Open Access

Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis

  • Authors:
    • Fei Hou
    • Ruixia Liu
    • Xiaoya Liu
    • Lijian Cui
    • Xiaozheng Yu
    • Yan Wen
    • Huiguo Ding
    • Chenghong Yin
  • View Affiliations

  • Published online on: December 22, 2017     https://doi.org/10.3892/ijmm.2017.3340
  • Pages: 1315-1322
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Arkadia is able to degrade key signaling molecules in the transforming growth factor (TGF)‑β1 signaling pathway; however, the expression of Arkadia in the liver during development and progression of TGF‑β1/Smad signaling‑regulated hepatic fibrosis remains to be elucidated. The present study aimed to examine Arkadia expression in the livers of two rat models of hepatic fibrosis induced by bile duct ligation and carbon tetrachloride intoxication, and in human liver samples from patients with hepatic fibrosis. Expression was analyzed by quantitative polymerase chain reaction, immunohistochemistry and western blot analysis. The results indicated that Arkadia was predominantly expressed in the cytoplasm of cholangiocytes and hepatocytes. The protein expression levels of Arkadia were significantly decreased in fibrotic livers, whereas the mRNA expression levels of Arkadia were significantly increased in fibrotic livers compared with in nonfibrotic livers. In conclusion, these data indicated that Arkadia may regulate the pathogenesis and progression of hepatic fibrosis.
View Figures
View References

Related Articles

Journal Cover

March 2018
Volume 41 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y. ... Yin, C. (2018). Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis. International Journal of Molecular Medicine, 41, 1315-1322. https://doi.org/10.3892/ijmm.2017.3340
MLA
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y., Ding, H., Yin, C."Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis". International Journal of Molecular Medicine 41.3 (2018): 1315-1322.
Chicago
Hou, F., Liu, R., Liu, X., Cui, L., Yu, X., Wen, Y., Ding, H., Yin, C."Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis". International Journal of Molecular Medicine 41, no. 3 (2018): 1315-1322. https://doi.org/10.3892/ijmm.2017.3340