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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2018 Volume 41 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

β-glucans and cholesterol (Review)

Petr Sima, Luca Vannucci, Vaclav Vetvicka
Pages: 1799-1808
Published online on: 22 January 2018

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Review Open Access

Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)

Jing‑Hua Pan, Hong Zhou, Xiao‑Xu Zhao, Hui Ding, Wei Li, Li Qin, Yun‑Long Pan
Pages: 1809-1816
Published online on: 11 January 2018

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Review

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)

Ji‑Dong Guo, Xin Zhao, Yang Li, Guang‑Ren Li, Xiao‑Liang Liu
Pages: 1817-1825
Published online on: 19 January 2018

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Article Open Access

D‑Pinitol alleviates cyclosporine A‑induced renal tubulointerstitial fibrosis via activating Sirt1 and Nrf2 antioxidant pathways

Eun Sil Koh, Soojeong Kim, Minyoung Kim, Yu Ah Hong, Seok Joon Shin, Cheol Whee Park, Yoon Sik Chang, Sungjin Chung, Ho‑Shik Kim
Pages: 1826-1834
Published online on: 19 January 2018

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Article Open Access

Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension

Jia Liu, Jiamei Liu, Linying Shi, Fan Zhang, Liping Yu, Xinchun Yang, Jun Cai
Pages: 1835-1844
Published online on: 23 January 2018

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Article Open Access

Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells

Jiexiang Yang, Yonggen Zou, Dianmin Jiang
Pages: 1845-1854
Published online on: 29 January 2018

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Article Open Access

miR‑21‑5p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3

Jun Chen, Chao Zhou, Junhe Li, Xiaojun Xiang, Ling Zhang, Jun Deng, Jianping Xiong
Pages: 1855-1866
Published online on: 18 January 2018

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Article Open Access

Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway

Maojun Liu, Yan Li, Biao Liang, Zining Li, Zhengtao Jiang, Chun Chu, Jun Yang
Pages: 1867-1876
Published online on: 23 January 2018

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Article Open Access

Increased expression of sterol regulatory element binding protein‑2 alleviates autophagic dysfunction in NAFLD

Chunwei Cheng, Xiaoling Deng, Keshu Xu
Pages: 1877-1886
Published online on: 16 January 2018

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Article Open Access

Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway

Qiuyu Wang, Peng Wang, Zhigang Xiao
Pages: 1887-1898
Published online on: 25 January 2018

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Article Open Access

miR‑186, a serum microRNA, induces endothelial cell apoptosis by targeting SMAD6 in Kawasaki disease

Rongzhou Wu, Danping Shen, Hareshwaree Sohun, Donghui Ge, Xianda Chen, Xuliang Wang, Ruiyao Chen, Yuqing Wu, Jingjing Zeng, Xing Rong, Xiaoping Su, Maoping Chu
Pages: 1899-1908
Published online on: 18 January 2018

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Article Open Access

MicroRNA-327 regulates cardiac hypertrophy and fibrosis induced by pressure overload

Yue Ji, Ming Qiu, Yejiao Shen, Li Gao, Yaqing Wang, Wei Sun, Xinli Li, Yan Lu, Xiangqing Kong
Pages: 1909-1916
Published online on: 25 January 2018

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Article Open Access

Aberrantly expressed long noncoding RNAs in hypertrophic scar fibroblasts in vitro: A microarray study

Longxiang Tu, Qi Huang, Shangfeng Fu, Dewu Liu
Pages: 1917-1930
Published online on: 26 January 2018

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Article Open Access

Extracorporeal shock wave therapy with low-energy flux density inhibits hypertrophic scar formation in an animal model

Jing-Chun Zhao, Bo-Ru Zhang, Lei Hong, Kai Shi, Wei-Wei Wu, Jia-Ao Yu
Pages: 1931-1938
Published online on: 29 January 2018

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Article Open Access

Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunction

Qiang Wan, Zhongyong Liu, Yuping Yang, Xiaobing Cui
Pages: 1939-1948
Published online on: 30 January 2018

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Article Open Access

EZH2-mediated suppression of lncRNA-LET promotes cell apoptosis and inhibits the proliferation of post-burn skin fibroblasts

Weicai Zheng, Aixiang Yu
Pages: 1949-1957
Published online on: 25 January 2018

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Article Open Access

Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis

Wenlong Cao, Weiyuan Wei, Zexu Zhan, Dongyi Xie, Yubo Xie, Qiang Xiao
Pages: 1958-1966
Published online on: 11 January 2018

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Article Open Access

Breast cancer stem-like cells are sensitized to tamoxifen induction of self-renewal inhibition with enforced Let-7c dependent on Wnt blocking

Xin Sun, Chongwen Xu, Guodong Xiao, Jinying Meng, Jichang Wang, Shou‑Ching Tang, Sida Qin, Ning Du, Gang Li, Hong Ren, Dapeng Liu
Pages: 1967-1975
Published online on: 15 January 2018

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Article Open Access

Interleukin-1β induces intercellular adhesion molecule-1 expression, thus enhancing the adhesion between mesenchymal stem cells and endothelial progenitor cells via the p38 MAPK signaling pathway

Jun Guo, Hongwei Zhang, Jie Xia, Jixue Hou, Yixiao Wang, Tao Yang, Sibo Wang, Xuyong Zhang, Xuelin Chen, Xiangwei Wu
Pages: 1976-1982
Published online on: 25 January 2018

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Article Open Access

MicroRNA‑32 silences WWP2 expression to maintain the pluripotency of human amniotic epithelial stem cells and β islet‑like cell differentiation

Gang Zou, Te Liu, Lihe Guo, Yongyi Huang, Ya Feng, Tao Duan
Pages: 1983-1991
Published online on: 29 January 2018

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Article Open Access

Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis

Xiongjian Wu, Fachao Zhi, Weijian Lun, Qiliang Deng, Wendi Zhang
Pages: 1992-2002
Published online on: 25 January 2018

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Article Open Access

Effect of midkine on gemcitabine resistance in biliary tract cancer

Yongliang Lu, Bing Yan, Huihui Guo, Li Qiu, Xinrong Sun, Xiang Wang, Qian Shi, Ying Bao
Pages: 2003-2011
Published online on: 18 January 2018

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Article Open Access

Two novel variants of the PHEX gene in patients with X‑linked dominant hypophosphatemic rickets and prenatal diagnosis for fetuses in these families

Hong Liao, Hong‑Mei Zhu, Hong‑Qian Liu, Ling‑Ping Li, Shan‑Ling Liu, He Wang
Pages: 2012-2020
Published online on: 18 January 2018

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Article Open Access

A 65‑gene signature for prognostic prediction in colon adenocarcinoma

Hui Jiang, Jun Du, Jiming Gu, Liugen Jin, Yong Pu, Bojian Fei
Pages: 2021-2027
Published online on: 18 January 2018

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Article Open Access

Dexamethasone-induced production of reactive oxygen species promotes apoptosis via endoplasmic reticulum stress and autophagy in MC3T3-E1 cells

Wanlin Liu, Zhenqun Zhao, Yuyan Na, Chenyang Meng, Jianzhong Wang, Rui Bai
Pages: 2028-2036
Published online on: 23 January 2018

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Article Open Access

Effect of leukocyte inhibitory factor on neuron differentiation from human induced pluripotent stem cell-derived neural precursor cells

Liping Xu, Jingyi Long, Chun Shi, Nianping Zhang, Ying Lv, Junda Feng, Aiguo Xuan, Xiaosong He, Qingqing Li, Yinshan Bai, Shanshan Liu, Dahong Long
Pages: 2037-2049
Published online on: 23 January 2018

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Article Open Access

miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells

Chen Lin, Liyi Xie, Yan Lu, Zhihuang Hu, Jianhua Chang
Pages: 2050-2058
Published online on: 11 January 2018

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Article Open Access

Gastrodin protects MC3T3-E1 osteoblasts from dexamethasone-induced cellular dysfunction and promotes bone formation via induction of the NRF2 signaling pathway

Shengye Liu, Tao Fang, Liyu Yang, Zhiguang Chen, Shuai Mu, Qin Fu
Pages: 2059-2069
Published online on: 23 January 2018

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Article Open Access

A 63 signature genes prediction system is effective for glioblastoma prognosis

Yang Zhang, Jiaming Xu, Xiangdong Zhu
Pages: 2070-2078
Published online on: 25 January 2018

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Article Open Access

Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

Fei Xing, Wen‑Juan Yi, Fang Miao, Meng‑Yun Su, Tie‑Chi Lei
Pages: 2079-2085
Published online on: 16 January 2018

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Article Open Access

Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway

Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kong
Pages: 2086-2098
Published online on: 17 January 2018

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Article Open Access

Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study

Hao Feng, Zhibo Yang, Xue Bai, Meirong Yang, Yuan Fang, Xiaonan Zhang, Qiqiang Guo, Hong Ning
Pages: 2099-2107
Published online on: 18 January 2018

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Article Open Access

Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin

Qiang Liu, Jinxin Song, Hong Li, Lei Dong, Shejiao Dai
Pages: 2108-2116
Published online on: 19 January 2018

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Article Open Access

Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways

Pengcheng Wang, Zekai Mao, Qiyong Pan, Rui Lu, Xiaojian Huang, Xiaobin Shang, Rui Zhang, Hongbo You
Pages: 2117-2127
Published online on: 22 January 2018

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Article Open Access

Bu-Fei decoction and modified Bu-Fei decoction inhibit the growth of non-small cell lung cancer, possibly via inhibition of apurinic/apyrimidinic endonuclease 1

Shan‑Tong Jiang, Shu‑Yan Han, Li‑Na Pang, Yan‑Na Jiao, Xi‑Ran He, Ping‑Ping Li
Pages: 2128-2138
Published online on: 30 January 2018

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Article Open Access

MicroRNA-139-5p/Flt1/Wnt/β-catenin regulatory crosstalk modulates the progression of glioma

Qiong Wang, Bin Xu, Jixiang Du, Xinnv Xu, Chao Shang, Xiuyu Wang, Jinhuan Wang
Pages: 2139-2149
Published online on: 30 January 2018

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Article Open Access

Nano-hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro Corrigendum in /10.3892/ijmm.2020.4743 Corrigendum in /10.3892/ijmm.2022.5146

Xianfang Jiang, Yanping Zhong, Li Zheng, Jinmin Zhao
Pages: 2150-2158
Published online on: 26 January 2018

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Article

Expression level of 12-amino acid triggering receptor on myeloid cells-like transcript 1 derived peptide alleviates lipopolysaccharide-induced acute lung injury in mice

Ruili Shi, Jiancheng Zhang, Zhang Peng, Shiying Yuan, Sumin Gao, Lin Chen, Yin Yuan
Pages: 2159-2168
Published online on: 30 January 2018

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Article

Engineered zinc-finger transcription factors inhibit the replication and transcription of HBV in vitro and in vivo

Wei Luo, Junxia Wang, Dengfeng Xu, Huili Bai, Yangli Zhang, Yuhong Zhang, Xiaosong Li
Pages: 2169-2176
Published online on: 17 January 2018

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Article

Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice

Qiuying Ye, Ge Li, Shuhua Liu, Yalun Guan, Yunfeng Li, Jinling Li, Huanhuan Jia, Xuejiao Li, Qingnan Li, Ren Huang, Hui Wang, Yu Zhang
Pages: 2177-2184
Published online on: 17 January 2018

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Article

Annexin A9 promotes invasion and metastasis of colorectal cancer and predicts poor prognosis

Suyang Yu, Honglei Bian, Xin Gao, Lin Gui
Pages: 2185-2192
Published online on: 29 January 2018

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Article

Lentivirus-mediated overexpression of suppressor of cytokine signaling-3 reduces neutrophilic airway inflammation by suppressing T-helper 17 responses in mice with chronic Pseudomonas aeruginosa lung infections

Feng‑Ming Ding, Xing‑Yi Zhang, Yu‑Qing Chen, Ruo‑Min Liao, Guo‑Gang Xie, Peng‑Yu Zhang, Ping Shao, Min Zhang
Pages: 2193-2200
Published online on: 23 January 2018

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Article Open Access

Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells

Sheng‑Xia Zheng, Jian Wang, Xue‑Li Wang, Asim Ali, Li‑Min Wu, Yu‑Sheng Liu
Pages: 2201-2212
Published online on: 23 January 2018

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Article

Effects of silencing the DUSP1 gene using lentiviral vector-mediated siRNA on the release of proinflammatory cytokines through regulation of the MAPK signaling pathway in mice with acute pancreatitis

Bo Zhang, Shu‑Liang Li, Hua‑Lei Xie, Jia‑Wei Fan, Chuan‑Wei Gu, Chao Kang, Mu‑Jian Teng
Pages: 2213-2224
Published online on: 25 January 2018

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Article

Downregulation of adult and neonatal Nav1.5 in the dorsal root ganglia and axon of peripheral sensory neurons of rats with spared nerve injury

Jun Wang, Shao-Wu Ou, Yun-Fei Bai, Yun-Jie Wang, Zhi-Qing David Xu, Guo-Ming Luan
Pages: 2225-2232
Published online on: 30 January 2018

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Article

Adaptive unfolded protein response promotes cell survival in rifampicin-treated L02 cells

Weiping Zhang, Jianming Xu
Pages: 2233-2242
Published online on: 29 January 2018

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Article

MicroRNA let-7g inhibits angiotensin II-induced endothelial senescence via the LOX-1-independent mechanism

Po‑Yuan Hsu, Wen‑Yi Lin, Ruey‑Tay Lin, Suh‑Hang H. Juo
Pages: 2243-2251
Published online on: 23 January 2018

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Article

Magnolol protects against ischemic-reperfusion brain damage following oxygen-glucose deprivation and transient focal cerebral ischemia

Sheng‑Yang Huang, Shih‑Huang Tai, Che‑Chao Chang, Yi‑Fang Tu, Chih‑Han Chang, E‑Jian Lee
Pages: 2252-2262
Published online on: 15 January 2018

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Article

Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway

Iván Delgado‑Enciso, Uriel A. López‑Lemus, Jose A. Valcarcel‑Gamiño, Iram P. Rodriguez‑Sanchez, Salvador Valle‑Reyes, Margarita L. Martinez‑Fierro, Valery Melnikov, José Guzmán‑Esquivel, Felipe Vaca‑Paniagua, Laura L. Valdez‑Velazquez, Luz M. Baltazar‑Rodriguez, Alejandro D. Soriano‑Hernandez, Brenda Paz‑Michel, Francisco Espinoza‑Gómez
Pages: 2263-2269
Published online on: 17 January 2018

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Article

CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling

Qi Zhang, Zong‑Sheng Yin, Fu‑Wen Zhang, Kun Cao, He‑Yan Sun
Pages: 2270-2278
Published online on: 18 January 2018

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Article

The NALP3 inflammasome is required for collagen synthesis via the NF‑κB pathway

Ju Kuang, Min Xie, Xiaolin Wei
Pages: 2279-2287
Published online on: 18 January 2018

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Article

Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells

Shi‑Xiang Yuan, Jun‑Liang Li, Xin‑Ke Xu, Wei Chen, Cheng Chen, Kun‑Qi Kuang, Fang‑Yu Wang, Kai Wang, Fang‑Cheng Li
Pages: 2288-2296
Published online on: 18 January 2018

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Article

Carbon monoxide releasing molecule‑3 promotes the osteogenic differentiation of rat bone marrow mesenchymal stem cells by releasing carbon monoxide

Jingyuan Li, Ling Song, Meng Hou, Ping Wang, Lingling Wei, Hui Song
Pages: 2297-2305
Published online on: 29 January 2018

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Article

NOX4/ROS mediate ethanol‑induced apoptosis via MAPK signal pathway in L‑02 cells

Cheng‑Fang Yang, Yu‑Juan Zhong, Zuheng Ma, Li Li, Lin Shi, Li Chen, Chen Li, Dan Wu, Qi Chen, Yong‑Wen Li
Pages: 2306-2316
Published online on: 16 January 2018

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Article

TNF-α induces Drp1-mediated mitochondrial fragmentation during inflammatory cardiomyocyte injury

Yue‑Liang Shen, Ying‑Zhou Shi, Gai‑Ge Chen, Lin‑Lin Wang, Ming‑Zhi Zheng, Hong‑Feng Jin, Ying‑Ying Chen
Pages: 2317-2327
Published online on: 15 January 2018

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Article

Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes

Xiaojian Weng, Xiaodan Zhang, Xiaofei Lu, Jin Wu, Shitong Li
Pages: 2328-2338
Published online on: 12 January 2018

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Article

Decreased ZONAB expression promotes excessive transdifferentiation of alveolar epithelial cells in hyperoxia-induced bronchopulmonary dysplasia

Ana Hou, Jianhua Fu, Yongyan Shi, Lin Qiao, Jun Li, Yujiao Xing, Xindong Xue
Pages: 2339-2349
Published online on: 23 January 2018

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Article

miR-195 suppresses abdominal aortic aneurysm through the TNF-α/NF-κB and VEGF/PI3K/Akt pathway

Xiaohui Ma, Hairong Yao, Yuhong Yang, Long Jin, Yu Wang, Lina Wu, Shengli Yang, Kang Cheng
Pages: 2350-2358
Published online on: 25 January 2018

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Article

Low-dose cadmium activates the JNK signaling pathway in human renal podocytes

Xiaocui Chen, Yinghua Xu, Zuowang Cheng, Hong Su, Xiu Liu, Dongmei Xu, Carolyn Kapron, Ju Liu
Pages: 2359-2365
Published online on: 30 January 2018

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Article

Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family

Eriko Kudo, Manabu Taura, Mary Ann Suico, Hiroki Goto, Hirofumi Kai, Seiji Okada
Pages: 2366-2374
Published online on: 15 January 2018

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Article

Renal transplantation increases angiotensin II receptor-mediated vascular contractility associated with changes of epigenetic mechanisms

Yakun Zhao, Qingguo Zhu, Shiping Sun, Yu Qiu, Jingquan Li, Wei Liu, Gangjun Yuan, Hua Ma
Pages: 2375-2388
Published online on: 29 January 2018

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Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway

Chin-Cheng Su
Pages: 2389-2396
Published online on: 19 January 2018

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Genetic correction of adipose tissue-derived mesenchymal stem cells mediated by TALEN targeting the GDF5 gene

Baofeng Li, Ying Zhang, Mei Li, Xiaoliang Zhao, Huibin Xie, Xiaoze Guo, Fei Wang, Hong Xia, Bei Chen
Pages: 2397-2405
Published online on: 30 January 2018

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Neuroprotective effects of p53/microRNA‑22 regulate inflammation and apoptosis in subarachnoid hemorrhage

Shui Yu, Yi‑Jun Zeng, Xiao‑Chuan Sun
Pages: 2406-2412
Published online on: 16 January 2018

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Redox induces diverse effects on recombinant human wild-type PrP and mutated PrP with inserted or deleted octarepeats

Qi Shi, Cao Chen, Bao‑Yun Zhang, Wei Zhou, Kang Xiao, Xiao‑Ping Dong
Pages: 2413-2419
Published online on: 30 January 2018

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Relaxant and vasoprotective effects of ginger extracts on porcine coronary arteries

Hsing‑Chen Wu, Chi‑Ting Horng, Shih‑Chang Tsai, You‑Li Lee, Shou‑Cheng Hsu, Yi‑Jen Tsai, Fuu‑Jen Tsai, Jo‑Hua Chiang, Daih‑Huang Kuo, Jai‑Sing Yang
Pages: 2420-2428
Published online on: 11 January 2018

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Identification of tumor suppressive role of microRNA-132 and its target gene in tumorigenesis of prostate cancer

Shun-Lai Li, Ying Sui, Jie Sun, Ting-Qi Jiang, Gang Dong
Pages: 2429-2433
Published online on: 23 January 2018

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Journal Cover
January-2026 Volume 57 Issue 1

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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Article Open Access

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Article Open Access

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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