Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March-2018 Volume 41 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 41 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Retraction in: /10.3892/ijmm.2025.5711
  • Authors:
    • Guannan Wang
    • Xiaosan Fang
    • Meng Han
    • Xiaoming Wang
    • Qiang Huang
  • View Affiliations / Copyright

    Affiliations: Department of Pancreato-Biliary Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China, Department of Hepatobiliary Surgery, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu, Anhui 241001, P.R. China
  • Pages: 1740-1748
    |
    Published online on: January 2, 2018
       https://doi.org/10.3892/ijmm.2018.3358
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to explore the role of miR‑493-5p in liver cancer tissues and cell lines, and its effect on cell behavioral characteristics. The expression of miR-493-5p was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in liver cancer tissues and cell lines (hepatic cell line HL-7702 and the liver cancer cell lines HCCC-9810, HuH-7 and HepG2). In addition, the mechanism by which miR-493-5p mediates its effects was analyzed via the transfection of miR-493-5p mimic and negative control miRNA into HepG2 cells. The viability, proliferation, apoptosis and invasion of the cells were analyzed using MTT assay, flow cytometry and Transwell chamber experiments. Furthermore, the effect of miR-493-5p on the expression of vesicle associated membrane protein 2 (VAMP2) was assayed using a dual-luciferase reporter system, and VAMP2 protein levels were determined by western blot analysis. In addition, following the cotransfection of HepG2 cells with pcDNA3.1‑VAMP2 plasmid and miR‑493-5p mimic, the role of miR-493-5p as a regulator of VAMP2 was evaluated using MTT assay, flow cytometry and Transwell chamber experiments. RT-qPCR analysis indicated that the expression of miR-493-5p in liver cancer tissues and cell lines was decreased significantly compared with that in adjacent normal liver tissues and normal liver cell lines, respectively. Compared with the control group, the cells transfected with miR-493-5p mimic (the miR-493-5p overexpression group) exhibited reduced cell viability, a reduced percentage of cells in the S phase and an increased percentage of apoptotic cells. In addition, fewer cells passed through the Transwell membrane in the miR-493-5p overexpression group compared with the control group. In the dual-luciferase reporter assay, luciferase activity in the miR‑493-5p overexpression group was attenuated compared with that in the control group. In addition, western blot analysis indicated that the VAMP2 protein levels in the miR‑493-5p overexpression group were lower than those in the control group. Furthermore, in cells overexpressing miR-493-5p and VAMP2 simultaneously, the biological behavior of the cells, including cell viability, cell cycle and cell invasiveness, was significantly rescued compared with that of the control group transfected with miR‑493-5p alone. In conclusion, miR-493-5p is indicated to be a tumor suppressor gene, and is downregulated in human liver cancer. miR-493-5p overexpression promotes cell apoptosis and inhibits the proliferation and migration of liver cancer cells by negatively regulating the expression of VAMP. These observations suggest the potential of treating liver cancer by the overexpression of microRNA-493-5p.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ingle PV, Samsudin SZ, Chan PQ, Ng MK, Heng LX, Yap SC, Chai AS and Wong AS: Development and novel therapeutics in hepatocellular carcinoma: A review. Ther Clin Risk Manag. 12:445–455. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Altekruse SF, Henley SJ, Cucinelli JE and McGlynn KA: Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. Am J Gastroenterol. 109:542–553. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Li H, Wei Y, Li B and Peng B: The first case of total laparoscopic living donor right hemihepatectomy in mainland China and literature review. Surg Laparosc Endosc Percutan Tech. 26:172–175. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Wu L, Shen F, Xia Y and Yang YF: Evolving role of radiopharmaceuticals in hepatocellular carcinoma treatment. Anticancer Agents Med Chem. 16:1155–1165. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Navadgi S, Chang CC, Bartlett A, McCall J and Pandanaboyana S: Systematic review and meta-analysis of outcomes after liver resection in patients with hepatocellular carcinoma (HCC) with and without bile duct thrombus. HPB (Oxford). 18:312–316. 2016. View Article : Google Scholar

6 

Li YW, Yang FC, Lu HQ and Zhang JS: Hepatocellular carcinoma and hepatitis B surface protein. World J Gastroenterol. 22:1943–1952. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Yu SJ: A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world: 2010–2016. Clin Mol Hepatol. 22:7–17. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Dost S, Baichoo E and Dieterich DT: Chronic hepatitis B and C infection in the United States: A review of current guidelines, disease burden and cost effectiveness of screening. Expert Rev Anti Infect Ther. 14:511–521. 2016. View Article : Google Scholar

9 

Moirangthem A and Patel T: Mesenchymal stem cell derived extracellular vesicles: A promising new therapeutic approach for hepatic injury. Biotarget. 1:122017. View Article : Google Scholar

10 

Pascual S, Herrera I and Irurzun J: New advances in hepatocellular carcinoma. World J Hepatol. 8:421–438. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Taketomi A: Development and future directions of antiangiogenic therapy in hepatocellular carcinoma. Int J Clin Oncol. 21:2052016. View Article : Google Scholar : PubMed/NCBI

12 

Griffith OL, Griffith M, Krysiak K, Magrini V, Ramu A, Skidmore ZL, Kunisaki J, Austin R, McGrath S, Zhang J, et al: A genomic case study of mixed fibrolamellar hepatocellular carcinoma. Ann Oncol. 27:1148–1154. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Li R, Yang D, Tang CL, Cai P, Ma KS, Ding SY, Zhang XH, Guo DY and Yan XC: Combined hepatocellular carcinoma and cholangiocarcinoma (biphenotypic) tumors: Clinical characteristics, imaging features of contrast-enhanced ultrasound and computed tomography. BMC Cancer. 16:1582016. View Article : Google Scholar : PubMed/NCBI

14 

Lu SC, Mato JM, Espinosa-Diez C and Lamas S: Micro-RNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease. Free Radic Biol Med. 100:66–72. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Tornesello ML, Buonaguro L, Izzo F and Buonaguro FM: Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections. Oncotarget. 7:25087–25102. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Parasramka MA, Maji S, Matsuda A, Yan IK and Patel T: Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma. Pharmacol Ther. 161:67–78. 2016. View Article : Google Scholar : PubMed/NCBI

17 

D'Costa N, Chavez-Munoz C and So A: Role of fibroblast growth factor receptor in sunitinib-resistant renal cell carcinoma. Biotarget. 1:32017. View Article : Google Scholar

18 

Liu YR, Tang RX, Huang WT, Ren FH, He RQ, Yang LH, Luo DZ, Dang YW and Chen G: Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism. World J Hepatol. 7:2781–2791. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Gonzalez-Rodriguez A and Valverde AM: RNA interference as a therapeutic strategy for the treatment of liver diseases. Curr Pharm Des. 21:4574–4586. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Xie QY, Almudevar A, Whitney-Miller CL, Barry CT and McCall MN: A microRNA biomarker of hepatocellular carcinoma recurrence following liver transplantation accounting for within-patient heterogeneity. BMC Med Genomics. 9:182016. View Article : Google Scholar : PubMed/NCBI

21 

Lee CH, Kim JH and Lee SW: The role of microRNA in pathogenesis and as markers of HCV chronic infection. Curr Drug Targets. 17:12016.

22 

Fang Q, Xu T, Wu C, Zhou S and Sun H: Biotargets in neural regeneration. Biotarget. 1:62017. View Article : Google Scholar

23 

Afonso MB, Rodrigues PM, Simão AL and Castro RE: Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma. J Clin Med. 5:52016. View Article : Google Scholar

24 

Wang L, Yue Y, Wang X and Jin H: Function and clinical potential of microRNAs in hepatocellular carcinoma. Oncol Lett. 10:3345–3353. 2015. View Article : Google Scholar

25 

Mizuguchi Y, Takizawa T, Yoshida H and Uchida E: Dysregulated miRNA in progression of hepatocellular carcinoma: a systematic review. Hepatol Res. 46:391–406. 2016. View Article : Google Scholar

26 

Wang Q, Wei L, Guan X, Wu Y, Zou Q and Ji Z: Briefing in family characteristics of microRNAs and their applications in cancer research. Biochim Biophys Acta. 1844(1 Pt B): 191–197. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Kaplan BB, Kar AN, Gioio AE and Aschrafi A: MicroRNAs in the axon and presynaptic nerve terminal. Front Cell Neurosci. 7:1262013. View Article : Google Scholar : PubMed/NCBI

28 

Li M, Fu W, Wo L, Shu X, Liu F and Li C: miR-128 and its target genes in tumorigenesis and metastasis. Exp Cell Res. 319:3059–3064. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Leite-Moreira AM, Lourenço AP, Falcão-Pires I and Leite-Moreira AF: Pivotal role of microRNAs in cardiac physiology and heart failure. Drug Discov Today. 18:1243–1249. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Piva R, Spandidos DA and Gambari R: From microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment (Review). Int J Oncol. 43:985–994. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Palumbo S, Miracco C, Pirtoli L and Comincini S: Emerging roles of microRNA in modulating cell-death processes in malignant glioma. J Cell Physiol. 229:277–286. 2014. View Article : Google Scholar

32 

Zhang WC, Liu J, Xu X and Wang G: The role of microRNAs in lung cancer progression. Med Oncol. 30:6752013. View Article : Google Scholar : PubMed/NCBI

33 

Yu JJ and Xia SJ: Novel role of microRNAs in prostate cancer. Chin Med J (Engl). 126:2960–2964. 2013.

34 

Wu Y and Jiang M: The revolution of lung cancer treatment: From vaccines, to immune checkpoint inhibitors, to chimeric antigen receptor T therapy. Biotarget. 1:72017. View Article : Google Scholar

35 

Lanaya H, Natarajan A, Komposch K, Li L, Amberg N, Chen L, Wculek SK, Hammer M, Zenz R, Peck-Radosavljevic M, et al: EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nat Cell Biol. 16:972–977. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Wang L, Yao J, Shi X, Hu LL, Li ZF, Song TS and Huang C: MicroRNA-302b suppresses cell proliferation by targeting EGFR in human hepatocellular carcinoma SMMC-7721 cells. BMC Cancer. 13:4482013. View Article : Google Scholar : PubMed/NCBI

37 

Wang W, Zhang H, Wang L, Zhang S and Tang M: miR-613 inhibits the growth and invasiveness of human hepatocellular carcinoma via targeting DCLK1. Biochem Biophys Res Commun. 473:987–992. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Zhou X, Zhu HQ, Ma CQ, Li HG, Liu FF, Chang H and Lu J: miR-1180 promoted the proliferation of hepatocellular carcinoma cells by repressing TNIP2 expression. Biomed Pharmacother. 79:315–320. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Zhou W, Zhang C, Jiang H, Zhang Z, Xie L and He X: miR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC. Iran J Basic Med Sci. 18:1027–1033. 2015.

40 

Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Kracht M, Nakagama H and Okamoto K: MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. Cancer Sci. 105:425–430. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

42 

Tzeng CW, Tzeng WS, Lin LT, Lee CW, Yen FL and Lin CC: Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system. Phytomedicine. 23:528–540. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Mouli S, Hickey R, Thornburg B, Sato KT, Desai K, Gabr A, Kallini JR, Niemeri H, Kircher S, Mulcahy MF, et al: Single-versus triple-drug chemoembolization for hepatocellular carcinoma: Comparing outcomes by toxicity, imaging response, and survival. J Vasc Interv Radiol. 27:1279–1287. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Ren Y, Qiu L, Lü F, Ru X, Li S, Xiang Y, Yu S and Zhang Y: TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells. Sci Rep. 6:237752016. View Article : Google Scholar

45 

Zhang D, Cao C, Liu L and Wu D: Up-regulation of lncRNA SNHG20 predicts poor prognosis in hepatocellular carcinoma. J Cancer. 7:608–617. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Gao JZ, Li J, Du JL and Li XL: Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence. Oncol Lett. 11:1791–1798. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Vira D, Basak SK, Veena MS, Wang MB, Batra RK and Srivatsan ES: Cancer stem cells, microRNAs, and therapeutic strategies including natural products. Cancer Metastasis Rev. 31:733–751. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Link A, Kupcinskas J, Wex T and Malfertheiner P: Macro-role of microRNA in gastric cancer. Dig Dis. 30:255–267. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Tambe M, Pruikkonen S, Mäki-Jouppila J, Chen P, Elgaaen BV, Straume AH, Huhtinen K, Cárpen O, Lønning PE, Davidson B, et al: Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel. Oncotarget. 7:12267–12285. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Okamoto K, Ishiguro T, Midorikawa Y, Ohata H, Izumiya M, Tsuchiya N, Sato A, Sakai H and Nakagama H: miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. EMBO J. 31:1752–1763. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Han Q, Hong Y, Fu Z, Zhang M, Cao X, Liu Y, Ma S, Guo Y, Lu K, Zhu C, et al: Characterization of VAMP2 in Schistosoma japonicum and the evaluation of protective efficacy induced by recombinant SjVAMP2 in mice. PLoS One. 10:e01445842015. View Article : Google Scholar : PubMed/NCBI

52 

Ropert N, Jalil A and Li D: Expression and cellular function of vSNARE proteins in brain astrocytes. Neuroscience. 323:76–83. 2016. View Article : Google Scholar

53 

Kosiorek M, Zylinska L, Zablocki K and Pikula S: Calcineurin/NFAT signaling represses genes Vamp1 and Vamp2 via PMCA-dependent mechanism during dopamine secretion by pheochromocytoma cells. PLoS One. 9:e921762014. View Article : Google Scholar : PubMed/NCBI

54 

Mohankumar S and Patel T: Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer. Brief Funct Genomics. 15:249–256. 2016. View Article : Google Scholar :

55 

Nie H, Cao Q, Zhu L, Gong Y, Gu J and He Z: Acetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma. PLoS One. 8:e616782013. View Article : Google Scholar : PubMed/NCBI

56 

Rodrigues HA, Fonseca Mde C, Camargo WL, Lima PM, Martinelli PM, Naves LA, Prado VF, Prado MA and Guatimosim C: Reduced expression of the vesicular acetylcholine transporter and neurotransmitter content affects synaptic vesicle distribution and shape in mouse neuromuscular junction. PloS One. 8:e783422013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang G, Fang X, Han M, Wang X and Huang Q: MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711. Int J Mol Med 41: 1740-1748, 2018.
APA
Wang, G., Fang, X., Han, M., Wang, X., & Huang, Q. (2018). MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711. International Journal of Molecular Medicine, 41, 1740-1748. https://doi.org/10.3892/ijmm.2018.3358
MLA
Wang, G., Fang, X., Han, M., Wang, X., Huang, Q."MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711". International Journal of Molecular Medicine 41.3 (2018): 1740-1748.
Chicago
Wang, G., Fang, X., Han, M., Wang, X., Huang, Q."MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711". International Journal of Molecular Medicine 41, no. 3 (2018): 1740-1748. https://doi.org/10.3892/ijmm.2018.3358
Copy and paste a formatted citation
x
Spandidos Publications style
Wang G, Fang X, Han M, Wang X and Huang Q: MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711. Int J Mol Med 41: 1740-1748, 2018.
APA
Wang, G., Fang, X., Han, M., Wang, X., & Huang, Q. (2018). MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711. International Journal of Molecular Medicine, 41, 1740-1748. https://doi.org/10.3892/ijmm.2018.3358
MLA
Wang, G., Fang, X., Han, M., Wang, X., Huang, Q."MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711". International Journal of Molecular Medicine 41.3 (2018): 1740-1748.
Chicago
Wang, G., Fang, X., Han, M., Wang, X., Huang, Q."MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2 Retraction in /10.3892/ijmm.2025.5711". International Journal of Molecular Medicine 41, no. 3 (2018): 1740-1748. https://doi.org/10.3892/ijmm.2018.3358
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team