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miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1

  • Authors:
    • Yuying Tang
    • Leilei Zheng
    • Jie Zhou
    • Yang Chen
    • Lan Yang
    • Feng Deng
    • Yun Hu
  • View Affiliations / Copyright

    Affiliations: Department of Endodontics, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing 401147, P.R. China, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing 401147, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1595-1607
    |
    Published online on: January 9, 2018
       https://doi.org/10.3892/ijmm.2018.3373
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Abstract

Certain microRNAs (miRs) have important roles in the maintenance of bone development and metabolism, and a variety of miRs are known to be deregulated in diabetes. The present study investigated the role of miR‑203‑3p in the regulation of bone loss by assessing jaw bones of a rat model of type 2 diabetes. The results indicated that miR‑203‑3p inhibited osteogenesis in the jaws of diabetic rats and in rat bone marrow mesenchymal stem cells cultured in high‑glucose medium. A luciferase re­porter assay was used to verify the bioinformatics prediction that miR‑203‑3p targets the 3'‑untranslated region of Smad1, which is an important mediator of the bone morphogenetic protein (BMP)/Smad pathway. Overexpression of Smad1 attenuated the miR‑203‑3p‑mediated suppres­sion of osteogenic differentiation. It was therefore indicated that the BMP/Smad pathway is attenuated and the transforming growth factor‑β/activin pathway is promoted by Smad1 reduction. Taken together, it was indicated that miR‑203‑3p inhibits osteogenesis in jaw bones of diabetic rats by targeting Smad1 to inhibit the BMP/Smad pathway.
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1 

Clementini M, Rossetti PH, Penarrocha D, Micarelli C, Bonachela WC and Canullo L: Systemic risk factors for peri-implant bone loss: A systematic review and meta-analysis. Int J Oral Maxillofac Surg. 43:323–334. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Nemtoi A, Ladunca O, Dragan E, Budacu C, Mihai C and Haba D: Quantitative and qualitative bone assessment of the posterior mandible in patients with diabetes mellitus: A cone beam computed tomography study. Rev Med Chir Soc Med Nat Iasi. 117:1002–1008. 2013.

3 

de Morais JA, Trindade-Suedam IK, Pepato MT, Marcantonio E Jr, Wenzel A and Scaf G: Effect of diabetes mellitus and insulin therapy on bone density around osseointegrated dental implants: A digital subtraction radiography study in rats. Clin Oral Implants Res. 20:796–801. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Fariñas I, Karsenty G and Grosschedl R: SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 125:971–986. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Liu Q and Paroo Z: Biochemical principles of small RNA pathways. Annu Rev Biochem. 79:295–319. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ha M and Kim VN: Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 15:509–524. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhang Y, Xie RL, Gordon J, LeBlanc K, Stein JL, Lian JB, van Wijnen AJ and Stein GS: Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem. 287:21926–21935. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Li Z, Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, Lian JB and Stein GS: A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci USA. 105:13906–13911. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Liu H, Sun Q, Wan C, Li L, Zhang L and Chen Z: MicroRNA-338-3p regulates osteogenic differentiation of mouse bone marrow stromal stem cells by targeting Runx2 and Fgfr2. J Cell Physiol. 229:1494–1502. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kim EJ, Kang IH, Lee JW, Jang WG and Koh JT: MiR-433 mediates ERRγ-suppressed osteoblast differentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells. Life Sci. 92:562–568. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Zuo B, Zhu J, Li J, Wang C, Zhao X, Cai G, Li Z, Peng J, Wang P, Shen C, et al: microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2. J Bone Miner Res. 30:330–345. 2015. View Article : Google Scholar

12 

Tomé M, López-Romero P, Albo C, Sepúlveda JC, Fernández- Gutiérrez B, Dopazo A, Bernad A and González MA: miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells. Cell Death Differ. 18:985–995. 2011. View Article : Google Scholar :

13 

Jia J, Tian Q, Ling S, Liu Y, Yang S and Shao Z: miR-145 suppresses osteogenic differentiation by targeting Sp7. FEBS Lett. 587:3027–3031. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Shi K, Lu J, Zhao Y, Wang L, Li J, Qi B, Li H and Ma C: MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix. Bone. 55:487–494. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Baglìo SR, Devescovi V, Granchi D and Baldini N: MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31. Gene. 527:321–331. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Goettsch C, Rauner M, Pacyna N, Hempel U, Bornstein SR and Hofbauer LC: miR-125b regulates calcification of vascular smooth muscle cells. Am J Pathol. 179:1594–1600. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Chen S, Yang L, Jie Q, Lin YS, Meng GL, Fan JZ, Zhang JK, Fan J, Luo ZJ and Liu J: MicroRNA-125b suppresses the proliferation and osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Mol Med Rep. 9:1820–1826. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Zhang JF, Fu WM, He ML, Wang H, Wang WM, Yu SC, Bian XW, Zhou J, Lin MC, Lu G, et al: miR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix. Mol Biol Cell. 22:3955–3961. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Itoh T, Nozawa Y and Akao Y: MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5. J Biol Chem. 284:19272–19279. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Xie Q, Wang Z, Bi X, Zhou H, Wang Y, Gu P and Fan X: Effects of miR-31 on the osteogenesis of human mesenchymal stem cells. Biochem Biophys Res Commun. 446:98–104. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Li J, Dong J, Zhang ZH, Zhang DC, You XY, Zhong Y, Chen MS and Liu SM: miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4. J Cell Physiol. 228:2324–2336. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Li Z, Hassan MQ, Jafferji M, Aqeilan RI, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS and Lian JB: Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem. 284:15676–15684. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Lin EA, Kong L, Bai XH, Luan Y and Liu CJ: miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J Biol Chem. 284:11326–11335. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Kureel J, Dixit M, Tyagi AM, Mansoori MN, Srivastava K, Raghuvanshi A, Maurya R, Trivedi R, Goel A and Singh D: miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation. Cell Death Dis. 5:e10502014. View Article : Google Scholar : PubMed/NCBI

25 

Luzi E, Marini F, Sala SC, Tognarini I, Galli G and Brandi ML: Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor. J Bone Miner Res. 23:287–295. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Zheng L, Tu Q, Meng S, Zhang L, Yu L, Song J, Hu Y, Sui L, Zhang J, Dard M, et al: Runx2/DICER/miRNA pathway in regulating osteogenesis. J Cell Physiol. 232:182–191. 2017. View Article : Google Scholar

27 

Ko JY, Chuang PC, Chen MW, Ke HC, Wu SL, Chang YH, Chen YS and Wang FS: MicroRNA-29a ameliorates gluco-corticoid-induced suppression of osteoblast differentiation by regulating β-catenin acetylation. Bone. 57:468–475. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Wang T and Xu Z: miR-27 promotes osteoblast differentiation by modulating Wnt signaling. Biochem Biophys Res Commun. 402:186–189. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, et al: miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 287:42084–42092. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Clark EA, Kalomoiris S, Nolta JA and Fierro FA: Concise review: MicroRNA function in multipotent mesenchymal stromal cells. Stem cells. 32:1074–1082. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Gaur T, Hussain S, Mudhasani R, Parulkar I, Colby JL, Frederick D, Kream BE, van Wijnen AJ, Stein JL, Stein GS, et al: Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse. Dev Biol. 340:10–21. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Lu H, Kraut D, Gerstenfeld LC and Graves DT: Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology. 144:346–352. 2003. View Article : Google Scholar

34 

García-Hernández A, Arzate H, Gil-Chavarria I, Rojo R and Moreno-Fierros L: High glucose concentrations alter the biomineralization process in human osteoblastic cells. Bone. 50:276–288. 2012. View Article : Google Scholar

35 

Ogawa N, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M and Sugimoto T: The combination of high glucose and advanced glycation end-products (AGEs) inhibits the mineralization of osteoblastic MC3T3-E1 cells through glucose-induced increase in the receptor for AGEs. Horm Metab Res. 39:871–875. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Gopalakrishnan V, Vignesh RC, Arunakaran J, Aruldhas MM and Srinivasan N: Effects of glucose and its modulation by insulin and estradiol on BMSC differentiation into osteoblastic lineages. Biochem Cell Biol. 84:93–101. 2006. View Article : Google Scholar : PubMed/NCBI

37 

van Rooij E: The art of microRNA research. Circ Res. 108:219–234. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Wang JC: miR-467f modulates osteogenic differentiation of mice bone mesenchymal stem cells in high glucose environment. Military Medical School; Beijing: 2013, In Chinese.

39 

Yang Z, Zhong L, Zhong S, Xian R and Yuan B: miR-203 protects microglia mediated brain injury by regulating inflammatory responses via feedback to MyD88 in ischemia. Mol Immunol. 65:293–301. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Okumura T, Shimada Y, Moriyama M, Takei Y, Omura T, Sekine S, Nagata T, Shimizu K and Tsukada K: MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architectur in vivo. Int J Oncol. 44:1923–1932. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Yu X, Jiang X, Li H, Guo L, Jiang W and Lu SH: miR-203 inhibits the proliferation and self-renewal of esophageal cancer stem-like cells by suppressing stem renewal factor Bmi-1. Stem Cells Dev. 23:576–585. 2014. View Article : Google Scholar

42 

Delic D, Eisele C, Schmid R, Luippold G, Mayoux E and Grempler R: Characterization of Micro-RNA changes during the progression of type 2 diabetes in Zucker diabetic fatty rats. Int J Mol Sci. 17:pii: E665. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Liu J, Xu Y, Shu B, Wang P, Tang J, Chen L, Qi S, Liu X and Xie J: Quantification of the differential expression levels of microRNA-203 in different degrees of diabetic foot. Int J Clin Exp Pathol. 8:13416–13420. 2015.

44 

Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L and Wrana JL: MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell. 85:489–500. 1996. View Article : Google Scholar : PubMed/NCBI

45 

Wang M, Jin H, Tang D, Huang S, Zuscik MJ and Chen D: Smad1 plays an essential role in bone development and postnatal bone formation. Osteoarthritis Cartilage. 19:751–762. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Ehnert S, Freude T, Ihle C, Mayer L, Braun B, Graeser J, Flesch I, Stöckle U, Nussler AK and Pscherer S: Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation-description of a novel in vitro model. Exp Cell Res. 332:247–258. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Miyazono K, Maeda S and Imamura T: Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins. Oncogene. 23:4232–4237. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Pfeilschifter J, Bonewald L and Mundy GR: Characterization of the latent transforming growth factor beta complex in bone. J Bone Miner Res. 5:49–58. 1990. View Article : Google Scholar : PubMed/NCBI

49 

Edwards JR, Nyman JS, Lwin ST, Moore MM, Esparza J, O'Quinn EC, Hart AJ, Biswas S, Patil CA, Lonning S, et al: Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo. J Bone Miner Res. 25:2419–2426. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, et al: Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One. 4:e52752009. View Article : Google Scholar : PubMed/NCBI

51 

Matsumoto Y, Otsuka F, Hino J, Miyoshi T, Takano M, Miyazato M, Makino H and Kangawa K: Bone morphogenetic protein-3b (BMP-3b) inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling. Mol Cell Endocrinol. 350:78–86. 2012. View Article : Google Scholar

52 

Taipaleenmaki H, Browne G, Akech J, Zustin J, van Wijnen AJ, Stein JL, Hesse E, Stein GS and Lian JB: Targeting of Runx2 by miR-135 and miR-203 impairs progression of breast cancer and metastatic bone disease. Cancer Res. 75:1433–1444. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Saini S, Majid S, Yamamura S, Tabatabai L, Suh SO, Shahryari V, Chen Y, Deng G, Tanaka Y and Dahiya R: Regulatory Role of mir-203 in prostate cancer progression and metastasis. Clin Cancer Res. 17:5287–5298. 2011. View Article : Google Scholar

54 

Lee MH, Kwon TG, Park HS, Wozney JM and Ryoo HM: BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem Biophys Res Commun. 309:689–694. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang Y, Zheng L, Zhou J, Chen Y, Yang L, Deng F and Hu Y: miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1. Int J Mol Med 41: 1595-1607, 2018.
APA
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., & Hu, Y. (2018). miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1. International Journal of Molecular Medicine, 41, 1595-1607. https://doi.org/10.3892/ijmm.2018.3373
MLA
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., Hu, Y."miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1". International Journal of Molecular Medicine 41.3 (2018): 1595-1607.
Chicago
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., Hu, Y."miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1". International Journal of Molecular Medicine 41, no. 3 (2018): 1595-1607. https://doi.org/10.3892/ijmm.2018.3373
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Y, Zheng L, Zhou J, Chen Y, Yang L, Deng F and Hu Y: miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1. Int J Mol Med 41: 1595-1607, 2018.
APA
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., & Hu, Y. (2018). miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1. International Journal of Molecular Medicine, 41, 1595-1607. https://doi.org/10.3892/ijmm.2018.3373
MLA
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., Hu, Y."miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1". International Journal of Molecular Medicine 41.3 (2018): 1595-1607.
Chicago
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., Hu, Y."miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1". International Journal of Molecular Medicine 41, no. 3 (2018): 1595-1607. https://doi.org/10.3892/ijmm.2018.3373
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