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International Journal of Molecular Medicine
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March-2018 Volume 41 Issue 3

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Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis

  • Authors:
    • Fei Hou
    • Ruixia Liu
    • Xiaoya Liu
    • Lijian Cui
    • Xiaozheng Yu
    • Yan Wen
    • Huiguo Ding
    • Chenghong Yin
  • View Affiliations / Copyright

    Affiliations: Department of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, Gastroenterology and Hepatology Department, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P.R. China, Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1315-1322
    |
    Published online on: December 22, 2017
       https://doi.org/10.3892/ijmm.2017.3340
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Abstract

Arkadia is able to degrade key signaling molecules in the transforming growth factor (TGF)‑β1 signaling pathway; however, the expression of Arkadia in the liver during development and progression of TGF‑β1/Smad signaling‑regulated hepatic fibrosis remains to be elucidated. The present study aimed to examine Arkadia expression in the livers of two rat models of hepatic fibrosis induced by bile duct ligation and carbon tetrachloride intoxication, and in human liver samples from patients with hepatic fibrosis. Expression was analyzed by quantitative polymerase chain reaction, immunohistochemistry and western blot analysis. The results indicated that Arkadia was predominantly expressed in the cytoplasm of cholangiocytes and hepatocytes. The protein expression levels of Arkadia were significantly decreased in fibrotic livers, whereas the mRNA expression levels of Arkadia were significantly increased in fibrotic livers compared with in nonfibrotic livers. In conclusion, these data indicated that Arkadia may regulate the pathogenesis and progression of hepatic fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Hou F, Liu R, Liu X, Cui L, Yu X, Wen Y, Ding H and Yin C: Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis. Int J Mol Med 41: 1315-1322, 2018.
APA
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y. ... Yin, C. (2018). Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis. International Journal of Molecular Medicine, 41, 1315-1322. https://doi.org/10.3892/ijmm.2017.3340
MLA
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y., Ding, H., Yin, C."Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis". International Journal of Molecular Medicine 41.3 (2018): 1315-1322.
Chicago
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y., Ding, H., Yin, C."Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis". International Journal of Molecular Medicine 41, no. 3 (2018): 1315-1322. https://doi.org/10.3892/ijmm.2017.3340
Copy and paste a formatted citation
x
Spandidos Publications style
Hou F, Liu R, Liu X, Cui L, Yu X, Wen Y, Ding H and Yin C: Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis. Int J Mol Med 41: 1315-1322, 2018.
APA
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y. ... Yin, C. (2018). Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis. International Journal of Molecular Medicine, 41, 1315-1322. https://doi.org/10.3892/ijmm.2017.3340
MLA
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y., Ding, H., Yin, C."Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis". International Journal of Molecular Medicine 41.3 (2018): 1315-1322.
Chicago
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y., Ding, H., Yin, C."Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis". International Journal of Molecular Medicine 41, no. 3 (2018): 1315-1322. https://doi.org/10.3892/ijmm.2017.3340
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