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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2018 Volume 41 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

β-glucans and cholesterol (Review)

Petr Sima, Luca Vannucci, Vaclav Vetvicka
Pages: 1799-1808
Published online on: 22 January 2018

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Review Open Access

Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)

Jing‑Hua Pan, Hong Zhou, Xiao‑Xu Zhao, Hui Ding, Wei Li, Li Qin, Yun‑Long Pan
Pages: 1809-1816
Published online on: 11 January 2018

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Review

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)

Ji‑Dong Guo, Xin Zhao, Yang Li, Guang‑Ren Li, Xiao‑Liang Liu
Pages: 1817-1825
Published online on: 19 January 2018

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Article Open Access

D‑Pinitol alleviates cyclosporine A‑induced renal tubulointerstitial fibrosis via activating Sirt1 and Nrf2 antioxidant pathways

Eun Sil Koh, Soojeong Kim, Minyoung Kim, Yu Ah Hong, Seok Joon Shin, Cheol Whee Park, Yoon Sik Chang, Sungjin Chung, Ho‑Shik Kim
Pages: 1826-1834
Published online on: 19 January 2018

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Article Open Access

Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension

Jia Liu, Jiamei Liu, Linying Shi, Fan Zhang, Liping Yu, Xinchun Yang, Jun Cai
Pages: 1835-1844
Published online on: 23 January 2018

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Article Open Access

Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells

Jiexiang Yang, Yonggen Zou, Dianmin Jiang
Pages: 1845-1854
Published online on: 29 January 2018

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Article Open Access

miR‑21‑5p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3

Jun Chen, Chao Zhou, Junhe Li, Xiaojun Xiang, Ling Zhang, Jun Deng, Jianping Xiong
Pages: 1855-1866
Published online on: 18 January 2018

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Article Open Access

Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway

Maojun Liu, Yan Li, Biao Liang, Zining Li, Zhengtao Jiang, Chun Chu, Jun Yang
Pages: 1867-1876
Published online on: 23 January 2018

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Article Open Access

Increased expression of sterol regulatory element binding protein‑2 alleviates autophagic dysfunction in NAFLD

Chunwei Cheng, Xiaoling Deng, Keshu Xu
Pages: 1877-1886
Published online on: 16 January 2018

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Article Open Access

Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway

Qiuyu Wang, Peng Wang, Zhigang Xiao
Pages: 1887-1898
Published online on: 25 January 2018

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Article Open Access

miR‑186, a serum microRNA, induces endothelial cell apoptosis by targeting SMAD6 in Kawasaki disease

Rongzhou Wu, Danping Shen, Hareshwaree Sohun, Donghui Ge, Xianda Chen, Xuliang Wang, Ruiyao Chen, Yuqing Wu, Jingjing Zeng, Xing Rong, Xiaoping Su, Maoping Chu
Pages: 1899-1908
Published online on: 18 January 2018

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Article Open Access

MicroRNA-327 regulates cardiac hypertrophy and fibrosis induced by pressure overload

Yue Ji, Ming Qiu, Yejiao Shen, Li Gao, Yaqing Wang, Wei Sun, Xinli Li, Yan Lu, Xiangqing Kong
Pages: 1909-1916
Published online on: 25 January 2018

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Article Open Access

Aberrantly expressed long noncoding RNAs in hypertrophic scar fibroblasts in vitro: A microarray study

Longxiang Tu, Qi Huang, Shangfeng Fu, Dewu Liu
Pages: 1917-1930
Published online on: 26 January 2018

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Article Open Access

Extracorporeal shock wave therapy with low-energy flux density inhibits hypertrophic scar formation in an animal model

Jing-Chun Zhao, Bo-Ru Zhang, Lei Hong, Kai Shi, Wei-Wei Wu, Jia-Ao Yu
Pages: 1931-1938
Published online on: 29 January 2018

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Article Open Access

Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunction

Qiang Wan, Zhongyong Liu, Yuping Yang, Xiaobing Cui
Pages: 1939-1948
Published online on: 30 January 2018

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Article Open Access

EZH2-mediated suppression of lncRNA-LET promotes cell apoptosis and inhibits the proliferation of post-burn skin fibroblasts

Weicai Zheng, Aixiang Yu
Pages: 1949-1957
Published online on: 25 January 2018

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Article Open Access

Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis

Wenlong Cao, Weiyuan Wei, Zexu Zhan, Dongyi Xie, Yubo Xie, Qiang Xiao
Pages: 1958-1966
Published online on: 11 January 2018

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Article Open Access

Breast cancer stem-like cells are sensitized to tamoxifen induction of self-renewal inhibition with enforced Let-7c dependent on Wnt blocking

Xin Sun, Chongwen Xu, Guodong Xiao, Jinying Meng, Jichang Wang, Shou‑Ching Tang, Sida Qin, Ning Du, Gang Li, Hong Ren, Dapeng Liu
Pages: 1967-1975
Published online on: 15 January 2018

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Article Open Access

Interleukin-1β induces intercellular adhesion molecule-1 expression, thus enhancing the adhesion between mesenchymal stem cells and endothelial progenitor cells via the p38 MAPK signaling pathway

Jun Guo, Hongwei Zhang, Jie Xia, Jixue Hou, Yixiao Wang, Tao Yang, Sibo Wang, Xuyong Zhang, Xuelin Chen, Xiangwei Wu
Pages: 1976-1982
Published online on: 25 January 2018

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Article Open Access

MicroRNA‑32 silences WWP2 expression to maintain the pluripotency of human amniotic epithelial stem cells and β islet‑like cell differentiation

Gang Zou, Te Liu, Lihe Guo, Yongyi Huang, Ya Feng, Tao Duan
Pages: 1983-1991
Published online on: 29 January 2018

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Article Open Access

Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis

Xiongjian Wu, Fachao Zhi, Weijian Lun, Qiliang Deng, Wendi Zhang
Pages: 1992-2002
Published online on: 25 January 2018

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Article Open Access

Effect of midkine on gemcitabine resistance in biliary tract cancer

Yongliang Lu, Bing Yan, Huihui Guo, Li Qiu, Xinrong Sun, Xiang Wang, Qian Shi, Ying Bao
Pages: 2003-2011
Published online on: 18 January 2018

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Article Open Access

Two novel variants of the PHEX gene in patients with X‑linked dominant hypophosphatemic rickets and prenatal diagnosis for fetuses in these families

Hong Liao, Hong‑Mei Zhu, Hong‑Qian Liu, Ling‑Ping Li, Shan‑Ling Liu, He Wang
Pages: 2012-2020
Published online on: 18 January 2018

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Article Open Access

A 65‑gene signature for prognostic prediction in colon adenocarcinoma

Hui Jiang, Jun Du, Jiming Gu, Liugen Jin, Yong Pu, Bojian Fei
Pages: 2021-2027
Published online on: 18 January 2018

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Article Open Access

Dexamethasone-induced production of reactive oxygen species promotes apoptosis via endoplasmic reticulum stress and autophagy in MC3T3-E1 cells

Wanlin Liu, Zhenqun Zhao, Yuyan Na, Chenyang Meng, Jianzhong Wang, Rui Bai
Pages: 2028-2036
Published online on: 23 January 2018

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Article Open Access

Effect of leukocyte inhibitory factor on neuron differentiation from human induced pluripotent stem cell-derived neural precursor cells

Liping Xu, Jingyi Long, Chun Shi, Nianping Zhang, Ying Lv, Junda Feng, Aiguo Xuan, Xiaosong He, Qingqing Li, Yinshan Bai, Shanshan Liu, Dahong Long
Pages: 2037-2049
Published online on: 23 January 2018

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Article Open Access

miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells

Chen Lin, Liyi Xie, Yan Lu, Zhihuang Hu, Jianhua Chang
Pages: 2050-2058
Published online on: 11 January 2018

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Article Open Access

Gastrodin protects MC3T3-E1 osteoblasts from dexamethasone-induced cellular dysfunction and promotes bone formation via induction of the NRF2 signaling pathway

Shengye Liu, Tao Fang, Liyu Yang, Zhiguang Chen, Shuai Mu, Qin Fu
Pages: 2059-2069
Published online on: 23 January 2018

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Article Open Access

A 63 signature genes prediction system is effective for glioblastoma prognosis

Yang Zhang, Jiaming Xu, Xiangdong Zhu
Pages: 2070-2078
Published online on: 25 January 2018

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Article Open Access

Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

Fei Xing, Wen‑Juan Yi, Fang Miao, Meng‑Yun Su, Tie‑Chi Lei
Pages: 2079-2085
Published online on: 16 January 2018

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Article Open Access

Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway

Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kong
Pages: 2086-2098
Published online on: 17 January 2018

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Article Open Access

Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study

Hao Feng, Zhibo Yang, Xue Bai, Meirong Yang, Yuan Fang, Xiaonan Zhang, Qiqiang Guo, Hong Ning
Pages: 2099-2107
Published online on: 18 January 2018

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Article Open Access

Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin

Qiang Liu, Jinxin Song, Hong Li, Lei Dong, Shejiao Dai
Pages: 2108-2116
Published online on: 19 January 2018

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Article Open Access

Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways

Pengcheng Wang, Zekai Mao, Qiyong Pan, Rui Lu, Xiaojian Huang, Xiaobin Shang, Rui Zhang, Hongbo You
Pages: 2117-2127
Published online on: 22 January 2018

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Article Open Access

Bu-Fei decoction and modified Bu-Fei decoction inhibit the growth of non-small cell lung cancer, possibly via inhibition of apurinic/apyrimidinic endonuclease 1

Shan‑Tong Jiang, Shu‑Yan Han, Li‑Na Pang, Yan‑Na Jiao, Xi‑Ran He, Ping‑Ping Li
Pages: 2128-2138
Published online on: 30 January 2018

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Article Open Access

MicroRNA-139-5p/Flt1/Wnt/β-catenin regulatory crosstalk modulates the progression of glioma

Qiong Wang, Bin Xu, Jixiang Du, Xinnv Xu, Chao Shang, Xiuyu Wang, Jinhuan Wang
Pages: 2139-2149
Published online on: 30 January 2018

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Article Open Access

Nano-hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro Corrigendum in /10.3892/ijmm.2020.4743 Corrigendum in /10.3892/ijmm.2022.5146

Xianfang Jiang, Yanping Zhong, Li Zheng, Jinmin Zhao
Pages: 2150-2158
Published online on: 26 January 2018

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Article

Expression level of 12-amino acid triggering receptor on myeloid cells-like transcript 1 derived peptide alleviates lipopolysaccharide-induced acute lung injury in mice

Ruili Shi, Jiancheng Zhang, Zhang Peng, Shiying Yuan, Sumin Gao, Lin Chen, Yin Yuan
Pages: 2159-2168
Published online on: 30 January 2018

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Article

Engineered zinc-finger transcription factors inhibit the replication and transcription of HBV in vitro and in vivo

Wei Luo, Junxia Wang, Dengfeng Xu, Huili Bai, Yangli Zhang, Yuhong Zhang, Xiaosong Li
Pages: 2169-2176
Published online on: 17 January 2018

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Article

Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice

Qiuying Ye, Ge Li, Shuhua Liu, Yalun Guan, Yunfeng Li, Jinling Li, Huanhuan Jia, Xuejiao Li, Qingnan Li, Ren Huang, Hui Wang, Yu Zhang
Pages: 2177-2184
Published online on: 17 January 2018

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Article

Annexin A9 promotes invasion and metastasis of colorectal cancer and predicts poor prognosis

Suyang Yu, Honglei Bian, Xin Gao, Lin Gui
Pages: 2185-2192
Published online on: 29 January 2018

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Article

Lentivirus-mediated overexpression of suppressor of cytokine signaling-3 reduces neutrophilic airway inflammation by suppressing T-helper 17 responses in mice with chronic Pseudomonas aeruginosa lung infections

Feng‑Ming Ding, Xing‑Yi Zhang, Yu‑Qing Chen, Ruo‑Min Liao, Guo‑Gang Xie, Peng‑Yu Zhang, Ping Shao, Min Zhang
Pages: 2193-2200
Published online on: 23 January 2018

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Article Open Access

Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells

Sheng‑Xia Zheng, Jian Wang, Xue‑Li Wang, Asim Ali, Li‑Min Wu, Yu‑Sheng Liu
Pages: 2201-2212
Published online on: 23 January 2018

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Article

Effects of silencing the DUSP1 gene using lentiviral vector-mediated siRNA on the release of proinflammatory cytokines through regulation of the MAPK signaling pathway in mice with acute pancreatitis

Bo Zhang, Shu‑Liang Li, Hua‑Lei Xie, Jia‑Wei Fan, Chuan‑Wei Gu, Chao Kang, Mu‑Jian Teng
Pages: 2213-2224
Published online on: 25 January 2018

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Article

Downregulation of adult and neonatal Nav1.5 in the dorsal root ganglia and axon of peripheral sensory neurons of rats with spared nerve injury

Jun Wang, Shao-Wu Ou, Yun-Fei Bai, Yun-Jie Wang, Zhi-Qing David Xu, Guo-Ming Luan
Pages: 2225-2232
Published online on: 30 January 2018

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Article

Adaptive unfolded protein response promotes cell survival in rifampicin-treated L02 cells

Weiping Zhang, Jianming Xu
Pages: 2233-2242
Published online on: 29 January 2018

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Article

MicroRNA let-7g inhibits angiotensin II-induced endothelial senescence via the LOX-1-independent mechanism

Po‑Yuan Hsu, Wen‑Yi Lin, Ruey‑Tay Lin, Suh‑Hang H. Juo
Pages: 2243-2251
Published online on: 23 January 2018

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Article

Magnolol protects against ischemic-reperfusion brain damage following oxygen-glucose deprivation and transient focal cerebral ischemia

Sheng‑Yang Huang, Shih‑Huang Tai, Che‑Chao Chang, Yi‑Fang Tu, Chih‑Han Chang, E‑Jian Lee
Pages: 2252-2262
Published online on: 15 January 2018

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Article

Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway

Iván Delgado‑Enciso, Uriel A. López‑Lemus, Jose A. Valcarcel‑Gamiño, Iram P. Rodriguez‑Sanchez, Salvador Valle‑Reyes, Margarita L. Martinez‑Fierro, Valery Melnikov, José Guzmán‑Esquivel, Felipe Vaca‑Paniagua, Laura L. Valdez‑Velazquez, Luz M. Baltazar‑Rodriguez, Alejandro D. Soriano‑Hernandez, Brenda Paz‑Michel, Francisco Espinoza‑Gómez
Pages: 2263-2269
Published online on: 17 January 2018

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Article

CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling

Qi Zhang, Zong‑Sheng Yin, Fu‑Wen Zhang, Kun Cao, He‑Yan Sun
Pages: 2270-2278
Published online on: 18 January 2018

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Article

The NALP3 inflammasome is required for collagen synthesis via the NF‑κB pathway

Ju Kuang, Min Xie, Xiaolin Wei
Pages: 2279-2287
Published online on: 18 January 2018

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Article

Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells

Shi‑Xiang Yuan, Jun‑Liang Li, Xin‑Ke Xu, Wei Chen, Cheng Chen, Kun‑Qi Kuang, Fang‑Yu Wang, Kai Wang, Fang‑Cheng Li
Pages: 2288-2296
Published online on: 18 January 2018

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Article

Carbon monoxide releasing molecule‑3 promotes the osteogenic differentiation of rat bone marrow mesenchymal stem cells by releasing carbon monoxide

Jingyuan Li, Ling Song, Meng Hou, Ping Wang, Lingling Wei, Hui Song
Pages: 2297-2305
Published online on: 29 January 2018

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Article

NOX4/ROS mediate ethanol‑induced apoptosis via MAPK signal pathway in L‑02 cells

Cheng‑Fang Yang, Yu‑Juan Zhong, Zuheng Ma, Li Li, Lin Shi, Li Chen, Chen Li, Dan Wu, Qi Chen, Yong‑Wen Li
Pages: 2306-2316
Published online on: 16 January 2018

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Article

TNF-α induces Drp1-mediated mitochondrial fragmentation during inflammatory cardiomyocyte injury

Yue‑Liang Shen, Ying‑Zhou Shi, Gai‑Ge Chen, Lin‑Lin Wang, Ming‑Zhi Zheng, Hong‑Feng Jin, Ying‑Ying Chen
Pages: 2317-2327
Published online on: 15 January 2018

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Article

Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes

Xiaojian Weng, Xiaodan Zhang, Xiaofei Lu, Jin Wu, Shitong Li
Pages: 2328-2338
Published online on: 12 January 2018

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Article

Decreased ZONAB expression promotes excessive transdifferentiation of alveolar epithelial cells in hyperoxia-induced bronchopulmonary dysplasia

Ana Hou, Jianhua Fu, Yongyan Shi, Lin Qiao, Jun Li, Yujiao Xing, Xindong Xue
Pages: 2339-2349
Published online on: 23 January 2018

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Article

miR-195 suppresses abdominal aortic aneurysm through the TNF-α/NF-κB and VEGF/PI3K/Akt pathway

Xiaohui Ma, Hairong Yao, Yuhong Yang, Long Jin, Yu Wang, Lina Wu, Shengli Yang, Kang Cheng
Pages: 2350-2358
Published online on: 25 January 2018

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Article

Low-dose cadmium activates the JNK signaling pathway in human renal podocytes

Xiaocui Chen, Yinghua Xu, Zuowang Cheng, Hong Su, Xiu Liu, Dongmei Xu, Carolyn Kapron, Ju Liu
Pages: 2359-2365
Published online on: 30 January 2018

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Article

Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family

Eriko Kudo, Manabu Taura, Mary Ann Suico, Hiroki Goto, Hirofumi Kai, Seiji Okada
Pages: 2366-2374
Published online on: 15 January 2018

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Article

Renal transplantation increases angiotensin II receptor-mediated vascular contractility associated with changes of epigenetic mechanisms

Yakun Zhao, Qingguo Zhu, Shiping Sun, Yu Qiu, Jingquan Li, Wei Liu, Gangjun Yuan, Hua Ma
Pages: 2375-2388
Published online on: 29 January 2018

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Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway

Chin-Cheng Su
Pages: 2389-2396
Published online on: 19 January 2018

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Article

Genetic correction of adipose tissue-derived mesenchymal stem cells mediated by TALEN targeting the GDF5 gene

Baofeng Li, Ying Zhang, Mei Li, Xiaoliang Zhao, Huibin Xie, Xiaoze Guo, Fei Wang, Hong Xia, Bei Chen
Pages: 2397-2405
Published online on: 30 January 2018

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Article

Neuroprotective effects of p53/microRNA‑22 regulate inflammation and apoptosis in subarachnoid hemorrhage

Shui Yu, Yi‑Jun Zeng, Xiao‑Chuan Sun
Pages: 2406-2412
Published online on: 16 January 2018

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Article

Redox induces diverse effects on recombinant human wild-type PrP and mutated PrP with inserted or deleted octarepeats

Qi Shi, Cao Chen, Bao‑Yun Zhang, Wei Zhou, Kang Xiao, Xiao‑Ping Dong
Pages: 2413-2419
Published online on: 30 January 2018

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Article

Relaxant and vasoprotective effects of ginger extracts on porcine coronary arteries

Hsing‑Chen Wu, Chi‑Ting Horng, Shih‑Chang Tsai, You‑Li Lee, Shou‑Cheng Hsu, Yi‑Jen Tsai, Fuu‑Jen Tsai, Jo‑Hua Chiang, Daih‑Huang Kuo, Jai‑Sing Yang
Pages: 2420-2428
Published online on: 11 January 2018

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Article

Identification of tumor suppressive role of microRNA-132 and its target gene in tumorigenesis of prostate cancer

Shun-Lai Li, Ying Sui, Jie Sun, Ting-Qi Jiang, Gang Dong
Pages: 2429-2433
Published online on: 23 January 2018

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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