|
1
|
Brunt EM, Wong VW, Nobili V, Day CP,
Sookoian S, Maher JJ, Bugianesi E, Sirlin CB, Neuschwander-Tetri BA
and Rinella ME: Nonalcoholic fatty liver disease. Nat Rev Dis
Primers. 1:150802015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Wang FS, Fan JG, Zhang Z, Gao B and Wang
HY: The global burden of liver disease: The major impact of China.
Hepatology. 60:2099–2108. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Cheung O and Sanyal AJ: Recent advances in
nonalcoholic fatty liver disease. Curr Opin Gastroenterol.
26:202–208. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Neuschwander-Tetri BA: Hepatic
lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis:
The central role of nontriglyceride fatty acid metabolites.
Hepatology. 52:774–788. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Li S, Li J, Shen C, Zhang X, Sun S, Cho M,
Sun C and Song Z: Tert-Butylhydroquinone (tBHQ) protects
hepatocytes against lipotoxicity via inducing autophagy
independently of Nrf2 activation. Biochim Biophys Acta. 1841:22–33.
2014. View Article : Google Scholar
|
|
6
|
Wu J, Wu JJ, Yang LJ, Wei LX and Zou DJ:
Rosiglitazone protects against palmitate-induced pancreatic
beta-cell death by activation of autophagy via 5′-AMP-activated
protein kinase modulation. Endocrine. 44:87–98. 2013. View Article : Google Scholar
|
|
7
|
Ryter SW, Cloonan SM and Choi AM:
Autophagy: A critical regulator of cellular metabolism and
homeostasis. Mol Cells. 36:7–16. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Singh R, Kaushik S, Wang Y, Xiang Y, Novak
I, Komatsu M, Tanaka K, Cuervo AM and Czaja MJ: Autophagy regulates
lipid metabolism. Nature. 458:1131–1135. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Fukuo Y, Yamashina S, Sonoue H, Arakawa A,
Nakadera E, Aoyama T, Uchiyama A, Kon K, Ikejima K and Watanabe S:
Abnormality of autophagic function and cathepsin expression in the
liver from patients with non-alcoholic fatty liver disease. Hepatol
Res. 44:1026–1036. 2014. View Article : Google Scholar
|
|
10
|
González-Rodríguez Á, Mayoral R, Agra N,
Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillón J,
Lo Iacono O, Corazzari M, Fimia GM, et al: Impaired autophagic flux
is associated with increased endoplasmic reticulum stress during
the development of NAFLD. Cell Death Dis. 5:e11792014. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Yang L, Li P, Fu S, Calay ES and
Hotamisligil GS: Defective hepatic autophagy in obesity promotes ER
stress and causes insulin resistance. Cell Metab. 11:467–478. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi
J, Liu Z and Cao W: Hepatic autophagy is suppressed in the presence
of insulin resistance and hyperinsulinemia: Inhibition of
FoxO1-dependent expression of key autophagy genes by insulin. J
Biol Chem. 284:31484–31492. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Czaja MJ: Functions of autophagy in
hepatic and pancreatic physiology and disease. Gastroenterology.
140:1895–1908. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Koga H, Kaushik S and Cuervo AM: Altered
lipid content inhibits autophagic vesicular fusion. FASEB J.
24:3052–3065. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Inami Y, Yamashina S, Izumi K, Ueno T,
Tanida I, Ikejima K and Watanabe S: Hepatic steatosis inhibits
autophagic proteolysis via impairment of autophagosomal
acidification and cathepsin expression. Biochem Biophys Res Commun.
412:618–625. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Park HW, Park H, Semple IA, Jang I, Ro SH,
Kim M, Cazares VA, Stuenkel EL, Kim JJ, Kim JS and Lee JH:
Pharmacological correction of obesity-induced autophagy arrest
using calcium channel blockers. Nat Commun. 5:48342014. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Seo YK, Jeon TI, Chong HK, Biesinger J,
Xie X and Osborne TF: Genome-wide localization of SREBP-2 in
hepatic chromatin predicts a role in autophagy. Cell Metab.
13:367–375. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2−ΔΔC T method. Methods. 25:402–408.
2001. View Article : Google Scholar
|
|
19
|
Pan X, Wang P, Luo J, Wang Z, Song Y, Ye J
and Hou X: Adipogenic changes of hepatocytes in a high-fat
diet-induced fatty liver mice model and non-alcoholic fatty liver
disease patients. Endocrine. 48:834–847. 2015. View Article : Google Scholar
|
|
20
|
Choi SE, Lee SM, Lee YJ, Li LJ, Lee SJ,
Lee JH, Kim Y, Jun HS, Lee KW and Kang Y: Protective role of
autophagy in palmitate-induced INS-1 beta-cell death.
Endocrinology. 150:126–134. 2009. View Article : Google Scholar
|
|
21
|
Mei S, Ni HM, Manley S, Bockus A, Kassel
KM, Luyendyk JP, Copple BL and Ding WX: Differential roles of
unsaturated and saturated fatty acids on autophagy and apoptosis in
hepatocytes. J Pharmacol Exp Ther. 339:487–498. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Mizushima N, Yoshimori T and Levine B:
Methods in mammalian autophagy research. Cell. 140:313–326. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Klionsky DJ, Abdelmohsen K, Abe A, Abedin
MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD,
Adeli K, et al: Guidelines for the use and interpretation of assays
for monitoring autophagy (3rd edition). Autophagy. 12:1–222. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Jaishy B, Zhang Q, Chung HS, Riehle C,
Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE and Abel ED:
Lipid-induced NOX2 activation inhibits autophagic flux by impairing
lysosomal enzyme activity. J Lipid Res. 56:546–561. 2015.
View Article : Google Scholar :
|
|
25
|
Osborne TF and Espenshade PJ: Evolutionary
conservation and adaptation in the mechanism that regulates SREBP
action: What a long, strange tRIP it's been. Genes Dev.
23:2578–2591. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Shao W and Espenshade PJ: Expanding roles
for SREBP in metabolism. Cell Metab. 16:414–419. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wong TY, Lin SM and Leung LK: The flavone
luteolin suppresses SREBP-2 expression and Post-translational
activation in hepatic cells. PLoS One. 10:e01356372015. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Levine B and Kroemer G: Autophagy in the
pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Wang K: Autophagy and apoptosis in liver
injury. Cell Cycle. 14:1631–1642. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Lavallard VJ and Gual P: Autophagy and
non-alcoholic fatty liver disease. Biomed Res Int. 2014:1201792014.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Mizushima N and Levine B: Autophagy in
mammalian development and differentiation. Nat Cell Biol.
12:823–830. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Codogno P and Meijer AJ: Autophagy: A
potential link between obesity and insulin resistance. Cell Metab.
11:449–451. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Tan SH, Shui G, Zhou J, Li JJ, Bay BH,
Wenk MR and Shen HM: Induction of autophagy by palmitic acid via
protein kinase C-mediated signaling pathway independent of mTOR
(mammalian target of rapamycin). J Biol Chem. 287:14364–14376.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Ogata M, Hino S, Saito A, Morikawa K,
Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K,
et al: Autophagy is activated for cell survival after endoplasmic
reticulum stress. Mol Cell Biol. 26:9220–9231. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Yorimitsu T and Klionsky DJ: Endoplasmic
reticulum stress: A new pathway to induce autophagy. Autophagy.
3:160–162. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Park M, Sabetski A, Kwan Chan Y, Turdi S
and Sweeney G: Palmitate induces ER stress and autophagy in H9c2
cells: Implications for apoptosis and adiponectin resistance. J
Cell Physiol. 230:630–639. 2015. View Article : Google Scholar
|
|
37
|
Cai N, Zhao X, Jing Y, Sun K, Jiao S, Chen
X, Yang H, Zhou Y and Wei L: Autophagy protects against
palmitate-induced apoptosis in hepatocytes. Cell Biosci. 4:282014.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Liu J, Chang F, Li F, Fu H, Wang J, Zhang
S, Zhao J and Yin D: Palmitate promotes autophagy and apoptosis
through ROS-dependent JNK and p38 MAPK. Biochem Biophys Res Commun.
463:262–267. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Kim KY, Jang HJ, Yang YR, Park KI, Seo J,
Shin IW, Jeon TI, Ahn SC, Suh PG, Osborne TF and Seo YK:
Corrigendum: SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver
disease through activation of autophagy. Sci Rep. 6:357322016.
View Article : Google Scholar
|
