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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2018 Volume 41 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review)

Maria Teresa Valenti, Luca Dalle Carbonare, Monica Mottes
Pages: 2441-2449
Published online on: 01 February 2018

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Article

Sphingosine kinase inhibitors: A patent review

Mengda Cao, Chunmei Ji, Yanjun Zhou, Wen Huang, Weiwei Ni, Xunliang Tong, Ji-Fu Wei
Pages: 2450-2460
Published online on: 20 February 2018

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Article Open Access

Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway

Xiaoyu Chai, Dan Sun, Qian Han, Liang Yi, Yanping Wu, Xinmin Liu
Pages: 2461-2472
Published online on: 06 February 2018

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Article Open Access

Antiproliferative effects of the CDK6 inhibitor PD0332991 and its effect on signaling networks in gastric cancer cells

Daguang Wang, Yabin Sun, Wei Li, Fei Ye, Yang Zhang, Yuchen Guo, David Y. Zhang, Jian Suo
Pages: 2473-2484
Published online on: 06 February 2018

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Article Open Access

Resveratrol protects against sodium nitroprusside induced nucleus pulposus cell apoptosis by scavenging ROS

Kang Li, Yan Li, Jie Mi, Lu Mao, Xiuguo Han, Jie Zhao
Pages: 2485-2492
Published online on: 06 February 2018

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Article Open Access

Stage‑dependent changes of β2‑adrenergic receptor signaling in right ventricular remodeling in monocrotaline‑induced pulmonary arterial hypertension

Fengjiao Sun, Zhiqiang Lu, Yidan Zhang, Shihan Geng, Mengxi Xu, Liman Xu, Yingying Huang, Pengwei Zhuang, Yanjun Zhang
Pages: 2493-2504
Published online on: 01 February 2018

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Article Open Access

Seawater inhalation induces acute lung injury via ROS generation and the endoplasmic reticulum stress pathway

Peng‑Cheng Li, Bo‑Rong Wang, Cong‑Cong Li, Xi Lu, Wei‑Sheng Qian, Yu‑Juan Li, Fa‑Guang Jin, De‑Guang Mu
Pages: 2505-2516
Published online on: 12 February 2018

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Article Open Access

Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells

Ling-Zhi Ding, Xiao Teng, Zhao-Bo Zhang, Chang-Jun Zheng, Shi-Hong Chen
Pages: 2517-2526
Published online on: 20 February 2018

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Article Open Access

Tracking of transplanted human umbilical cord-derived mesenchymal stem cells labeled with fluorescent probe in a mouse model of acute lung injury

Genglong Liu, Haijin Lv, Yuling An, Xuxia Wei, Xiaomeng Yi, Huimin Yi
Pages: 2527-2534
Published online on: 13 February 2018

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Article Open Access

AMP-activated protein kinase stimulates osteoblast differentiation and mineralization through autophagy induction

Yi Li, Jiajia Su, Wenchao Sun, Lin Cai, Zhouming Deng
Pages: 2535-2544
Published online on: 16 February 2018

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Article Open Access

Human umbilical cord mesenchymal stem cells inhibit proliferation of hepatic stellate cells in vitro

Li-Ting Zhang, Xue-Bin Peng, Xue-Qin Fang, Jun-Feng Li, Hong Chen, Xiao-Rong Mao
Pages: 2545-2552
Published online on: 16 February 2018

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Article Open Access

Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration

Weiheng Wang, Guoying Deng, Yuanyuan Qiu, Xiaodong Huang, Yanhai Xi, Jiangming Yu, Xiangqun Yang, Xiaojian Ye
Pages: 2553-2564
Published online on: 02 February 2018

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Article Open Access

Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia

Rui Chen, Jiehua Xu, Yanling She, Ting Jiang, Shanyao Zhou, Huacai Shi, Cheng Li
Pages: 2565-2572
Published online on: 06 February 2018

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Article Open Access

Inhibition of cell migration by focal adhesion kinase: Time-dependent difference in integrin-induced signaling between endothelial and hepatoblastoma cells

Hongchi Yu, Min Gao, Yunlong Ma, Lijuan Wang, Yang Shen, Xiaoheng Liu
Pages: 2573-2588
Published online on: 23 February 2018

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Article Open Access

Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177

Kou‑Gi  Shyu, Marappan  Velusamy, Chih‑Wei  Hsia, Chih‑Hao  Yang, Chih‑Hsuan  Hsia, Duen‑Suey  Chou, Thanasekaran  Jayakumar, Joen‑Rong  Sheu, Jiun‑Yi  Li
Pages: 2589-2600
Published online on: 07 February 2018

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Article Open Access

LicA induces autophagy through ULK1/Atg13 and ROS pathway in human hepatocellular carcinoma cells

Qiang Niu, Wei Zhao, Jin Wang, Chunming Li, Tao Yan, Wei Lv, Guojing Wang, Weihong Duan, Tao Zhang, Kunnan Wang, Dinghua Zhou
Pages: 2601-2608
Published online on: 16 February 2018

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Article Open Access

Decreased hyperpolarization-activated cyclic nucleotide-gated channels are involved in bladder dysfunction associated with spinal cord injury

Qian Liu, Chao Wu, Shengquan Huang, Qingjian Wu, Tao Zhou, Xiaobing Liu, Xin Liu, Xiaoyan Hu, Longkun Li
Pages: 2609-2618
Published online on: 13 February 2018

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Article Open Access

DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway

Li Cong, Shuting Yang, Yong Zhang, Jianguo Cao, Xiaohua Fu
Pages: 2619-2628
Published online on: 23 February 2018

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Article Open Access

Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment

Yuanmin Li, Jingping Liu, Guangneng Liao, Jie Zhang, Younan Chen, Lan Li, Li Li, Fang Liu, Bo Chen, Gang Guo, Chengshi Wang, Lichuan Yang, Jingqiu Cheng, Yangrong Lu
Pages: 2629-2639
Published online on: 16 February 2018

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Article Open Access

The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion

Binyu Luo, Kang Chen, Qi Feng, Weidong Xiao, Dan Ma, Hua Yang, Chaojun Zhang
Pages: 2640-2650
Published online on: 09 February 2018

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Article Open Access

Methylation-induced downregulation and tumor-suppressive role of microRNA-98 in glioma through targeting Sal-like protein 4 Retraction in /10.3892/ijmm.2021.4962

Zhiwei Xia, Dongxu Qiu, Jun Deng, Xiao Jiao, Ronghe Yang, Zhongyi Sun, Xin Wan, Jing Li
Pages: 2651-2659
Published online on: 06 February 2018

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Article Open Access

BCL6B suppresses proliferation and migration of colorectal carcinoma cells through inhibition of the PI3K/AKT signaling pathway

Yue Gu, Aifang Li, Hui Sun, Xueru Li, He Zha, Jiali Zhao, Jiaqing Xie, Zongyue Zeng, Lan Zhou
Pages: 2660-2668
Published online on: 01 February 2018

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Article Open Access

Protective effect of adenovirus-mediated erythropoietin expression on the spiral ganglion neurons in the rat inner ear

Cheng Zhong, Zhendong Jiang, Qiang Guo, Xueyuan Zhang
Pages: 2669-2677
Published online on: 05 February 2018

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Article Open Access

Iron limitation promotes the atrophy of skeletal myocytes, whereas iron supplementation prevents this process in the hypoxic conditions

Kamil Kobak, Monika Kasztura, Magdalena Dziegala, Jacek Bania, Violetta Kapuśniak, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska
Pages: 2678-2686
Published online on: 12 February 2018

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Article Open Access

Microenvironment‑driven resistance to B‑Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts

Ondřej Kodet, Barbora Dvořánková, Běla Bendlová, Vlasta Sýkorová, Ivana Krajsová, Jiří Štork, Jan Kučera, Pavol Szabo, Hynek Strnad, Michal Kolář, Čestmír Vlček, Karel Smetana, Lukáš Lacina
Pages: 2687-2703
Published online on: 01 February 2018

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Article Open Access

Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats

Li Ling, Zhen Tan, Changning Zhang, Shuyan Gui, Yuanyuan Hu, Libo Chen
Pages: 2704-2714
Published online on: 05 February 2018

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Article Open Access

Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition

Jin‑Lin Shang, Qing Cheng, Sheng‑Jie Duan, Lu Li, Li‑Ya Jia
Pages: 2715-2723
Published online on: 12 February 2018

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Article Open Access

Identification of novel hyper- or hypomethylated CpG sites and genes associated with atherosclerotic plaque using an epigenome-wide association study

Yoshiji Yamada, Hideki Horibe, Mitsutoshi Oguri, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Motoji Sawabe
Pages: 2724-2732
Published online on: 02 February 2018

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Article Open Access

microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects

Kaile Zhang, Jun Chen, Dongliang Zhang, Lin Wang, Weixin Zhao, David Yun-Te Lin, Rong Chen, Hong Xie, Xiaoyong Hu, Xiaolan Fang, Qiang Fu
Pages: 2733-2743
Published online on: 12 February 2018

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Article Open Access

Structural characterization, immune regulation and antioxidant activity of a new heteropolysaccharide from Cantharellus cibarius Fr.

Daqun Zhao, Xiang Ding, Yiling Hou, Wanru Hou, Lu Liu, Ting Xu, Danni Yang
Pages: 2744-2754
Published online on: 01 February 2018

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Article Open Access

LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling

Yan-Song Qiu, Ning-Ning Jiang, Yan Zhou, Kuai-Yun Yu, Hong-Yan Gong, Guang-Jun Liao
Pages: 2755-2763
Published online on: 08 February 2018

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Article Open Access

Experimental study on the neurotoxic effect of β-amyloid on the cytoskeleton of PC12 cells

Lai Wang, Jingjing Cao, Zhenyu Shi, Wenjuan Fan, Hongliang Liu, Jinbo Deng, Jiexin Deng
Pages: 2764-2770
Published online on: 07 February 2018

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Article Open Access

Amelioration of inflammatory responses by Socheongryong-Tang, a traditional herbal medicine, in RAW 264.7 cells and rats

Sang Mi Park, Tae Hoon Lee, Rongjie Zhao, Youn Sook Kim, Ji Yun Jung, Chung A. Park, Kyung Hwan Jegal, Sae Kwang Ku, Jae Kwang Kim, Chul Won Lee, Young Woo Kim, Il Je Cho, Won G. An, Sang Chan Kim
Pages: 2771-2783
Published online on: 06 February 2018

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Article Open Access

Sitagliptin ameliorates diabetic nephropathy by blocking TGF-β1/Smad signaling pathway

Dongdong Wang, Guanying Zhang, Xiao Chen, Tong Wei, Chenxu Liu, Chun Chen, Yinhan Gong, Qunli Wei
Pages: 2784-2792
Published online on: 16 February 2018

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Article Open Access

The antitumor activity screening of chemical constituents from Camellia nitidissima Chi

Xiaoying Hou, Hongzhi Du, Rui Yang, Jing Qi, Yue Huang, Shuyun Feng, Yao Wu, Sensen Lin, Zhixin Liu, Ai-Qun Jia, Shengtao Yuan, Li Sun
Pages: 2793-2801
Published online on: 16 February 2018

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Article Open Access

Rhein protects against cerebral ischemic‑/reperfusion‑induced oxidative stress and apoptosis in rats

Qipeng Zhao, Xiaobo Wang, Ailing Chen, Xiuli Cheng, Guoxin Zhang, Jianmin Sun, Yunsheng Zhao, Yu Huang, Yafei Zhu
Pages: 2802-2812
Published online on: 13 February 2018

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Article Open Access

Downregulated miR-23b-3p expression acts as a predictor of hepatocellular carcinoma progression: A study based on public data and RT-qPCR verification

Rong-Quan He, Pei-Rong Wu, Xue-Lian Xiang, Xia Yang, Hai-Wei Liang, Xiao-Hui Qiu, Li-Hua Yang, Zhi-Gang Peng, Gang Chen
Pages: 2813-2831
Published online on: 23 February 2018

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Article

The PI3K/Akt/FOXO3a pathway regulates regeneration following spinal cord injury in adult rats through TNF-α and p27kip1 expression

Honghui Lu, Li-Hai Zhang, Lin Yang, Pei-Fu Tang
Pages: 2832-2838
Published online on: 06 February 2018

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Article

17β-estradiol protects INS-1 insulinoma cells from mitophagy via G protein-coupled estrogen receptors and the PI3K/Akt signaling pathway

Liang Zhang, Yuyan Zhao, Lei Guo
Pages: 2839-2846
Published online on: 07 February 2018

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Article

L‑histidine augments the oxidative damage against Gram‑negative bacteria by hydrogen peroxide

Tamiko Nagao, Haruyuki Nakayama‑Imaohji, Miad Elahi, Ayano Tada, Emika Toyonaga, Hisashi Yamasaki, Katsuichiro Okazaki, Hirokazu Miyoshi, Koichiro Tsuchiya, Tomomi Kuwahara
Pages: 2847-2854
Published online on: 07 February 2018

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Article

α‑lipoic acid can greatly alleviate the toxic effect of AGES on SH‑SY5Y cells

Guifen Niu, Jianfei Guo, Yaqiang Tian, Kexiang Zhao, Jian Li, Qian Xiao
Pages: 2855-2864
Published online on: 08 February 2018

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Article

Ang-(1-7) protects HUVECs from high glucose-induced injury and inflammation via inhibition of the JAK2/STAT3 pathway

Jianfang Chen, Wei Zhang, Qing Xu, Jihua Zhang, Wei Chen, Zhengrong Xu, Chaosheng Li, Zhenhua Wang, Yao Zhang, Yulan Zhen, Jianqiang Feng, Jun Chen, Jingfu Chen
Pages: 2865-2878
Published online on: 22 February 2018

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Article

Zoledronate suppresses VEGF‑induced capillary tube formation and inhibits expression of interferon‑induced transmembrane protein‑1 in human umbilical vein endothelial cells

Beom Su Kim, Sun‑Sik  Yang, Cheol‑Sang  Kim, Jun  Lee
Pages: 2879-2884
Published online on: 16 February 2018

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Article

Changed immune and miRNA response in RAW264.7 cells infected with cell wall deficient mycobacterium tuberculosis

Zhengjun Yi, Kunshan Gao, Ruifang Li, Yurong Fu
Pages: 2885-2892
Published online on: 07 February 2018

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Article

Downregulation of secreted clusterin potentiates the lethality of sorafenib in hepatocellular carcinoma in association with the inhibition of ERK1/2 signals

Jingtao Zhong, Xiaoming Yu, Xiaofeng Dong, Hong Lu, Wuyuan Zhou, Lei Li, Zhongchao Li, Pengfei Sun, Xuetao Shi
Pages: 2893-2900
Published online on: 06 February 2018

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Article

Concomitant modulation of PTEN and Livin in gastric cancer treatment

Chun‑Lin Zhao, Sheng‑Na Han, Zhi‑Ju Wang, Shu‑Hui Wang, Guo‑Qiang Zhao, Xie‑Fu Zhang, Jia‑Xiang Wang
Pages: 2901-2908
Published online on: 08 February 2018

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Article

Cav 1.2 and Cav 2.2 expression is regulated by different endogenous ghrelin levels in pancreatic acinar cells during acute pancreatitis

Jie Zhou, Mengbin Qin, Huilin Wang, Jiaping He, Hongzong Fu, Huirong Shi, Zhihai Liang, Guodu Tang
Pages: 2909-2916
Published online on: 13 February 2018

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Article

BAG3 promotes the phenotypic transformation of primary rat vascular smooth muscle cells via TRAIL

Yao Fu, Ye Chang, Shuang Chen, Yuan Li, Yintao Chen, Guozhe Sun, Shasha Yu, Ning Ye, Chao Li, Yingxian Sun
Pages: 2917-2926
Published online on: 14 February 2018

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Article

Effect of placental sex hormone-binding globulin single nucleotide polymorphism rs6259 on protein and function in gestational diabetes mellitus

Xuan Zhang, Lei Sun, Zhen Jin
Pages: 2927-2934
Published online on: 16 February 2018

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Article

The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway

Yan Wang, Caifu Luan, Guili Zhang, Chengming Sun
Pages: 2935-2942
Published online on: 23 February 2018

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Article

The expression and activation of sex steroid receptors in the preeclamptic placenta

Mee‑Na Park, Kyung‑Hee Park, Jae‑Eon Lee, Ye Young Shin, Sung‑Min An, Seong Soo Kang, Wan‑Seob Cho, Beum‑Soo An, Seung Chul Kim
Pages: 2943-2951
Published online on: 08 February 2018

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Article

Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

Sarmila Nepali, Do‑Kuk Kim, Hoon‑Yeon Lee, Hyeon‑Hui Ki, Bo‑Ram Kim, Sung‑Woo Hwang, Min Park, Dae‑Ki Kim, Young‑Mi Lee
Pages: 2952-2960
Published online on: 16 February 2018

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Article

Interplay between the NF‑κB and hedgehog signaling pathways predicts prognosis in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy

Lingyun Wei, Nang Yan, Lei Sun, Chuanen Bao, Demin Li
Pages: 2961-2967
Published online on: 01 February 2018

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Article

The effects of TRAF6 on proliferation, apoptosis and invasion in osteosarcoma are regulated by miR-124

Qingbing Meng, Wensheng Zhang, Xingli Xu, Jian Li, Hongxin Mu, Xiaolan Liu, Ling Qin, Xiaoqi Zhu, Minqian Zheng
Pages: 2968-2976
Published online on: 05 February 2018

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Article

GLP‑1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF‑κB signaling pathways in streptozotocin‑induced diabetic rats

Jingjing Ma, Min Shi, Xiangcheng Zhang, Xiaoning Liu, Juan Chen, Ridong Zhang, Xingzhou Wang, Hong Zhang
Pages: 2977-2985
Published online on: 23 February 2018

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Article

Homeobox protein MSX1 inhibits the growth and metastasis of breast cancer cells and is frequently silenced by promoter methylation

Yujuan Yue, Ying Yuan, Lili Li, Jiangxia Fan, Chen Li, Weiyan Peng, Guosheng Ren
Pages: 2986-2996
Published online on: 07 February 2018

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Article

Mitochondrial protective mechanism of simvastatin protects against amyloid β peptide-induced injury in SH-SY5Y cells

Yunzi Li, Qian Liu, Jing Sun, Jin Wang, Xinfeng Liu, Jing Gao
Pages: 2997-3005
Published online on: 05 February 2018

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Article

Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study

Yanyun Li, Minjian Chen, Cuiping Liu, Yankai Xia, Bo Xu, Yanhui Hu, Ting Chen, Meiping Shen, Wei Tang
Pages: 3006-3014
Published online on: 16 February 2018

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Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats

Fang-Hua Qi, Ping-Ping Cai, Xiang Liu, Guo-Min Si
Pages: 3015-3023
Published online on: 12 February 2018

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Article

Fingerprint analysis and pharmacological evaluation of Ailanthus altissima

Qiaoyan He, Huimin Xiao, Jie Li, Yang Liu, Min Jia, Fang Wang, Ya Zhang, Wen Wang, Siwang Wang
Pages: 3024-3032
Published online on: 14 February 2018

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Article

Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation

Andrew Octavian Sasmita, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Rhun Yian Koh, Ying Pei Wong
Pages: 3033-3040
Published online on: 09 February 2018

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Article

UVB induces apoptosis via downregulation of CALML3-dependent JNK1/2 and ERK1/2 pathways in cataract

Yin Jia, Qin Qin, Chao‑Ping Fang, Wei Shen, Ting‑Ting Sun, Yuan‑Lan Huang, Wen‑Jie Li, An‑Mei Deng
Pages: 3041-3050
Published online on: 09 February 2018

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Article

Ferroptosis is associated with oxygen-glucose deprivation/reoxygenation-induced Sertoli cell death

Li Li, Yu Hao, Yu Zhao, Huijuan Wang, Xiujun Zhao, Yan Jiang, Fulu Gao
Pages: 3051-3062
Published online on: 07 February 2018

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Article

Exosomes derived from human umbilical cord mesenchymal stem cells improve myocardial repair via upregulation of Smad7

Xin‑Long Wang, Yuan‑Yuan Zhao, Li Sun, Yu Shi, Zhu‑Qian Li, Xiang‑Dong Zhao, Chang‑Gen Xu, Hong‑Ge Ji, Mei Wang, Wen‑Rong Xu, Wei Zhu
Pages: 3063-3072
Published online on: 16 February 2018

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Article

Black rice (Oryza sativa L.) extract modulates ultraviolet-induced expression of matrix metalloproteinases and procollagen in a skin cell model

Mira Han, Jung‑Soo Bae, Jae‑Jun Ban, Hee Soon Shin, Dong Hun Lee, Jin Ho Chung
Pages: 3073-3080
Published online on: 22 February 2018

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Article

RP105 protects PC12 cells from oxygen‑glucose deprivation/reoxygenation injury via activation of the PI3K/AKT signaling pathway

Yanpeng Sun, Lu Liu, Jiang Yuan, Qiang Sun, Na Wang, Yunfu Wang
Pages: 3081-3089
Published online on: 12 February 2018

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Article

Anti‑apoptotic effects of glycosaminoglycans via inhibition of ERK/AP‑1 signaling in TNF‑α‑stimulated human dermal fibroblasts

Jungtae Na, Dong‑Ho Bak, Song I Im, Hyangtae Choi, Jung Hyun Hwang, Su Yeon Kong, Yeon A No, Yonghee Lee, Beom Joon Kim
Pages: 3090-3098
Published online on: 12 February 2018

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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