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Article

Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway

  • Authors:
    • Iván Delgado‑Enciso
    • Uriel A. López‑Lemus
    • Jose A. Valcarcel‑Gamiño
    • Iram P. Rodriguez‑Sanchez
    • Salvador Valle‑Reyes
    • Margarita L. Martinez‑Fierro
    • Valery Melnikov
    • José Guzmán‑Esquivel
    • Felipe Vaca‑Paniagua
    • Laura L. Valdez‑Velazquez
    • Luz M. Baltazar‑Rodriguez
    • Alejandro D. Soriano‑Hernandez
    • Brenda Paz‑Michel
    • Francisco Espinoza‑Gómez
  • View Affiliations / Copyright

    Affiliations: Department of Public Health, School of Medicine, University of Colima, Colima, Colima 28030, Mexico, Department of Chemical Sciences, School of Chemical Sciences, University of Colima, Coquimatlán, Colima 28400, Mexico, Genetics Department, School of Medicine, Nuevo León Autonomous University, Monterrey, Nuevo León 64460, Mexico, Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Zacatecas Autonomous University, Zacatecas, Zacatecas 98160, Mexico, Department of Research, Mexican Social Security Institute, Villa de Alvarez, Colima 28983, Mexico, Biomedicine Unit, School of Graduate Studies‑Iztacala, National Autonomous University of Mexico, Mexico City, State of Mexico 04510, Mexico, Esteripharma Mexico, Mexico City, State of Mexico 03100, Mexico
  • Pages: 2263-2269
    |
    Published online on: January 17, 2018
       https://doi.org/10.3892/ijmm.2018.3395
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Abstract

Dengue virus (DENV) is currently considered as one of the most important mosquito-borne viral pathogens affecting humans. Genetic variations in viruses are likely to be a condition for more effective evasion of the immune system and resulting in severe clinical consequences. The DENV‑1 NS5 gene was sequenced to establish whether during an epidemic burst there were genetic variations of the virus and whether any variant was associated (through a case‑control design) with severe clinical behavior. A total of 31 patients positive for DENV‑1 were enrolled. Among the nucleotide differences between the sequences, only two generated amino acid changes. The variants 124Met/166Ser (amino acid positions according to the report GenBank AJL35015.1), were associated with a severe clinical course of the disease. Via in silico tests, it was identified that the variations generate changes in the protein probably affecting the function of type‑1 interferon, either at the level of its receptor or by interfering with the Janus kinase‑signal transducer and activator of transcription signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Delgado‑Enciso I, López‑Lemus UA, Valcarcel‑Gamiño JA, Rodriguez‑Sanchez IP, Valle‑Reyes S, Martinez‑Fierro ML, Melnikov V, Guzmán‑Esquivel J, Vaca‑Paniagua F, Valdez‑Velazquez LL, Valdez‑Velazquez LL, et al: Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway. Int J Mol Med 41: 2263-2269, 2018.
APA
Delgado‑Enciso, I., López‑Lemus, U.A., Valcarcel‑Gamiño, J.A., Rodriguez‑Sanchez, I.P., Valle‑Reyes, S., Martinez‑Fierro, M.L. ... Espinoza‑Gómez, F. (2018). Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway. International Journal of Molecular Medicine, 41, 2263-2269. https://doi.org/10.3892/ijmm.2018.3395
MLA
Delgado‑Enciso, I., López‑Lemus, U. A., Valcarcel‑Gamiño, J. A., Rodriguez‑Sanchez, I. P., Valle‑Reyes, S., Martinez‑Fierro, M. L., Melnikov, V., Guzmán‑Esquivel, J., Vaca‑Paniagua, F., Valdez‑Velazquez, L. L., Baltazar‑Rodriguez, L. M., Soriano‑Hernandez, A. D., Paz‑Michel, B., Espinoza‑Gómez, F."Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway". International Journal of Molecular Medicine 41.4 (2018): 2263-2269.
Chicago
Delgado‑Enciso, I., López‑Lemus, U. A., Valcarcel‑Gamiño, J. A., Rodriguez‑Sanchez, I. P., Valle‑Reyes, S., Martinez‑Fierro, M. L., Melnikov, V., Guzmán‑Esquivel, J., Vaca‑Paniagua, F., Valdez‑Velazquez, L. L., Baltazar‑Rodriguez, L. M., Soriano‑Hernandez, A. D., Paz‑Michel, B., Espinoza‑Gómez, F."Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway". International Journal of Molecular Medicine 41, no. 4 (2018): 2263-2269. https://doi.org/10.3892/ijmm.2018.3395
Copy and paste a formatted citation
x
Spandidos Publications style
Delgado‑Enciso I, López‑Lemus UA, Valcarcel‑Gamiño JA, Rodriguez‑Sanchez IP, Valle‑Reyes S, Martinez‑Fierro ML, Melnikov V, Guzmán‑Esquivel J, Vaca‑Paniagua F, Valdez‑Velazquez LL, Valdez‑Velazquez LL, et al: Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway. Int J Mol Med 41: 2263-2269, 2018.
APA
Delgado‑Enciso, I., López‑Lemus, U.A., Valcarcel‑Gamiño, J.A., Rodriguez‑Sanchez, I.P., Valle‑Reyes, S., Martinez‑Fierro, M.L. ... Espinoza‑Gómez, F. (2018). Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway. International Journal of Molecular Medicine, 41, 2263-2269. https://doi.org/10.3892/ijmm.2018.3395
MLA
Delgado‑Enciso, I., López‑Lemus, U. A., Valcarcel‑Gamiño, J. A., Rodriguez‑Sanchez, I. P., Valle‑Reyes, S., Martinez‑Fierro, M. L., Melnikov, V., Guzmán‑Esquivel, J., Vaca‑Paniagua, F., Valdez‑Velazquez, L. L., Baltazar‑Rodriguez, L. M., Soriano‑Hernandez, A. D., Paz‑Michel, B., Espinoza‑Gómez, F."Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway". International Journal of Molecular Medicine 41.4 (2018): 2263-2269.
Chicago
Delgado‑Enciso, I., López‑Lemus, U. A., Valcarcel‑Gamiño, J. A., Rodriguez‑Sanchez, I. P., Valle‑Reyes, S., Martinez‑Fierro, M. L., Melnikov, V., Guzmán‑Esquivel, J., Vaca‑Paniagua, F., Valdez‑Velazquez, L. L., Baltazar‑Rodriguez, L. M., Soriano‑Hernandez, A. D., Paz‑Michel, B., Espinoza‑Gómez, F."Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway". International Journal of Molecular Medicine 41, no. 4 (2018): 2263-2269. https://doi.org/10.3892/ijmm.2018.3395
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