Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
April-2018 Volume 41 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 41 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

  • Authors:
    • Fei Xing
    • Wen‑Juan Yi
    • Fang Miao
    • Meng‑Yun Su
    • Tie‑Chi Lei
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China
    Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 2079-2085
    |
    Published online on: January 16, 2018
       https://doi.org/10.3892/ijmm.2018.3391
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Baicalin is a traditional Chinese herbal medicine commonly used for hair loss, the precise molecular mechanism of which is unknown. In the present study, the mechanism of baicalin was investigated via the topical application of baicalin to reconstituted hair follicles on mice dorsa and evaluating the effect on canonical Wnt/β‑catenin signaling in the hair follicles and the activity of dermal papillar cells. The results indicate that baicalin stimulates the expression of Wnt3a, Wnt5a, frizzled 7 and disheveled 2 whilst inhibiting the Axin/casein kinase 1α/adenomatous polyposis coli/glycogen synthase kinase 3β degradation complex, leading to accumulation of β‑catenin and activation of Wnt/β‑catenin signaling. In addition, baicalin was observed to increase the alkaline phosphatase levels in dermal papillar cells, a process which was dependent on Wnt pathway activation. Given its non‑toxicity and ease of topical application, baicalin represents a promising treatment for alopecia and other forms of hair loss. Further studies of baicalin using human hair follicle transplants are warranted in preparation for future clinical use.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Lee J and Tumbar T: Hairy tale of signaling in hair follicle development and cycling. Semin Cell Dev Biol. 23:906–916. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Santos Z, Avci P and Hamblin MR: Drug discovery for alopecia: Gone today, hair tomorrow. Expert Opin Drug Dis. 10:269–292. 2015. View Article : Google Scholar

3 

Liang YY, Jiang QE and Li G: The clinical effects of Chinese Medicine Hair Restorer on androgenetic alopecia. Hebei Chinese Med. 1156–1157. 2012.In Chinese.

4 

Moghaddam E, Teoh BT, Sam SS, Lani R, Hassandarvish P, Chik Z, Yueh A, Abubakar S and Zandi K: Baicalin, a metabolite of baicalein with antiviral activity against dengue virus. Sci Rep. 4:54522014. View Article : Google Scholar : PubMed/NCBI

5 

Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, et al: Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 1813:1465–1474. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Shin SH, Bak S, Kim MK, Sung YK and Kim JC: Baicalin, a flavonoid, affects the activity of human dermal papilla cells and promotes anagen induction in mice. Naunyn Schmiedebergs Arch Pharmacol. 388:583–586. 2015. View Article : Google Scholar

7 

Zhu HQ, Fan WX and Zhang H: In vitro effects of baicalin on the growth of human hair follicles and secretion of vascular endothelial growth factor by human dermal papilla cells. Chin J Dermatol. 40:416–418. 2007.

8 

Guo AJ, Choi RC, Cheung AW, Chen VP, Xu SL, Dong TT, Chen JJ and Tsim KW: Baicalin, a flavone, induces the differentiation of cultured osteoblasts: An action via the Wnt/beta-catenin signaling pathway. J Biol Chem. 286:27882–27893. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ohyama M, Zheng Y, Paus R and Stenn KS: The mesenchymal component of hair follicle neogenesis: Background, methods and molecular characterization. Exp Dermatol. 19:89–99. 2010. View Article : Google Scholar

10 

Lichti U, Anders J and Yuspa SH: Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc. 3:799–810. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Ehama R, Ishimatsu-Tsuji Y, Iriyama S, Ideta R, Soma T, Yano K, Kawasaki C, Suzuki S, Shirakata Y, Hashimoto K and Kishimoto J: Hair follicle using grafted rodent and human cells. J Invest Dermatol. 127:2106–2115. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Rao X, Huang X, Zhou Z and Lin X: An improvement of the 2^(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath. 3:71–85. 2013.PubMed/NCBI

13 

Gupta PS, Folger JK, Rajput SK, Lv L, Yao J, Ireland J and Smith GW: Regulation and regulatory role of WNT signaling in potentiating FSH action during bovine dominant follicle selection. PLoS One. 9:e1002012014. View Article : Google Scholar : PubMed/NCBI

14 

Qi J and Garza LA: An overview of alopecias. Cold Spring Harb Perspect Med. 4:pii:a013615. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Shirai A, Ikeda J, Kawashima S, Tamaoki T and Kamiya T: KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models. J Dermatol Sci. 25:213–218. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Wang X, Zhu Y, Sun C, Wang T, Shen Y, Cai W, Sun J, Chi L, Wang H, Song N, et al: Feedback activation of basic fibroblast growth factor signaling via the Wnt/β-catenin pathway in skin fibroblasts. Front Pharmacol. 8:322017.

17 

Andl T, Reddy ST, Gaddapara T and Millar SE: WNT signals are required for the initiation of hair follicle development. Dev Cell. 2:643–653. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Rishikaysh P, Dev K, Diaz D, Qureshi W, Filip S and Mokry J: Signaling involved in hair follicle morphogenesis and development. Int J Mol Sci. 15:1647–1670. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Schneider MR, Schmidt-Ullrich R and Paus R: The hair follicle as a dynamic miniorgan. Curr Biol. 19:R132–R142. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Yang CC and Cotsarelis G: Review of hair follicle dermal cells. J Dermatol Sci. 57:2–11. 2010. View Article : Google Scholar :

21 

Van Camp JK, Beckers S, Zegers D and Van Hul W: Wnt signaling and the control of human stem cell fate. Stem Cell Rev Rep. 10:207–229. 2014. View Article : Google Scholar

22 

Schmidt-Ullrich R and Paus R: Molecular principles of hair follicle induction and morphogenesis. Bioessays. 27:247–261. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Kishimoto J, Burgeson RE and Morgan BA: Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev. 14:1181–1185. 2000.PubMed/NCBI

25 

Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, et al: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 5:100–107. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Hardy MH: The secret life of the hair follicle. Trends Genet. 8:55–61. 1992. View Article : Google Scholar : PubMed/NCBI

27 

Millar SE: Molecular mechanisms regulating hair follicle development. J Invest Dermatol. 118:216–225. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Paus R and Cotsarelis G: The biology of hair follicles. N Engl J Med. 341:491–497. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Iida M, Ihara S and Matsuzaki T: Hair cycle-dependent changes of alkaline phosphatase activity in the mesenchyme and epithelium in mouse. Dev Growth Differ. 49:185–195. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Handjiski BK, Eichmüller S, Hofmann U, Czarnetzki BM and Paus R: Alkaline phosphatase activity and localization during the murine hair cycle. Br J Dermatol. 131:303–310. 1994. View Article : Google Scholar : PubMed/NCBI

31 

Wu X, Scott L Jr, Washenik K and Stenn K: Full-thickness skin with mature hair follicles generated from tissue culture expanded human cells. Tissue Eng Part A. 20:3314–3321. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xing F, Yi WJ, Miao F, Su MY and Lei TC: Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice. Int J Mol Med 41: 2079-2085, 2018.
APA
Xing, F., Yi, W., Miao, F., Su, M., & Lei, T. (2018). Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice. International Journal of Molecular Medicine, 41, 2079-2085. https://doi.org/10.3892/ijmm.2018.3391
MLA
Xing, F., Yi, W., Miao, F., Su, M., Lei, T."Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice". International Journal of Molecular Medicine 41.4 (2018): 2079-2085.
Chicago
Xing, F., Yi, W., Miao, F., Su, M., Lei, T."Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice". International Journal of Molecular Medicine 41, no. 4 (2018): 2079-2085. https://doi.org/10.3892/ijmm.2018.3391
Copy and paste a formatted citation
x
Spandidos Publications style
Xing F, Yi WJ, Miao F, Su MY and Lei TC: Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice. Int J Mol Med 41: 2079-2085, 2018.
APA
Xing, F., Yi, W., Miao, F., Su, M., & Lei, T. (2018). Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice. International Journal of Molecular Medicine, 41, 2079-2085. https://doi.org/10.3892/ijmm.2018.3391
MLA
Xing, F., Yi, W., Miao, F., Su, M., Lei, T."Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice". International Journal of Molecular Medicine 41.4 (2018): 2079-2085.
Chicago
Xing, F., Yi, W., Miao, F., Su, M., Lei, T."Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice". International Journal of Molecular Medicine 41, no. 4 (2018): 2079-2085. https://doi.org/10.3892/ijmm.2018.3391
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team