Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, et al: MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest. 122:2884–2897. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Fleischhacker SN, Bauersachs S, Wehner A, Hartmann K and Weber K: Differential expression of circulating microRNAs in diabetic and healthy lean cats. Vet J. 197:688–693. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, et al: MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell. 158:607–619. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS and Rudensky AY: Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol Cell. 48:760–770. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB and Sharp PA: Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat Struct Mol Biol. 18:237–244. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Chi SW, Zang JB, Mele A and Darnell RB: Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 460:479–486. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Cantley LC: The phosphoinositide 3-kinase pathway. Science. 296:1655–1657. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR and Mandarino LJ: Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest. 105:311–320. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE and White MF: Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 277:1531–1537. 2002. View Article : Google Scholar

44 

Yamauchi T, Kaburagi Y, Ueki K, Tsuji Y, Stark GR, Kerr IM, Tsushima T, Akanuma Y, Komuro I, Tobe K, et al: Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase. J Biol Chem. 273:15719–15726. 1998. View Article : Google Scholar : PubMed/NCBI

45 

Ye J, Zheng R, Wang Q, Liao L, Ying Y, Lu H, Cianflone K, Ning Q and Luo X: Downregulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth. Pediatr Res. 72:550–559. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K and Ozanne SE: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Diabetologia. 59:1266–1275. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Sohi G, Revesz A and Hardy DB: Nutritional mismatch in postnatal life of low birth weight rat offspring leads to increased phosphorylation of hepatic eukaryotic initiation factor 2α in adulthood. Metabolism. 62:1367–1374. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Berends LM, Fernandez-Twinn DS, Martin-Gronert MS, Cripps RL and Ozanne SE: Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue. Int J Obes. 37:1051–1057. 2013. View Article : Google Scholar

49 

Kamel MA, Helmy MH, Hanafi MY, Mahmoud SA and Abo Elfetooh H: Impaired peripheral glucose sensing in F1 offspring of diabetic pregnancy. J Physiol Biochem. 70:685–699. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Reeves PG: Components of the AIN-93 Diets as improvements in the AIN-96A diet. J Nutr. 127:838S–841S. 1997.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Sun X, Xiao X, Zheng J, Li M, Yu M, Ping F, Wang Z, Qi C, Wang T, Wang T, et al: Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA. Int J Mol Med 41: 1547-1559, 2018.
APA
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M. ... Wang, X. (2018). Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA. International Journal of Molecular Medicine, 41, 1547-1559. https://doi.org/10.3892/ijmm.2017.3328
MLA
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, Z., Qi, C., Wang, T., Wang, X."Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA". International Journal of Molecular Medicine 41.3 (2018): 1547-1559.
Chicago
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, Z., Qi, C., Wang, T., Wang, X."Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA". International Journal of Molecular Medicine 41, no. 3 (2018): 1547-1559. https://doi.org/10.3892/ijmm.2017.3328
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Sun X, Xiao X, Zheng J, Li M, Yu M, Ping F, Wang Z, Qi C, Wang T, Wang T, et al: Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA. Int J Mol Med 41: 1547-1559, 2018.
APA
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M. ... Wang, X. (2018). Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA. International Journal of Molecular Medicine, 41, 1547-1559. https://doi.org/10.3892/ijmm.2017.3328
MLA
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, Z., Qi, C., Wang, T., Wang, X."Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA". International Journal of Molecular Medicine 41.3 (2018): 1547-1559.
Chicago
Zhang, Q., Sun, X., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, Z., Qi, C., Wang, T., Wang, X."Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA". International Journal of Molecular Medicine 41, no. 3 (2018): 1547-1559. https://doi.org/10.3892/ijmm.2017.3328
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team