Open Access

miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1

  • Authors:
    • Yuying Tang
    • Leilei Zheng
    • Jie Zhou
    • Yang Chen
    • Lan Yang
    • Feng Deng
    • Yun Hu
  • View Affiliations

  • Published online on: January 9, 2018     https://doi.org/10.3892/ijmm.2018.3373
  • Pages: 1595-1607
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Certain microRNAs (miRs) have important roles in the maintenance of bone development and metabolism, and a variety of miRs are known to be deregulated in diabetes. The present study investigated the role of miR‑203‑3p in the regulation of bone loss by assessing jaw bones of a rat model of type 2 diabetes. The results indicated that miR‑203‑3p inhibited osteogenesis in the jaws of diabetic rats and in rat bone marrow mesenchymal stem cells cultured in high‑glucose medium. A luciferase re­porter assay was used to verify the bioinformatics prediction that miR‑203‑3p targets the 3'‑untranslated region of Smad1, which is an important mediator of the bone morphogenetic protein (BMP)/Smad pathway. Overexpression of Smad1 attenuated the miR‑203‑3p‑mediated suppres­sion of osteogenic differentiation. It was therefore indicated that the BMP/Smad pathway is attenuated and the transforming growth factor‑β/activin pathway is promoted by Smad1 reduction. Taken together, it was indicated that miR‑203‑3p inhibits osteogenesis in jaw bones of diabetic rats by targeting Smad1 to inhibit the BMP/Smad pathway.
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March 2018
Volume 41 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., & Hu, Y. (2018). miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1. International Journal of Molecular Medicine, 41, 1595-1607. https://doi.org/10.3892/ijmm.2018.3373
MLA
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., Hu, Y."miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1". International Journal of Molecular Medicine 41.3 (2018): 1595-1607.
Chicago
Tang, Y., Zheng, L., Zhou, J., Chen, Y., Yang, L., Deng, F., Hu, Y."miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1". International Journal of Molecular Medicine 41, no. 3 (2018): 1595-1607. https://doi.org/10.3892/ijmm.2018.3373