Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review)

  • Authors:
    • Maria Teresa Valenti
    • Luca Dalle Carbonare
    • Monica Mottes
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  • Published online on: February 1, 2018     https://doi.org/10.3892/ijmm.2018.3452
  • Pages: 2441-2449
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Abstract

MicroRNAs (miRNAs) are considered ‘micro- managers of gene expression’ and awareness of their fundamental role in the control of biological functions is constantly increasing. Bone formation and homeostasis are complex processes involving the differentiation and interaction of various cell types. Several miRNAs have been shown to be involved in different pathways and stages in the regulation of normal and abnormal bone formation and turnover. This present review focuses on the involvement of miRNAs in terms of their effect on the commitment of bone marrow mesenchymal stem cells towards osteogenesis, adipogenesis and chondrogenesis, respectively. The miRNAs involved in regulating osteoblast, chondroblast and osteoclast activity, are also taken into consideration, as are their interactions. miRNA expression levels, which may differ significantly in healthy versus pathological conditions, can be readily monitored and represent useful biomarkers. Several studies have suggested that miRNAs offer potential as useful biomarkers of bone pathologies, including osteoporosis and osteosarcoma. The development of efficient methods of delivering miRNA mimics or miRNA inhibitors into specific cells remains a challenge for novel therapeutic applications in the field of personalized medicine.
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May-2018
Volume 41 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Valenti M, Dalle Carbonare L and Mottes M: Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review). Int J Mol Med 41: 2441-2449, 2018
APA
Valenti, M., Dalle Carbonare, L., & Mottes, M. (2018). Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review). International Journal of Molecular Medicine, 41, 2441-2449. https://doi.org/10.3892/ijmm.2018.3452
MLA
Valenti, M., Dalle Carbonare, L., Mottes, M."Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review)". International Journal of Molecular Medicine 41.5 (2018): 2441-2449.
Chicago
Valenti, M., Dalle Carbonare, L., Mottes, M."Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review)". International Journal of Molecular Medicine 41, no. 5 (2018): 2441-2449. https://doi.org/10.3892/ijmm.2018.3452