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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2018 Volume 41 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review)

Maria Teresa Valenti, Luca Dalle Carbonare, Monica Mottes
Pages: 2441-2449
Published online on: 01 February 2018

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Article

Sphingosine kinase inhibitors: A patent review

Mengda Cao, Chunmei Ji, Yanjun Zhou, Wen Huang, Weiwei Ni, Xunliang Tong, Ji-Fu Wei
Pages: 2450-2460
Published online on: 20 February 2018

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Article Open Access

Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway

Xiaoyu Chai, Dan Sun, Qian Han, Liang Yi, Yanping Wu, Xinmin Liu
Pages: 2461-2472
Published online on: 06 February 2018

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Article Open Access

Antiproliferative effects of the CDK6 inhibitor PD0332991 and its effect on signaling networks in gastric cancer cells

Daguang Wang, Yabin Sun, Wei Li, Fei Ye, Yang Zhang, Yuchen Guo, David Y. Zhang, Jian Suo
Pages: 2473-2484
Published online on: 06 February 2018

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Article Open Access

Resveratrol protects against sodium nitroprusside induced nucleus pulposus cell apoptosis by scavenging ROS

Kang Li, Yan Li, Jie Mi, Lu Mao, Xiuguo Han, Jie Zhao
Pages: 2485-2492
Published online on: 06 February 2018

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Article Open Access

Stage‑dependent changes of β2‑adrenergic receptor signaling in right ventricular remodeling in monocrotaline‑induced pulmonary arterial hypertension

Fengjiao Sun, Zhiqiang Lu, Yidan Zhang, Shihan Geng, Mengxi Xu, Liman Xu, Yingying Huang, Pengwei Zhuang, Yanjun Zhang
Pages: 2493-2504
Published online on: 01 February 2018

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Article Open Access

Seawater inhalation induces acute lung injury via ROS generation and the endoplasmic reticulum stress pathway

Peng‑Cheng Li, Bo‑Rong Wang, Cong‑Cong Li, Xi Lu, Wei‑Sheng Qian, Yu‑Juan Li, Fa‑Guang Jin, De‑Guang Mu
Pages: 2505-2516
Published online on: 12 February 2018

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Article Open Access

Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells

Ling-Zhi Ding, Xiao Teng, Zhao-Bo Zhang, Chang-Jun Zheng, Shi-Hong Chen
Pages: 2517-2526
Published online on: 20 February 2018

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Article Open Access

Tracking of transplanted human umbilical cord-derived mesenchymal stem cells labeled with fluorescent probe in a mouse model of acute lung injury

Genglong Liu, Haijin Lv, Yuling An, Xuxia Wei, Xiaomeng Yi, Huimin Yi
Pages: 2527-2534
Published online on: 13 February 2018

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Article Open Access

AMP-activated protein kinase stimulates osteoblast differentiation and mineralization through autophagy induction

Yi Li, Jiajia Su, Wenchao Sun, Lin Cai, Zhouming Deng
Pages: 2535-2544
Published online on: 16 February 2018

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Article Open Access

Human umbilical cord mesenchymal stem cells inhibit proliferation of hepatic stellate cells in vitro

Li-Ting Zhang, Xue-Bin Peng, Xue-Qin Fang, Jun-Feng Li, Hong Chen, Xiao-Rong Mao
Pages: 2545-2552
Published online on: 16 February 2018

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Article Open Access

Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration

Weiheng Wang, Guoying Deng, Yuanyuan Qiu, Xiaodong Huang, Yanhai Xi, Jiangming Yu, Xiangqun Yang, Xiaojian Ye
Pages: 2553-2564
Published online on: 02 February 2018

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Article Open Access

Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia

Rui Chen, Jiehua Xu, Yanling She, Ting Jiang, Shanyao Zhou, Huacai Shi, Cheng Li
Pages: 2565-2572
Published online on: 06 February 2018

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Article Open Access

Inhibition of cell migration by focal adhesion kinase: Time-dependent difference in integrin-induced signaling between endothelial and hepatoblastoma cells

Hongchi Yu, Min Gao, Yunlong Ma, Lijuan Wang, Yang Shen, Xiaoheng Liu
Pages: 2573-2588
Published online on: 23 February 2018

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Article Open Access

Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177

Kou‑Gi  Shyu, Marappan  Velusamy, Chih‑Wei  Hsia, Chih‑Hao  Yang, Chih‑Hsuan  Hsia, Duen‑Suey  Chou, Thanasekaran  Jayakumar, Joen‑Rong  Sheu, Jiun‑Yi  Li
Pages: 2589-2600
Published online on: 07 February 2018

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Article Open Access

LicA induces autophagy through ULK1/Atg13 and ROS pathway in human hepatocellular carcinoma cells

Qiang Niu, Wei Zhao, Jin Wang, Chunming Li, Tao Yan, Wei Lv, Guojing Wang, Weihong Duan, Tao Zhang, Kunnan Wang, Dinghua Zhou
Pages: 2601-2608
Published online on: 16 February 2018

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Article Open Access

Decreased hyperpolarization-activated cyclic nucleotide-gated channels are involved in bladder dysfunction associated with spinal cord injury

Qian Liu, Chao Wu, Shengquan Huang, Qingjian Wu, Tao Zhou, Xiaobing Liu, Xin Liu, Xiaoyan Hu, Longkun Li
Pages: 2609-2618
Published online on: 13 February 2018

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Article Open Access

DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway

Li Cong, Shuting Yang, Yong Zhang, Jianguo Cao, Xiaohua Fu
Pages: 2619-2628
Published online on: 23 February 2018

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Article Open Access

Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment

Yuanmin Li, Jingping Liu, Guangneng Liao, Jie Zhang, Younan Chen, Lan Li, Li Li, Fang Liu, Bo Chen, Gang Guo, Chengshi Wang, Lichuan Yang, Jingqiu Cheng, Yangrong Lu
Pages: 2629-2639
Published online on: 16 February 2018

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Article Open Access

The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion

Binyu Luo, Kang Chen, Qi Feng, Weidong Xiao, Dan Ma, Hua Yang, Chaojun Zhang
Pages: 2640-2650
Published online on: 09 February 2018

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Article Open Access

Methylation-induced downregulation and tumor-suppressive role of microRNA-98 in glioma through targeting Sal-like protein 4 Retraction in /10.3892/ijmm.2021.4962

Zhiwei Xia, Dongxu Qiu, Jun Deng, Xiao Jiao, Ronghe Yang, Zhongyi Sun, Xin Wan, Jing Li
Pages: 2651-2659
Published online on: 06 February 2018

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Article Open Access

BCL6B suppresses proliferation and migration of colorectal carcinoma cells through inhibition of the PI3K/AKT signaling pathway

Yue Gu, Aifang Li, Hui Sun, Xueru Li, He Zha, Jiali Zhao, Jiaqing Xie, Zongyue Zeng, Lan Zhou
Pages: 2660-2668
Published online on: 01 February 2018

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Article Open Access

Protective effect of adenovirus-mediated erythropoietin expression on the spiral ganglion neurons in the rat inner ear

Cheng Zhong, Zhendong Jiang, Qiang Guo, Xueyuan Zhang
Pages: 2669-2677
Published online on: 05 February 2018

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Article Open Access

Iron limitation promotes the atrophy of skeletal myocytes, whereas iron supplementation prevents this process in the hypoxic conditions

Kamil Kobak, Monika Kasztura, Magdalena Dziegala, Jacek Bania, Violetta Kapuśniak, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska
Pages: 2678-2686
Published online on: 12 February 2018

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Article Open Access

Microenvironment‑driven resistance to B‑Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts

Ondřej Kodet, Barbora Dvořánková, Běla Bendlová, Vlasta Sýkorová, Ivana Krajsová, Jiří Štork, Jan Kučera, Pavol Szabo, Hynek Strnad, Michal Kolář, Čestmír Vlček, Karel Smetana, Lukáš Lacina
Pages: 2687-2703
Published online on: 01 February 2018

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Article Open Access

Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats

Li Ling, Zhen Tan, Changning Zhang, Shuyan Gui, Yuanyuan Hu, Libo Chen
Pages: 2704-2714
Published online on: 05 February 2018

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Article Open Access

Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition

Jin‑Lin Shang, Qing Cheng, Sheng‑Jie Duan, Lu Li, Li‑Ya Jia
Pages: 2715-2723
Published online on: 12 February 2018

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Article Open Access

Identification of novel hyper- or hypomethylated CpG sites and genes associated with atherosclerotic plaque using an epigenome-wide association study

Yoshiji Yamada, Hideki Horibe, Mitsutoshi Oguri, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Motoji Sawabe
Pages: 2724-2732
Published online on: 02 February 2018

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Article Open Access

microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects

Kaile Zhang, Jun Chen, Dongliang Zhang, Lin Wang, Weixin Zhao, David Yun-Te Lin, Rong Chen, Hong Xie, Xiaoyong Hu, Xiaolan Fang, Qiang Fu
Pages: 2733-2743
Published online on: 12 February 2018

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Article Open Access

Structural characterization, immune regulation and antioxidant activity of a new heteropolysaccharide from Cantharellus cibarius Fr.

Daqun Zhao, Xiang Ding, Yiling Hou, Wanru Hou, Lu Liu, Ting Xu, Danni Yang
Pages: 2744-2754
Published online on: 01 February 2018

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Article Open Access

LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling

Yan-Song Qiu, Ning-Ning Jiang, Yan Zhou, Kuai-Yun Yu, Hong-Yan Gong, Guang-Jun Liao
Pages: 2755-2763
Published online on: 08 February 2018

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Article Open Access

Experimental study on the neurotoxic effect of β-amyloid on the cytoskeleton of PC12 cells

Lai Wang, Jingjing Cao, Zhenyu Shi, Wenjuan Fan, Hongliang Liu, Jinbo Deng, Jiexin Deng
Pages: 2764-2770
Published online on: 07 February 2018

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Article Open Access

Amelioration of inflammatory responses by Socheongryong-Tang, a traditional herbal medicine, in RAW 264.7 cells and rats

Sang Mi Park, Tae Hoon Lee, Rongjie Zhao, Youn Sook Kim, Ji Yun Jung, Chung A. Park, Kyung Hwan Jegal, Sae Kwang Ku, Jae Kwang Kim, Chul Won Lee, Young Woo Kim, Il Je Cho, Won G. An, Sang Chan Kim
Pages: 2771-2783
Published online on: 06 February 2018

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Article Open Access

Sitagliptin ameliorates diabetic nephropathy by blocking TGF-β1/Smad signaling pathway

Dongdong Wang, Guanying Zhang, Xiao Chen, Tong Wei, Chenxu Liu, Chun Chen, Yinhan Gong, Qunli Wei
Pages: 2784-2792
Published online on: 16 February 2018

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Article Open Access

The antitumor activity screening of chemical constituents from Camellia nitidissima Chi

Xiaoying Hou, Hongzhi Du, Rui Yang, Jing Qi, Yue Huang, Shuyun Feng, Yao Wu, Sensen Lin, Zhixin Liu, Ai-Qun Jia, Shengtao Yuan, Li Sun
Pages: 2793-2801
Published online on: 16 February 2018

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Article Open Access

Rhein protects against cerebral ischemic‑/reperfusion‑induced oxidative stress and apoptosis in rats

Qipeng Zhao, Xiaobo Wang, Ailing Chen, Xiuli Cheng, Guoxin Zhang, Jianmin Sun, Yunsheng Zhao, Yu Huang, Yafei Zhu
Pages: 2802-2812
Published online on: 13 February 2018

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Article Open Access

Downregulated miR-23b-3p expression acts as a predictor of hepatocellular carcinoma progression: A study based on public data and RT-qPCR verification

Rong-Quan He, Pei-Rong Wu, Xue-Lian Xiang, Xia Yang, Hai-Wei Liang, Xiao-Hui Qiu, Li-Hua Yang, Zhi-Gang Peng, Gang Chen
Pages: 2813-2831
Published online on: 23 February 2018

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Article

The PI3K/Akt/FOXO3a pathway regulates regeneration following spinal cord injury in adult rats through TNF-α and p27kip1 expression

Honghui Lu, Li-Hai Zhang, Lin Yang, Pei-Fu Tang
Pages: 2832-2838
Published online on: 06 February 2018

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Article

17β-estradiol protects INS-1 insulinoma cells from mitophagy via G protein-coupled estrogen receptors and the PI3K/Akt signaling pathway

Liang Zhang, Yuyan Zhao, Lei Guo
Pages: 2839-2846
Published online on: 07 February 2018

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Article

L‑histidine augments the oxidative damage against Gram‑negative bacteria by hydrogen peroxide

Tamiko Nagao, Haruyuki Nakayama‑Imaohji, Miad Elahi, Ayano Tada, Emika Toyonaga, Hisashi Yamasaki, Katsuichiro Okazaki, Hirokazu Miyoshi, Koichiro Tsuchiya, Tomomi Kuwahara
Pages: 2847-2854
Published online on: 07 February 2018

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Article

α‑lipoic acid can greatly alleviate the toxic effect of AGES on SH‑SY5Y cells

Guifen Niu, Jianfei Guo, Yaqiang Tian, Kexiang Zhao, Jian Li, Qian Xiao
Pages: 2855-2864
Published online on: 08 February 2018

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Article

Ang-(1-7) protects HUVECs from high glucose-induced injury and inflammation via inhibition of the JAK2/STAT3 pathway

Jianfang Chen, Wei Zhang, Qing Xu, Jihua Zhang, Wei Chen, Zhengrong Xu, Chaosheng Li, Zhenhua Wang, Yao Zhang, Yulan Zhen, Jianqiang Feng, Jun Chen, Jingfu Chen
Pages: 2865-2878
Published online on: 22 February 2018

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Article

Zoledronate suppresses VEGF‑induced capillary tube formation and inhibits expression of interferon‑induced transmembrane protein‑1 in human umbilical vein endothelial cells

Beom Su Kim, Sun‑Sik  Yang, Cheol‑Sang  Kim, Jun  Lee
Pages: 2879-2884
Published online on: 16 February 2018

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Article

Changed immune and miRNA response in RAW264.7 cells infected with cell wall deficient mycobacterium tuberculosis

Zhengjun Yi, Kunshan Gao, Ruifang Li, Yurong Fu
Pages: 2885-2892
Published online on: 07 February 2018

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Article

Downregulation of secreted clusterin potentiates the lethality of sorafenib in hepatocellular carcinoma in association with the inhibition of ERK1/2 signals

Jingtao Zhong, Xiaoming Yu, Xiaofeng Dong, Hong Lu, Wuyuan Zhou, Lei Li, Zhongchao Li, Pengfei Sun, Xuetao Shi
Pages: 2893-2900
Published online on: 06 February 2018

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Article

Concomitant modulation of PTEN and Livin in gastric cancer treatment

Chun‑Lin Zhao, Sheng‑Na Han, Zhi‑Ju Wang, Shu‑Hui Wang, Guo‑Qiang Zhao, Xie‑Fu Zhang, Jia‑Xiang Wang
Pages: 2901-2908
Published online on: 08 February 2018

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Article

Cav 1.2 and Cav 2.2 expression is regulated by different endogenous ghrelin levels in pancreatic acinar cells during acute pancreatitis

Jie Zhou, Mengbin Qin, Huilin Wang, Jiaping He, Hongzong Fu, Huirong Shi, Zhihai Liang, Guodu Tang
Pages: 2909-2916
Published online on: 13 February 2018

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Article

BAG3 promotes the phenotypic transformation of primary rat vascular smooth muscle cells via TRAIL

Yao Fu, Ye Chang, Shuang Chen, Yuan Li, Yintao Chen, Guozhe Sun, Shasha Yu, Ning Ye, Chao Li, Yingxian Sun
Pages: 2917-2926
Published online on: 14 February 2018

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Article

Effect of placental sex hormone-binding globulin single nucleotide polymorphism rs6259 on protein and function in gestational diabetes mellitus

Xuan Zhang, Lei Sun, Zhen Jin
Pages: 2927-2934
Published online on: 16 February 2018

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Article

The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway

Yan Wang, Caifu Luan, Guili Zhang, Chengming Sun
Pages: 2935-2942
Published online on: 23 February 2018

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Article

The expression and activation of sex steroid receptors in the preeclamptic placenta

Mee‑Na Park, Kyung‑Hee Park, Jae‑Eon Lee, Ye Young Shin, Sung‑Min An, Seong Soo Kang, Wan‑Seob Cho, Beum‑Soo An, Seung Chul Kim
Pages: 2943-2951
Published online on: 08 February 2018

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Article

Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

Sarmila Nepali, Do‑Kuk Kim, Hoon‑Yeon Lee, Hyeon‑Hui Ki, Bo‑Ram Kim, Sung‑Woo Hwang, Min Park, Dae‑Ki Kim, Young‑Mi Lee
Pages: 2952-2960
Published online on: 16 February 2018

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Article

Interplay between the NF‑κB and hedgehog signaling pathways predicts prognosis in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy

Lingyun Wei, Nang Yan, Lei Sun, Chuanen Bao, Demin Li
Pages: 2961-2967
Published online on: 01 February 2018

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Article

The effects of TRAF6 on proliferation, apoptosis and invasion in osteosarcoma are regulated by miR-124

Qingbing Meng, Wensheng Zhang, Xingli Xu, Jian Li, Hongxin Mu, Xiaolan Liu, Ling Qin, Xiaoqi Zhu, Minqian Zheng
Pages: 2968-2976
Published online on: 05 February 2018

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Article

GLP‑1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF‑κB signaling pathways in streptozotocin‑induced diabetic rats

Jingjing Ma, Min Shi, Xiangcheng Zhang, Xiaoning Liu, Juan Chen, Ridong Zhang, Xingzhou Wang, Hong Zhang
Pages: 2977-2985
Published online on: 23 February 2018

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Article

Homeobox protein MSX1 inhibits the growth and metastasis of breast cancer cells and is frequently silenced by promoter methylation

Yujuan Yue, Ying Yuan, Lili Li, Jiangxia Fan, Chen Li, Weiyan Peng, Guosheng Ren
Pages: 2986-2996
Published online on: 07 February 2018

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Article

Mitochondrial protective mechanism of simvastatin protects against amyloid β peptide-induced injury in SH-SY5Y cells

Yunzi Li, Qian Liu, Jing Sun, Jin Wang, Xinfeng Liu, Jing Gao
Pages: 2997-3005
Published online on: 05 February 2018

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Article

Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study

Yanyun Li, Minjian Chen, Cuiping Liu, Yankai Xia, Bo Xu, Yanhui Hu, Ting Chen, Meiping Shen, Wei Tang
Pages: 3006-3014
Published online on: 16 February 2018

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Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats

Fang-Hua Qi, Ping-Ping Cai, Xiang Liu, Guo-Min Si
Pages: 3015-3023
Published online on: 12 February 2018

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Fingerprint analysis and pharmacological evaluation of Ailanthus altissima

Qiaoyan He, Huimin Xiao, Jie Li, Yang Liu, Min Jia, Fang Wang, Ya Zhang, Wen Wang, Siwang Wang
Pages: 3024-3032
Published online on: 14 February 2018

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Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation

Andrew Octavian Sasmita, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Rhun Yian Koh, Ying Pei Wong
Pages: 3033-3040
Published online on: 09 February 2018

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Article

UVB induces apoptosis via downregulation of CALML3-dependent JNK1/2 and ERK1/2 pathways in cataract

Yin Jia, Qin Qin, Chao‑Ping Fang, Wei Shen, Ting‑Ting Sun, Yuan‑Lan Huang, Wen‑Jie Li, An‑Mei Deng
Pages: 3041-3050
Published online on: 09 February 2018

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Article

Ferroptosis is associated with oxygen-glucose deprivation/reoxygenation-induced Sertoli cell death

Li Li, Yu Hao, Yu Zhao, Huijuan Wang, Xiujun Zhao, Yan Jiang, Fulu Gao
Pages: 3051-3062
Published online on: 07 February 2018

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Article

Exosomes derived from human umbilical cord mesenchymal stem cells improve myocardial repair via upregulation of Smad7

Xin‑Long Wang, Yuan‑Yuan Zhao, Li Sun, Yu Shi, Zhu‑Qian Li, Xiang‑Dong Zhao, Chang‑Gen Xu, Hong‑Ge Ji, Mei Wang, Wen‑Rong Xu, Wei Zhu
Pages: 3063-3072
Published online on: 16 February 2018

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Article

Black rice (Oryza sativa L.) extract modulates ultraviolet-induced expression of matrix metalloproteinases and procollagen in a skin cell model

Mira Han, Jung‑Soo Bae, Jae‑Jun Ban, Hee Soon Shin, Dong Hun Lee, Jin Ho Chung
Pages: 3073-3080
Published online on: 22 February 2018

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Article

RP105 protects PC12 cells from oxygen‑glucose deprivation/reoxygenation injury via activation of the PI3K/AKT signaling pathway

Yanpeng Sun, Lu Liu, Jiang Yuan, Qiang Sun, Na Wang, Yunfu Wang
Pages: 3081-3089
Published online on: 12 February 2018

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Article

Anti‑apoptotic effects of glycosaminoglycans via inhibition of ERK/AP‑1 signaling in TNF‑α‑stimulated human dermal fibroblasts

Jungtae Na, Dong‑Ho Bak, Song I Im, Hyangtae Choi, Jung Hyun Hwang, Su Yeon Kong, Yeon A No, Yonghee Lee, Beom Joon Kim
Pages: 3090-3098
Published online on: 12 February 2018

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review)

Yanqin Fan, Hongtu Hu, Jing Cheng
Article Number: 202
Published online on: 27 May 2026

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Retraction Open Access

[Retracted] BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury

Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Article Number: 201
Published online on: 25 May 2026

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Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 200
Published online on: 22 May 2026

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Article Open Access

Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome

Jinghui Zhai, Yueming Zhang, Jiawei Gong, Li Fu, Sixi Zhang
Article Number: 199
Published online on: 22 May 2026

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Article Open Access

Identification of diagnostic markers for diabetic kidney disease by weighted gene co‑expression network analysis and machine learning

Qiming Xu, Chunjing Xu, Ziyang Liu, Jianrao Lu, Jing Hu, Lin Liao
Article Number: 198
Published online on: 21 May 2026

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Article Open Access

CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats

Tianzhu Liu, Longqing Zhang, Wei Mei
Article Number: 197
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis

Zhaorui Sun, Cong Wang, Chaowen Shi, Fangfang Sun, Xiaomeng Xu, Weiping Qian, Shinan Nie, Xiaodong Han
Article Number: 196
Published online on: 20 May 2026

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Article Open Access

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice

Xin Jin, Xuan Liu, Yun-Juan Wang, Zi-Li Lei, Yan-Hong Yang
Article Number: 195
Published online on: 20 May 2026

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Article Open Access

Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment

Shi-Na Song, Jun-Ying Wu, Mao-Mei Song, Xiao-Feng Li, Jian-Ming Wang, Wen-Hui Jia, Chang-Xin Li, Sui-Yi Xu
Article Number: 194
Published online on: 19 May 2026

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Review Open Access

Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review)

Sen Chen, Xiaofei Cui
Article Number: 193
Published online on: 19 May 2026

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Review Open Access

Unraveling the molecular landscape of chronic radiation injury: From oxidative stress signaling to translational modeling (Review)

Zhenjun Xi, Xiaodong Li, Chunhui Yang, Li Wang, Jingxin Mao, Qianqian Liu, Chang Liu, Qian Li, Yuanfang Hou, Jie Wan, Chengzhuo Yang, Feiji Sun, Chao Yu, Miao Wang, Baocheng Yuan, Yongsheng Liu, Qing Hu, Li Zhang, Xuemei Li, Xiaobing Li
Article Number: 192
Published online on: 19 May 2026

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Retraction Open Access

[Retracted] Cocktail therapy with a combination of interferon, ribavirin and angiotensin‑II type 1 receptor blocker attenuates murine liver fibrosis development

Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Kosuke Kaji, Yosuke Aihara, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Hiroshi Fukui
Article Number: 191
Published online on: 18 May 2026

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Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)

Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu
Article Number: 190
Published online on: 14 May 2026

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Review Open Access

Primary cilia dysfunction: A critical driver of metabolic diseases (Review)

Xiaojing Wang, Yi Jin, Kejia Xie, Pengfei Yao, Liguo Song, Hongdan Liu, Yanjie Tan
Article Number: 189
Published online on: 14 May 2026

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Review Open Access

Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review)

Xigang Ma, Yongsen Zhao
Article Number: 188
Published online on: 14 May 2026

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Article Open Access

Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway

Yiwei Zhao, Zechao Qu, Lin Liu, Yong Zhang, Xiaohao Wang, Bo Zhang, Yining Gong, Liang Yan
Article Number: 187
Published online on: 13 May 2026

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Correction Open Access

[Corrigendum] Induction of cardiomyocyte‑like cells from hair follicle cells in mice

Yong-Hee Kim, Bang-Jin Kim, Seok-Man Kim, Sun-Uk Kim, Buom-Yong Ryu
Article Number: 186
Published online on: 13 May 2026

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Review Open Access

Spatial hepatology: Decoding liver zonation for metabolic and regenerative therapeutics (Review)

Guiqing Chen, Hongyan Jia, Kai Zhao, Chang Gao, Yue Liu, Hong Zhu, Dakai Yang, Yun Cai
Article Number: 185
Published online on: 13 May 2026

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Article Open Access

Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms

Hui Fang, Min Shu, Jiaju Wang, Heng Tian, Jianguo Zhang, Ying Hu, He Li, Huan Zhou, Kangsheng Gu, Zhenhua Ren
Article Number: 184
Published online on: 12 May 2026

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Review Open Access

Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review)

Chengyi Ming, Ni Zhu, You Yu, Hong Zhou, Meichun Hu
Article Number: 183
Published online on: 12 May 2026

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Review Open Access

Rab27: Molecular switch of tumor exosome secretion (Review)

Mengtian Tang, Zhongjian Zhu, Huaxin Duan, Shiming Tan, Mengzhou Shen, Xianjie Jiang, Qiu Peng, Linda Oyang, Zongyao Ren, Yujuan Zhou, Qianjin Liao
Article Number: 182
Published online on: 12 May 2026

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Article Open Access

IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia

Meng-Xin Zhang, Jing-Feng Tang, Mei Hong, Ying Yang, Yun Zhou, Shui-Qing Chi, Li-Ying Rong, Guo-Qing Cao, Xi Zhang, Jin-Xiang Zhang, Shao-Tao Tang
Article Number: 181
Published online on: 11 May 2026

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Article Open Access

CircRAD18 promotes glioblastoma proliferation, migration and invasion via the miR‑1231/LUC7L2 axis

Lumeng Song, Ping Xiong, Amu Jike, Xiaochao Xia, Lifang Mao, Zihao Wang, Yinchuan Cheng, Shumin Wang, Shizheng Tan, Dongnan Yu, Zheng Li, Xiaoping Tang, Shun Li
Article Number: 180
Published online on: 11 May 2026

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Correction Open Access

[Corrigendum] Expression of FKBP52 in the ovaries of PCOS rats

Shiyan Song, Yong Tan
Article Number: 179
Published online on: 11 May 2026

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Article Open Access

miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis

Xiaoyu Wang, Lin Song, Jiafeng Wang, Qianqian Xie, Yan Wang, Chunyan Li, Tianqi Wang, Yifeng Du
Article Number: 178
Published online on: 08 May 2026

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Review Open Access

Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review)

Siyuan Zhou, Yurong Jiang, Jixu Fan, Minjie Guo, Yi Wen, Chunhua Dai
Article Number: 177
Published online on: 08 May 2026

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Review Open Access

Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review)

Xiwei Wang, Shuang Li, Xiaotian Ge, Tao Xie, Sainan Li, Ruiqi Yuan, Tianxi Li, Hui Yuan
Article Number: 176
Published online on: 06 May 2026

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Expression of Concern Open Access

[Expression of Concern] ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple‑negative breast cancer cells

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Article Number: 175
Published online on: 06 May 2026

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Review Open Access

Phosphorylation beyond the plasma membrane: How secretory pathway kinases sculpt the cellular dialogue in cancer (Review)

Ziang Geng, Shu Guan, Shaoqi Du, Shuo Zhang, Jiaxin Hao, Siyuan Tian, Chen Zhu, Shaonan Du
Article Number: 174
Published online on: 06 May 2026

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Review Open Access

Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review)

Wenhui Gu, Haifeng Zhang, Lisha Ye, Fangming Liu, Ting Xu, Yinxian Yu, Guohua Wang
Article Number: 173
Published online on: 05 May 2026

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Retraction Open Access

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
Article Number: 172
Published online on: 04 May 2026

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Article Open Access

Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Article Open Access

Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Article Open Access

Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Review Open Access

Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Review Open Access

Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Review Open Access

Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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